%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Laurent Cotte, Tristan Ferry, Pascal Pugliese, Marc-Antoine Valantin, Clotilde Allavena, André Cabié, Isabelle Poizot-Martin, David Rey, Claudine Duvivier, Antoine Cheret, Pierre Dellamonica, Pierre Pradat, Jean-Jacques Parienti, Dat’AIDS study group
Effectiveness and tolerance of single tablet versus once daily multiple tablet regimens as first-line antiretroviral therapy - Results from a large french multicenter cohort study
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 12 0 R/Contents 13 0 R/TrimBox[0 0 612 792]>>
endobj
12 0 obj
[14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R]
endobj
14 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170661.ref001)>>
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170661.ref002)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170661.ref003)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170661.ref004)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170661.ref006)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170661.ref007)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170661.ref008)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170661.ref001)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170661.ref009)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170661.ref010)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170661.ref015)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170661.ref015)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170661.ref016)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170661.ref012)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170661.ref017)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0170661.ref018)>>
endobj
13 0 obj
[30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R]
endobj
30 0 obj
<>stream
q
0.45 0.36 0.35 0.01 k
0 w
575.9997 471.4546 m
199.9998 471.4546 l
199.9998 471.9546 l
575.9997 471.9546 l
f*
0.83 0.64 0.02 0 k
246.6142 328.9323 m
251.3764 328.9323 l
h
f*
554.3433 302.9102 m
559.1055 302.9102 l
h
f*
518.8535 276.9449 m
523.6157 276.9449 l
h
f*
512.1638 250.9228 m
516.8693 250.9228 l
h
f*
522.085 250.9228 m
526.8472 250.9228 l
h
f*
410.3433 224.9008 m
415.1055 224.9008 l
h
f*
417.3732 224.9008 m
422.1354 224.9008 l
h
f*
550.6583 211.9181 m
555.4205 211.9181 l
h
f*
557.6882 211.9181 m
562.4504 211.9181 l
h
f*
223.7669 185.8961 m
233.2913 185.8961 l
h
f*
238.4504 185.8961 m
247.9748 185.8961 l
h
f*
398.7213 185.8961 m
408.189 185.8961 l
h
f*
410.4567 185.8961 m
419.9811 185.8961 l
h
f*
203.4142 146.948 m
212.9386 146.948 l
h
f*
215.1496 146.948 m
224.674 146.948 l
h
f*
530.0787 120.926 m
539.6031 120.926 l
h
f*
0 g
1 j
1 J
11.4998 0 0 11.4998 200.0125 706.3937 cm
BT
/F2 1 Tf
1 TL
-0.0035 Tc
0 0 Td
(Results)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 200.0125 689.3858 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(Overall,)Tj
3.6283 0 Td
(3212)Tj
2.4169 0 Td
(patients)Tj
3.6761 0 Td
(\(STR)Tj
2.5422 0 Td
(499,)Tj
2.1424 0 Td
