G. Mortality, Causes of Death C. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the global burden of disease study, Lancet, vol.385, issue.9963, pp.117-71, 2013.

E. J. Kuipers, W. M. Grady, D. Lieberman, T. Seufferlein, J. J. Sung et al., Colorectal cancer. Nat Rev Dis Primers, vol.1, p.15065, 2015.

, Comprehensive molecular characterization of human colon and rectal cancer, Cancer Genome Atlas N, vol.487, issue.7407, pp.330-337, 2012.

M. Bianchini, E. Levy, C. Zucchini, V. Pinski, C. Macagno et al., Comparative study of gene expression by cDNA microarray in human colorectal cancer tissues and normal mucosa, Int J Oncol, vol.29, issue.1, pp.83-94, 2006.

L. Peng, X. W. Bian, D. K. Li, C. Xu, G. M. Wang et al., Large-scale RNASeq Transcriptome analysis of 4043 cancers and 548 normal tissue controls across 12 TCGA cancer types, Sci Rep, vol.5, p.13413, 2015.

B. Liang, C. Li, and J. Zhao, Identification of key pathways and genes in colorectal cancer using bioinformatics analysis, Med Oncol, vol.33, issue.10, p.111, 2016.

G. Chen, H. Li, X. Niu, G. Li, N. Han et al., Identification of key genes associated with colorectal cancer based on the transcriptional network, Pathol Oncol Res, vol.21, issue.3, pp.719-744, 2015.

A. L. Barabasi, N. Gulbahce, and J. Loscalzo, Network medicine: a network-based approach to human disease, Nat Rev Genet, vol.12, issue.1, pp.56-68, 2011.

H. Yu, P. M. Kim, E. Sprecher, V. Trifonov, and M. Gerstein, The importance of bottlenecks in protein networks: correlation with gene essentiality and expression dynamics, PLoS Comput Biol, vol.3, issue.4, p.59, 2007.

T. D. Schmittgen and K. J. Livak, Analyzing real-time PCR data by the comparative C(T) method, Nat Protoc, vol.3, issue.6, pp.1101-1109, 2008.

C. L. Andersen, J. L. Jensen, and T. F. Orntoft, Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets, Cancer Res, vol.64, issue.15, pp.5245-50, 2004.

J. Vandesompele, D. Preter, K. Pattyn, F. Poppe, B. Van-roy et al., Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes, Genome Biol, vol.3, issue.7, p.34, 2002.

D. Szklarczyk, A. Franceschini, S. Wyder, K. Forslund, D. Heller et al., STRING v10: protein-protein interaction networks, integrated over the tree of life, Nucleic Acids Res, vol.43, pp.447-52, 2015.

P. Shannon, A. Markiel, O. Ozier, N. S. Baliga, J. T. Wang et al., Cytoscape: a software environment for integrated models of biomolecular interaction networks, Genome Res, vol.13, issue.11, pp.2498-504, 2003.

Y. Assenov, F. Ramirez, S. E. Schelhorn, T. Lengauer, and M. Albrecht, Computing topological parameters of biological networks, Bioinformatics, vol.24, issue.2, pp.282-286, 2008.

M. Pesson, A. Volant, A. Uguen, K. Trillet, P. De-la-grange et al., A gene expression and premRNA splicing signature that marks the adenoma-adenocarcinoma progression in colorectal cancer, PLoS One, vol.9, issue.2, p.87761, 2014.
URL : https://hal.archives-ouvertes.fr/hal-00976068

D. M. Muzny, M. N. Bainbridge, K. Chang, H. H. Dinh, J. A. Drummond et al., Comprehensive molecular characterization of human colon and rectal cancer, Nature, vol.487, issue.7407, pp.330-337, 2012.

N. Sun, Q. Meng, and A. Tian, Expressions of the anti-apoptotic genes Bag-1 and Bcl-2 in colon cancer and their relationship, Am J Surg, vol.200, issue.3, pp.341-346, 2010.

