Cardiac Regeneration and Repair, 2014. ,
Stem cell transplantation in traumatic spinal cord injury: a systematic review and metaanalysis of animal studies, PLoS Biol, vol.11, p.1001738, 2013. ,
Mesenchymal stem cells in osteoarticular pediatric diseases: An update, Pediatr Res, vol.71, pp.452-458, 2012. ,
Mesenchymal stem cells in osteoarticular diseases, Regen Med, vol.6, pp.44-51, 2011. ,
Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease, Cell Stem Cell, vol.10, pp.244-258, 2012. ,
The life and fate of mesenchymal stem cells, Front Immunol, vol.5, p.148, 2014. ,
Mesenchymal stem cells: Paracrine signaling and differentiation during cutaneous wound repair, Exp Cell Res, vol.316, pp.2213-2219, 2010. ,
Stromal cell-derived factor-1 retention and cardioprotection for ischemic myocardium, Circ Heart Fail, vol.4, pp.509-518, 2011. ,
Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction, Stem Cell Res (Amst), vol.6, pp.206-214, 2011. ,
Mouse induced pluripotent stem cell microenvironment generates epithelial-mesenchymal transition in mouse Lewis lung cancer cells, Am J Cancer Res, vol.4, pp.80-88, 2014. ,
Stem cell-conditioned medium accelerates distraction osteogenesis through multiple regenerative mechanisms, Bone, vol.61, pp.82-90, 2014. ,
Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice, Circ Res, vol.106, pp.971-980, 2010. ,
Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells, STEM CELLS, vol.26, pp.2173-2182, 2008. ,
Low oxygen tension inhibits osteogenic differentiation and enhances stemness of human MIAMI cells, Bone, vol.39, pp.513-522, 2006. ,
Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells ,
, Biochem Biophys Res Commun, vol.358, pp.948-953, 2007.
Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespan, Aging Cell, vol.6, pp.745-757, 2007. ,
Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells, BMC Cell Biol, vol.11, p.11, 2010. ,
Hypoxia affects mesenchymal stromal cell osteogenic differentiation and angiogenic factor expression, Bone, vol.40, pp.1078-1087, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-01758625
Hypoxia promotes murine bone-marrow-derived stromal cell migration and tube formation, STEM CELLS, vol.21, pp.337-347, 2003. ,
Bone marrowderived mesenchymal stem cells: Isolation, expansion, characterization, viral transduction, and production of conditioned medium, Methods Mol Biol, vol.482, pp.281-294, 2009. ,
,
, Low-molecular-weight fucoidan enhances the proangiogenic phenotype of endothelial progenitor cells, Biochem Pharmacol, vol.70, pp.1167-1175, 2005.
Cytokines profiling by multiplex analysis in experimental arthritis: Which pathophysiological relevance for articular versus systemic mediators?, Arthritis Res Ther, vol.14, p.60, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-01715286
Mesenchymal stem/stromal cells as a pharmacological and therapeutic approach to accelerate angiogenesis, Pharmacol Ther, vol.143, pp.181-196, 2014. ,
Mechanisms of mesenchymal stromal cell immunomodulation, Immunol Cell Biol, vol.91, pp.19-26, 2013. ,
Mesenchymal stem cells in regenerative medicine applied to rheumatic diseases: Role of secretome and exosomes, Biochimie, vol.95, pp.2229-2234, 2013. ,
URL : https://hal.archives-ouvertes.fr/inserm-00832507
Mesenchymal stem cells secrete multiple cytokines that promote angiogenesis and have contrasting effects on chemotaxis and apoptosis, PLoS One, vol.7, p.35685, 2012. ,
The systems biology of stem cell released molecules-based therapeutics, ISRN Stem Cells, p.784541, 2013. ,
, Oxygen Tension and Mesenchymal Stem Cell Secretome ©AlphaMed Press 2015 STEM CELLS TRANSLATIONAL MEDICINE
Chaperonins facilitate KNOTTED1 cell-to-cell trafficking and stem cell function, Science, vol.333, pp.1141-1144, 2011. ,
Secretome from mesenchymal stem cells induces angiogenesis via Cyr61, J Cell Physiol, vol.219, pp.563-571, 2009. ,
Comparison of angiogenic potency between mesenchymal stem cells and mononuclear cells in a rat model of hindlimb ischemia, Cardiovasc Res, vol.66, pp.543-551, 2005. ,
Inflammatory cells and chemokines sustain FGF2induced angiogenesis ,
, Eur Cytokine Netw, vol.20, pp.39-50, 2009.
Mesenchymal stromal cells: Sensors and switchers of inflammation, Cell Stem Cell, vol.13, pp.392-402, 2013. ,
Action at a distance: Systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF-a stimulated gene/protein 6, STEM CELLS, vol.29, pp.1572-1579, 2011. ,
A new mesenchymal stem cell (MSC) paradigm: Polarization into a pro-inflammatory MSC1 or an immunosuppressive MSC2 phenotype, PLoS One, vol.5, p.10088, 2010. ,
Mesenchymal stem cell 1 (MSC1)-based therapy attenuates tumor growth whereas MSC2-treatment promotes tumor growth and metastasis, PLoS One, vol.7, p.45590, 2012. ,
Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis, Cell Death Differ, vol.19, pp.743-755, 2012. ,
Conditioned medium from hypoxic bone marrow-derived mesenchymal stem cells enhances wound healing in mice, PLoS One, vol.9, p.96161, 2014. ,
Hypoxic conditioned medium from human amniotic fluid-derived mesenchymal stem cells accelerates skin wound healing through TGF-b/SMAD2 and PI3K/Akt pathways, Int J Mol Sci, vol.15, pp.605-628, 2014. ,
Spatially defined oxygen gradients and vascular endothelial growth factor expression in an engineered 3D cell model, Cell Mol Life Sci, vol.65, pp.177-186, 2008. ,
Tibial fracture decreases oxygen levels at the site of injury ,
, Iowa Orthop J, vol.28, pp.14-21, 2008.
Oxygen tension of nonunion of fractured femurs in the rabbit, Surg Gynecol Obstet, vol.135, pp.379-385, 1972. ,
Overcoming hypoxia to improve tissue-engineering approaches to regenerative medicine, J Tissue Eng Regen Med, vol.7, pp.505-514, 2013. ,
Ischemia is the prime but not the only cause of human multipotent stromal cell death in tissue-engineered constructs in vivo, Tissue Eng Part A, vol.18, pp.2084-2094, 2012. ,
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