(non-STR)Tj
4.1893 0 Td
(2713\))Tj
2.7451 0 Td
(were)Tj
2.3632 0 Td
(included.)Tj
4.1654 0 Td
(Median)Tj
3.4612 0 Td
(time)Tj
2.0887 0 Td
(to)Tj
1.0503 0 Td
(treatment)Tj
-34.4691 -1.474 Td
(discontinuation)Tj
6.8031 0 Td
(was)Tj
1.9812 0 Td
(shorter)Tj
3.3002 0 Td
(in)Tj
0.9786 0 Td
(non-STR)Tj
4.1893 0 Td
(patients)Tj
3.6821 0 Td
(than)Tj
2.1424 0 Td
(in)Tj
0.9846 0 Td
(STR)Tj
2.2081 0 Td
(patients,)Tj
3.9565 0 Td
(both)Tj
2.1484 0 Td
(in)Tj
0.9846 0 Td
(the)Tj
1.5934 0 Td
(IPWT)Tj
-34.9525 -1.468 Td
(\(HR)Tj
1.9812 0 Td
(=)Tj
0.7997 0 Td
(0.61,)Tj
2.4169 0 Td
(p)Tj
/F4 1 Tf
[( )]TJ
/F0 1 Tf
(0.0001\))Tj
4.7025 0 Td
(and)Tj
1.8679 0 Td
(the)Tj
1.5933 0 Td
(PSM)Tj
2.3752 0 Td
(cohort)Tj
2.9718 0 Td
(\(HR)Tj
1.9813 0 Td
(=)Tj
0.7997 0 Td
(0.55,)Tj
2.4228 0 Td
(p)Tj
/F4 1 Tf
[( )]TJ
/F0 1 Tf
(0.0001\).)Tj
4.9771 0 Td
(This)Tj
2.0886 0 Td
(difference)Tj
4.5593 0 Td
(disap-)Tj
-35.5373 -1.474 Td
(peared)Tj
3.2941 0 Td
(when)Tj
2.578 0 Td
(censoring)Tj
4.5056 0 Td
(ART)Tj
2.208 0 Td
(modification)Tj
5.4903 0 Td
(for)Tj
1.3725 0 Td
(simplification)Tj
5.6514 0 Td
(,)Tj
0.4953 0 Td
(both)Tj
2.1424 0 Td
(in)Tj
0.9847 0 Td
(the)Tj
1.5933 0 Td
(IPWT)Tj
2.7213 0 Td
(\(HR)Tj
1.9813 0 Td
(=)Tj
0.7996 0 Td
(0.97,)Tj
-35.8178 -1.474 Td
(p)Tj
0.7698 0 Td
(=)Tj
0.7996 0 Td
(0.65\))Tj
2.4707 0 Td
(and)Tj
1.8678 0 Td
(the)Tj
1.5934 0 Td
(PSM)Tj
2.3751 0 Td
(cohort)Tj
2.9719 0 Td
(\(HR)Tj
1.9813 0 Td
(=)Tj
0.7996 0 Td
(0.91,)Tj
2.4229 0 Td
(p)Tj
0.7698 0 Td
(=)Tj
0.7997 0 Td
(0.33\).)Tj
2.7511 0 Td
(A)Tj
0.8832 0 Td
(lower)Tj
2.578 0 Td
(rate)Tj
1.9216 0 Td
(of)Tj
1.0444 0 Td
(virological)Tj
4.601 0 Td
(failure)Tj
2.9003 0 Td
(was)Tj
-36.3012 -1.474 Td
(observed)Tj
4.2847 0 Td
(with)Tj
1.9753 0 Td
(STRs)Tj
2.7093 0 Td
(than)Tj
2.1424 0 Td
(with)Tj
1.9753 0 Td
(non-STRs)Tj
4.6846 0 Td
(in)Tj
0.9847 0 Td
(both)Tj
2.1424 0 Td
(cohorts)Tj
3.4672 0 Td
(\(HR)Tj
1.9812 0 Td
(=)Tj
0.7997 0 Td
(0.23;)Tj
2.4229 0 Td
(p)Tj
0.7638 0 Td
(=)Tj
0.8057 0 Td
(0.002)Tj
2.6914 0 Td
(and)Tj
1.8619 0 Td
(HR)Tj
1.653 0 Td
(=)Tj
-37.3455 -1.474 Td
(0.22,)Tj
2.4169 0 Td
(p)Tj
0.7698 0 Td
(=)Tj
0.7996 0 Td
(0.003,)Tj
2.9719 0 Td
(respectively\).)Tj
6.0453 0 Td
(A)Tj
0.8832 0 Td
(lower)Tj
2.578 0 Td
(rate)Tj
1.9216 0 Td
(of)Tj
1.0503 0 Td
(treatment)Tj
4.4041 0 Td
(modification)Tj
5.4903 0 Td
(for)Tj
1.3785 0 Td
(adverse)Tj
3.7358 0 Td
(event)Tj
2.6436 0 Td
(was)Tj
-37.0889 -1.4741 Td
(observed)Tj
4.2847 0 Td
(with)Tj
1.9753 0 Td
(non-STRs)Tj
4.6846 0 Td
(in)Tj
0.9847 0 Td
(the)Tj
1.5934 0 Td
(IPWT)Tj
2.7152 0 Td
(cohort)Tj
2.9719 0 Td
(\(HR)Tj
1.9813 0 Td
(=)Tj
0.7997 0 Td
(1.46,)Tj
2.4228 0 Td
(p)Tj
/F4 1 Tf
[( )]TJ
/F0 1 Tf
(0.0001\),)Tj
4.9771 0 Td
(but)Tj
1.5933 0 Td
(not)Tj
1.5934 0 Td
(in)Tj
0.9846 0 Td
(the)Tj
1.5934 0 Td
(PSM)Tj
-35.1554 -1.474 Td
(cohort)Tj
2.9659 0 Td
(\(HR)Tj
1.9812 0 Td
(=)Tj
0.7997 0 Td
(1.22,)Tj
2.4229 0 Td
(p)Tj
0.7698 0 Td
(=)Tj
0.7997 0 Td
(0.11\).)Tj
ET
Q
q
1 j
1 J
0 w
11.4998 0 0 11.4998 200.0125 529.9653 cm
BT
/F2 1 Tf
1 TL
-0.0035 Tc
0 0 Td
