Prosthetic groups for radioiodination and astatination of peptides and proteins: a comparative study of five potential bioorthogonal labeling strategies

Laurent Navarro 1 Marion Berdal 1 Michel Chérel 1 Frédéric Pecorari 1 Jean-François Gestin 1 François Guérard 1, *
* Auteur correspondant
1 CRCINA - Département NOHMAD - Equipe 13 - Oncologie nucléaire
CRCINA - Centre de recherche de Cancérologie et d'Immunologie / Nantes - Angers
Abstract : 125I- and 211At-labeled azide and tetrazine (Tz) based prosthetic groups for bioorthogonal conjugation were designed and tested in a comparative study of five bioorthogonal systems. All five bioconjugation reactions conducted on a model clickable peptide led to quantitative yields within less than a minute to several hours depending on the system used. Transferability to the labeling of an IgG was demonstrated with one of the bioorthogonal system. This study provides several new alternatives to the conventional and suboptimal approach currently in use for radioiodination and astatination of biomolecules and should accelerate the development of new probes with these radionuclides for applications in nuclear imaging and targeted alpha-therapy.
Type de document :
Article dans une revue
Bioorganic & medicinal chemistry, Elsevier, In press, epub ahead of print. 〈10.1016/j.bmc.2018.11.034〉
Liste complète des métadonnées
https://www.hal.inserm.fr/inserm-01939636
Contributeur : Elizabeth Bernardo <>
Soumis le : jeudi 29 novembre 2018 - 15:56:57
Dernière modification le : jeudi 7 février 2019 - 16:56:15

Fichier

 Accès restreint
Fichier visible le : 2019-05-26

Connectez-vous pour demander l'accès au fichier

Identifiants

Collections

UNIV-ANGERS | CRCINA | UNIV-NANTES

Citation

Laurent Navarro, Marion Berdal, Michel Chérel, Frédéric Pecorari, Jean-François Gestin, et al.. Prosthetic groups for radioiodination and astatination of peptides and proteins: a comparative study of five potential bioorthogonal labeling strategies. Bioorganic & medicinal chemistry, Elsevier, In press, epub ahead of print. 〈10.1016/j.bmc.2018.11.034〉. 〈inserm-01939636〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

67

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD