Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon 523 adenocarcinoma cells by activating peroxisome proliferator-activated receptor gamma, p.522, 2013. ,
, Mol Cell Biol, vol.33, issue.7, pp.1303-1316
, , 2015.
, Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells, Cell, vol.527, issue.2, pp.367-380
, , 2011.
, Induction of colonic regulatory T cells by indigenous Clostridium species, Science, vol.530, issue.6015, pp.337-341
, , 2002.
, Proteomic analysis of cytokine induced proteins in human intestinal epithelial cells: 533 implications for inflammatory bowel diseases, Proteomics, vol.2, issue.5, pp.551-560
Microbiome-Modulated 536 Metabolites at the Interface of Host Immunity, J Immunol, vol.198, issue.2, pp.572-580, 2017. ,
, , 1991.
, Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of 540 the dihydrofolate reductase gene in vitro and in vivo, J Clin Invest, vol.88, issue.5, pp.1613-1621
Lactate is mainly fermented to butyrate by human intestinal microfloras but 544 inter-individual variation is evident, J Appl Microbiol, vol.543, issue.1, pp.201-212, 2005. ,
Indoleamine 2,3-dioxygenase in intestinal immunity and inflammation, 2009. ,
, Inflamm Bowel Dis, vol.15, issue.9, pp.1391-1396
Cooperative role of interferon 549 regulatory factor 1 and p91 (STAT1) response elements in interferon-gamma550 inducible expression of human indoleamine 2,3-dioxygenase gene, J Biol Chem, vol.551, issue.29, pp.17247-17252, 1996. ,
Indoleamine 2,3 dioxygenase in intestinal disease, Gastroenterol, vol.553, issue.2, pp.146-152, 2013. ,
, , p.555
Induction of IDO-1 by immunostimulatory DNA limits severity of 556 experimental colitis, J Immunol, vol.184, issue.7, pp.3907-3916, 2010. ,
, , 2015.
, Functional metagenomic discovery of bacterial effectors in the human microbiome 559 and isolation of commendamide, a GPCR G2A/132 agonist, Proc Natl Acad Sci U S A, vol.560, issue.35, pp.4825-4834
, , 1987.
, Short chain fatty acids in human large intestine, portal, hepatic and venous blood, Gut, vol.563, issue.10, pp.1221-1227
Inhibition of histone deacetylase activity by butyrate, J Nutr, vol.133, issue.7, pp.565-2485, 2003. ,
Indoleamine 2,3-dioxygenase: from 567 catalyst to signaling function, Eur J Immunol, vol.42, issue.8, pp.1932-1937, 2012. ,
Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota620 mediated metabolic health, Nat Med, p.619, 2018. ,
Tolerogenic Phenotype of 622 IFN-gamma-Induced IDO+ Dendritic Cells Is Maintained via an Autocrine IDO623, 2016. ,
, J Immunol, vol.197, issue.3
Constitutive IDO expression in human cancer is sustained by an autocrine 627 signaling loop involving IL-6, STAT3 and the AHR, Oncotarget, vol.5, issue.4, pp.1038-1051, 2014. ,
Small Ubiquitin-like Modifier Alters IFN Response, J Immunol, vol.195, issue.5, pp.2312-631, 2015. ,
, , p.633
Butyrate produced by gut commensal bacteria activates TGF-beta1 634 expression through the transcription factor SP1 in human intestinal epithelial cells, vol.8, 2018. ,
Gut 637 CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T 638 regulatory/T effector cell balance and oral tolerance induction, Gut, vol.59, issue.5, pp.595-604, 2010. ,
Indoleamine 2,3-Dioxygenase Fine-Tunes Immune Homeostasis in 641 Atherosclerosis and Colitis through Repression of Interleukin-10 Production, Metab, vol.642, issue.3, pp.460-471, 2015. ,
Indoleamine 2 3-dioxygenase knockout limits angiotensin II-induced 645 aneurysm in low density lipoprotein receptor-deficient mice fed with high fat diet, vol.644, 2018. ,
, PLoS One, vol.13, issue.3, p.193737
Indoleamine 2,3-dioxygenase and tumor-induced 648 tolerance, J Clin Invest, vol.117, issue.5, pp.1147-1154, 2007. ,
, , 1997.
, Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative 651 human colon cancer cell line, J Biol Chem, vol.272, issue.35, pp.22199-22206
Butyrate produced by commensal bacteria potentiates phorbol esters 654 induced AP-1 response in human intestinal epithelial cells, PLoS One, vol.7, issue.12, 2012. ,
, , 2005.
, Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite, Science, vol.658, issue.5749, pp.850-855
Understanding the Holobiont: How Microbial Metabolites 660, 2017. ,
, Affect Human Health and Shape the Immune System, Cell Metab, vol.26, issue.1
A 663 human gut microbial gene catalogue established by metagenomic sequencing, Nature, vol.664, issue.7285, pp.59-65, 2010. ,
Developmentally regulated intestinal 666 expression of IFN-gamma and its target genes and the age-specific response to enteric 667 Salmonella infection, J Immunol, vol.175, issue.2, pp.1127-1136, 2005. ,
Dietary inhibitors of histone 669 deacetylases in intestinal immunity and homeostasis, Front Immunol, vol.4, p.226, 2013. ,
Gut microbiota in health 672 and disease, Physiol Rev, vol.90, issue.3, pp.859-904, 2010. ,
Severity of DSS674 induced colitis is reduced in Ido1-deficient mice with down-regulation of TLR675, 2015. ,
, MyD88-NF-kB transcriptional networks, Sci Rep, vol.5, p.17305
Use of axenic animals in studying the 677 adaptation of mammals to their commensal intestinal microbiota, Semin Immunol, vol.678, issue.2, pp.59-69, 2007. ,
IDO1 680 plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in 681 mice, J Immunol, vol.191, issue.6, pp.3057-3064, 2013. ,
SLIM is a nuclear ubiquitin E3 ligase 683 that negatively regulates STAT signaling, Immunity, vol.22, issue.6, pp.729-736, 2005. ,
Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G687 protein-coupled receptor FFAR2, Diabetes, vol.61, issue.2, pp.364-371, 2012. ,
Revealing the bacterial butyrate synthesis 689 pathways by analyzing (meta)genomic data, MBio, vol.5, issue.2, p.889, 2014. ,
Noncanonical NF-kappaB 692 activation mediates STAT3-stimulated IDO upregulation in myeloid-derived 693 suppressor cells in breast cancer, J Immunol, vol.193, issue.5, pp.2574-2586, 2014. ,
Smurf1 protein negatively regulates 696 interferon-gamma signaling through promoting STAT1 protein ubiquitination and 697 degradation, J Biol Chem, vol.287, issue.21, pp.17006-17015, 2012. ,
Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and 700 balance mucosal reactivity via interleukin-22, Immunity, vol.39, issue.2, pp.372-385, 2013. ,
Indoleamine 2,3-dioxygenase expression 703 in human inflammatory bowel disease, Eur J Gastroenterol Hepatol, vol.24, issue.6, 2012. ,