D. S. Geller and R. Gorlick, Osteosarcoma: a review of diagnosis, management, and treatment strategies, Clin Adv Hematol Oncol, vol.8, pp.705-718, 2010.

N. Marina, M. Gebhardt, L. Teot, and R. Gorlick, Biology and therapeutic advances for pediatric osteosarcoma, Oncologist, vol.9, pp.422-441, 2004.

G. Ottaviani and N. Jaffe, The epidemiology of osteosarcoma, Cancer Treat Res, vol.152, pp.3-13, 2009.

R. Gorlick, Current concepts on the molecular biology of osteosarcoma, Cancer Treat Res, vol.152, pp.467-478, 2009.

E. Kobayashi, F. J. Hornicek, and Z. Duan, MicroRNA Involvement in Osteosarcoma, Sarcoma, p.359739, 2012.

O. O. Ogunwobi, W. Puszyk, H. J. Dong, and C. Liu, Epigenetic upregulation of HGF and c-Met drives metastasis in hepatocellular carcinoma, PLoS One, vol.8, p.63765, 2013.

G. Cassinelli, C. Lanzi, G. Petrangolini, M. Tortoreto, G. Pratesi et al., Inhibition of c-Met and prevention of spontaneous metastatic spreading by the 2-indolinone RPI

, Mol Cancer Ther, vol.5, pp.2388-2397, 2006.

H. Y. Ebrahim, H. E. Elsayed, M. M. Mohyeldin, M. R. Akl, J. Bhattacharjee et al., Norstictic Acid Inhibits Breast Cancer Cell Proliferation, Migration, Invasion, and In Vivo Invasive Growth Through Targeting C-Met, Phytother Res, vol.30, pp.557-566, 2016.
DOI : 10.1002/ptr.5551
URL : http://europepmc.org/articles/pmc5045260?pdf=render

M. F. Gayyed, A. El-maqsoud, N. M. , E. El-heeny, A. A. Mohammed et al., c-MET expression in colorectal adenomas and primary carcinomas with its corresponding metastases, J Gastrointest Oncol, vol.6, pp.618-627, 2015.

L. Cantiani, M. C. Manara, C. Zucchini, D. Sanctis, P. Zuntini et al., Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling, Cancer Res, vol.67, pp.7675-7685, 2007.
DOI : 10.1158/0008-5472.can-06-4697
URL : http://cancerres.aacrjournals.org/content/67/16/7675.full.pdf

S. P. Nana-sinkam and C. M. Croce, Clinical applications for microRNAs in cancer, Clin Pharmacol Ther, vol.93, pp.98-104, 2013.

J. Shen, S. A. Stass, and F. Jiang, MicroRNAs as potential biomarkers in human solid tumors, Cancer Lett, vol.329, pp.125-136, 2013.

R. C. Lee, R. L. Feinbaum, and A. V. , The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14, Cell, vol.75, pp.843-854, 1993.
URL : https://hal.archives-ouvertes.fr/in2p3-00597159

A. E. Pasquinelli and G. Ruvkun, Control of developmental timing by micrornas and their targets, Annu Rev Cell Dev Biol, vol.18, pp.495-513, 2002.

, MicroRNAs in cancer: small molecules with a huge impact, J Clin Oncol, vol.15, pp.5848-5856, 2009.

A. Esquela-kerscher and F. J. Slack, Oncomirs-microRNAs with a role in cancer, Nat Rev Cancer, vol.6, pp.259-269, 2006.

H. Zhao, M. Guo, G. Zhao, Q. Ma, B. Ma et al., miR-183 inhibits the metastasis of osteosarcoma via downregulation of the expression of Ezrin in F5M2 cells, Int J Mol Med, vol.30, pp.1013-1020, 2012.

H. Zhang, X. Cai, Y. Wang, H. Tang, D. Tong et al., microRNA-143, down-regulated in osteosarcoma, promotes apoptosis and suppresses tumorigenicity by targeting Bcl-2, Oncol Rep, vol.24, pp.1363-1369, 2010.

Q. C. Song, Z. B. Shi, Y. T. Zhang, J. L. Wang, K. Z. Duan et al., Downregulation of microRNA-26a is associated with metastatic potential and the poor prognosis of osteosarcoma patients, Oncol Rep, vol.31, pp.1263-1270, 2014.

G. Niu, B. Li, J. Sun, and L. Sun, miR-454 is down-regulated in osteosarcomas and suppresses cell proliferation and invasion by directly targeting c-Met, Cell Prolif, vol.48, pp.348-355, 2015.

R. Garzon, G. Marcucci, and C. M. Croce, Targeting microRNAs in cancer: rationale, strategies and challenges, Nat Rev Drug Discov, vol.9, pp.775-789, 2010.

L. Wu, J. Fan, and J. G. Belasco, MicroRNAs direct rapid deadenylation of mRNA, Proc Natl Acad Sci, vol.103, pp.4034-4039, 2006.

G. Hu, D. Chen, X. Li, K. Yang, H. Wang et al., miR-133b regulates the MET proto-oncogene and inhibits the growth of colorectal cancer cells in vitro and in vivo, Cancer Biol Ther, vol.10, pp.190-197, 2010.

S. Tan, R. Li, K. Ding, P. E. Lobie, and T. Zhu, miR-198 inhibits migration and invasion of hepatocellular carcinoma cells by targeting the HGF/c-MET pathway, FEBS Lett, vol.585, pp.2229-2234, 2011.

