M. G. Goll, F. Kirpekar, K. A. Maggert, J. A. Yoder, and C. L. Hsieh, Methylation of tRNAAsp by the DNA methyltransferase homolog DNMT2, Science, vol.311, pp.395-403, 2006.

M. Okano, S. Xie, and E. Li, DNMT2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells, Nucleic Acids Res, vol.26, pp.2536-2576, 1998.

M. Negishi, T. Chiba, A. Saraya, S. Miyagi, and A. Iwama, Dmap1 plays an essential role in the maintenance of genome integrity through the DNA repair process, Genes Cells, vol.14, pp.1347-57, 2009.

J. B. Margot, A. E. Ehrenhofer-murray, and H. Leonhardt, Interactions within the mammalian DNA methyltransferase family, BMC Mol Biol, vol.4, p.7, 2003.

R. Goyal, P. Rathert, H. Laser, H. Gowher, and A. Jeltsch, Phosphorylation of serine515 activates the mammalian maintenance methyltransferase Dnmt1, Epigenetics, vol.2, pp.155-60, 2007.

G. Vilkaitis, I. Suetake, S. Klimasauskas, and S. Tajima, Processive methylation of hemimethylated CpG sites by mouse Dnmt1 DNA methyltransferase, J Biol Chem, vol.280, pp.64-72, 2005.

A. Bacolla, S. Pradhan, R. J. Roberts, and R. D. Wells, Recombinant human DNA (cytosine-5) methyltransferase. II. Steady-state kinetics reveal allosteric activation by methylated DNA, J Biol Chem, vol.274, pp.33011-33020, 1999.
DOI : 10.1074/jbc.274.46.33011
URL : http://www.jbc.org/content/274/46/33011.full.pdf

M. Okano, D. W. Bell, D. A. Haber, and L. E. , DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development, Cell, vol.99, pp.247-57, 1999.

S. Pradhan, A. Bacolla, R. D. Wells, and R. J. Roberts, Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation, J Biol Chem, vol.274, pp.33002-33012, 1999.

A. Hermann, R. Goyal, and A. Jeltsch, The Dnmt1 DNA-(cytosine-C5)methyltransferase methylates DNA processively with high preference for hemimethylated target sites, J Biol Chem, vol.279, pp.48350-48359, 2004.

M. Pradhan, P. O. Esteve, H. G. Chin, M. Samaranayke, and G. D. Kim, CXXC domain of human DNMT1 is essential for enzymatic activity, Biochemistry, vol.47, pp.10000-10009, 2008.

K. Fellinger, U. Rothbauer, M. Felle, G. Langst, and H. Leonhardt, Dimerization of DNA methyltransferase 1 is mediated by its regulatory domain, J Cell Biochem, vol.106, pp.521-529, 2009.

P. M. Vertino, J. A. Sekowski, J. M. Coll, N. Applegren, and S. Han, DNMT1 is a component of a multiprotein DNA replication complex, Cell Cycle, vol.1, pp.416-439, 2002.

S. Shimamura and F. Ishikawa, Interaction between DNMT1 and DNA replication reactions in the SV40 in vitro replication system, Cancer Sci, vol.99, pp.1960-1966, 2008.

T. H. Bestor, Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain, EMBO J, vol.11, pp.2611-2618, 1992.

F. Spada, A. Haemmer, D. Kuch, U. Rothbauer, and L. Schermelleh, DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells, J Cell Biol, vol.176, pp.565-71, 2007.

T. Iida, I. Suetake, S. Tajima, H. Morioka, and S. Ohta, PCNA clamp facilitates action of DNA cytosine methyltransferase 1 on hemimethylated DNA, Genes Cells, vol.7, pp.997-1007, 2002.

L. S. Chuang, H. I. Ian, T. W. Koh, H. H. Ng, and G. Xu, Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1, Science, vol.277, pp.1996-2000, 1997.

L. Schermelleh, A. Haemmer, F. Spada, N. Rosing, and D. Meilinger, Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation, Nucleic Acids Res, vol.35, pp.4301-4313, 2007.

M. Bostick, J. K. Kim, P. O. Esteve, A. Clark, and S. Pradhan, UHRF1 plays a role in maintaining DNA methylation in mammalian cells, Science, vol.317, pp.1760-1764, 2007.

J. Sharif, M. Muto, S. Takebayashi, I. Suetake, and A. Iwamatsu, The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA, Nature, vol.450, pp.908-920, 2007.

