J. L. Bresson, S. Jeay, M. C. Gagnerault, C. Kayser, N. Beressi et al., Growth hormone (GH) and prolactin receptors in human peripheral blood mononuclear cells: relation with age and GH-binding protein, 2. Gagnerault MC, Postel-Vinay MC, Dardenne M, vol.140, pp.1719-1745, 1996.

O. Thellin, B. Coumans, W. Zorzi, R. Barnard, G. Hennen et al., Expression of growth hormone receptors by lymphocyte subpopulations in the human tonsil, Dev Immunol, vol.6, pp.295-304, 1998.

G. Valerio, H. M. Bond, R. Badolato, A. Petrella, D. Maio et al., Expression of growth hormone receptor by peripheral blood lymphocytes in children: evaluation in clinical conditions of impaired growth, Clin Endocrinol. (Oxf), vol.47, pp.329-364, 1997.

H. W. Su, N. J. Lanning, D. L. Morris, L. S. Argetsinger, C. N. Lumeng et al., Phosphorylation of the adaptor protein SH2B1beta regulates its ability to enhance growth hormone-dependent macrophage motility, J Cell Sci, vol.126, pp.1733-1776, 2013.

C. J. Wiedermann, M. Niedermuhlbichler, D. Geissler, H. Beimpold, and H. Braunsteiner, Priming of normal human neutrophils by recombinant human growth hormone, Br J Haematol, vol.78, pp.19-22, 1991.

C. J. Wiedermann, N. Reinisch, and H. Braunsteiner, Stimulation of monocyte chemotaxis by human growth hormone and its deactivation by somatostatin, Blood, vol.82, pp.954-60, 1993.

K. Sumita, N. Hattori, and C. Inagaki, Effects of growth hormone on the differentiation of mouse B-lymphoid precursors, J Pharmacol Sci, vol.97, pp.408-424, 2005.

M. C. Postel-vinay, V. De-mello-coelho, M. C. Gagnerault, and M. Dardenne, Growth hormone stimulates the proliferation of activated mouse T lymphocytes, Endocrinology, vol.138, pp.1816-1836, 1997.

L. Lempereur, D. Brambilla, G. M. Scoto, D. 'alcamo, M. Goffin et al., Growth hormone protects human lymphocytes from irradiation-induced cell death, Br J Pharmacol, vol.138, pp.1411-1417, 2003.

K. Dorshkind and N. D. Horseman, The roles of prolactin, growth hormone, insulin-like growth factor-I, and thyroid hormones in lymphocyte development and function: insights from genetic models of hormone and hormone receptor deficiency, Endocr Rev, vol.21, pp.292-312, 2000.

K. Dorshkind and N. D. Horseman, Anterior pituitary hormones, stress, and immune system homeostasis, Bioessays, vol.23, pp.288-94, 2001.

M. Alba and R. Salvatori, A mouse with targeted ablation of the growth hormonereleasing hormone gene: a new model of isolated growth hormone deficiency, Endocrinology, vol.145, pp.4134-4177, 2004.

G. Bodart, K. Farhat, R. , C. Becker, G. Plenevaux et al., The severe deficiency of the somatotrope GH-releasing hormone/growth hormone/insulin-like growth factor 1 axis of Ghrh-/-mice is associated with an important splenic atrophy and relative B lymphopenia, Front Endocrinol, vol.9, p.296, 2018.

T. Van-der-poll and S. M. Opal, Pathogenesis, treatment, and prevention of pneumococcal pneumonia, Lancet, vol.374, pp.1543-56, 2009.

J. J. Mond, A. Lees, and C. M. Snapper, T cell-independent antigens type 2, Annu Rev Immunol, vol.13, pp.655-92, 1995.

K. E. Stein, Thymus-independent and thymus-dependent responses to polysaccharide antigens, J Infect Dis, pp.49-52, 1992.

J. J. Mond, Q. Vos, A. Lees, and C. M. Snapper, T cell independent antigens, Curr Opin Immunol, vol.7, pp.349-54, 1995.

K. M. Haas, J. C. Poe, D. A. Steeber, and T. F. Tedder, B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae, Immunity, vol.23, pp.7-18, 2005.

D. M. Musher, R. Sampath, and M. C. Rodriguez-barradas, The potential role for protein-conjugate pneumococcal vaccine in adults: what is the supporting evidence?, Clin Infect Dis, vol.52, pp.633-673, 2011.

