C. Monneret and R. A. Jacquesy, Enjeux scientifiques, éthiques et sociétaux. l'Actualité Chimique, vol.407, p.6, 2016.

C. H. Arrowsmith, C. Bountra, P. V. Fish, K. Lee, and M. Schapira, Epigenetic protein families: A new frontier for drug discovery, Nat. Rev. Drug Discov, vol.11, 2012.

M. Duvic and J. Vu, Vorinostat: A new oral histone deacetylase inhibitor approved for cutaneous T-cell lymphoma, Expert. Opin. Investig. Drugs, vol.16, 1111.

C. Grant, F. Rahman, R. Piekarz, C. Peer, R. Frye et al., Romidepsin: A new therapy for cutaneous T-cell lymphoma and a potential therapy for solid tumors, Expert Rev. Anticancer Ther, vol.10, 2010.

R. Poole, Belinostat: First Global Approval, Drugs, vol.74, p.1543, 2014.

M. P. Fenichel and . Fda, Approves New Agent for Multiple Myeloma, J. Natl. Cancer Inst, vol.107, 2015.

N. Martinet and P. Bertrand, Interpreting clinical assays for histone deacetylase inhibitors, Cancer Manag. Res, vol.3, pp.117-141, 2011.

H. Maeda, Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity, Adv. Drug Deliv. Rev, vol.91, 2015.

N. L. Sato, S. Niimura, N. Fujisawa, and Y. Maeda, Characterization of vascular permeability-increasing component isolated from solid tumors and the effect of highly polymerized dextran sulfate on its activity, Jpn. J. Pharmacol, vol.41, pp.163-171, 1986.

Y. Yang, H. Sun, Y. Liu, W. Hou, Y. Yang et al., Self-assembled aptamer-grafted hyperbranched polymer nanocarrier for targeted and photoresponsive drug delivery, Ang. Chem. Int. Ed, 2018.

E. Mohamed, Y. Zhao, M. Meshali, C. Remsberg, T. Borg et al., Vorinostat with sustained exposure and high solubility in poly(ethylene glycol)-b-poly(DL-lactic acid) micelle nanocarriers: Characterization and effects on pharmacokinetics in rat serum and urine, J. Pharm. Sci, vol.101, pp.3787-3798, 2012.

, Biomolecules, vol.9, pp.60-73, 2019.

T. Tran, T. Ramasamy, D. Truong, B. Shin, H. Choi et al., Development of vorinostat-loaded solid lipid nanoparticles to enhance pharmacokinetics and efficacy against multidrug-resistant cancer cells, Pharm. Res, vol.31, 1978.

R. Sankar and V. Ravikumar, Biocompatibility and biodistribution of suberoylanilide hydroxamic acid loaded poly (DL-lactide-co-glycolide) nanoparticles for targeted drug delivery in cancer, Biomed. Pharmacother, vol.68, pp.865-871, 2014.

R. Sankar, S. Karthik, N. Subramanian, V. Krishnaswami, J. Sonnemann et al., Nanostructured delivery system for Suberoylanilide hydroxamic acid against lung cancer cells, Mater. Sci. Eng. C. Mater. Biol. Appl, vol.51, pp.362-368, 2015.

E. Wang, Y. Min, R. Palm, J. Fiordalisi, K. Wagner et al., Nanoparticle formulations of histone deacetylase inhibitors for effective chemoradiotherapy in solid tumors, Biomaterials, vol.51, pp.208-215, 2015.

T. Tran, D. Chu, D. Truong, J. Tak, J. Jeong et al., Development of lipid nanoparticles for a histone deacetylases inhibitor as a promising anticancer therapeutic, Drug Deliv, vol.2015, pp.1-9

F. Foglietta, L. Serpe, R. Canaparo, N. Vivenza, G. Riccio et al., Modulation of butyrate anticancer activity by solid lipid nanoparticle delivery: An in vitro investigation on human breast cancer and leukemia cell lines, J. Pharm. Pharm. Sci, vol.17, pp.231-247, 2014.

T. Tran, J. Choi, T. Ramasamy, D. Truong, C. Nguyen et al., Hyaluronic acid-coated solid lipid nanoparticles for targeted delivery of vorinostat to CD44 overexpressing cancer cells, Carbohydr. Polym, vol.114, pp.407-415, 2014.

K. Xiao, Y. Li, C. Wang, S. Ahmad, M. Vu et al., Disulfide cross-linked micelles of novel HDAC inhibitor thailandepsin A for the treatment of breast cancer, Biomaterials, vol.67, pp.183-193, 2015.

D. Martin, C. Hoimes, H. Kaimakliotis, C. Cheng, K. Zhang et al., Nanoparticles for urothelium penetration and delivery of the histone deacetylase inhibitor belinostat for treatment of bladder cancer, Nanomedicine, vol.9, pp.1124-1134, 2013.

T. Kwak, D. Kim, Y. Jeong, and D. Kang, Antitumor activity of vorinostat-incorporated nanoparticles against human cholangiocarcinoma cells, J. Nanobiotechnol, vol.13, 2015.

S. Kiran-rompicharla, P. Trivedi, P. Kumari, P. Ghanta, B. Ghosh et al., Polymeric micelles of suberoylanilide hydroxamic acid to enhance the anticancer potential in vitro and in vivo, Nanomedicine, vol.12, pp.43-58, 2017.

L. Han, T. Wang, J. Wu, X. Yin, H. Fang et al., A facile route to form self-carried redox-responsive vorinostat nanodrug for effective solid tumor therapy, Int. J. Nanomed, vol.11, pp.6003-6022, 2016.

R. Delatouche, P. Bertrand, F. Collette, V. Héroguez, F. Gueugnon et al., Nanovecteurs ou particules polymères et leur utilisation comme médicament et/ou agent de diagnostic, 2013.

R. Delatouche, I. Denis, M. Grinda, F. El-bahhaj, E. Baucher et al., Design of pH responsive clickable prodrugs applied to histone deacetylases inhibitors: A new strategy for anticancer therapy, Eur. J. Pharm. Biopharm, vol.85, pp.862-872, 2013.

M. Mondon, R. Delatouche, C. Bachmann, G. Frapper, C. Len et al., Triazolyl Derivatives for Acidic Release of Alcohols, Eur. J. Org. Chem, vol.11, pp.2111-2119, 2011.

F. El-bahhaj, I. Denis, L. Pichavant, R. Delatouche, F. Collette et al., Histone Deacetylase Inhibitors Delivery using Nanoparticles with Intrinsic Passive Tumor Targeting Properties for Tumor Therapy, vol.6, pp.795-807, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-01299450

F. Gueugnon, I. Denis, D. Pouliquen, F. Collette, R. Delatouche et al., Nanoparticles produced by ring-opening metathesis polymerization using norbornenyl-poly(ethylene oxide) as a ligand-free generic platform for highly selective in vivo tumor targeting, Biomacromolecules, vol.14, pp.239-2402, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00931576

, Biomolecules, vol.9, pp.60-74, 2019.

F. Collette, R. Delatouche, C. Blanquart, F. Gueugnon, M. Grégoire et al., An easy and effective method to produce functionalized particles for cellular uptake, J. Polym. Sci. Part A Polym. Chem, vol.51, pp.176-189, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00918361

C. Blanquart, M. Francois, C. Charrier, P. Bertrand, and M. Gregoire, Pharmacological characterization of histone deacetylase inhibitor and tumor cell-growth inhibition properties of new benzofuranone compounds. Curr. Cancer Drug Targets, vol.11, pp.919-928, 2011.

I. Denis, F. El-bahhaj, F. Collette, R. Delatouche, F. Gueugnon et al., Histone deacetylase inhibitor-polymer conjugate nanoparticles for acid-responsive drug delivery, Eur. J. Med. Chem, vol.95, pp.369-376, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01368838

I. Denis, F. El-bahhaj, F. Collette, R. Delatouche, F. Gueugnon et al., Vorinostat-polymer conjugate nanoparticles for Acid-responsive delivery and passive tumor targeting, Biomacromolecules, vol.15, pp.4534-4543, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01369441

F. Gueugnon, P. Cartron, C. Charrier, P. Bertrand, J. Fonteneau et al., New histone deacetylase inhibitors improve cisplatin antitumor properties against thoracic cancer cells, Oncotarget, vol.5, pp.4504-4515, 2014.

S. Leclercq, F. Gueugnon, B. Boutin, F. Guillot, C. Blanquart et al., A 5-aza-2-deoxycytidine/valproate combination induces cytotoxic T-cell response against mesothelioma, Eur. Respir. J, vol.38, pp.1105-1116, 2011.

C. Charrier, J. Clarhaut, J. Gesson, G. Estiu, O. Wiest et al., Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression, J. Med. Chem, vol.52, pp.3112-3115, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00438795

R. Thapa, H. Nguyen, J. Jeong, B. Shin, S. Ku et al., Synergistic anticancer activity of combined histone deacetylase and proteasomal inhibitor-loaded zein nanoparticles in metastatic prostate cancers, Nanomedicine, vol.13, pp.885-896, 2017.

P. Kumar, L. Wasim, M. Chopra, and A. Chhikara, Co-delivery of Vorinostat and Etoposide Via Disulfide Cross-Linked Biodegradable Polymeric Nanogels: Synthesis, Characterization, Biodegradation, and Anticancer Activity, AAPS PharmSciTech, vol.19, pp.634-647, 2018.

H. Ruttala, T. Ramasamy, B. Poudal, Y. Choi, J. Choi et al., Molecularly targeted co-delivery of a histone deacetylase inhibitor and paclitaxel by lipid-protein hybrid nanoparticles for synergistic combinational chemotherapy, Oncotarget, vol.8, pp.14925-14940, 2017.

S. Xu, X. Zhu, W. Huang, Y. Zhou, and D. Yan, Supramolecular cisplatin-vorinostat nanodrug for overcoming drug resistance in cancer synergistic therapy, J. Control. Release, vol.266, pp.36-46, 2017.