N. Yagihashi, H. Kasajima, S. Sugai, K. Matsumoto, Y. Ebina et al., Increased in situ expression of nitric oxide synthase in human colorectal cancer, Virchows Arch, vol.436, issue.2, pp.109-123, 2000.

J. X. Yu, L. Cui, Q. Y. Zhang, H. Chen, J. P. Wei et al., Expression of NOS and HIF-1alpha in human colorectal carcinoma and implication in tumor angiogenesis, World J Gastroenterol, vol.12, issue.29, pp.4660-4664, 2006.

V. Yagublu, J. R. Arthur, S. N. Babayeva, F. Nicol, S. Post et al., Expression of selenium-containing proteins in human colon carcinoma tissue, Anticancer Res, vol.31, issue.9, pp.2693-2701, 2011.

I. Nalkiran, S. Turan, S. Arikan, O. T. Kahraman, L. Acar et al., Determination of gene expression and serum levels of MnSOD and GPX1 in colorectal cancer, Anticancer Res, vol.35, issue.1, pp.255-264, 2015.

I. V. Demidyuk, A. V. Shubin, E. V. Gasanov, A. M. Kurinov, V. V. Demkin et al., Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios, PLoS One, vol.8, issue.2, p.55752, 2013.

H. Li, C. P. Ren, X. J. Tan, X. Y. Yang, H. B. Zhang et al., Identification of genes related to nasopharyngeal carcinoma with the help of pathway-based networks, Acta Biochim Biophys Sin Shanghai, vol.38, issue.12, pp.900-910, 2006.

R. Reuss, S. Aberle, K. Klingel, M. Sauter, A. Greschniok et al., The expression of the carboxyl ester lipase gene in pancreas and pancreatic adenocarcinomas, Int J Oncol, vol.29, issue.3, pp.649-54, 2006.

A. Etcheverry, M. Aubry, M. De-tayrac, E. Vauleon, R. Boniface et al., DNA methylation in glioblastoma: impact on gene expression and clinical outcome, BMC Genomics, vol.11, p.701, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00663706

D. F. Peng, M. Razvi, H. Chen, K. Washington, A. Roessner et al., DNA hypermethylation regulates the expression of members of the mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma, Gut, vol.58, issue.1, pp.5-15, 2009.

J. Follet, L. Corcos, G. Baffet, F. Ezan, F. Morel et al., The association of statins and taxanes: an efficient combination trigger of cancer cell apoptosis, Br J Cancer, vol.106, issue.4, pp.685-92, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00684528

D. Szklarczyk, A. Santos, C. Von-mering, L. J. Jensen, P. Bork et al., STITCH 5: augmenting protein-chemical interaction networks with tissue and affinity data, Nucleic Acids Res, vol.44, issue.D1, pp.380-384, 2016.

K. Sikora, S. Chan, G. Evan, H. Gabra, N. Markham et al., C-myc oncogene expression in colorectal cancer, Cancer, vol.59, issue.7, pp.1289-95, 1987.

S. J. Garte, The c-myc oncogene in tumor progression, Crit Rev Oncog, vol.4, issue.4, pp.435-484, 1993.

A. Nastase, L. Paslaru, V. Herlea, M. Ionescu, D. Tomescu et al., Expression of interleukine-8 as an independent prognostic factor for sporadic colon cancer dissemination, J Med Life, vol.7, issue.2, pp.215-224, 2014.

W. Jiang, X. Li, S. Rao, L. Wang, L. Du et al., Constructing disease-specific gene networks using pair-wise relevance metric: application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements, BMC Syst Biol, vol.2, p.72, 2008.

R. Zhang, G. L. Xu, Y. Li, L. J. He, L. M. Chen et al., The role of insulin-like growth factor 1 and its receptor in the formation and development of colorectal carcinoma, J Int Med Res, vol.41, issue.4, pp.1228-1263, 2013.