S. Weller, C. A. Reynaud, and J. C. Weill, Vaccination against encapsulated bacteria in humans: paradoxes, Trends Immunol, vol.26, pp.85-94, 2005.
URL : https://hal.archives-ouvertes.fr/inserm-00337048

A. Kadioglu, N. A. Gingles, K. Grattan, A. Kerr, T. J. Mitchell et al., Host cellular immune response to pneumococcal lung infection in mice, Infect Immun, vol.68, pp.492-501, 2000.
DOI : 10.1128/iai.68.4.2390-2390.2000

URL : https://iai.asm.org/content/68/4/2390.full.pdf

N. Munoz, L. Van-maele, J. M. Marques, A. Rial, J. C. Sirard et al., Mucosal administration of flagellin protects mice from Streptococcus pneumoniae lung infection, Infect Immun, vol.78, pp.4226-4259, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00520159

S. Knapp, J. C. Leemans, S. Florquin, J. Branger, N. A. Maris et al., Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia, Am J Respir Crit Care Med, vol.167, pp.171-180, 2003.
DOI : 10.1164/rccm.200207-698oc

J. S. Brown, T. Hussell, S. M. Gilliland, D. W. Holden, J. C. Paton et al., The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice, Proc Natl Acad Sci, vol.99, pp.16969-74, 2002.

J. M. Marques, A. Rial, N. Munoz, F. X. Pellay, L. Van-maele et al., Protection against Streptococcus pneumoniae serotype 1 acute infection shows a signature of Th17-and IFN-gamma-mediated immunity, Immunobiology, vol.217, pp.420-429, 2012.

C. M. Wernette, C. E. Frasch, D. Madore, G. Carlone, D. Goldblatt et al., Enzyme-linked immunosorbent assay for quantitation of human antibodies to pneumococcal polysaccharides, Clin Diagn Lab Immunol, vol.10, pp.514-523, 2003.

H. Zemlickova, M. I. Crisostomo, M. C. Brandileone, T. Camou, E. Castaneda et al., Serotypes and clonal types of penicillin-susceptible streptococcus pneumoniae causing invasive disease in children in five Latin American countries, Microb Drug Resist, vol.11, pp.195-204, 2005.

K. J. Livak and T. D. Schmittgen, Analysis of relative gene expression data using realtime quantitative PCR and the 2(-Delta Delta C(T)) Method, Methods, vol.25, pp.402-410, 2001.

M. M. Garigliany, A. Habyarimana, B. Lambrecht, E. Van-de-paar, A. Cornet et al., Influenza A strain-dependent pathogenesis in fatal H1N1 and H5N1 subtype infections of mice, Emerg Infect Dis, vol.16, pp.595-603, 2010.

T. Casanova, E. Van-de-paar, D. Desmecht, and M. M. Garigliany, Hyporeactivity of alveolar macrophages and higher respiratory cell permissivity characterize DBA/2J mice infected by influenza a virus, J Interferon Cytokine Res, vol.35, pp.808-828, 2015.

S. Reagan-shaw, M. Nihal, and N. Ahmad, Dose translation from animal to human studies revisited, FASEB J, vol.22, pp.659-61, 2008.
DOI : 10.1096/fj.07-9574lsf

F. Mawas, I. M. Feavers, and M. J. Corbel, Serotype of Streptococcus pneumoniae capsular polysaccharide can modify the Th1/Th2 cytokine profile and IgG subclass response to pneumococal-CRM(197) conjugate vaccines in a murine model, Vaccine, vol.19, pp.1159-66, 2000.

C. Biondo, G. Mancuso, A. Midiri, G. Signorino, M. Domina et al., The interleukin-1beta/CXCL1/2/neutrophil axis mediates host protection against group B streptococcal infection, Infect. Immun, vol.82, pp.4508-4525, 2014.

S. Knapp, L. Hareng, A. W. Rijneveld, P. Bresser, J. S. Van-der-zee et al., Activation of neutrophils and inhibition of the proinflammatory cytokine response by endogenous granulocyte colony-stimulating factor in murine pneumococcal pneumonia, J Infect Dis, vol.189, pp.1506-1521, 2004.

A. M. Manicone, K. M. Burkhart, B. Lu, and J. G. Clark, CXCR3 ligands contribute to Th1-induced inflammation but not to homing of Th1 cells into the lung, Exp Lung Res, vol.34, pp.391-407, 2008.

R. Koike, T. Nishimura, R. Yasumizu, H. Tanaka, Y. Hataba et al., The splenic marginal zone is absent in alymphoplastic aly mutant mice, Eur J Immunol, vol.26, pp.669-75, 1996.

D. W. Wara, Host defense against Streptococcus pneumoniae: the role of the spleen, Rev Infect Dis, vol.3, pp.299-309, 1981.

M. G. Dorrington, A. M. Roche, S. E. Chauvin, Z. Tu, K. L. Mossman et al., MARCO is required for TLR2-and Nod2-mediated responses to Streptococcus pneumoniae and clearance of pneumococcal colonization in the murine nasopharynx, J Immunol, vol.190, pp.250-258, 2013.

G. M. Dingjan, A. Maas, M. C. Nawijn, L. Smit, J. S. Voerman et al., Severe B cell deficiency and disrupted splenic architecture in transgenic mice expressing the E41K mutated form of Bruton's tyrosine kinase, EMBO J, vol.17, pp.5309-5329, 1998.

M. C. Karlsson, R. Guinamard, S. Bolland, M. Sankala, R. M. Steinman et al., Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone, J Exp Med, vol.198, pp.333-373, 2003.

D. L. Barnard, Animal models for the study of influenza pathogenesis and therapy, Antiviral Res, vol.82, pp.110-132, 2009.

M. Alba, D. Fintini, and R. Salvatori, Effects of recombinant mouse growth hormone treatment on growth and body composition in GHRH knock out mice

, Growth Horm IGF Res, vol.15, pp.275-82, 2005.

R. Shohreh, C. A. Pardo, F. Guaraldi, A. V. Schally, R. Salvatori et al., , vol.152, pp.3803-3813, 2011.

M. W. Pletz, U. Maus, N. Krug, T. Welte, and H. Lode, Pneumococcal vaccines: mechanism of action, impact on epidemiology and adaption of the species, Int J Antimicrob Agents, vol.32, pp.199-206, 2008.

A. Bartke and J. J. Kopchick, The forgotten lactogenic of growth hormone: important implications for rodent studies, Endocrinology, vol.165, pp.1620-1642, 2015.

M. Chignard and V. Balloy, Neutrophil recruitment and increased permeability during acute lung injury induced by lipopolysaccharide, Am J Physiol Lung Cell Mol Physiol, vol.279, 2000.
DOI : 10.1152/ajplung.2000.279.6.l1083

R. H. Simon, P. D. Dehart, R. F. Todd, and . Iii, Neutrophil-induced injury of rat pulmonary alveolar epithelial cells, J Clin Invest, vol.78, pp.1375-86, 1986.

M. Eliasson, M. Morgelin, J. M. Farber, A. Egesten, and B. Albiger, Streptococcus pneumoniae induces expression of the antibacterial CXC chemokine MIG/CXCL9 via MyD88-dependent signaling in a murine model of airway infection, Microbes Infect, vol.12, pp.565-73, 2010.

S. J. Aujla, P. J. Dubin, and J. K. Kolls, Interleukin-17 in pulmonary host defense, Exp Lung Res, vol.33, pp.507-525, 2007.
DOI : 10.1080/01902140701756604

T. Kawabe, M. Matsushima, N. Hashimoto, K. Imaizumi, and Y. Hasegawa, CD40/CD40 ligand interactions in immune responses and pulmonary immunity, Nagoya J Med Sci, vol.73, pp.69-78, 2011.

Y. J. Lu, J. Gross, D. Bogaert, A. Finn, L. Bagrade et al., Interleukin-17A mediates acquired immunity to pneumococcal colonization, PLoS Pathog, vol.4, p.1000159, 2008.
DOI : 10.1371/journal.ppat.1000159

URL : https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000159&type=printable

N. D. Ritchie, R. Ritchie, H. K. Bayes, T. J. Mitchell, and T. J. Evans, IL-17 can be protective or deleterious in murine pneumococcal pneumonia, PLoS Pathog, vol.14, p.1007099, 2018.
DOI : 10.1371/journal.ppat.1007099

URL : https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007099&type=printable

M. H. Kaplan and J. E. Volanakis, Interaction of C-reactive protein complexes with the complement system. I. Consumption of human complement associated with the reaction of C-reactive protein with pneumococcal C-polysaccharide and with the choline phosphatides, lecithin and sphingomyelin, J Immunol, vol.112, pp.2135-2139, 1974.

A. M. Roche, S. J. King, and J. N. Weiser, Live attenuated Streptococcus pneumoniae strains induce serotype-independent mucosal and systemic protection in mice, Infect Immun, vol.75, pp.2469-75, 2007.
DOI : 10.1128/iai.01972-06

URL : https://iai.asm.org/content/75/5/2469.full.pdf

Y. Fukuyama, J. D. King, K. Kataoka, R. Kobayashi, R. S. Gilbert et al., Secretory-IgA antibodies play an important role in the immunity to Streptococcus pneumoniae, J Immunol, vol.185, pp.1755-62, 2010.

H. M. Marriott, K. A. Gascoyne, R. Gowda, I. Geary, M. J. Nicklin et al., Interleukin-1beta regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophages, Infect Immun, vol.80, pp.1140-1149, 2012.

