H. I. Huppertz, M. Böhme, S. M. Standaert, H. Karch, and S. A. Plotkin, Incidence of Lyme borreliosis in the Würzburg region of Germany, Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol, vol.18, issue.10, pp.697-703, 1999.

R. Koch-institut, Meldepflicht für Lyme-Borreliose in Bayern-eine erste Bilanz, Epidemiol Bull, vol.23, pp.56-62, 2015.

B. Lohr, I. Müller, M. Mai, D. E. Norris, O. Schöffski et al., Epidemiology and cost of hospital care for Lyme borreliosis in Germany: lessons from a health care utilization database analysis, Ticks Tick-Borne Dis, vol.6, issue.1, pp.56-62, 2015.

H. I. Huppertz, Childhood Lyme borreliosis in Europe, Eur J Pediatr, vol.149, issue.12, pp.814-835, 1990.
DOI : 10.1007/bf02072065

B. H. Skogman, S. Croner, M. Nordwall, M. Eknefelt, J. Ernerudh et al., Lyme neuroborreliosis in children: a prospective study of clinical features, prognosis, and outcome, Pediatr Infect Dis J, vol.27, issue.12, pp.1089-94, 2008.

M. Wilke, H. Eiffert, H. J. Christen, and F. Hanefeld, Primarily chronic and cerebrovascular course of Lyme neuroborreliosis: case reports and literature review, Arch Dis Child, vol.83, issue.1, pp.67-71, 2000.
DOI : 10.1136/adc.83.1.67

URL : https://adc.bmj.com/content/83/1/67.full.pdf

J. J. Halperin, E. D. Shapiro, E. Logigian, A. L. Belman, L. Dotevall et al., Practice parameter: treatment of nervous system Lyme disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology, Neurology, vol.69, issue.1, pp.91-102, 2007.

R. Kaiser and . Neuroborreliosis, J Neurol Mai, vol.245, issue.5, pp.247-55, 1998.

A. Mygland, U. Ljøstad, V. Fingerle, T. Rupprecht, E. Schmutzhard et al., EFNS guidelines on the diagnosis and management of European Lyme neuroborreliosis, Eur J Neurol, vol.17, issue.1, pp.8-16, 2010.

M. Dehnert, V. Fingerle, C. Klier, T. Talaska, M. Schlaud et al., Seropositivity of Lyme borreliosis and associated risk factors: a populationbased study in Children and Adolescents in Germany (KiGGS), PLoS One, vol.7, issue.8, p.41321, 2012.

H. I. Huppertz, G. Horneff, U. Neudorf, and H. Karch, Acute childhood neuroborreliosis with a selective immune response to a low molecular weight protein expressed by Borrelia garinii, Eur J Pediatr, vol.153, issue.12, pp.898-902, 1994.

I. S. Szer, E. Taylor, and A. C. Steere, The long-term course of Lyme arthritis in children, N Engl J Med, vol.325, issue.3, pp.159-63, 1991.

J. Bensch, P. Olcén, and L. Hagberg, Destructive chronic borrelia meningoencephalitis in a child untreated for 15 years, Scand J Infect Dis, vol.19, issue.6, pp.697-700, 1987.

F. A. Tager, B. A. Fallon, J. Keilp, M. Rissenberg, C. R. Jones et al., A controlled study of cognitive deficits in children with chronic Lyme disease, J Neuropsychiatry Clin Neurosci, vol.13, issue.4, pp.500-507, 2001.

S. Zotter, J. Koch, K. Schlachter, S. Katzensteiner, L. Dorninger et al., Neuropsychological profile of children after an episode of neuroborreliosis, Neuropediatrics, vol.44, issue.6, pp.346-53, 2013.

G. P. Wormser, R. J. Dattwyler, E. D. Shapiro, J. J. Halperin, A. C. Steere et al., The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America, Clin Infect Dis Off Publ Infect Dis Soc Am, vol.43, issue.9, pp.1089-134, 2006.

D. Cameron, A. Gaito, N. Harris, G. Bach, S. Bellovin et al., Evidence-based guidelines for the management of Lyme disease, Expert Rev Anti Infect Ther, vol.2, issue.1, pp.1-13, 2004.