M. Achour, X. Jacq, P. Ronde, M. Alhosin, and C. Charlot, The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression, Oncogene, vol.27, pp.2187-97, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00284782

K. Arita, M. Ariyoshi, H. Tochio, Y. Nakamura, and M. Shirakawa, Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism, Nature, vol.455, pp.818-839, 2008.

G. V. Avvakumov, J. R. Walker, S. Xue, Y. Li, and S. Duan, Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1, Nature, vol.455, pp.822-827, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00339497

H. Hashimoto, J. R. Horton, X. Zhang, M. Bostick, and S. E. Jacobsen, The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix, Nature, vol.455, pp.826-835, 2008.

C. Qian, S. Li, J. Jakoncic, L. Zeng, and M. J. Walsh, Structure and hemimethylated CpG binding of the SRA domain from human UHRF1, J Biol Chem, vol.283, pp.34490-34494, 2008.

E. Hervouet, L. Lalier, E. Debien, M. Cheray, and A. Geairon, Disruption of Dnmt1/PCNA/UHRF1 interactions promotes tumorigenesis from human and mice glial cells, PLoS One, vol.5, p.11333, 2010.

E. Hervouet, . Ll, E. Debien, M. Cheray, A. Geairon et al., Cartron PF Tumour induction by disruption of the Dnmt1, PCNA, UHRF1 interactions, Nature Precedings, 2008.

M. F. Robert, S. Morin, N. Beaulieu, F. Gauthier, and I. C. Chute, DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells, Nat Genet, vol.33, pp.61-66, 2003.

F. Gaudet, J. G. Hodgson, A. Eden, L. Jackson-grusby, and J. Dausman, Induction of tumors in mice by genomic hypomethylation, Science, vol.300, pp.489-92, 2003.

R. Jaenisch and A. Bird, Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals, Nat Genet, vol.33, pp.245-54, 2003.

T. Chen, S. Hevi, F. Gay, N. Tsujimoto, and T. He, Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells, Nat Genet, vol.39, pp.391-397, 2007.

F. Fuks, W. A. Burgers, A. Brehm, L. Hughes-davies, and T. Kouzarides, DNA methyltransferase Dnmt1 associates with histone deacetylase activity, Nat Genet, vol.24, pp.88-91, 2000.

Z. Xin, M. Tachibana, M. Guggiari, E. Heard, and Y. Shinkai, Role of histone methyltransferase G9a in CpG methylation of the Prader-Willi syndrome imprinting center, J Biol Chem, vol.278, pp.14996-5000, 2003.

S. Sharma, D. S. Gerke, H. F. Han, S. Jeong, and M. R. Stallcup, Lysine methyltransferase G9a is not required for DNMT3A/3B anchoring to methylated nucleosomes and maintenance of DNA methylation in somatic cells, Epigenetics Chromatin, vol.5, p.3, 2012.

A. Rottach, C. Frauer, G. Pichler, I. M. Bonapace, and F. Spada, The multidomain protein Np95 connects DNA methylation and histone modification, Nucleic Acids Res, vol.38, pp.1796-804, 2010.

X. Liu, Q. Gao, P. Li, Q. Zhao, and J. Zhang, UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9, Nat Commun, vol.4, p.1563, 2013.

P. O. Esteve, H. G. Chin, A. Smallwood, G. R. Feehery, and O. Gangisetty, Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication, Genes Dev, vol.20, pp.3089-103, 2006.

J. K. Kim, P. O. Esteve, S. E. Jacobsen, and S. Pradhan, UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells, Nucleic Acids Res, vol.37, pp.493-505, 2009.

A. K. Robertson, T. M. Geiman, U. T. Sankpal, G. L. Hager, and K. D. Robertson, Effects of chromatin structure on the enzymatic and DNA binding functions of DNA methyltransferases DNMT1 and Dnmt3a in vitro, Biochem Biophys Res Commun, vol.322, pp.110-118, 2004.

B. Lehnertz, Y. Ueda, A. A. Derijck, U. Braunschweig, and L. Perez-burgos, Suv39hmediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin, Curr Biol, vol.13, pp.1192-200, 2003.

F. Fuks, P. J. Hurd, R. Deplus, and T. Kouzarides, The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase, Nucleic Acids Res, vol.31, pp.2305-2317, 2003.

