Temporal trend of the proportion of patients presenting with advanced HIV in French Guiana: stuck on the asymptote?

Mathieu Nacher 1, 2, * Florence Huber 2 Leïla Adriouch 2 Félix Djossou 3 Antoine Adenis 1 Pierre Couppié 4
* Corresponding author
1 CIC - Antilles Guyane - Centre d'Investigation Clinique Antilles-Guyane
2 COREVIH Guyane - Coordination Régionale de la lutte contre le Virus de l'Immunodéficience Humaine
3 UMIT - Unité des Maladies Infectieuses et Tropicales
4 Service de Dermatologie
Abstract : OBJECTIVE: In French Guiana, the French territory with the most preoccupying HIV epidemic, there have been great efforts to intensify and diversify HIV testing strategies. The aim of the present study was to review the temporal trends of patients diagnosed with advanced HIV disease in French Guiana. Data trends from the HIV cohort of French Guiana between 1996 and 2016 were thus analyzed. RESULTS: The proportion of patients diagnosed with advanced disease did not decline over time. Males had lower CD4 counts at the time of diagnosis and there was a plateau for both males (around 40%) and females (around 25%) with no apparent reduction of the proportion of advanced disease. Older age groups and migrants presented more often with advanced disease. By contrast, the proportion of patients diagnosed with stage B and C disease declined over time and the CD4 count at antiretroviral initiation and the CD4 nadir increased over time. Despite some progress, the group of patients with advanced disease reached a plateau around 30% suggesting this particular group still has epidemiological importance in driving the epidemic and in fueling morbidity and mortality, and thus remains a challenge for testing strategies.
Keywords : HIV Advanced disease CD4 AIDS French Guiana
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Mathieu Nacher, Florence Huber, Leïla Adriouch, Félix Djossou, Antoine Adenis, et al.. Temporal trend of the proportion of patients presenting with advanced HIV in French Guiana: stuck on the asymptote?. BMC Research Notes, BioMed Central, 2018, 11 (1), pp.831. ⟨10.1186/s13104-018-3944-y⟩. ⟨inserm-02078196⟩

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