M. Marcou, L. Gal, . Toulemonde, . Beauvallet, . Mebirouk et al., A Fescia, the biological resource center (CV-P, LB, VS) and all the GENESIS collaborating cancer clinics, We thank the genetic epidemiology platform (the PIGE, Plateforme d'Investigation en Génétique et Epidémiologie: SEM

. Hôpital-saint-jacques, :. Besançon, and . Collonge-rame,

C. and B. Audebert,

. Centre-françois-baclesse,

H. Dieu, :. Chambéry, and . Fert-ferrer,

C. Centre-jean-perrin, . Pasteur, :. Colmar, and . Limacher,

C. and F. De-france,

. Chu-albert-michallon, :. Grenoble, . Leroux;-hôpital, L. Flaubert, and . Havre,

O. Centre, . Lambret, :. Lille, ?. Vennin, and C. Adenis,

. Hôpital-jeanne-de-flandre, :. Lille, . Lejeune-dumoulin, ;. Manouvier-hanu, and . Chru-dupuytren,

. Centre-léon-bérard, :. Lyon, . Lasset, and . Bonadona,

E. Hôpital, . Herriot, :. Lyon, . Paolicalmettes, :. Marseille et al.,

, Montpellier: I Coupier, P Pujol

. Centre-rené-gauducheau, :. Nantes, . Delnatte;-centre-catherine-de-sienne-;-m-frénay, and . Mari,

H. Caremeau,

. Réseau-oncogénétique-poitou-charente, :. Niort, . Gesta;-institut-curie, :. Paris, . Stoppa-lyonnet et al.,

H. Saint-louis,

C. Viggo-petersen and P. Cornélis, Hôpital Tenon

. Gh-pitié-salpétrière, P. Beaujon, . Colas, . Soubrier, . Hammel et al.,

. Institut-jean-godinot, :. Reims, . Pennet, and . Td-nguyen,

. Centre-eugène-marquis, :. Rennes, H. Dugast;-centre, . Becquerel, :. Rouen et al.,

, Hôpital René Huguenin/ Institut Curie

P. Centre, . Strauss, :. Strasbourg, H. Fricker, and . Nehme-schuster,

H. Civil, :. Strasbourg, C. Caron, and . Maugard,

. Centre-alexis-vautrin and . Vandoeuvre-lesnancy:-e-luporsi, P Jonveaux

G. Roussy, :. Villejuif, ?. Chompret, and . Caron,

A. Clop, F. Marcq, and H. Takeda, A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep, Nat Genet, vol.38, pp.813-818, 2006.

A. Wojcicka, A. De-la-chapelle, and K. Jazdzewski, MicroRNA-related sequence variations in human cancers, Hum Genet, vol.133, pp.463-469, 2014.

X. Chen, T. Paranjape, and C. Stahlhut, Targeted resequencing of the microRNAome and 3'UTRome reveals functional germline DNA variants with altered prevalence in epithelial ovarian cancer, Oncogene, vol.34, pp.2125-2137, 2015.

J. Feng, G. Sun, and Y. J. , Evidence for X-chromosomal schizophrenia associated with microRNA alterations, PLoS ONE, vol.4, p.6121, 2009.

M. T. Blahna and A. Hata, Regulation of miRNA biogenesis as an integrated component of growth factor signaling, Curr Opin Cell Biol, vol.25, pp.233-240, 2013.

B. D. Adams, A. L. Kasinski, and F. J. Slack, Aberrant regulation and function of microRNAs in cancer, Curr Biol, vol.24, pp.762-776, 2014.

N. Mavaddat, A. C. Antoniou, D. F. Easton, and M. Garcia-closas, Genetic susceptibility to breast cancer, Mol Oncol, vol.4, pp.174-191, 2010.

P. Economopoulou, G. Dimitriadis, and A. Psyrri, Beyond BRCA: new hereditary breast cancer susceptibility genes, Cancer Treat Rev, vol.41, pp.1-8, 2015.

K. Michailidou, J. Beesley, and S. Lindstrom, Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer, Nat Genet, vol.47, pp.373-380, 2015.

H. D. Meeks, H. Song, and K. Michailidou, BRCA2 polymorphic stop codon K3326X and the risk of breast, prostate and ovarian cancers, J Natl Cancer Inst, vol.108, p.315, 2015.