A. Smallwood, P. O. Esteve, S. Pradhan, and M. Carey, Functional cooperation between HP1 and DNMT1 mediates gene silencing, Genes Dev, vol.21, pp.1169-78, 2007.

J. Espada, E. Ballestar, M. F. Fraga, A. Villar-garea, and A. Juarranz, Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern, J Biol Chem, vol.279, pp.37175-84, 2004.

M. Macaluso, C. Cinti, G. Russo, A. Russo, and A. Giordano, pRb2/p130-E2F4/5HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptoralpha in breast cancer, Oncogene, vol.22, pp.3511-3518, 2003.

K. Rai, L. D. Nadauld, S. Chidester, E. J. Manos, and S. R. James, Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development, Mol Cell Biol, vol.26, pp.7077-85, 2006.

E. G. Clements, H. P. Mohammad, B. R. Leadem, H. Easwaran, and Y. Cai, DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes, Nucleic Acids Res, vol.40, pp.4334-4380, 2012.

J. S. Butler, J. H. Lee, and D. G. Skalnik, CFP1 interacts with DNMT1 independently of association with the Setd1 Histone H3K4 methyltransferase complexes, DNA Cell Biol, vol.27, pp.533-576, 2008.

M. Cheray, A. Nadaradjane, P. Bonnet, S. Routier, and F. M. Vallette, Specific inhibition of DNMT1/CFP1 reduces cancer phenotypes and enhances chemotherapy effectiveness, Epigenomics, vol.6, pp.267-75, 2014.

K. I. Tatematsu, T. Yamazaki, and F. Ishikawa, MBD2-MBD3 complex binds to hemimethylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase, Genes Cells, vol.5, pp.677-88, 2000.

H. Kimura and K. Shiota, Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1, J Biol Chem, vol.278, pp.4806-4818, 2003.

R. Muromoto, K. Sugiyama, A. Takachi, S. Imoto, and N. Sato, Physical and functional interactions between Daxx and DNA methyltransferase 1associated protein, DMAP1, J Immunol, vol.172, pp.2985-93, 2004.

M. R. Rountree, K. E. Bachman, and S. B. Baylin, DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci, Nat Genet, vol.25, pp.269-77, 2000.

H. Xin, H. G. Yoon, P. B. Singh, J. Wong, and J. Qin, Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in mammalian cells, J Biol Chem, vol.279, pp.9539-9585, 2004.

Z. Liu and R. A. Fisher, RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity, J Biol Chem, vol.279, pp.14120-14128, 2004.
DOI : 10.1074/jbc.m309547200
URL : http://www.jbc.org/content/279/14/14120.full.pdf

E. Hervouet, P. Hulin, F. M. Vallette, and P. F. Cartron, Proximity ligation in situ assay for monitoring the global DNA methylation in cells, BMC Biotechnol, vol.11, p.31, 2011.
URL : https://hal.archives-ouvertes.fr/inserm-00587414

M. Cheray, R. Pacaud, A. Nadaradjane, F. M. Vallette, and P. F. Cartron, Specific inhibition of one DNMT1-including complex influences tumor initiation and progression, Clin Epigenetics, vol.5, p.9, 2013.
URL : https://hal.archives-ouvertes.fr/inserm-00851207

W. A. Burgers, L. Blanchon, S. Pradhan, Y. De-launoit, and T. Kouzarides, Viral oncoproteins target the DNA methyltransferases, Oncogene, vol.26, pp.1650-1655, 2007.
URL : https://hal.archives-ouvertes.fr/hal-01918641

W. Pan, S. Zhu, M. Yuan, H. Cui, and L. Wang, MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1, J Immunol, vol.184, pp.6773-81, 2010.

R. Garzon, S. Liu, M. Fabbri, Z. Liu, and C. E. Heaphy, MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1, Blood, vol.113, pp.6411-6419, 2009.

Y. Sugiyama, N. Hatano, N. Sueyoshi, I. Suetake, and S. Tajima, The DNA-binding activity of mouse DNA methyltransferase 1 is regulated by phosphorylation with casein kinase 1delta/epsilon, Biochem J, vol.427, pp.489-97, 2010.

G. Lavoie, P. O. Esteve, N. B. Laulan, S. Pradhan, and Y. St-pierre, PKC isoforms interact with and phosphorylate DNMT1, BMC Biol, vol.9, p.31, 2011.
DOI : 10.1186/1741-7007-9-31
URL : https://hal.archives-ouvertes.fr/pasteur-00723261

P. O. Esteve, Y. Chang, M. Samaranayake, A. K. Upadhyay, and J. R. Horton, A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability, Nat Struct Mol Biol, vol.18, pp.42-50, 2011.

