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Journal articles
Acute renal failure with lambda light chain-derived crystals in a patient with IgD myeloma
Abstract : Kidney involvement with immunoglobulin crystals usually relates to a light chain of the kappa type, in MGUS or smoldering myeloma, frequently causing Fanconi's syndrome with progressive renal insufficiency. We report on a case with severe myeloma featuring lambda light chain-derived crystals and acute kidney injury. Histology showed acute tubular necrosis and tubule obstruction with crystals, which were also abundant inside tubule epithelial cells, macrophages and bone marrow plasma cells. The light chain variable domain had a normal overall primary structure but included 11 somatic mutations, 3 of which likely increased the surface hydrophobicity, as observed in previously reported kappa-type crystals.
Cited literature [14 references]
https://www.hal.inserm.fr/inserm-01931323
Contributor : Pierre Aucouturier Connect in order to contact the contributor
Submitted on : Thursday, November 22, 2018 - 4:40:25 PM
Last modification on : Monday, March 22, 2021 - 3:34:01 PM
Long-term archiving on: : Saturday, February 23, 2019 - 3:11:51 PM
Contributor : Pierre Aucouturier Connect in order to contact the contributor
Submitted on : Thursday, November 22, 2018 - 4:40:25 PM
Last modification on : Monday, March 22, 2021 - 3:34:01 PM
Long-term archiving on: : Saturday, February 23, 2019 - 3:11:51 PM
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