I. Tsimafeyeu, A. Khasanova, E. Stepanova, M. Gordiev, D. Khochenkov et al., FGFR2 overexpression predicts survival outcome in patients with metastatic papillary renal cell carcinoma, Clin Transl Oncol, 2016.

Z. Timsah, J. Berrout, M. Suraokar, C. Behrens, J. Song et al., Expression pattern of FGFR2, Grb2 and Plcgamma1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma, Am J Cancer Res, vol.5, issue.10, pp.3135-3183, 2015.

D. Tastekin, S. Kargin, M. Karabulut, N. Yaldiz, M. Tambas et al., Synuclein-gamma predicts poor clinical outcome in esophageal cancer patients, Tumour Biol, vol.35, issue.12, pp.11871-11878, 2014.

P. Mhawech-fauceglia, D. Wang, S. Syriac, H. Godoy, N. Dupont et al., Synuclein-gamma (SNCG) protein expression is associated with poor outcome in endometrial adenocarcinoma, Gynecol Oncol, vol.124, issue.1, pp.148-52, 2012.

J. K. Park, J. H. Song, T. C. He, S. W. Nam, J. Y. Lee et al., Overexpression of Wnt-2 in colorectal cancers, Neoplasma, vol.56, issue.2, pp.119-142, 2009.

Y. Chen, J. Jiang, M. Zhao, X. Luo, Z. Liang et al., microRNA-374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway, Oncotarget, vol.7, issue.27, pp.41306-41325, 2016.

A. P. Kipp, M. F. Muller, E. M. Goken, S. Deubel, and R. Brigelius-flohe, The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signalling in the intestinal epithelium, Biochim Biophys Acta, vol.1820, issue.10, pp.1588-96, 2012.

E. L. Huttlin, L. Ting, R. J. Bruckner, F. Gebreab, M. P. Gygi et al., The BioPlex network: a systematic exploration of the human Interactome, Cell, vol.162, issue.2, pp.425-465, 2015.

P. Agrawal, K. Yu, A. R. Salomon, and J. M. Sedivy, Proteomic profiling of Mycassociated proteins, Cell Cycle, vol.9, issue.24, pp.4908-4929, 2010.

A. M. Bailey, L. Zhan, D. Maru, I. Shureiqi, C. R. Pickering et al., FXR silencing in human colon cancer by DNA methylation and KRAS signaling, Am J Physiol Gastrointest Liver Physiol, vol.306, issue.1, pp.48-58, 2014.

K. W. Fisher, B. Das, H. S. Kim, B. K. Clymer, D. Gehring et al., AMPK promotes aberrant PGC1beta expression to support human colon tumor cell survival, Mol Cell Biol, vol.35, issue.22, pp.3866-79, 2015.

M. Karikoski, F. Marttila-ichihara, K. Elima, P. Rantakari, M. Hollmen et al., Clever-1/stabilin-1 controls cancer growth and metastasis, Clin Cancer Res, vol.20, issue.24, pp.6452-64, 2014.

C. David, J. P. Nance, J. Hubbard, M. Hsu, D. Binder et al., Stabilin-1 expression in tumor associated macrophages, Brain Res, vol.1481, pp.71-79, 2012.

A. Chatr-aryamontri, B. J. Breitkreutz, S. Heinicke, L. Boucher, A. Winter et al., The BioGRID interaction database: 2013 update, Nucleic Acids Res, vol.41, pp.816-839, 2013.

A. R. Kristensen, J. Gsponer, and L. J. Foster, A high-throughput approach for measuring temporal changes in the interactome, Nat Methods, vol.9, issue.9, pp.907-916, 2012.

P. J. Mullen, R. Yu, J. Longo, M. C. Archer, and L. Z. Penn, The interplay between cell signalling and the mevalonate pathway in cancer, Nat Rev Cancer, vol.16, issue.11, pp.718-749, 2016.

Y. Wu, K. Chen, X. Liu, L. Huang, D. Zhao et al., Srebp-1 interacts with c-Myc to enhance somatic cell reprogramming, Stem Cells, vol.34, issue.1, pp.83-92, 2016.