(Conclusion)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 200.0125 512.9574 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(First-line)Tj
4.0042 0 Td
(therapy)Tj
3.521 0 Td
(with)Tj
1.9753 0 Td
(STRs)Tj
2.7093 0 Td
(was)Tj
1.9812 0 Td
(associated)Tj
4.9413 0 Td
(with)Tj
1.9812 0 Td
(a)Tj
0.7639 0 Td
(longer)Tj
2.9599 0 Td
(time)Tj
2.0947 0 Td
(to)Tj
1.0443 0 Td
(treatment)Tj
4.4101 0 Td
(discontinuation)Tj
-32.3864 -1.474 Td
(than)Tj
2.1423 0 Td
(with)Tj
1.9753 0 Td
(non-STRs.)Tj
4.9592 0 Td
(However,)Tj
4.4041 0 Td
(when)Tj
2.584 0 Td
(ART)Tj
2.208 0 Td
(modification)Tj
5.4903 0 Td
(for)Tj
1.3725 0 Td
(simplification)Tj
5.8722 0 Td
(was)Tj
1.9812 0 Td
(not)Tj
1.5934 0 Td
(considered)Tj
-34.5825 -1.474 Td
(as)Tj
1.2651 0 Td
(a)Tj
0.7698 0 Td
(failure,)Tj
3.1808 0 Td
(STRs)Tj
2.7033 0 Td
(and)Tj
1.8679 0 Td
(non-STRs)Tj
4.6846 0 Td
(were)Tj
2.3632 0 Td
(similar.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 399.0047 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 381.9968 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(During)Tj
3.135 0 Td
(the)Tj
1.4684 0 Td
(past)Tj
1.8312 0 Td
(decades,)Tj
3.5659 0 Td
(HIV)Tj
2.0239 0 Td
(combined)Tj
4.2406 0 Td
(antiretroviral)Tj
5.5162 0 Td
(therapy)Tj
3.2485 0 Td
(\(ART\))Tj
2.812 0 Td
(has)Tj
1.5477 0 Td
(drastically)Tj
4.2803 0 Td
(evolved)Tj
-33.6697 -1.2982 Td
(with)Tj
1.9955 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(consequence)Tj
5.3404 0 Td
(a)Tj
0.652 0 Td
(better)Tj
2.5455 0 Td
(control)Tj
3.1181 0 Td
(of)Tj
1.0148 0 Td
(HIV)Tj
2.0239 0 Td
(infection)Tj
3.7927 0 Td
(and)Tj
1.7292 0 Td
(a)Tj
0.6519 0 Td
(reduction)Tj
4.1159 0 Td
(of)Tj
1.0148 0 Td
(HIV-related)Tj
5.0967 0 Td
(mor-)Tj
-34.7582 -1.3039 Td
(bidity)Tj
2.5341 0 Td
(and)Tj
1.7235 0 Td
(mortality.)Tj
4.1385 0 Td
(Adherence)Tj
4.5694 0 Td
(to)Tj
1.0148 0 Td
(treatment)Tj
4.1329 0 Td
(has)Tj
1.5364 0 Td
(been)Tj
2.1146 0 Td
(reported)Tj
3.6567 0 Td
(as)Tj
1.0091 0 Td
(a)Tj
0.6463 0 Td
(key)Tj
1.5874 0 Td
(factor)Tj
2.5398 0 Td
(for)Tj
1.3777 0 Td
(ART)Tj
2.1316 0 Td
(success)Tj
-34.7128 -1.2983 Td
(and)Tj
1.7291 0 Td
(international)Tj
5.4141 0 Td
(guidelines)Tj
4.2746 0 Td
(underscore)Tj
4.7055 0 Td
(the)Tj
1.4684 0 Td
(importance)Tj
4.8302 0 Td
(of)Tj
1.0148 0 Td
(simplifying)Tj
4.7224 0 Td
(regimens)Tj
3.9005 0 Td
(to)Tj
1.0261 0 Td
(improve)Tj
-33.0857 -1.2983 Td
(adherence)Tj
4.3199 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.6044 0 Td
(Treatment)Tj
4.4447 0 Td
(simplification)Tj
5.7316 0 Td
(first)Tj
1.8085 0 Td
(became)Tj
3.2485 0 Td
(possible)Tj
3.4129 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.4683 0 Td
(development)Tj
5.4142 0 Td
(of)Tj
1.0148 0 Td
(drugs)Tj
-34.4634 -1.2982 Td
(with)Tj
1.9955 0 Td
(longer)Tj
2.7836 0 Td
(half-lives)Tj
3.8154 0 Td
(hence)Tj
2.5682 0 Td
(allowing)Tj
3.617 0 Td
(once-daily)Tj
4.405 0 Td
(dosing.)Tj
3.1238 0 Td
(Adherence)Tj
4.5694 0 Td
(to)Tj
1.0261 0 Td
(these)Tj
2.2564 0 Td
(once-daily)Tj
4.3993 0 Td
(regi-)Tj
-34.5597 -1.3039 Td
(mens)Tj
2.3697 0 Td
(was)Tj
1.7008 0 Td
(shown)Tj