P. O. Esteve, H. G. Chin, J. Benner, G. R. Feehery, and M. Samaranayake, Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells, Proc Natl Acad Sci, vol.106, pp.5076-81, 2009.

J. Wang, S. Hevi, J. K. Kurash, H. Lei, and F. Gay, The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation, Nat Genet, vol.41, pp.125-134, 2009.

B. Lee and M. T. Muller, SUMOylation enhances DNA methyltransferase 1 activity, Biochem J, vol.421, pp.449-61, 2009.
DOI : 10.1042/bj20090142

J. Arand, D. Spieler, T. Karius, M. R. Branco, and D. Meilinger, In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases, PLoS Genet, vol.8, p.1002750, 2012.

J. Feng, Y. Zhou, S. L. Campbell, T. Le, and E. Li, Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons, Nat Neurosci, vol.13, pp.423-453, 2010.

G. D. Kim, J. Ni, N. Kelesoglu, R. J. Roberts, and S. Pradhan, Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases, EMBO J, vol.21, pp.4183-95, 2002.

G. Liang, M. F. Chan, Y. Tomigahara, Y. C. Tsai, and F. A. Gonzales, Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements, Mol Cell Biol, vol.22, pp.480-91, 2002.

T. Chen, Y. Ueda, J. E. Dodge, Z. Wang, and E. Li, Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b, Mol Cell Biol, vol.23, pp.5594-605, 2003.

S. Jeong, G. Liang, S. Sharma, J. C. Lin, and S. H. Choi, Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA, Mol Cell Biol, vol.29, pp.5366-76, 2009.

A. H. Ting, K. W. Jair, H. Suzuki, R. W. Yen, and S. B. Baylin, CpG island hypermethylation is maintained in human colorectal cancer cells after RNAimediated depletion of DNMT1, Nat Genet, vol.36, pp.582-586, 2004.

I. Rhee, K. E. Bachman, B. H. Park, K. W. Jair, and R. W. Yen, DNMT1 and DNMT3b cooperate to silence genes in human cancer cells, Nature, vol.416, pp.552-558, 2002.

J. Datta, S. Majumder, S. Bai, K. Ghoshal, and H. Kutay, Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells, Cancer Res, vol.65, pp.10891-900, 2005.

E. Hervouet, F. M. Vallette, and P. F. Cartron, Impact of the DNA methyltransferases expression on the methylation status of apoptosis-associated genes in glioblastoma multiforme, Cell Death Dis, vol.1, p.8, 2010.

H. Gowher and A. Jeltsch, Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases, J Biol Chem, vol.277, pp.20409-20423, 2002.

T. M. Geiman, U. T. Sankpal, A. K. Robertson, Y. Chen, and M. Mazumdar, Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery, Nucleic Acids Res, vol.32, pp.2716-2745, 2004.

J. B. Margot, M. C. Cardoso, and H. Leonhardt, Mammalian DNA methyltransferases show different subnuclear distributions, J Cell Biochem, vol.83, pp.373-382, 2001.
DOI : 10.1002/jcb.1236

M. Shamay, M. Greenway, G. Liao, R. F. Ambinder, and S. D. Hayward, De novo DNA methyltransferase DNMT3b interacts with NEDD8-modified proteins, J Biol Chem, vol.285, pp.36377-86, 2010.

J. L. Hu, B. O. Zhou, R. R. Zhang, K. L. Zhang, and J. Q. Zhou, The N-terminus of histone H3 is required for de novo DNA methylation in chromatin, Proc Natl Acad Sci, vol.106, pp.22187-92, 2009.

D. Jia, R. Z. Jurkowska, X. Zhang, A. Jeltsch, and X. Cheng, Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation, Nature, vol.449, pp.248-51, 2007.

S. K. Ooi, C. Qiu, E. Bernstein, K. Li, and D. Jia, DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA, Nature, vol.448, pp.714-721, 2007.

Y. Zhang, R. Jurkowska, S. Soeroes, A. Rajavelu, and A. Dhayalan, Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail, Nucleic Acids Res, vol.38, pp.4246-53, 2010.

J. Otani, T. Nankumo, K. Arita, S. Inamoto, and M. Ariyoshi, Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain, EMBO Rep, vol.10, pp.1235-1276, 2009.