J. Giacomazzi, M. S. Graudenz, and C. A. Osorio, Prevalence of the TP53 p.R337H mutation in breast cancer patients in Brazil, PLoS ONE, vol.9, issue.e99893, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01262543

A. I. Garcia, M. Buisson, and P. Bertrand, Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers, EMBO Mol Med, vol.3, pp.279-290, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00814005

E. Kumaraswamy, K. L. Wendt, and L. A. Augustine, BRCA1 regulation of epidermal growth factor receptor (EGFR) expression in human breast cancer cells involves microRNA-146a and is critical for its tumor suppressor function, Oncogene, vol.34, pp.4333-4346, 2014.

K. D. Taganov, M. P. Boldin, K. J. Chang, and D. Baltimore, NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses, Proc Natl Acad Sci, vol.103, pp.12481-12486, 2006.

O. M. Sinilnikova, M. G. Dondon, and S. Eon-marchais, A French national resource to study the missing heritability of breast cancer, BMC Cancer
URL : https://hal.archives-ouvertes.fr/hal-01662200

S. Lheureux, B. Lambert, and S. Krieger, Two novel variants in the 3'UTR of the BRCA1 gene in familial breast and/or ovarian cancer, Breast Cancer Res Treat, vol.125, pp.885-891, 2011.

J. F. Abelson, K. Y. Kwan, O. 'roak, and . Bj, Sequence variants in SLITRK1 are associated with Tourette's syndrome, Science, vol.310, pp.317-320, 2005.

M. Dusl, J. Senderek, and J. S. Muller, A 3?-UTR mutation creates a microRNA target site in the GFPT1 gene of patients with congenital myasthenic syndrome, Hum Mol Genet, vol.24, pp.3418-3426, 2015.

J. Shen, C. B. Ambrosone, R. A. Dicioccio, K. Odunsi, S. B. Lele et al., A functional polymorphism in the miR-146a gene and age of familial breast/ovarian cancer diagnosis, Carcinogenesis, vol.29, pp.1963-1966, 2008.

Z. Z. Nikolic, S. Pavicevic, D. L. Vucic, N. L. Romac, S. P. Brajuskovic et al., Association between a genetic variant in the hsa-miR-146a gene and cancer risk: an updated metaanalysis, Public Health Genomics, vol.18, pp.283-298, 2015.

B. L. Brewster, F. Rossiello, and J. D. French, Identification of fifteen novel germline variants in the BRCA1 3?UTR reveals a variant in a breast cancer case that introduces a functional miR-103 target site, Hum Mutat, vol.33, pp.1665-1675, 2012.

B. Newman, H. Mu, L. M. Butler, R. C. Millikan, P. G. Moorman et al., Frequency of breast cancer attributable to BRCA1 in a population-based series of American women, JAMA, vol.279, pp.915-921, 1998.

A. Pietschmann, P. Mehdipour, and M. Atri, Mutation analysis of BRCA1 and BRCA2 genes in Iranian high risk breast cancer families, J Cancer Res Clin Oncol, vol.131, pp.552-558, 2005.

M. Pongsavee, V. Yamkamon, and S. Dakeng, The BRCA1 3?-UTR: 5711+421T/T_5711

, +1286T/T genotype is a possible breast and ovarian cancer risk factor, Genet Test Mol Biomarkers, vol.13, pp.307-317, 2009.

N. Puget, D. Stoppa-lyonnet, and O. M. Sinilnikova, Screening for germ-line rearrangements and regulatory mutations in BRCA1 led to the identification of four new deletions, Cancer Res, vol.59, pp.455-461, 1999.

E. Erturk, G. Cecener, and V. Polatkan, Evaluation of genetic variations in miRNAbinding sites of BRCA1 and BRCA2 genes as risk factors for the development of earlyonset and/or familial breast cancer, Asian Pac J Cancer Prev, vol.15, pp.8319-8324, 2014.

S. Khan, D. Greco, and K. Michailidou, MicroRNA related polymorphisms and breast cancer risk, PLoS ONE, vol.9, p.109973, 2014.

C. Pelletier, W. C. Speed, and T. Paranjape, Rare BRCA1 haplotypes including 3?UTR SNPs associated with breast cancer risk, Cell Cycle, vol.10, pp.90-99, 2011.