2.8459 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(significantly)Tj
5.091 0 Td
(better)Tj
2.5399 0 Td
(than)Tj
2.0295 0 Td
(with)Tj
1.9956 0 Td
(3-times)Tj
3.2202 0 Td
(and)Tj
1.7291 0 Td
(4-times-daily)Tj
5.4935 0 Td
(regimens)Tj
3.9004 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
-35.0926 -1.2983 Td
(However,)Tj
4.0761 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.652 0 Td
(meta-analysis,)Tj
5.879 0 Td
(Parienti)Tj
3.3902 0 Td
(et)Tj
0.9411 0 Td
(al.)Tj
1.1225 0 Td
(reported)Tj
3.6624 0 Td
(only)Tj
1.9729 0 Td
(a)Tj
0.6576 0 Td
(modest)Tj
3.1578 0 Td
(beneficial)Tj
4.0478 0 Td
(effect)Tj
2.3641 0 Td
(of)Tj
1.0148 0 Td
(once-)Tj
-33.9758 -1.2983 Td
(daily)Tj
2.1486 0 Td
(regimens)Tj
3.9004 0 Td
(on)Tj
1.2756 0 Td
(adherence)Tj
4.32 0 Td
(to)Tj
1.0261 0 Td
(treatment)Tj
4.1386 0 Td
(compared)Tj
4.2406 0 Td
(with)Tj
2.0012 0 Td
(twice-daily)Tj
4.5978 0 Td
(regimens)Tj
3.8948 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(].)Tj
1.6044 0 Td
(In)Tj
1.1055 0 Td
(2006,)Tj
-34.2536 -1.3039 Td
(the)Tj
1.4683 0 Td
(first)Tj
1.8085 0 Td
(single)Tj
2.5285 0 Td
(tablet)Tj
2.4264 0 Td
(regimen)Tj
3.5376 0 Td
(\(STR\),)Tj
2.8347 0 Td
(a)Tj
0.6576 0 Td
(combination)Tj
5.3461 0 Td
(of)Tj
1.0148 0 Td
(tenofovir)Tj
3.8834 0 Td
(\(TDF\),)Tj
3.0047 0 Td
(emtricitabine)Tj
5.5672 0 Td
(\(FTC\),)Tj
-34.0778 -1.2983 Td
(and)Tj
1.7291 0 Td
(efavirenz)Tj
3.8437 0 Td
(\(EFV\))Tj
2.6929 0 Td
(became)Tj
3.2485 0 Td
(available)Tj
3.668 0 Td
(and)Tj
1.7291 0 Td
(recommended)Tj
6.0378 0 Td
(in)Tj
1.0375 0 Td
(first-line)Tj
3.6396 0 Td
(therapy)Tj
3.2485 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
2.5909 0 Td
(Several)Tj
-33.4656 -1.2982 Td
(other)Tj
2.347 0 Td
(STRs)Tj
2.2904 0 Td
(combining)Tj
4.5694 0 Td
(TDF/FTC/rilpivirin)Tj
7.92 0 Td
(e)Tj
0.6406 0 Td
(\(RPV\),)Tj
2.999 0 Td
(TDF/FTC/cobicista)Tj
7.8293 0 Td
(t/elvitegravir)Tj
5.3234 0 Td
(and)Tj
1.7291 0 Td
(aba-)Tj
-35.6482 -1.3039 Td
(cavir/lamivudine/dolutegravi)Tj
11.6503 0 Td
(r)Tj
0.5896 0 Td
(have)Tj
2.0579 0 Td
(been)Tj
2.126 0 Td
(developed)Tj
4.2689 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(])Tj
2.075 0 Td
(and)Tj
1.7348 0 Td
(as)Tj
1.0148 0 Td
(recommended)Tj
6.0321 0 Td
(by)Tj
1.1848 0 Td
(interna-)Tj
-32.7342 -1.2983 Td
(tional)Tj
2.5171 0 Td
(guidelines,)Tj
4.5071 0 Td
(STRs)Tj
2.2903 0 Td
(appear)Tj
2.914 0 Td
(now)Tj
1.9616 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(valid)Tj
2.1486 0 Td
(treatment)Tj
4.1386 0 Td
(strategy)Tj
3.3278 0 Td
(to)Tj
1.0205 0 Td
(decrease)Tj
3.6113 0 Td
(pill)Tj
1.4967 0 Td
(burden)Tj
3.1237 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(].)Tj
-34.7241 -1.2983 Td
(Compared)Tj
4.4843 0 Td
(with)Tj
1.9956 0 Td
(multiple)Tj
3.566 0 Td
(tablet)Tj
2.4264 0 Td
(regimens,)Tj
4.1272 0 Td
(some)Tj
2.3301 0 Td
(STRs)Tj
2.2904 0 Td
(have)Tj
2.0579 0 Td
(been)Tj
2.126 0 Td
(associated)Tj
4.2519 0 Td
(with)Tj
2.0013 0 Td
(better)Tj
2.5398 0 Td
(adher-)Tj
-34.1969 -1.3039 Td
(ence)Tj
2.0352 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(],)Tj
3.549 0 Td
(and)Tj
1.7291 0 Td