M. S. Kareta, Z. M. Botello, J. J. Ennis, C. Chou, and F. Chedin, Reconstitution and mechanism of the stimulation of de novo methylation by human DNMT3L, J Biol Chem, vol.281, pp.25893-902, 2006.

I. Suetake, F. Shinozaki, J. Miyagawa, H. Takeshima, and S. Tajima, DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction, J Biol Chem, vol.279, pp.27816-27839, 2004.

Z. X. Chen, J. R. Mann, C. L. Hsieh, A. D. Riggs, and F. Chedin, Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family, J Cell Biochem, vol.95, pp.902-919, 2005.

J. L. Glass, M. J. Fazzari, F. Smith, A. C. Greally, and J. M. , CG dinucleotide periodicities recognized by the Dnmt3a-Dnmt3L complex are distinctive at retroelements and imprinted domains, Mamm Genome, vol.20, pp.633-676, 2009.

M. Kaneda, M. Okano, K. Hata, T. Sado, and N. Tsujimoto, Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting, Nature, vol.429, pp.900-903, 2004.

K. Hata, M. Okano, H. Lei, and E. Li, Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice, Development, vol.129, pp.1983-93, 2002.

K. Nimura, C. Ishida, H. Koriyama, K. Hata, and S. Yamanaka, Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation, Genes Cells, vol.11, pp.1225-1262, 2006.

N. Feldman, A. Gerson, J. Fang, E. Li, and Y. Zhang, G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis, Nat Cell Biol, vol.8, pp.188-94, 2006.

H. Zhu, T. M. Geiman, S. Xi, Q. Jiang, and A. Schmidtmann, Lsh is involved in de novo methylation of DNA, EMBO J, vol.25, pp.335-380, 2006.

S. Xi, T. M. Geiman, V. Briones, G. Tao, Y. Xu et al., Lsh participates in DNA methylation and silencing of stem cell genes, Stem Cells, vol.27, pp.2691-702, 2009.

T. Fan, A. Schmidtmann, S. Xi, V. Briones, and H. Zhu, DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development, Epigenetics, vol.3, pp.134-176, 2008.

K. Myant and I. Stancheva, LSH cooperates with DNA methyltransferases to repress transcription, Mol Cell Biol, vol.28, pp.215-241, 2008.

R. Deplus, C. Brenner, W. A. Burgers, P. Putmans, and T. Kouzarides, Dnmt3L is a transcriptional repressor that recruits histone deacetylase, Nucleic Acids Res, vol.30, pp.3831-3839, 2002.

U. Aapola, I. Liiv, and P. Peterson, Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity, Nucleic Acids Res, vol.30, pp.3602-3610, 2002.

J. Datta, K. Ghoshal, S. M. Sharma, S. Tajima, and J. St, Biochemical fractionation reveals association of DNA methyltransferase (Dnmt) 3b with Dnmt1 and that of Dnmt 3a with a histone H3 methyltransferase and Hdac1, J Cell Biochem, vol.88, pp.855-64, 2003.

F. Fuks, W. A. Burgers, N. Godin, M. Kasai, and T. Kouzarides, Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription, EMBO J, vol.20, pp.2536-2580, 2001.

T. M. Geiman, U. T. Sankpal, A. K. Robertson, Y. Zhao, and K. D. Robertson, DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system, Biochem Biophys Res Commun, vol.318, pp.544-55, 2004.

Q. Zhao, G. Rank, Y. T. Tan, H. Li, and R. L. Moritz, PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing, Nat Struct Mol Biol, vol.16, pp.304-315, 2009.

A. Dhayalan, A. Rajavelu, P. Rathert, R. Tamas, and R. Z. Jurkowska, The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation, J Biol Chem, vol.285, pp.26114-26134, 2010.

S. Gopalakrishnan, B. A. Sullivan, S. Trazzi, D. Valle, G. Robertson et al., DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions, Hum Mol Genet, vol.18, pp.3178-93, 2009.

M. El-gazzar, B. K. Yoza, X. Chen, J. Hu, and G. A. Hawkins, G9a and HP1 couple histone and DNA methylation to TNFalpha transcription silencing during endotoxin tolerance, J Biol Chem, vol.283, pp.32198-208, 2008.

H. Li, T. Rauch, Z. X. Chen, P. E. Szabo, and A. D. Riggs, The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells, J Biol Chem, vol.281, pp.19489-500, 2006.