S. M. Holzbauer, M. M. Kemperman, and R. Lynfield, Death due to communityassociated Clostridium difficile in a woman receiving prolonged antibiotic therapy for suspected lyme disease, Clin Infect Dis Off Publ Infect Dis Soc Am, vol.51, issue.3, pp.369-70, 2010.

R. Patel, K. L. Grogg, W. D. Edwards, A. J. Wright, and N. M. Schwenk, Death from inappropriate therapy for Lyme disease, Clin Infect Dis Off Publ Infect Dis Soc Am, vol.31, issue.4, pp.1107-1116, 2000.

T. D. Gootz, The global problem of antibiotic resistance, Crit Rev Immunol, vol.30, issue.1, pp.79-93, 2010.

D. Hobusch, H. J. Christen, H. I. Huppertz, and R. Noack, Diagnosis and therapy of Lyme borreliosis in children. Practice guideline of the German Society for Pediatric Infectious Diseases, Klin Padiatr, vol.211, issue.2, pp.70-74, 1999.

R. Dersch, M. H. Freitag, S. Schmidt, H. Sommer, G. Rücker et al., Efficacy and safety of pharmacological treatments for neuroborreliosis-protocol for a systematic review, Syst Rev, vol.3, p.117, 2014.

J. Higgins and S. Green, Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated, 2011.

J. Sterne, J. Higgins, and B. Reeves, A Cochrane Risk Of Bias Assessment Tool: for Non-Randomized Studies of Interventions (ACROBATNRSI), Version, 2014.

G. Guyatt, A. D. Oxman, E. A. Akl, R. Kunz, G. Vist et al., GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables, J Clin Epidemiol, vol.64, issue.4, pp.383-94, 2011.

R. R. Müllegger, M. M. Millner, G. Stanek, and K. D. Spork, Penicillin G sodium and ceftriaxone in the treatment of neuroborreliosis in children-a prospective study, Infection, vol.19, issue.4, pp.279-83, 1991.

M. Millner, Neurologic manifestations of Lyme borreliosis in children, Wien Med Wochenschr, vol.145, issue.7-8, pp.178-82, 1946.

H. J. Jörbeck, P. M. Gustafsson, H. C. Lind, and G. T. Stiernstedt, Tick-borne Borreliameningitis in children. An outbreak in the Kalmar area during the summer of 1984, Acta Paediatr Scand, vol.76, issue.2, pp.228-261, 1987.

B. Skowronek-ba?a, E. Weso?owska, A. Gergont, and M. Kaci?ski, Neuroboreliosis with motoric disturbations in the developmental age, Przegla ?d Lek, vol.65, issue.11, pp.810-812, 2008.

C. Thorstrand, E. Belfrage, R. Bennet, P. Malmborg, and M. Eriksson, Successful treatment of neuroborreliosis with ten day regimens, Pediatr Infect Dis J, vol.21, issue.12, pp.1142-1147, 2002.

P. M. Bingham, S. L. Galetta, B. Athreya, and J. Sladky, Neurologic manifestations in children with Lyme disease, Pediatrics, vol.96, issue.6, pp.1053-1059, 1995.

R. B. Nadelman and G. P. Wormser, Lyme borreliosis, Lancet Lond Engl, vol.352, issue.9127, pp.557-65, 1998.

D. Cadavid, P. Auwaerter, J. Aucott, and J. Rumbaugh, Treatment for the neurological complications of Lyme disease (Protocol). Cochrane Database Syst Rev, 2008.

R. Dersch, M. H. Freitag, S. Schmidt, H. Sommer, S. Rauer et al., Efficacy and safety of pharmacological treatments for acute Lyme neuroborreliosisa systematic review, Eur J Neurol, vol.22, issue.9, pp.1249-59, 2015.

G. Stanek, V. Fingerle, K. Hunfeld, B. Jaulhac, R. Kaiser et al., Lyme borreliosis: clinical case definitions for diagnosis and management in Europe, Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis, vol.17, issue.1, pp.69-79, 2011.