L. Gibot, J. Follet, J. P. Metges, P. Auvray, B. Simon et al., Human caspase 7 is positively controlled by SREBP-1 and SREBP-2, Biochem J, vol.420, issue.3, pp.473-83, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00479110

G. Asher, J. Lotem, R. Kama, L. Sachs, and Y. Shaul, NQO1 stabilizes p53 through a distinct pathway, Proc Natl Acad Sci U S A, vol.99, issue.5, pp.3099-104, 2002.

S. Orchard, M. Ammari, B. Aranda, L. Breuza, L. Briganti et al., The MIntAct projectIntAct as a common curation platform for 11 molecular interaction databases, Nucleic Acids Res, vol.42, pp.358-63, 2014.

Y. Pommier, O. Sordet, V. A. Rao, H. Zhang, and K. W. Kohn, Targeting chk2 kinase: molecular interaction maps and therapeutic rationale, Curr Pharm Des, vol.11, issue.22, pp.2855-72, 2005.

C. Yang, H. Z. Liu, and Z. X. Fu, Effects of PEG-liposomal oxaliplatin on apoptosis, and expression of Cyclin a and Cyclin D1 in colorectal cancer cells, Oncol Rep, vol.28, issue.3, pp.1006-1018, 2012.

B. L. Adamsen, K. L. Kravik, O. P. Clausen, D. Angelis, and P. M. , Apoptosis, cell cycle progression and gene expression in TP53-depleted HCT116 colon cancer cells in response to short-term 5-fluorouracil treatment, Int J Oncol, vol.31, issue.6, pp.1491-500, 2007.

P. M. De-angelis, D. H. Svendsrud, K. L. Kravik, and T. Stokke, Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery, Mol Cancer, vol.5, p.20, 2006.

B. E. Batsaikhan, K. Yoshikawa, N. Kurita, T. Iwata, C. Takasu et al., Cyclopamine decreased the expression of sonic hedgehog and its downstream genes in colon cancer stem cells, Anticancer Res, vol.34, issue.11, pp.6339-6383, 2014.

C. C. Chin, J. M. Li, K. F. Lee, Y. C. Huang, K. C. Wang et al., Selective beta2-AR blockage suppresses colorectal cancer growth through regulation of EGFR-Akt/ERK1/2 signaling, G1-phase arrest, and apoptosis, J Cell Physiol, vol.231, issue.2, pp.459-72, 2016.

B. Delage, A. Rullier, M. Capdepont, E. Rullier, and P. Cassand, The effect of body weight on altered expression of nuclear receptors and cyclooxygenase-2 in human colorectal cancers, Nutr J, vol.6, p.20, 2007.

Y. Z. Liu, K. Q. Wang, D. H. Ji, L. C. Zhang, M. Bi et al., Correlations of MC4R and MSH2 expression with obesity in colon cancer patients, Eur Rev Med Pharmacol Sci, vol.21, issue.9, pp.2108-2121, 2017.

M. B. Eisen, P. T. Spellman, P. O. Brown, and D. Botstein, Cluster analysis and display of genome-wide expression patterns, Proc Natl Acad Sci U S A, vol.95, issue.25, pp.14863-14871, 1998.

X. Sun, R. Essalmani, R. Day, A. M. Khatib, N. G. Seidah et al., Proprotein convertase subtilisin/kexin type 9 deficiency reduces melanoma metastasis in liver, Neoplasia, vol.14, issue.12, pp.1122-1153, 2012.

M. Hilvo, C. Denkert, L. Lehtinen, B. Muller, S. Brockmoller et al., Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression, Cancer Res, vol.71, issue.9, pp.3236-3281, 2011.

C. Khenjanta, R. Thanan, A. Jusakul, A. Techasen, W. Jamnongkan et al., Association of CYP39A1, RUNX2 and oxidized alpha-1 antitrypsin expression in relation to cholangiocarcinoma progression, Asian Pac J Cancer Prev, vol.15, issue.23, pp.10187-92, 2014.