(improved)Tj
4.1102 0 Td
(quality)Tj
2.9537 0 Td
(of)Tj
1.0148 0 Td
(life)Tj
1.4456 0 Td
(\(QoL\))Tj
2.6929 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(].)Tj
3.2485 0 Td
(Moreover,)Tj
4.3994 0 Td
(since)Tj
2.245 0 Td
(adherence)Tj
4.32 0 Td
(to)Tj
1.0261 0 Td
(treat-)Tj
-34.7695 -1.2982 Td
(ment)Tj
2.3073 0 Td
(is)Tj
0.8504 0 Td
(correlated)Tj
4.2463 0 Td
(with)Tj
1.9956 0 Td
(hospitalization,)Tj
6.3382 0 Td
(some)Tj
2.3301 0 Td
(studies)Tj
2.9877 0 Td
(showed)Tj
3.2541 0 Td
(that)Tj
1.7745 0 Td
(STRs)Tj
2.2904 0 Td
(were)Tj
2.1259 0 Td
(also)Tj
1.7632 0 Td
(associated)Tj
-32.2637 -1.2983 Td
(with)Tj
1.9955 0 Td
(a)Tj
0.652 0 Td
(17%)Tj
1.9332 0 Td
(reduction)Tj
4.1102 0 Td
(in)Tj
1.0375 0 Td
(total)Tj
2.0069 0 Td
(health)Tj
2.6759 0 Td
(care)Tj
1.8709 0 Td
(costs)Tj
2.1713 0 Td
(mostly)Tj
2.9083 0 Td
(due)Tj
1.6951 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.6577 0 Td
(reduction)Tj
4.1102 0 Td
(in)Tj
1.0375 0 Td
(hospitalizations)Tj
-29.8883 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
3.2541 0 Td
(Recently,)Tj
3.8834 0 Td
(some)Tj
2.3301 0 Td
(authors)Tj
3.2485 0 Td
(described)Tj
4.0535 0 Td
(the)Tj
1.4683 0 Td
(different)Tj
3.6567 0 Td
(factors)Tj
2.9027 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(considered)Tj
4.5977 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(choice)Tj
-34.4293 -1.3039 Td
(of)Tj
1.0147 0 Td
(a)Tj
0.652 0 Td
(particular)Tj
4.1102 0 Td
(STR)Tj
1.9276 0 Td
(and)Tj
1.7348 0 Td
(stressed)Tj
3.3448 0 Td
(the)Tj
1.4684 0 Td
(need)Tj
2.1429 0 Td
(for)Tj
1.389 0 Td
(careful)Tj
2.931 0 Td
(clinical,)Tj
3.3052 0 Td
(virological)Tj
4.405 0 Td
(and)Tj
1.7348 0 Td
(immunological)Tj
-30.1604 -1.2983 Td
(monitoring)Tj
4.8188 0 Td
(along)Tj
2.4208 0 Td
(with)Tj
1.9956 0 Td
(regular)Tj
3.0614 0 Td
(adherence)Tj
4.3199 0 Td
(assessment)Tj
4.6148 0 Td
(to)Tj
1.0261 0 Td
(achieve)Tj
3.1748 0 Td
(treatment)Tj
4.1329 0 Td
(success)Tj
3.1011 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(].)Tj
-31.47 -1.2982 Td
(Since)Tj
2.3584 0 Td
(comparisons)Tj
5.3404 0 Td
(between)Tj
3.5263 0 Td
(STRs)Tj
2.2904 0 Td
(and)Tj
1.7291 0 Td
(non-STR)Tj
3.8834 0 Td
(once-daily)Tj
4.405 0 Td
(regimens)Tj
3.9005 0 Td
(are)Tj
1.4457 0 Td
(sparse,)Tj
2.9139 0 Td
(we)Tj
1.3267 0 Td
(com-)Tj
-34.316 -1.3039 Td
(pared)Tj
2.4944 0 Td
(the)Tj
1.4684 0 Td
(effectiveness,)Tj
5.4311 0 Td
(tolerance,)Tj
4.1216 0 Td
(and)Tj
1.7291 0 Td
(persistence)Tj
4.6374 0 Td
(on)Tj
1.2756 0 Td
(treatment)Tj
4.1329 0 Td
(of)Tj
1.0148 0 Td
(STRs)Tj
2.2904 0 Td
(with)Tj
2.0012 0 Td
(non-STR)Tj
3.8778 0 Td
(regi-)Tj
-34.4747 -1.2983 Td
(mens)Tj
2.3697 0 Td
(in)Tj
1.0375 0 Td
(patients)Tj
3.3675 0 Td
(receiving)Tj
3.8664 0 Td
(first-line)Tj
3.6397 0 Td
(ART)Tj
2.1373 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.652 0 Td
(French)Tj
3.0443 0 Td
(large)Tj
2.16 0 Td
(cohort)Tj
2.8517 0 Td
(of)Tj
1.0148 0 Td
(HIV-infected)Tj
5.5728 0 Td
(patients.)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 442.3181 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Single)Tj
