, 11 Department of Nephrology and Internal Medicine, Valenciennes General Hospital, Valenciennes, France. 12 Department of Nephrology, Duchenne Hospital, Maladies Systémiques et Auto-immunes Rares (Sclérodermie Systémique)

J. C. Jennette, R. J. Falk, P. A. Bacon, N. Basu, M. C. Cid et al., 2012 revised international Chapel Hill consensus conference nomenclature of Vasculitides, Arthritis Rheum, vol.65, pp.1-11, 2013.

L. Guillevin, B. Durand-gasselin, R. Cevallos, M. Gayraud, F. Lhote et al., Microscopic polyangiitis: clinical and laboratory findings in eighty-five patients, Arthritis Rheum, vol.42, pp.421-451, 1999.

L. Harper and C. O. Savage, ANCA-associated renal vasculitis at the end of the twentieth century--a disease of older patients, Rheumatology (Oxford), vol.44, pp.495-501, 2005.

R. A. Watts, S. E. Lane, G. Bentham, and D. G. Scott, Epidemiology of systemic vasculitis: a ten-year study in the United Kingdom, Arthritis Rheum, vol.43, pp.414-423, 2000.

C. F. Franssen, C. A. Stegeman, C. G. Kallenberg, R. O. Gans, D. Jong et al., Antiproteinase 3-and antimyeloperoxidase-associated vasculitis, Kidney Int, vol.57, pp.2195-206, 2000.

O. Flossmann, A. Berden, K. De-groot, C. Hagen, L. Harper et al., Long-term patient survival in ANCA-associated vasculitis, Ann Rheum Dis, vol.70, pp.488-94, 2011.

M. A. Little, P. Nightingale, C. A. Verburgh, T. Hauser, D. Groot et al., Early mortality in systemic vasculitis: relative contribution of adverse events and active vasculitis, Ann Rheum Dis, vol.69, pp.1036-1079, 2010.

M. E. Charlson, P. Pompei, K. L. Ales, and C. R. Mackenzie, A new method of classifying prognostic comorbidity in longitudinal studies: development and validation, J Chronic Dis, vol.40, pp.373-83, 1987.

L. Guillevin, C. Pagnoux, R. Seror, A. Mahr, L. Mouthon et al., The five-factor score revisited: assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitis study group (FVSG) cohort, Medicine (Baltimore), vol.90, pp.19-27, 2011.

A. E. Berden, F. Ferrario, E. C. Hagen, D. R. Jayne, J. C. Jennette et al., Histopathologic classification of ANCA-associated glomerulonephritis, J Am Soc Nephrol, vol.21, pp.1628-1664, 2010.

A. Aboua, M. Eb, G. Rey, G. Pavillon, and E. Jougla, Mortality data in France, the main causes of death in 2008 and trends since, BEH, vol.22, pp.249-55, 2000.

M. Chen, F. Yu, Y. Zhang, and M. H. Zhao, Antineutrophil cytoplasmic autoantibodyassociated vasculitis in older patients, Medicine (Baltimore), vol.87, pp.203-212, 2008.

T. Lee, A. Gasim, V. K. Derebail, Y. Chung, J. G. Mcgregor et al., Predictors of treatment outcomes in ANCA-associated vasculitis with severe kidney failure, Clin J Am Soc Nephrol, vol.9, pp.905-918, 2014.

M. Walsh, O. Flossmann, A. Berden, K. Westman, P. Höglund et al., Risk factors for relapse of antineutrophil cytoplasmic antibodyassociated vasculitis, Arthritis Rheum, vol.64, pp.542-550, 2012.

S. Lionaski, S. L. Hogan, C. Jennette, J. B. Hamra, and J. C. Jennette, The clinical course of ANCA small-vessel vasculitis on chronic dialysis, Kidney Int, vol.76, pp.644-51, 2009.

J. G. Mcgregor, R. Negrete-lopez, C. J. Poulton, J. M. Kidd, S. L. Katsanos et al., Adverse events and infectious burden, microbes and temporal outline from immunosuppressive therapy in antineutrophil cytoplasmic antibodyassociated vasculitis with native renal function, Nephrol.Dial. Transplantation, vol.30, pp.171-189, 2015.

A. S. Fauci, P. Katz, B. F. Haynes, and S. M. Wolff, Cyclophosphamide therapy of severe systemic necrotizing vasculitis, N Engl J Med, vol.301, pp.235-243, 1979.

M. Weiner, S. M. Goh, A. J. Mohammad, Z. Hruskova, A. Tanna et al., Outcome and treatment of elderly patients with ANCA-associated vasculitis, Clin J Am Soc Nephrol, vol.10, pp.1128-1163, 2015.

K. Disease, Improving Global Outcomes (KDIGO) Glomerulonephritis Work Group. KDIGO Clinical Practice Guideline for Glomerulonephritis. Kidney inter, Suppl, vol.2, pp.139-274, 2012.

J. Franklin, M. Lunt, D. Bunn, D. Symmons, and A. Silman, Risk and predictors of infection leading to hospitalisation in a large primary-care-derived cohort of patients with inflammatory polyarthritis, Ann Rheum Dis, vol.66, pp.308-320, 2007.

J. G. Mcgregor, S. L. Hogan, and Y. Hu, Glucocorticoids and relapse and infection rates in anti-neutrophil cytoplasmic antibody disease, Clin J Am Soc Nephrol, vol.7, pp.240-247, 2012.

C. Pagnoux, T. Quéméneur, J. Ninet, E. Diot, X. Kyndt et al., Treatment of systemic necrotizing vasculitides in patients aged sixty-five years or older: results of a multicenter, open-label, randomized controlled trial of corticosteroid and cyclophosphamide-based induction therapy, Arthritis Rheumatol, vol.67, pp.1117-1144, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01936437

M. D. Van-de-wetering, M. A. De-witte, L. C. Kremer, M. Offringa, R. J. Scholten et al., Efficacy of oral prophylactic antibiotics in neutropenic afebrile oncology patients: a systematic review of randomised controlled trials, Eur J Cancer, vol.41, issue.10, pp.1372-82, 2005.

Á. Haris, K. Polner, J. Arányi, H. Braunitzer, I. Kaszás et al., Clinical outcomes of ANCA-associated vasculitis in elderly patients, Int Urol Nephrol, vol.46, pp.1595-600, 2014.

S. Ofer-shiber and Y. Molad, Association of the Charlson comorbidity index with renal outcome and all-cause mortality in antineutrophil cytoplasmatic antibody-associated vasculitis, Medicine (Baltimore), vol.93, p.152, 2014.

P. Peduzzi, J. Concato, E. Kemper, T. R. Holford, and A. R. Feinstein, A simulation study of the number of events per variable in logistic regression analysis, J Clin Epidemiol, vol.49, issue.12, pp.1373-1382, 1996.