D. M. Meerzaman, C. Yan, Q. R. Chen, M. N. Edmonson, C. F. Schaefer et al., Genome-wide transcriptional sequencing identifies novel mutations in metabolic genes in human hepatocellular carcinoma, Cancer Genomics Proteomics, vol.11, issue.1, pp.1-12, 2014.

V. Hlavac, V. Brynychova, R. Vaclavikova, M. Ehrlichova, D. Vrana et al., The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients, Medicine (Baltimore), vol.93, issue.28, p.255, 2014.

M. H. Zhang, Q. H. Shen, Z. M. Qin, Q. L. Wang, and X. Chen, Systematic tracking of disrupted modules identifies significant genes and pathways in hepatocellular carcinoma, Oncol Lett, vol.12, issue.5, pp.3285-95, 2016.

L. Simi, F. Malentacchi, P. Luciani, S. Gelmini, C. Deledda et al., Seladin-1 expression is regulated by promoter methylation in adrenal cancer, BMC Cancer, vol.10, p.201, 2010.

M. C. Battista, M. O. Guimond, C. Roberge, A. A. Doueik, L. Fazli et al., Inhibition of DHCR24/seladin-1 impairs cellular homeostasis in prostate cancer, Prostate, vol.70, issue.9, pp.921-954, 2010.

T. Todenhofer, J. Hennenlotter, U. Kuhs, V. Gerber, G. Gakis et al., Altered expression of farnesyl pyrophosphate synthase in prostate cancer: evidence for a role of the mevalonate pathway in disease progression?, World J Urol, vol.31, issue.2, pp.345-50, 2013.

Q. Long, J. Xu, A. O. Osunkoya, S. Sannigrahi, B. A. Johnson et al., Global transcriptome analysis of formalinfixed prostate cancer specimens identifies biomarkers of disease recurrence, Cancer Res, vol.74, issue.12, pp.3228-3265, 2014.

F. G. Kapp, A. Sommer, T. Kiefer, G. Dolken, and B. Haendler, 5-alpha-reductase type I (SRD5A1) is up-regulated in non-small cell lung cancer but does not impact proliferation, cell cycle distribution or apoptosis, Cancer Cell Int, vol.12, issue.1, p.1, 2012.

M. Stanbrough, G. J. Bubley, K. Ross, T. R. Golub, M. A. Rubin et al., Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer, Cancer Res, vol.66, issue.5, pp.2815-2840, 2006.

K. Wako, T. Kawasaki, K. Yamana, K. Suzuki, S. Jiang et al., Expression of androgen receptor through androgen-converting enzymes is associated with biological aggressiveness in prostate cancer, J Clin Pathol, vol.61, issue.4, pp.448-54, 2008.

M. J. Lewis, J. P. Wiebe, and J. G. Heathcote, Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma, BMC Cancer, vol.4, p.27, 2004.

M. R. Bani, M. I. Nicoletti, N. W. Alkharouf, C. Ghilardi, D. Petersen et al., Gene expression correlating with response to paclitaxel in ovarian carcinoma xenografts, Mol Cancer Ther, vol.3, issue.2, pp.111-132, 2004.

Y. Tsukamoto, T. Uchida, S. Karnan, T. Noguchi, L. T. Nguyen et al., Genome-wide analysis of DNA copy number alterations and gene expression in gastric cancer, J Pathol, vol.216, issue.4, pp.471-82, 2008.

Y. Fukuma, H. Matsui, H. Koike, Y. Sekine, I. Shechter et al., Role of squalene synthase in prostate cancer risk and the biological aggressiveness of human prostate cancer, Prostate Cancer Prostatic Dis, vol.15, issue.4, pp.339-384, 2012.

G. G. Fernandez-ranvier, J. Weng, R. F. Yeh, D. Shibru, E. Khafnashar et al., Candidate diagnostic markers and tumor suppressor genes for adrenocortical carcinoma by expression profile of genes on chromosome 11q13, World J Surg, vol.32, issue.5, pp.873-81, 2008.

