Evaluation of a hydrogel membrane on bone regeneration in furcation periodontal defects in dogs

Abstract : The aim of the study was to evaluate bone regeneration using a canine model with surgically created periodontal defects filled for 12 weeks using a stratified biomaterial consisting in a biphasic calcium phosphate (BCP) covered with a crosslinking hydrogel acting as polymer membrane of silated hydroxypropyl methylcellulose (Si-HPMC) as the tested new concept. Bilateral, critical-sized, defects were surgically created at the mandibular premolar teeth of six adult beagle dogs. The defects were randomly allocated and: (i) left empty for spontaneous healing or filled with: (ii) BCP and a collagen membrane; (iii) BCP and hydrogel Si-HPMC membrane. At 12 weeks, the experimental conditions resulted in significantly enhanced bone regeneration in the test BCP/Si-HPMC group. Within the limits of this study, we suggest that the hydrogel Si-HPMC may act as an occlusive barrier to protect bone area from soft connective tissue invasion and then effectively contribute to enhance bone regeneration.
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Xavier Struillou, Aurélien Fruchet, Mia Rakic, Zahi Badran, Gildas Réthoré, et al.. Evaluation of a hydrogel membrane on bone regeneration in furcation periodontal defects in dogs. Dental Materials Journal, Japanese Society for Dental Materials and Devices, 2018, 37 (5), pp.825-834. ⟨10.4012/dmj.2017-238⟩. ⟨inserm-02060762⟩

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