2.9409 0 Td
(tablet)Tj
2.615 0 Td
(regimens)Tj
4.2662 0 Td
(as)Tj
1.2543 0 Td
(first-line)Tj
3.6497 0 Td
(ART)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.4748 0 Td
(DOI:10.137)Tj
5.0387 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.0170)Tj
3.5434 0 Td
(661)Tj
2.6362 0 Td
(February)Tj
4.1599 0 Td
(2,)Tj
1.0417 0 Td
(2017)Tj
37.8995 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(12)Tj
/F8 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(support)Tj
3.0968 0 Td
(from)Tj
2.0126 0 Td
(Gilead,)Tj
2.7355 0 Td
(Janssen,)Tj
3.4937 0 Td
(BMS,)Tj
2.2536 0 Td
(ViiV)Tj
-13.5922 -1.3748 Td
(Healthcare,)Tj
4.3653 0 Td
(MSD,)Tj
2.3103 0 Td
(Abbott,)Tj
2.9055 0 Td
(outside)Tj
2.9268 0 Td
(the)Tj
1.3748 0 Td
(submitted)Tj
-13.8827 -1.3749 Td
(work)Tj
2.0622 0 Td
(and)Tj
1.5874 0 Td
(personal)Tj
3.4087 0 Td
(fees)Tj
1.7362 0 Td
(from)Tj
2.0126 0 Td
(Gilead,)Tj
2.7284 0 Td
(Janssen,)Tj
-13.5355 -1.3748 Td
(BMS,)Tj
2.2464 0 Td
(ViiV)Tj
1.6583 0 Td
(Healthcare,)Tj
4.3654 0 Td
(MSD,)Tj
2.3173 0 Td
(Abbott.)Tj
2.8985 0 Td
(Dr)Tj
1.1126 0 Td
(Ferry)Tj
2.0976 0 Td
(has)Tj
-16.6961 -1.3748 Td
(nothing)Tj
3.033 0 Td
(to)Tj
0.9497 0 Td
(disclose.)Tj
3.4653 0 Td
(Dr)Tj
1.1126 0 Td
(Pugliese)Tj
3.345 0 Td
(has)Tj
1.5378 0 Td
(nothing)Tj
3.0331 0 Td
(to)Tj
-16.4765 -1.3748 Td
(disclose.)Tj
3.4653 0 Td
(Dr)Tj
1.1126 0 Td
(Valantin)Tj
3.1749 0 Td
(reports)Tj
2.8842 0 Td
(personal)Tj
3.4016 0 Td
(fees)Tj
1.7434 0 Td
(from)Tj
-15.782 -1.3748 Td
(ViiV)Tj
1.6582 0 Td
(Healthcare,)Tj
4.3654 0 Td
(personal)Tj
3.4087 0 Td
(fees)Tj
1.7362 0 Td
(from)Tj
2.0127 0 Td
(Janssen,)Tj
3.4937 0 Td
(other)Tj
-16.6749 -1.3748 Td
(conflict)Tj
2.9055 0 Td
(of)Tj
0.9496 0 Td
(interest)Tj
2.9693 0 Td
(from)Tj
2.0126 0 Td
(BMS)Tj
2.0197 0 Td
(and)Tj
1.5874 0 Td
(MSD,)Tj
2.3103 0 Td
(outside)Tj
2.9339 0 Td
(the)Tj
-17.6883 -1.3748 Td
(submitted)Tj
3.9401 0 Td
(work.)Tj
2.289 0 Td
(Dr)Tj
1.1126 0 Td
(Allavena)Tj
3.2883 0 Td
(reports)Tj
2.8842 0 Td
(personal)Tj
3.4016 0 Td
(fees)Tj
-16.9158 -1.3748 Td
(from)Tj
2.0126 0 Td
(Gilead,)Tj
2.7283 0 Td
(BMS,)Tj
2.2536 0 Td
(ViiV)Tj
1.6583 0 Td
(Health)Tj
2.3457 0 Td
(care,)Tj
2.0197 0 Td
(MSD)Tj
2.0834 0 Td
(and)Tj
-15.1016 -1.3749 Td
(Janssen,)Tj
3.5008 0 Td
(outside)Tj
2.9268 0 Td
(the)Tj
1.3748 0 Td
(submitt)Tj
2.8205 0 Td
(ed)Tj
1.1197 0 Td
(work.)Tj
2.2819 0 Td
(Dr)Tj
1.1197 0 Td
(Cabie)Tj
0 Tc
1.6724 0.0284 Td
()Tj
-0.025 Tc
-16.8166 -1.4032 Td
(reports)Tj
2.8771 0 Td
(non-financial)Tj
4.9961 0 Td
(support)Tj
3.0969 0 Td
(from)Tj
2.0126 0 Td
(Gilead,)Tj
-12.9827 -1.3748 Td
(Janssen,)Tj
3.5008 0 Td
(ViiV)Tj
1.6512 0 Td
(Healthcare,)Tj
4.3724 0 Td
(MSD,)Tj
2.3103 0 Td
(outside)Tj
2.9339 0 Td
(the)Tj
-14.7686 -1.3748 Td
(submitted)Tj
3.9401 0 Td
(work.)Tj
2.289 0 Td
(Dr)Tj
1.1126 0 Td
(Poizot-Mar)Tj
4.0678 0 Td
(tin)Tj
1.1409 0 Td
(reports)Tj
2.8843 0 Td
(personal)Tj
-15.4347 -1.3748 Td
(fees)Tj
1.7362 0 Td
(from)Tj
2.0126 0 Td
(Gilead,)Tj
2.7355 0 Td
(personal)Tj
3.4016 0 Td
(fees)Tj
1.7433 0 Td
(from)Tj
2.0126 0 Td
(BMS,)Tj
-13.6418 -1.3748 Td
(personal)Tj