M. D. Williams, L. Zhang, D. D. Elliott, N. D. Perrier, G. Lozano et al., Differential gene expression profiling of aggressive and nonaggressive follicular carcinomas, Hum Pathol, vol.42, issue.9, pp.1213-1233, 2011.

S. M. Singel, K. Batten, C. Cornelius, G. Jia, G. Fasciani et al., Receptor-interacting protein kinase 2 promotes triple-negative breast cancer cell migration and invasion via activation of nuclear factor-kappaB and c-Jun N-terminal kinase pathways, Breast Cancer Res, vol.16, issue.2, p.28, 2014.

H. Zhang and A. I. Chin, Role of Rip2 in development of tumor-infiltrating MDSCs and bladder cancer metastasis, PLoS One, vol.9, issue.4, p.94793, 2014.

X. Wang, W. Jiang, N. Duan, Y. Qian, Q. Zhou et al., RIP2 and Caspase12 are potentially novel biomarkers for oral squamous cell carcinoma development and progression, Int J Clin Exp Pathol, vol.7, issue.4, pp.1677-86, 2014.

T. Yamashita, M. Honda, H. Takatori, R. Nishino, H. Minato et al., Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma, J Hepatol, vol.50, issue.1, pp.100-110, 2009.

T. J. Macdonald, I. F. Pollack, H. Okada, S. Bhattacharya, and J. Lyons-weiler, Progression-associated genes in astrocytoma identified by novel microarray gene expression data reanalysis, Methods Mol Biol, vol.377, pp.203-225, 2007.

A. Bell, D. Bell, R. S. Weber, and A. K. El-naggar, CpG island methylation profiling in human salivary gland adenoid cystic carcinoma, Cancer, vol.117, issue.13, pp.2898-909, 2011.

S. Lee, H. C. Kwon, S. H. Kim, S. Y. Oh, J. H. Lee et al., Identification of genes underlying different methylation profiles in refractory anemia with excess blast and refractory cytopenia with multilineage dysplasia in myelodysplastic syndrome, Korean J Hematol, vol.47, issue.3, pp.186-93, 2012.

J. Espinal-enriquez, S. Munoz-montero, I. Imaz-rosshandler, A. Huerta-verde, C. Mejia et al., Genome-wide expression analysis suggests a crucial role of dysregulation of matrix metalloproteinases pathway in undifferentiated thyroid carcinoma, BMC Genomics, vol.16, p.207, 2015.

Y. F. Li, Y. H. Hsiao, Y. H. Lai, Y. C. Chen, Y. J. Chen et al., DNA methylation profiles and biomarkers of oral squamous cell carcinoma, Epigenetics, vol.10, issue.3, pp.229-265, 2015.

S. D. Spivack, G. J. Hurteau, M. J. Fasco, and L. S. Kaminsky, Phase I and II carcinogen metabolism gene expression in human lung tissue and tumors, Clin Cancer Res, vol.9, issue.16, pp.6002-6013, 2003.

I. Osman, D. F. Bajorin, T. T. Sun, H. Zhong, D. Douglas et al., Novel blood biomarkers of human urinary bladder cancer, Clin Cancer Res, vol.12, issue.11, pp.3374-80, 2006.

H. Y. Dong, A. Shahsafaei, and D. M. Dorfman, CD148 and CD27 are expressed in B cell lymphomas derived from both memory and naive B cells, Leuk Lymphoma, vol.43, issue.9, pp.1855-1863, 2002.

D. Hui, N. Satkunam, A. Kaptan, M. Reiman, T. Lai et al., Pathway-specific apoptotic gene expression profiling in chronic lymphocytic leukemia and follicular lymphoma, Mod Pathol, vol.19, issue.9, pp.1192-202, 2006.
DOI : 10.1038/modpathol.3800632
URL : https://www.nature.com/articles/3800632.pdf

S. N. Metodieva, D. N. Nikolova, R. V. Cherneva, I. I. Dimova, D. B. Petrov et al., Expression analysis of angiogenesis-related genes in Bulgarian patients with early-stage non-small cell lung cancer, Tumori, vol.97, issue.1, pp.86-94, 2011.