P. Han, W. Li, J. Yang, C. Shang, and C. H. Lin, Epigenetic response to environmental stress: assembly of BRG1-G9a/GLP-DNMT3 repressive chromatin complex on Myh6 promoter in pathologically stressed hearts, Biochim Biophys Acta, vol.1863, pp.1772-81, 2016.

Y. Chang, L. Sun, K. Kokura, J. R. Horton, and M. Fukuda, MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a, Nat Commun, vol.2, p.533, 2011.

D. Meilinger, K. Fellinger, S. Bultmann, U. Rothbauer, and I. M. Bonapace, Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells, EMBO Rep, vol.10, pp.1259-64, 2009.

M. Fatemi, A. Hermann, H. Gowher, and A. Jeltsch, Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA, Eur J Biochem, vol.269, pp.4981-4985, 2002.

K. W. Jair, K. E. Bachman, H. Suzuki, A. H. Ting, and I. Rhee, De novo CpG island methylation in human cancer cells, Cancer Res, vol.66, pp.682-92, 2006.

G. Egger, S. Jeong, S. G. Escobar, C. C. Cortez, and T. W. Li, Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival, Proc Natl Acad Sci, vol.103, pp.14080-14085, 2006.

M. Fatemi, A. Hermann, S. Pradhan, and A. Jeltsch, The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA, J Mol Biol, vol.309, pp.1189-99, 2001.

M. Felle, S. Joppien, A. Nemeth, S. Diermeier, and V. Thalhammer, The USP7/ Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1, Nucleic Acids Res, vol.39, pp.8355-65, 2011.

G. Foltz, J. G. Yoon, H. Lee, T. C. Ryken, and Z. Sibenaller, DNA methyltransferase-mediated transcriptional silencing in malignant glioma: a combined whole-genome microarray and promoter array analysis, Oncogene, vol.28, pp.2667-77, 2009.

I. G. Lin, L. Han, A. Taghva, L. E. O'brien, and C. L. Hsieh, Murine de novo methyltransferase Dnmt3a demonstrates strand asymmetry and site preference in the methylation of DNA in vitro, Mol Cell Biol, vol.22, pp.704-727, 2002.

M. Takahashi, Y. Kamei, T. Ehara, X. Yuan, and T. Suganami, Analysis of DNA methylation change induced by Dnmt3b in mouse hepatocytes, Biochem Biophys Res Commun, vol.434, pp.873-881, 2013.

O. Mortusewicz, L. Schermelleh, J. Walter, M. C. Cardoso, and H. Leonhardt, Recruitment of DNA methyltransferase I to DNA repair sites, Proc Natl Acad Sci, vol.102, pp.8905-8914, 2005.

G. Guo, W. Wang, and A. Bradley, Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells, Nature, vol.429, pp.891-896, 2004.

Z. Yu, Q. Kong, and B. C. Kone, Aldosterone reprograms promoter methylation to regulate alphaENaC transcription in the collecting duct, Am J Physiol Renal Physiol, vol.305, pp.1006-1019, 2013.

M. J. Boland and J. K. Christman, Characterization of Dnmt3b:thymine-DNA glycosylase interaction and stimulation of thymine glycosylase-mediated repair by DNA methyltransferase(s) and RNA, J Mol Biol, vol.379, pp.492-504, 2008.

Y. Q. Li, P. Z. Zhou, X. D. Zheng, C. P. Walsh, and G. L. Xu, Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair, Nucleic Acids Res, vol.35, pp.390-400, 2007.

O. Hagan, H. M. Mohammad, H. P. Baylin, and S. B. , Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island, PLoS Genet, vol.4, p.1000155, 2008.

R. Metivier, R. Gallais, C. Tiffoche, L. Peron, C. Jurkowska et al., Cyclical DNA methylation of a transcriptionally active promoter, Nature, vol.452, pp.45-50, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00266245

C. Gazin, N. Wajapeyee, S. Gobeil, C. M. Virbasius, and M. R. Green, An elaborate pathway required for Ras-mediated epigenetic silencing, Nature, vol.449, pp.1073-1080, 2007.

M. Negishi, A. Saraya, S. Miyagi, K. Nagao, and Y. Inagaki, Bmi1 cooperates with Dnmt1-associated protein 1 in gene silencing, Biochem Biophys Res Commun, vol.353, pp.992-1000, 2007.