3.4016 0 Td
(fees)Tj
1.7433 0 Td
(from)Tj
2.0126 0 Td
(Abbvie,)Tj
2.948 0 Td
(personal)Tj
3.4087 0 Td
(fees)Tj
1.7363 0 Td
(from)Tj
2.0126 0 Td
(ViiV)Tj
-17.2631 -1.3748 Td
(Healthcare,)Tj
4.3653 0 Td
(outside)Tj
2.9339 0 Td
(the)Tj
1.3677 0 Td
(submitted)Tj
3.9473 0 Td
(work.)Tj
2.2819 0 Td
(Dr)Tj
1.1126 0 Td
(Rey)Tj
-16.0087 -1.3749 Td
(reports)Tj
2.8771 0 Td
(personal)Tj
3.4087 0 Td
(fees)Tj
1.7363 0 Td
(from)Tj
2.0126 0 Td
(Gilead,)Tj
2.7354 0 Td
(non-financ)Tj
3.9615 0 Td
(ial)Tj
-16.7316 -1.3819 Td
(support)Tj
3.0968 0 Td
(from)Tj
2.0126 0 Td
(Gilead,)Tj
2.7355 0 Td
(MSD,)Tj
2.3102 0 Td
(and)Tj
1.5875 0 Td
(BMS,)Tj
2.2464 0 Td
(outside)Tj
2.9339 0 Td
(the)Tj
-16.9229 -1.3748 Td
(submitted)Tj
3.9401 0 Td
(work.)Tj
2.289 0 Td
(Dr)Tj
1.1126 0 Td
(Duvivier)Tj
3.2386 0 Td
(reports)Tj
2.8772 0 Td
(grants)Tj
2.5725 0 Td
(from)Tj
-16.03 -1.3748 Td
(Gilead,)Tj
2.7354 0 Td
(grants)Tj
2.5725 0 Td
(from)Tj
2.0055 0 Td
(BMS,)Tj
2.2536 0 Td
(Janssen,)Tj
3.4937 0 Td
(ViiV)Tj
1.6583 0 Td
(Healthcare,)Tj
-14.719 -1.3748 Td
(and)Tj
1.5874 0 Td
(MSD,)Tj
2.3102 0 Td
(outside)Tj
2.9339 0 Td
(the)Tj
1.3677 0 Td
(submitted)Tj
3.9402 0 Td
(work.)Tj
2.289 0 Td
(Dr)Tj
1.1126 0 Td
(Che)Tj
0 Tc
1.063 0.0354 Td
()Tj
-0.025 Tc
0.3614 -0.0354 Td
(ret)Tj
-16.9654 -1.3748 Td
(has)Tj
1.5378 0 Td
(nothing)Tj
3.0331 0 Td
(to)Tj
0.9496 0 Td
(disclose.)Tj
3.4653 0 Td
(Dr)Tj
1.1127 0 Td
(Dellamonica)Tj
4.7764 0 Td
(has)Tj
-14.8749 -1.3748 Td
(nothing)Tj
3.033 0 Td
(to)Tj
0.9497 0 Td
(disclose.)Tj
3.4653 0 Td
(Dr)Tj
1.1126 0 Td
(Parienti)Tj
3.0119 0 Td
(has)Tj
1.5378 0 Td
(nothing)Tj
3.0331 0 Td
(to)Tj
-16.1434 -1.3748 Td
(disclose.)Tj
3.4653 0 Td
(Pierre)Tj
2.3953 0 Td
(Pradat)Tj
2.6221 0 Td
(performed)Tj
4.1103 0 Td
(medica)Tj
2.6787 0 Td
(l)Tj
0.4181 0 Td
(writing)Tj
-15.6898 -1.3749 Td
(services)Tj
3.2456 0 Td
(and)Tj
1.5945 0 Td
(received)Tj
3.2953 0 Td
(financial)Tj
3.267 0 Td
(support)Tj
3.0969 0 Td
(from)Tj
-14.4993 -1.3748 Td
(Dat'AIDS.)Tj
3.7984 0 Td
(This)Tj
1.7788 0 Td
(does)Tj
2.0126 0 Td
(not)Tj
1.4173 0 Td
(alter)Tj
1.8213 0 Td
(our)Tj
1.474 0 Td
(adherence)Tj
4.0536 0 Td
(to)Tj
-16.356 -1.3748 Td
(PLOS)Tj
2.3315 0 Td
(ONE)Tj
1.8708 0 Td
(policies)Tj
3.0119 0 Td
(on)Tj
1.1622 0 Td
(sharing)Tj
2.9835 0 Td
(data)Tj
1.7929 0 Td
(and)Tj
ET
endstream
endobj
31 0 obj
<>stream
endstream
endobj
32 0 obj
<>stream
endstream
endobj
33 0 obj
<>stream
endstream
endobj
34 0 obj
<>stream
endstream
endobj
35 0 obj
<>stream
endstream
endobj
36 0 obj
<>stream
endstream
endobj
37 0 obj
<>stream
endstream
endobj
38 0 obj
<>stream
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
BT
14.7402 46.9633 Td
(materials.)Tj
ET
Q
endstream
endobj
46 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 50 0 R/Contents 51 0 R/TrimBox[0 0 612 792]>>
endobj
48 0 obj
<>
endobj
52 0 obj
<>
endobj
53 0 obj
<>stream
%!PS-AdobeFont-1.0
11 dict begin
/FontName /TeX_CM_Maths_Symbols def
/FontType 1 def
/FontBBox {-20 -958 1114 770} readonly def
/FontMatrix [0.001 0 0 0.001 0 0] readonly def
/PaintType 0 def
/FontInfo 8 dict dup begin