C. R. Antonescu, A. Yoshida, T. Guo, N. E. Chang, L. Zhang et al., KDR activating mutations in human angiosarcomas are sensitive to specific kinase inhibitors, Cancer Res, vol.69, issue.18, pp.7175-7184, 2009.
DOI : 10.1158/0008-5472.can-09-2068
URL : http://cancerres.aacrjournals.org/content/69/18/7175.full.pdf

A. Muller, K. Lange, T. Gaiser, M. Hofmann, H. Bartels et al., Expression of angiopoietin-1 and its receptor TEK in hematopoietic cells from patients with myeloid leukemia, Leuk Res, vol.26, issue.2, pp.163-171, 2002.

G. Bunone, P. Vigneri, L. Mariani, S. Buto, P. Collini et al., Expression of angiogenesis stimulators and inhibitors in human thyroid tumors and correlation with clinical pathological features, Am J Pathol, vol.155, issue.6, pp.1967-76, 1999.

J. P. Dales, S. Garcia, P. Bonnier, F. Duffaud, S. Meunier-carpentier et al., Tie2/Tek expression in breast carcinoma: correlations of immunohistochemical assays and long-term follow-up in a series of 909 patients, Int J Oncol, vol.22, issue.2, pp.391-398, 2003.

S. Alinezhad, R. M. Vaananen, J. Mattsson, Y. Li, T. Tallgren et al., Validation of novel biomarkers for prostate cancer progression by the combination of bioinformatics, Clinical and Functional Studies, PLoS One, vol.11, issue.5, p.155901, 2016.

H. Jiang, F. Li, C. He, X. Wang, Q. Li et al., Expression of Gli1 and Wnt2B correlates with progression and clinical outcome of pancreatic cancer, Int J Clin Exp Pathol, vol.7, issue.7, pp.4531-4539, 2014.

M. Katoh, H. Kirikoshi, H. Terasaki, and K. Shiokawa, WNT2B2 mRNA, up-regulated in primary gastric cancer, is a positive regulator of the WNT-beta-catenin-TCF signaling pathway, Biochem Biophys Res Commun, vol.289, issue.5, pp.1093-1101, 2001.

J. M. Bonifas, S. Pennypacker, P. T. Chuang, A. P. Mcmahon, M. Williams et al., Activation of expression of hedgehog target genes in basal cell carcinomas, J Invest Dermatol, vol.116, issue.5, pp.739-781, 2001.

H. Nuckel, M. Switala, C. H. Collins, L. Sellmann, H. Grosse-wilde et al., High CD49d protein and mRNA expression predicts poor outcome in chronic lymphocytic leukemia, Clin Immunol, vol.131, issue.3, pp.472-80, 2009.

Y. Wu, J. Zuo, J. G. Saiyin, H. Liu, X. Yin et al., Proapoptotic function of integrin beta(3) in human hepatocellular carcinoma cells, Clin Cancer Res, vol.15, issue.1, pp.60-69, 2009.

K. Partheen, K. Levan, L. Osterberg, I. Claesson, G. Fallenius et al., Four potential biomarkers as prognostic factors in stage III serous ovarian adenocarcinomas, Int J Cancer, vol.123, issue.9, pp.2130-2137, 2008.

F. Lerebours, S. Vacher, C. Andrieu, M. Espie, M. Marty et al., NFkappa B genes have a major role in inflammatory breast cancer, BMC Cancer, vol.8, p.41, 2008.
DOI : 10.1186/1471-2407-8-41
URL : https://doi.org/10.1186/1471-2407-8-41

J. Park, H. S. Yun, K. H. Lee, K. T. Lee, J. K. Lee et al., Discovery and validation of biomarkers that distinguish Mucinous and Nonmucinous pancreatic cysts, Cancer Res, vol.75, issue.16, pp.3227-3262, 2015.