D. Yan, D. Xda, E. Chen, X. Wang, L. Lu et al., MicroRNA-1/206 targets c-Met and inhibits rhabdomyosarcoma development, J Biol Chem, vol.284, pp.29596-29604, 2009.
DOI : 10.1074/jbc.m109.020511
URL : http://www.jbc.org/content/284/43/29596.full.pdf

I. J. Fidler, The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited, Nat Rev Cancer, vol.3, pp.453-458, 2003.

L. Zhu, M. M. Mcmanus, and D. P. Hughes, Understanding the Biology of Bone Sarcoma from Early Initiating Events through Late Events in Metastasis and Disease Progression, Front Oncol, vol.3, p.230, 2013.

G. Duan, C. Ren, Y. Zhang, and S. Feng, MicroRNA-26b inhibits metastasis of osteosarcoma via targeting CTGF and Smad1, Tumour Biol, vol.36, pp.6201-6209, 2015.

N. Xu, Z. Li, Z. Yu, F. Yan, Y. Liu et al., MicroRNA33b suppresses migration and invasion by targeting c-Myc in osteosarcoma cells, PLoS One, vol.9, p.115300, 2014.

O. Surriga, V. K. Rajasekhar, G. Ambrosini, Y. Dogan, R. Huang et al., Crizotinib, a c-Met inhibitor, prevents metastasis in a metastatic uveal melanoma model, Mol Cancer Ther, vol.12, pp.2817-2826, 2013.

R. Paumelle, D. Tulasne, Z. Kherrouche, S. Plaza, C. Leroy et al., Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway, Oncogene, vol.21, pp.2309-2319, 2002.

A. Y. Hui, J. A. Meens, C. Schick, S. L. Organ, H. Qiao et al., Src and FAK mediate cell-matrix adhesion-dependent activation of Met during transformation of breast epithelial cells, J Cell Biochem, vol.107, pp.1168-1181, 2009.

G. Tang, Z. Zhang, H. Qian, J. Chen, Y. Wang et al., Epigallocatechin-3-gallate inhibits osteosarcoma cell invasiveness by inhibiting the MEK/ERK signaling pathway in human osteosarcoma cells, J Environ Pathol Toxicol Oncol, vol.34, pp.85-93, 2015.

C. H. Hou, F. L. Lin, S. M. Hou, and J. F. Liu, Cyr61 promotes epithelial-mesenchymal transition and tumor metastasis of osteosarcoma by Raf-1/MEK/ERK/Elk-1/TWIST-1 signaling pathway, Mol Cancer, vol.13, p.236, 2014.

L. B. Zhu, J. Jiang, X. P. Zhu, T. F. Wang, X. Y. Chen et al., Knockdown of Aurora-B inhibits osteosarcoma cell invasion and migration via modulating PI3K/Akt/NF-kappaB signaling pathway, Int J Clin Exp Pathol, vol.7, pp.3984-3991, 2014.

M. Tsubaki, T. Satou, T. Itoh, M. Imano, M. Ogaki et al., Reduction of metastasis, cell invasion, and adhesion in mouse osteosarcoma by YM529/ONO-5920induced blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathway, Toxicol Appl Pharmacol, vol.259, pp.402-410, 2012.

S. Zhang, Y. Zhao, and L. Wang, MicroRNA-198 inhibited tumorous behaviors of human osteosarcoma through directly targeting ROCK1, Biochem Biophys Res Commun, vol.472, pp.557-565, 2016.

Z. Cui, X. Zheng, and D. Kong, Decreased miR-198 expression and its prognostic significance in human gastric cancer, World J Surg Oncol, vol.14, p.33, 2016.

S. Wu, G. Zhang, P. Li, S. Chen, F. Zhang et al., miR-198 targets SHMT1 to inhibit cell proliferation and enhance cell apoptosis in lung adenocarcinoma, Tumour Biol, vol.37, pp.5193-202, 2016.

M. Wang, J. Wang, X. Kong, H. Chen, Y. Wang et al., MiR-198 represses tumor growth and metastasis in colorectal cancer by targeting fucosyl transferase 8, Sci Rep, vol.4, p.6145, 2014.

C. Zhang, C. Yao, H. Li, G. Wang, and X. He, Serum levels of microRNA-133b and microRNA-206 expression predict prognosis in patients with osteosarcoma, Int J Clin Exp Pathol, vol.7, pp.4194-4203, 2014.

Y. P. Bao, Y. Yi, L. L. Peng, J. Fang, K. B. Liu et al., Roles of microRNA-206 in osteosarcoma pathogenesis and progression, Asian Pac J Cancer Prev, vol.14, pp.3751-3755, 2013.

J. Rousseau, V. Escriou, P. Perrot, G. Picarda, C. Charrier et al., Advantages of bioluminescence imaging to follow siRNA or chemotherapeutic treatments in osteosarcoma preclinical models, Cancer Gene Ther, vol.17, pp.387-397, 2010.

A. Patino-garcia, M. Zalacain, C. Folio, C. Zandueta, L. Sierrasesumaga et al., Profiling of chemonaive osteosarcoma and paired-normal cells identifies EBF2 as a mediator of osteoprotegerin inhibition to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis, Clin Cancer Res, vol.15, pp.5082-5091, 2009.

C. Luo, P. W. Tetteh, P. R. Merz, E. Dickes, A. Abukiwan et al., miR137 inhibits the invasion of melanoma cells through downregulation of multiple oncogenic target genes, J Invest Dermatol, vol.133, pp.768-775, 2013.