/FullName (TeX_CM_Maths_Symbols) readonly def
/BaseFontName (TeX_CM_Maths_Symbols) def
end def
/Encoding 256 array
0 1 255 {1 index exch /.notdef put} for
dup 0 /C0 put
dup 1 /C1 put
dup 2 /C2 put
dup 3 /C3 put
dup 4 /C4 put
dup 5 /C5 put
dup 6 /C6 put
dup 7 /C7 put
dup 8 /C8 put
dup 9 /C9 put
dup 10 /C10 put
dup 11 /C11 put
dup 12 /C12 put
dup 13 /C13 put
dup 14 /C14 put
dup 15 /C15 put
dup 16 /C16 put
dup 17 /C17 put
dup 18 /C18 put
dup 19 /C19 put
dup 20 /C20 put
dup 21 /C21 put
dup 22 /C22 put
dup 23 /C23 put
dup 24 /C24 put
dup 25 /C25 put
dup 26 /C26 put
dup 27 /C27 put
dup 28 /C28 put
dup 29 /C29 put
dup 30 /C30 put
dup 31 /C31 put
dup 32 /space put
dup 33 /exclam put
dup 34 /quotedbl put
dup 35 /numbersign put
dup 36 /dollar put
dup 37 /percent put
dup 38 /ampersand put
dup 39 /quoteright put
dup 40 /parenleft put
dup 41 /parenright put
dup 42 /asterisk put
dup 43 /plus put
dup 44 /comma put
dup 45 /hyphen put
dup 46 /period put
dup 47 /slash put
dup 48 /zero put
dup 49 /one put
dup 50 /two put
dup 51 /three put
dup 52 /four put
dup 53 /five put
dup 54 /six put
dup 55 /seven put
dup 56 /eight put
dup 57 /nine put
dup 58 /colon put
dup 59 /semicolon put
dup 60 /less put
dup 61 /equal put
dup 62 /greater put
dup 63 /question put
dup 64 /at put
dup 65 /A put
dup 66 /B put
dup 67 /C put
dup 68 /D put
dup 69 /E put
dup 70 /F put
dup 71 /G put
dup 72 /H put
dup 73 /I put
dup 74 /J put
dup 75 /K put
dup 76 /L put
dup 77 /M put
dup 78 /N put
dup 79 /O put
dup 80 /P put
dup 81 /Q put
dup 82 /R put
dup 83 /S put
dup 84 /T put
dup 85 /U put
dup 86 /V put
dup 87 /W put
dup 88 /X put
dup 89 /Y put
dup 90 /Z put
dup 91 /bracketleft put
dup 92 /backslash put
dup 93 /bracketright put
dup 94 /asciicircum put
dup 95 /underscore put
dup 96 /quoteleft put
dup 97 /a put
dup 98 /b put
dup 99 /c put
dup 100 /d put
dup 101 /e put
dup 102 /f put
dup 103 /g put
dup 104 /h put
dup 105 /i put
dup 106 /j put
dup 107 /k put
dup 108 /l put
dup 109 /m put
dup 110 /n put
dup 111 /o put
dup 112 /p put
dup 113 /q put
dup 114 /r put
dup 115 /s put
dup 116 /t put
dup 117 /u put
dup 118 /v put
dup 119 /w put
dup 120 /x put
dup 121 /y put
dup 122 /z put
dup 123 /braceleft put
dup 124 /bar put
dup 125 /braceright put
dup 126 /asciitilde put
dup 127 /Euro put
dup 128 /ff put
dup 129 /ffi put
dup 130 /ffl put
dup 131 /C131 put
dup 132 /Eth put
dup 133 /eth put
dup 134 /Thorn put
dup 135 /thorn put
dup 136 /onequarter put
dup 137 /onehalf put
dup 138 /C138 put
readonly def
currentdict end
currentfile eexec
M#1H5 J6o\&rtS(#v\0\V7Fe༙OYx5-cY9^%Y6
(efIOldN"wȰ;)UƽoFg/rvV$JS8_oc@
o9-eGJp}[Do]mN=4*{ܯq=eU^t6¤(HwK7X7
Mr:E%]3<Ӝ$wrAQ4ADt%̏>E hAجm*pu@>#6aZi}NRmƼ%
,OgX' EX?ڞ\#JEG<IXS}Eh[ş8ї48ٶ.w4bJ?_nfulqD?둓\C%+' { L9K7isW+ӕ(6oɧVҺlS;5K
Z%.oQՕW*9Qk_S+B-}%lYC@WP0b\KKdi>t,n_S[ '9`-z+cڦEb#c@;yɸoAT O_H~i -6ϰ豟Ae&BF+
wNX!=hhUF8(hZ6pgJc m'9dx*^wXc
գ<.쯶c ln)/LvXY2jbF:ȸ3'>\Ȥmzj,!:ZK' (q/ -&&S ؤ-bm KQSxLGu `D3yԱKaVMU§ %iq5%s 2SdR#ho45H.4TdՊa<K>BqG- Ao, (e&F2gG`z8*༠&
x#B
B;8!93~T/ \>nLazCSKm~,!_<ӾX@X@N2vEt בFmBYa wRG[i;+oM+%(8 jԀlIW>t