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Journal articles
Evaluation of a hydrogel membrane on bone regeneration in furcation periodontal defects in dogs
Abstract : The aim of the study was to evaluate bone regeneration using a canine model with surgically created periodontal defects filled for 12 weeks using a stratified biomaterial consisting in a biphasic calcium phosphate (BCP) covered with a crosslinking hydrogel acting as polymer membrane of silated hydroxypropyl methylcellulose (Si-HPMC) as the tested new concept. Bilateral, critical-sized, defects were surgically created at the mandibular premolar teeth of six adult beagle dogs. The defects were randomly allocated and: (i) left empty for spontaneous healing or filled with: (ii) BCP and a collagen membrane; (iii) BCP and hydrogel Si-HPMC membrane. At 12 weeks, the experimental conditions resulted in significantly enhanced bone regeneration in the test BCP/Si-HPMC group. Within the limits of this study, we suggest that the hydrogel Si-HPMC may act as an occlusive barrier to protect bone area from soft connective tissue invasion and then effectively contribute to enhance bone regeneration.
Cited literature [51 references]
https://www.hal.inserm.fr/inserm-02060762
Contributor : Valérie Pecqueret <>
Submitted on : Thursday, March 7, 2019 - 3:54:57 PM
Last modification on : Thursday, June 18, 2020 - 12:32:06 PM
Long-term archiving on: : Sunday, June 9, 2019 - 10:17:31 AM
Contributor : Valérie Pecqueret <>
Submitted on : Thursday, March 7, 2019 - 3:54:57 PM
Last modification on : Thursday, June 18, 2020 - 12:32:06 PM
Long-term archiving on: : Sunday, June 9, 2019 - 10:17:31 AM