A. Amphoux, V. Vialou, and E. Drescher, Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain, Neuropharmacology, vol.50, pp.941-952, 2006.

A. E. Busch, U. Karbach, and D. Miska, Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine, Mol. Pharmacol, vol.54, pp.342-352, 1998.

K. Engel and J. Wang, Interaction of organic cations with a newly identified plasma membrane monoamine transporter, Mol. Pharmacol, vol.68, pp.1397-1407, 2005.

K. Engel, M. Zhou, and J. Wang, Identification and characterization of a novel monoamine transporter in the human brain, J. Biol. Chem, vol.279, pp.50042-50049, 2004.

N. Feng, B. Mo, P. L. Johnson, M. Orchinik, C. A. Lowry et al., Local inhibition of organic cation transporters increases extracellular serotonin in the medial hypothalamus, Brain Res, vol.1063, pp.69-76, 2005.

B. Friedgen, R. Wolfel, H. Russ, E. Schömig, and K. H. Graefe, The role of extraneuronal amine transport systems for the removal of extracellular catecholamines in the rabbit, Naunyn Schmiedebergs Arch. Pharmacol, vol.354, pp.275-286, 1996.

S. Gaillet, J. Lachuer, F. Malaval, I. Assenmacher, and A. Szafarczyk, The involvement of noradrenergic ascending pathways in the stress-induced activation of ACTH and corticosterone secretions is dependent on the nature of stressors, Experimental brain research. Experimentelle Hirnforschung, vol.87, pp.173-180, 1991.

P. J. Gasser, C. A. Lowry, and M. Orchinik, Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: potential role for organic cation transporter 3 in stress-induced modulation of monoaminergic neurotransmission, J. Neurosci, vol.26, pp.8758-8766, 2006.

B. Giros and M. G. Caron, Molecular characterization of the dopamine transporter, Trends Pharmacol. Sci, vol.14, pp.43-49, 1993.

D. Grundemann, S. Koster, N. Kiefer, T. Breidert, M. Engelhardt et al., Transport of monoamine transmitters by the organic cation transporter type 2, OCT2, J. Biol. Chem, vol.273, pp.30915-30920, 1998.

D. Grundemann, B. Schechinger, G. A. Rappold, and E. Schömig, Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter, Nat. Neurosci, vol.1, pp.349-351, 1998.

D. Grundemann, G. Liebich, N. Kiefer, S. Koster, and E. Schomig, Selective substrates for non-neuronal monoamine transporters, Mol. Pharmacol, vol.56, pp.1-10, 1999.

C. Haag, R. Berkels, D. Gründemann, A. Lazar, D. Taubert et al., The localisation of the extraneuronal monoamine transporter (EMT) in rat brain, J. Neurochem, vol.88, pp.291-297, 2004.

M. Hayer-zillgen, M. Brüss, and H. Bönisch, Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3, Br. J. Pharmacol, vol.136, pp.829-836, 2002.

E. D. Hendley, K. M. Taylor, and S. H. Snyder, 3H-normetanephrine uptake in rat brain slices. Relationship to extraneuronal accumulation of norepinephrine, Eur. J. Pharmacol, vol.12, pp.167-179, 1970.

J. P. Herman, H. Figueiredo, N. K. Mueller, Y. Ulrich-lai, M. M. Ostrander et al., Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness, Front. Neuroendocrinol, vol.24, pp.151-180, 2003.

S. E. Hyman, R. C. Malenka, and E. J. Nestler, Neural mechanisms of addiction: the role of reward-related learning and memory, Annu. Rev. Neurosci, vol.29, pp.565-598, 2006.

L. L. Iversen, The uptake of catecholamines at high perfusion concentrations in the rat isolated heart: a novel catechol amine uptake process, Brit. J. Pharmacol, vol.25, pp.18-33, 1965.

R. Kekuda, P. D. Prasad, X. Wu, H. Wang, Y. J. Fei et al., Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta, J. Biol. Chem, vol.273, pp.15971-15979, 1998.

K. Kitaichi, M. Fukuda, H. Nakayama, N. Aoyama, Y. Ito et al., Behavioral changes following antisense oligonucleotide-induced reduction of organic cation transporter-3 in mice, Neurosci. Lett, vol.382, pp.195-200, 2005.

A. Lazar, S. Walitza, and A. Jetter, Novel mutations of the extraneuronal monoamine transporter gene in children and adolescents with obsessive-compulsive disorder, Int. J. Neuropsychopharmacol, vol.11, pp.35-48, 2008.

K. S. Lips, C. Volk, B. M. Schmitt, U. Pfeil, P. Arndt et al., Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium, Am. J. Respir. Cell Mol. Biol, vol.33, pp.79-88, 2005.

H. Nakayama, K. Kitaichi, and Y. Ito, The role of organic cation transporter-3 in methamphetamine disposition and its behavioral response in rats, Brain Res, vol.1184, pp.260-269, 2007.

K. Pacak, M. Palkovits, I. J. Kopin, and D. S. Goldstein, Stressinduced norepinephrine release in the hypothalamic paraventricular nucleus and pituitary-adrenocortical and sympathoadrenal activity: in vivo microdialysis studies, Front. Neuroendocrinol, vol.16, pp.89-150, 1995.

H. Russ, K. Staust, F. Martel, M. Gliese, and E. Schömig, The extraneuronal transporter for monoamine transmitters exists in cells derived from human central nervous system glia, Eur. J. Neurosci, vol.8, pp.1256-1264, 1996.

E. Schömig, H. Russ, K. Staudt, F. Martel, M. Gliese et al., The extraneuronal monoamine transporter exists in human central nervous system glia, Adv. Pharmacol, vol.42, pp.356-359, 1998.

S. Streich, M. Bruss, and H. Bönisch, Expression of the extraneuronal monoamine transporter (uptake2) in human glioma cells, Naunyn Schmiedebergs Arch. Pharmacol, vol.353, pp.328-333, 1996.

G. E. Torres, R. R. Gainetdinov, and M. G. Caron, Plasma membrane monoamine transporters: structure, regulation and function, Nat. Rev. Neurosci, vol.4, pp.13-25, 2003.

U. Trendelenburg, The extraneuronal uptake and metabolism of catecholamaines, Handbook of Experimental Pharmacology, vol.90, pp.279-319, 1988.

B. Springer,

V. Vialou, A. Amphoux, R. Zwart, B. Giros, and S. Gautron, Organic cation transporter 3 (Slc22a3) is implicated in salt-intake regulation, J. Neurosci, vol.24, pp.2846-2851, 2004.
URL : https://hal.archives-ouvertes.fr/inserm-02008093

V. G. Wilson, M. Grohmann, and U. Trendelenburg, The uptake and O-methylation of 3H-(+/-)-isoprenaline in rat cerebral cortex slices, Naunyn Schmiedebergs Arch. Pharmacol, vol.337, pp.397-405, 1988.

X. Wu, R. Kekuda, W. Huang, Y. J. Fei, F. H. Leibach et al., Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain, J. Biol. Chem, vol.273, pp.32776-32786, 1998.

X. Zhuang, R. S. Oosting, S. R. Jones, R. R. Gainetdinov, G. W. Miller et al., Hyperactivity and impaired response habituation in hyperdopaminergic mice, Proc. Natl Acad. Sci. USA, vol.98, pp.1982-1987, 2001.

R. Zwart, S. Verhaagh, M. Buitelaar, C. Popp-snijders, and D. P. Barlow, Impaired activity of the extraneuronal monoamine transporter system known as uptake-2 in Orct3/Slc22a3-deficient mice, Mol. Cell. Biol, vol.21, pp.4188-4196, 2001.

, International Society for Neurochemistry, Journal Compilation Ó, vol.106, pp.1471-1482, 2008.

, The Authors, 2008.