A. Moiani, Y. Paleari, D. Sartori, R. Mezzadra, A. Miccio et al., Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts, J Clin Invest, vol.122, issue.5, pp.1653-66, 2012.

M. Wu, S. Chen, and X. Wu, Differences in cytochrome P450 2C19 (CYP2C19) expression in adjacent normal and tumor tissues in Chinese cancer patients, Med Sci Monit, vol.12, issue.5, pp.174-182, 2006.

A. M. Horning, J. A. Awe, C. M. Wang, J. Liu, Z. Lai et al., DNA methylation screening of primary prostate tumors identifies SRD5A2 and CYP11A1 as candidate markers for assessing risk of biochemical recurrence, Prostate, vol.75, issue.15, pp.1790-801, 2015.

M. Sinreih, N. Hevir, and T. L. Rizner, Altered expression of genes involved in progesterone biosynthesis, metabolism and action in endometrial cancer, Chem Biol Interact, vol.202, issue.1-3, pp.210-217, 2013.

D. Lu, Y. Zhao, R. Tawatao, H. B. Cottam, M. Sen et al., Activation of the Wnt signaling pathway in chronic lymphocytic leukemia, Proc Natl Acad Sci U S A, vol.101, issue.9, pp.3118-3141, 2004.

A. Memarian, M. Hojjat-farsangi, H. Asgarian-omran, V. Younesi, M. Jeddi-tehrani et al., Variation in WNT genes expression in different subtypes of chronic lymphocytic leukemia, Leuk Lymphoma, vol.50, issue.12, pp.2061-70, 2009.

S. Mangioni, P. Vigano, D. Lattuada, A. Abbiati, M. Vignali et al., Overexpression of the Wnt5b gene in leiomyoma cells: implications for a role of the Wnt signaling pathway in the uterine benign tumor, J Clin Endocrinol Metab, vol.90, issue.9, pp.5349-55, 2005.

Y. W. Lin, Y. L. Shih, G. S. Lien, F. M. Suk, C. B. Hsieh et al., Promoter methylation of SFRP3 is frequent in hepatocellular carcinoma, Dis Markers, p.351863, 2014.

P. N. Kongkham, P. A. Northcott, S. E. Croul, C. A. Smith, M. D. Taylor et al., The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma, Oncogene, vol.29, issue.20, pp.3017-3041, 2010.

C. J. Marsit, E. A. Houseman, B. C. Christensen, L. Gagne, M. R. Wrensch et al., Identification of methylated genes associated with aggressive bladder cancer, PLoS One, vol.5, issue.8, p.12334, 2010.

E. J. Ekstrom, V. Sherwood, and T. Andersson, Methylation and loss of secreted frizzled-related protein 3 enhances melanoma cell migration and invasion, PLoS One, vol.6, issue.4, p.18674, 2011.

T. Byun, M. Karimi, J. L. Marsh, T. Milovanovic, F. Lin et al., Expression of secreted Wnt antagonists in gastrointestinal tissues: potential role in stem cell homeostasis, J Clin Pathol, vol.58, issue.5, pp.515-524, 2005.

F. Ugolini, A. J. , C. , E. Nguyen, C. Jacquemier et al., Differential expression assay of chromosome arm 8p genes identifies frizzled-related (FRP1/FRZB) and fibroblast growth factor receptor 1 (FGFR1) as candidate breast cancer genes, Oncogene, vol.18, issue.10, pp.1903-1913, 1999.

C. Geraud, C. Mogler, A. Runge, K. Evdokimov, S. Lu et al., Endothelial transdifferentiation in hepatocellular carcinoma: loss of Stabilin-2 expression in peri-tumourous liver correlates with increased survival, Liver Int, vol.33, issue.9, pp.1428-1468, 2013.