, World Health Organisation. Global Tuberculosis Report, p.214, 2016.

A. Gupta, R. Wood, R. Kaplan, L. G. Bekker, and S. D. Lawn, Prevalent and Incident Tuberculosis Are Independent Risk Factors for Mortality among Patients Accessing Antiretroviral Therapy in South Africa, PLoS One, vol.8, 2013.

R. K. Gupta, S. B. Lucas, K. L. Fielding, and S. D. Lawn, Prevalence of tuberculosis in post-mortem studies of HIV-infected adults and children in resource-limited settings: a systematic review and meta-analysis, AIDS, vol.29, pp.1987-2002, 2015.

, Policy statement: automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB/RIF system. Geneva: World Health Organisation, 2011.

C. C. Boehme, M. P. Nicol, P. Nabeta, J. S. Michael, E. Gotuzzo et al., Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study, Lancet, vol.377, 2011.

H. Albert, R. R. Nathavitharana, C. Isaacs, M. Pai, C. M. Denkinger et al., Development, roll-out and impact of Xpert MTB/RIF for tuberculosis: What lessons have we learnt and how can we do better?, Eur Respir J, vol.2016, pp.543-2016, 2016.

S. E. Dorman, S. G. Schumacher, D. Alland, P. Nabeta, D. T. Armstrong et al., Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study, Lancet Infect. Dis, vol.18, pp.76-84, 2018.

O. Koole, S. Thai, K. E. Khun, R. Pe, J. Van-griensven et al., Evaluation of the 2007 WHO guideline to improve the diagnosis of tuberculosis in ambulatory HIV-positive adults, PLoS One, vol.6, 2011.

J. Walley, S. Kunutsor, M. Evans, J. Thoulass, E. Katabira et al., Validation in Uganda of the New WHO Diagnostic Algorithm for SmearNegative Pulmonary Tuberculosis in HIV Prevalent Settings, J Acquir Immune Defic Syndr, vol.15, issue.5, pp.93-100, 2011.

H. Huerga, F. Varaine, E. Okwaro, M. Bastard, E. Ardizzoni et al., Performance of the 2007 WHO algorithm to diagnose smear-negative pulmonary tuberculosis in a HIV prevalent setting, PLoS One, vol.7, 2012.

K. R. Steingart, I. Schiller, D. J. Horne, M. Pai, C. C. Boehme et al., Xpert® MTB/ RIF assay for pulmonary tuberculosis and rifampicin resistance in adults

K. R. Steingart and . Cochrane, Database Syst Rev, 2014.

S. Walusimbi, F. Bwanga, D. Costa, A. Haile, M. Joloba et al., Metaanalysis to compare the accuracy of GeneXpert, MODS and the WHO 2007 algorithm for diagnosis of smear-negative pulmonary tuberculosis, BMC Infect Dis, vol.13, p.507, 2013.

G. Theron, J. Peter, D. Dowdy, I. Langley, S. B. Squire et al., Do high rates of empirical treatment undermine the potential effect of new diagnostic tests for tuberculosis in high-burden settings?, Lancet Infect Dis, pp.527-559, 2014.

G. Theron, L. Zijenah, D. Chanda, P. Clowes, A. Rachow et al., Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled trial, Lancet, vol.383, pp.424-459, 2014.

H. S. Cox, S. Mbhele, N. Mohess, A. Whitelaw, O. Muller et al., Impact of Xpert MTB/RIF for TB diagnosis in a primary care clinic with high TB and HIV prevalence in South Africa: a pragmatic randomised trial, PLoS Med, vol.11, 2014.

B. Durovni, V. Saraceni, S. Van-den-hof, A. Trajman, M. Cordeiro-santos et al., Impact of replacing smear microscopy with Xpert MTB/ RIF for diagnosing tuberculosis in Brazil: a stepped-wedge clusterrandomized trial, PLoS Med, vol.11, 2014.

G. J. Churchyard, W. S. Stevens, L. D. Mametja, K. M. Mccarthy, V. Chihota et al., Xpert MTB/RIF versus sputum microscopy as the initial diagnostic test for tuberculosis: A cluster-randomised trial embedded in South African roll-out of Xpert MTB/RIF, Lancet Glob. Heal, vol.3, pp.450-457, 2015.

W. Katagira, N. D. Walter, S. Den-boon, N. Kalema, I. Ayakaka et al., Empiric TB treatment of severely ill patients with HIV and presumed pulmonary TB improves survival, JAIDS J Acquir Immune Defic Syndr, vol.72, 2016.

M. C. Hosseinipour, G. P. Bisson, S. Miyahara, X. Sun, A. Moses et al., Empiric Tuberculosis Therapy versus Isoniazid in Advanced HIV-infected Adult Outpatients Initiating Antiretroviral Therapy: a Multi-Country Randomized Controlled Trial, Lancet, vol.387, pp.1198-209, 2016.

G. Lui, R. Y. Wong, F. Li, M. K. Lee, R. W. Lai et al., High mortality in adults hospitalized for active tuberculosis in a low HIV prevalence setting, PLoS One, vol.18, issue.3, p.92077, 2014.

S. M. Hermans, J. A. Babirye, O. Mbabazi, F. Kakooza, R. Colebunders et al., Treatment decisions and mortality in HIV-positive presumptive smear-negative TB in the Xpert® MTB/RIF era: a cohort study

, Dis, vol.17, p.433, 2017.

A. Van-rie, D. Westreich, and I. Sanne, Impact of three empirical anti-tuberculosis treatment strategies for people initiating antiretroviral therapy, Int J Tuberc. Lung Dis, vol.18, pp.1340-1346, 2014.

H. Huerga, G. Ferlazzo, P. Bevilacqua, B. Kirubi, E. Oduor et al., Added value of including Xpert MTB/RIF in an algorithm to diagnose smear-negative tuberculosis in a HIV prevalent resource-constraint setting, Union world Conf. Lung heal, 2014.

, Nairobi: National Tuberculosis Leprosy and Lung Diseases Program, 2014.

, Ministry of Health. Kenya HIV estimates. Nairobi: Ministry of Health, 2014.

G. I. Mejia, L. Castrillon, H. Trujillo, and J. A. Robledo, Improving the diagnosis and treatment of smear-negative pulmonary and extrapulmonary tuberculosis among adults and adolescents. Recommendations for HIV-prevalent and resourceconstrained settings. Geneva: World Health Organisation, Int J Tuberc Lung Dis, vol.3, pp.138-180, 1999.

, Xpert MTB/RIF implementation manual. Geneva: World Health Organization, 2014.

F. De, . Am, I. Coimbra, B. J. Arc, M. Maruza et al., Empirical treatment for TB in HIV: lessons from a cohort study of people living with HIV treated in Recife, Brazil, BMC Public Health, vol.14, p.289, 2014.

S. D. Lawn, H. Ayles, S. Egwaga, B. Williams, Y. D. Mukadi et al., Potential utility of empirical tuberculosis treatment for HIV-infected patients with advanced immunodeficiency in high TB-HIV burden settings, Int J Tuberc Lung Dis, vol.15, pp.287-95, 2011.

F. Blanc, A. D. Badje, M. Bonnet, D. Gabillard, E. Messou et al., Systematic vs test-guided tuberculosis treatment: data of the statis randomized trial, CROI, editor. Conf. Retroviruses Opportunistic Infect, 2018.