M. Yamashita, M. Kuwahara, A. Suzuki, K. Hirahara, and R. Shinnaksu, Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene, J Exp Med, vol.205, pp.1109-1129, 2008.

X. Wu, Y. Gong, J. Yue, B. Qiang, and J. Yuan, Cooperation between EZH2, NSPc1-mediated histone H2A ubiquitination and Dnmt1 in HOX gene silencing, Nucleic Acids Res, vol.36, pp.3590-3599, 2008.

E. Vire, C. Brenner, R. Deplus, L. Blanchon, and M. Fraga, The polycomb group protein EZH2 directly controls DNA methylation, Nature, vol.439, pp.871-875, 2006.
URL : https://hal.archives-ouvertes.fr/hal-01918637

B. Jin, B. Yao, J. L. Li, C. R. Fields, and A. L. Delmas, DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer, Cancer Res, vol.69, pp.7412-7433, 2009.

M. Rush, R. Appanah, S. Lee, L. L. Lam, and P. Goyal, Targeting of EZH2 to a defined genomic site is sufficient for recruitment of Dnmt3a but not de novo DNA methylation, Epigenetics, vol.4, pp.404-418, 2009.

R. Athanasiadou, D. De-sousa, K. Myant, C. Merusi, and I. Stancheva, Targeting of de novo DNA methylation throughout the Oct-4 gene regulatory region in differentiating embryonic stem cells, PLoS One, vol.5, p.9937, 2010.

P. Gu, X. Xu, L. Menuet, D. Chung, A. C. Cooney et al., Differential recruitment of methyl CpG-binding domain factors and DNA methyltransferases by the orphan receptor germ cell nuclear factor initiates the repression and silencing of Oct4, Stem Cells, vol.29, pp.1041-51, 2011.

S. Epsztejn-litman, N. Feldman, M. Abu-remaileh, Y. Shufaro, and A. Gerson, De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes, Nat Struct Mol Biol, vol.15, pp.1176-83, 2008.

D. L. Zheng, L. Zhang, N. Cheng, X. Xu, and Q. Deng, Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A, J Hepatol, vol.50, pp.377-87, 2009.

I. Y. Park, B. H. Sohn, Y. E. Suh, D. J. Chung, and Y. H. , Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein, Gastroenterology, vol.132, pp.1476-94, 2007.
DOI : 10.1053/j.gastro.2007.01.034

Y. Zhou and I. Grummt, The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing, Curr Biol, vol.15, pp.1434-1442, 2005.

S. Majumder, K. Ghoshal, J. Datta, D. S. Smith, and S. Bai, Role of DNA methyltransferases in regulation of human ribosomal RNA gene transcription, J Biol Chem, vol.281, pp.22062-72, 2006.

E. Hervouet, F. M. Vallette, and P. F. Cartron, Dnmt1/transcription factor interactions: an alternative mechanism of DNA methylation inheritance, Genes Cancer, vol.1, pp.434-477, 2010.

E. Hervouet, A. Nadaradjane, M. Gueguen, F. M. Vallette, and P. F. Cartron, Kinetics of DNA methylation inheritance by the Dnmt1-including complexes during the cell cycle, Cell Div, vol.7, p.5, 2012.
URL : https://hal.archives-ouvertes.fr/inserm-00680687

P. O. Esteve, H. G. Chin, and S. Pradhan, Human maintenance DNA (cytosine-5)methyltransferase and p53 modulate expression of p53-repressed promoters, Proc Natl Acad Sci, vol.102, pp.1000-1005, 2005.

N. Hayashi, M. Kobayashi, A. Shamma, Y. Morimura, and C. Takahashi, Regulatory interaction between NBS1 and DNMT1 responding to DNA damage, J Biochem, 2013.

L. Gac, G. Esteve, P. O. Ferec, C. Pradhan, and S. , DNA damage-induced downregulation of human Cdc25C and Cdc2 is mediated by cooperation between p53 and maintenance DNA (cytosine-5) methyltransferase 1, J Biol Chem, vol.281, pp.24161-70, 2006.

R. Arabsolghar, T. Azimi, and M. Rasti, Mutant p53 binds to estrogen receptor negative promoter via DNMT1 and HDAC1 in MDA-MB-468 breast cancer cells, Mol Biol Rep, vol.40, issue.3, pp.2617-2642, 2013.

S. Liu, T. Shen, L. Huynh, M. I. Klisovic, and L. J. Rush, Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia, Cancer Res, vol.65, issue.4, pp.1277-84, 2005.

