Altered default mode network connectivity in adolescents with post-traumatic stress disorder: default mode network in severe adolescent PTSD

Abstract : Post-traumatic stress disorder (PTSD) is characterized by intrusions, re-experiencing, avoidance and hyperarousal. These symptoms might be linked to dysfunction in core neurocognitive networks subserving self-referential mental processing (default mode network, DMN), detection of salient stimuli (salience network, SN) and cognitive dysfunction (central executive network, CEN). Resting state studies in adolescent PTSD are scarce and findings are inconsistent, probably due to differences in patient symptom severity. Resting state brain activity was measured in 14 adolescents with severe PTSD and 24 age-matched controls. Seed-based connectivity analyses were used to examine connectivity between the DMN and the whole brain, including regions from other networks (SN and CEN). The relationships of network properties with symptom dimensions (severity, anxiety and depression) and episodic memory were also examined. Analyses revealed decreased within-DMN connectivity (between PCC and occipital cortex) in patients compared to controls. Furthermore, within- DMN connectivity (between PCC and hippocampus) correlated negatively with symptom dimensions (severity and anxiety), while increased connectivity (DMN-SN and DMN-CEN) correlated positively with episodic memory measures. These abnormal network properties found in adolescent PTSD corroborate those previously reported in PTSD adults. Decreased within-DMN connectivity and disrupted DMN-SN and DMN-CEN coupling could form the basis for intrusive trauma recollection and impaired episodic autobiographical recall in PTSD.
Complete list of metadatas

Cited literature [53 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-02044845
Contributor : Francis Eustache <>
Submitted on : Thursday, February 21, 2019 - 4:38:02 PM
Last modification on : Tuesday, October 15, 2019 - 9:06:02 AM
Long-term archiving on : Wednesday, May 22, 2019 - 9:28:04 PM

Files

Viard_Neuroimage Clinical_2019...
Files produced by the author(s)

Identifiers

  • HAL Id : inserm-02044845, version 1

Collections

Citation

Armelle Viard, Justine Mutlu, Sandra Chanraud, Fabian Guénolé, Pierre-Jean Egler, et al.. Altered default mode network connectivity in adolescents with post-traumatic stress disorder: default mode network in severe adolescent PTSD. Neuroimage-Clinical, Elsevier, In press, Epub ahead of print. ⟨inserm-02044845⟩

Share

Metrics

Record views

65

Files downloads

19