A. J. Lammers, A. P. De-porto, S. Florquin, O. J. De-boer, H. J. Bootsma et al., Enhanced vulnerability for Streptococcus pneumoniae sepsis during asplenia is determined by the bacterial capsule, Immunobiology, vol.216, pp.863-70, 2011.

B. M. William, N. Thawani, S. Sae-tia, and G. R. Corazza, Hyposplenism: a comprehensive review. Part II: clinical manifestations, diagnosis, and management, Hematology, vol.12, pp.89-98, 2007.
DOI : 10.1080/10245330600938422

M. Garg and B. Subbarao, Immune responses of systemic and mucosal lymphoid organs to Pnu-Imune vaccine as a function of age and the efficacy of monophosphoryl lipid A as an adjuvant, Infect Immun, vol.60, pp.2329-2365, 1992.

G. Kraal, Cells in the marginal zone of the spleen, Int Rev Cytol, vol.132, pp.31-74, 1992.

A. M. Oliver, F. Martin, G. L. Gartland, R. H. Carter, and J. F. Kearney, Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses, Eur J Immunol, vol.27, pp.2366-74, 1997.

M. J. Shlomchik and F. Weisel, Germinal centers, Immunol Rev, vol.247, pp.5-10, 2012.

R. Berland and H. H. Wortis, Origins and functions of B-1 cells with notes on the role of CD5, Annu Rev Immunol, vol.20, pp.253-300, 2002.

D. Allman and S. Pillai, Peripheral B cell subsets, Curr Opin Immunol, vol.20, pp.149-57, 2008.

F. Martin, A. M. Oliver, and J. F. Kearney, Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens, Immunity, vol.14, pp.617-646, 2001.

Y. Chen, T. Pikkarainen, O. Elomaa, R. Soininen, T. Kodama et al., Defective microarchitecture of the spleen marginal zone and impaired response to a thymus-independent type 2 antigen in mice lacking scavenger receptors MARCO and SR-A, J Immunol, vol.175, pp.8173-80, 2005.

A. Tumanov, D. Kuprash, M. Lagarkova, S. Grivennikov, K. Abe et al., Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues, Immunity, vol.17, pp.239-50, 2002.

C. K. Edwards, . Iii, L. M. Yunger, R. M. Lorence, R. Dantzer et al., The pituitary gland is required for protection against lethal effects of Salmonella typhimurium, Proc Natl Acad Sci, vol.88, pp.2274-2281, 1991.

K. A. Lacey and J. M. Parkin, Causes of short stature. A community study of children in Newcastle upon Tyne, Lancet, vol.1, pp.42-47, 1974.

R. Lindsay, M. Feldkamp, D. Harris, J. Robertson, and M. Rallison, Utah growth study: growth standards and the prevalence of growth hormone deficiency, J Pediatr, vol.125, pp.29-35, 1994.

R. J. Rona and J. M. Tanner, Aetiology of idiopathic growth hormone deficiency in England and Wales, Arch Dis Child, vol.52, pp.197-208, 1977.

G. V. Vimpani, A. F. Vimpani, G. P. Lidgard, E. H. Cameron, and J. W. Farquhar, Prevalence of severe growth hormone deficiency, Br Med J, vol.2, pp.427-457, 1977.

M. H. Aguiar-oliveira, F. T. Oliveira, R. M. Pereira, C. R. Oliveira, A. Blackford et al., Longevity in untreated congenital growth hormone deficiency due to a homozygous mutation in the GHRH receptor gene, J Clin Endocrinol Metab, vol.95, pp.714-735, 2010.

M. H. Aguiar-oliveira, A. Souza, C. Oliveira, V. C. Campos, L. A. Oliveiraneto et al., Mechanisms in endocrinology: the multiple facets of GHRH/GH/IGF-I axis: lessons from lifetime, untreated, isolated GH deficiency due to a GHRH receptor gene mutation, Eur J Endocrinol, vol.177, pp.85-97, 2017.

V. C. Campos, M. R. Barrios, R. Salvatori, R. P. De-almeida, E. V. De-melo et al., Infectious diseases and immunological responses in adult subjects with lifetime untreated, congenital GH deficiency, Endocrine, vol.54, pp.182-90, 2016.

C. R. Oliveira, R. Salvatori, L. M. Nobrega, E. O. Carvalho, M. Menezes et al., Sizes of abdominal organs in adults with severe short stature due to severe, untreated, congenital GH deficiency caused by a homozygous mutation in the GHRH receptor gene, Clin Endocrinol (Oxf), vol.69, pp.153-161, 2008.