E. Sajedi, C. Gaston-massuet, C. L. Andoniadou, M. Signore, and P. J. Hurd, DNMT1 interacts with the developmental transcriptional repressor HESX1, Biochim Biophys Acta, vol.1783, pp.131-174, 2008.

Q. Zhang, H. Y. Wang, M. Marzec, P. N. Raghunath, and T. Nagasawa, STAT3and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes, Proc Natl Acad Sci U S A, vol.102, pp.6948-53, 2005.

L. A. Puto and J. C. Reed, Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylation, Genes Dev, vol.22, pp.998-1010, 2008.

H. Zhang, J. He, J. Li, D. Tian, and L. Gu, Methylation of RASSF1A gene promoter is regulated by p53 and DAXX, FASEB J, vol.27, pp.232-274, 2013.

Y. A. Wang, Y. Kamarova, K. C. Shen, Z. Jiang, and M. J. Hahn, DNA methyltransferase-3a interacts with p53 and represses p53-mediated gene expression, Cancer Biol Ther, vol.4, pp.1138-1181, 2005.

M. Suzuki, T. Yamada, F. Kihara-negishi, T. Sakurai, and E. Hara, Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b, Oncogene, vol.25, pp.2477-88, 2006.

V. Senyuk, K. Premanand, P. Xu, Z. Qian, and G. Nucifora, The oncoprotein EVI1 and the DNA methyltransferase Dnmt3 co-operate in binding and de novo methylation of target DNA, PLoS One, vol.6, p.20793, 2011.

M. Cheray, R. Pacaud, A. Nadaradjane, L. Oliver, and F. M. Vallette, Specific inhibition of DNMT3A/ISGF3gamma interaction increases the temozolomide efficiency to reduce tumor growth, Theranostics, vol.6, pp.1988-99, 2016.

C. Brenner, R. Deplus, C. Didelot, A. Loriot, and E. Vire, Myc represses transcription through recruitment of DNA methyltransferase corepressor, EMBO J, vol.24, pp.336-382, 2005.

E. Hervouet, F. M. Vallette, and P. F. Cartron, Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation, Epigenetics, vol.4, pp.487-99, 2009.

J. Zhang, C. Zhou, H. Jiang, L. Liang, and W. Shi, ZEB1 induces ER-alpha promoter hypermethylation and confers antiestrogen resistance in breast cancer, Cell Death Dis, vol.8, p.2732, 2017.
DOI : 10.1038/cddis.2017.154
URL : https://www.nature.com/articles/cddis2017154.pdf

C. Zhou, H. Jiang, Z. Zhang, G. Zhang, and H. Wang, ZEB1 confers stem celllike properties in breast cancer by targeting neurogenin-3, Oncotarget, vol.8, pp.54388-401, 2017.

L. Di-croce, V. A. Raker, M. Corsaro, F. Fazi, and M. Fanelli, Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor, Science, vol.295, pp.1079-82, 2002.

G. Velasco, F. Hube, J. Rollin, D. Neuillet, and C. Philippe, Dnmt3b recruitment through E2F6 transcriptional repressor mediates germ-line gene silencing in murine somatic tissues, Proc Natl Acad Sci, vol.107, pp.9281-9287, 2010.
DOI : 10.1073/pnas.1000473107
URL : https://hal.archives-ouvertes.fr/hal-02127331

K. D. Robertson, A. , S. Yokochi, T. Wade, P. A. Jones et al., DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters, Nat Genet, vol.25, pp.338-380, 2000.
DOI : 10.1038/77124

M. Shamay, A. Krithivas, J. Zhang, and S. D. Hayward, Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA, Proc Natl Acad Sci, vol.103, pp.14554-14563, 2006.

R. Pacaud, Q. Sery, L. Oliver, F. M. Vallette, and J. Tost, DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: role of the DNMT3L/DNMT3B/p65-NFkappaB complex in the (de-)methylation of TRAF1, Biochimie, vol.104, pp.36-49, 2014.

P. F. Cartron, C. Blanquart, E. Hervouet, M. Gregoire, and F. M. Vallette, HDAC1mSin3a-NCOR1, Dnmt3b-HDAC1-Egr1 and Dnmt1-PCNA-UHRF1-G9a regulate the NY-ESO1 gene expression, Mol Oncol, 2012.
DOI : 10.1016/j.molonc.2012.11.004
URL : https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/j.molonc.2012.11.004