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Journal articles
Acute renal failure with lambda light chain-derived crystals in a patient with IgD myeloma
Cécile Toly-Ndour
1, 2
Julie Peltier
3
Remi Piedagnel
2, 4
Paul Coppo
5, 1
Emmanuelle Sachon
6
Pierre Ronco
2, 4, 7
Eric Rondeau
2, 7, 3
Patrice Callard
8
Pierre Aucouturier
1, 2, *
*
Corresponding author
Cécile Toly-Ndour 1, 2
Author
Julie Peltier 3
Author
Remi Piedagnel 2, 4
Author
Paul Coppo 5, 1
Mail :
Author
Emmanuelle Sachon 6
Mail :
Author
Pierre Ronco 2, 4, 7
Mail :
Author
Eric Rondeau 2, 7, 3
Mail :
Author
Patrice Callard 8
Author
Pierre Aucouturier 1, 2
Mail :
Correspondent author
1
CR Saint-Antoine - Centre de Recherche Saint-Antoine (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U938 (101, rue de Tolbiac, 75013 Paris - France)
- SU - Sorbonne Université (21 rue de l’École de médecine - 75006 Paris - France)
2
UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
3
Urgences néphrologiques et transplantation rénale [CHU Tenon] (4 rue de la Chine, Paris, 75020 - France)
- APHP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Tenon [APHP] (4 Rue de la Chine, 75020 Paris - France)
4
Remodelage et Reparation du Tissu Renal (Hopital Tenon PARIS VI 4, Rue de La Chine 75970 PARIS CEDEX 20 - France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U702 (101, rue de Tolbiac, 75013 Paris - France)
5
Service d'hématologie clinique et de thérapie cellulaire [CHU Saint-Antoine] (184, rue du Faubourg Saint-Antoine 75012 Paris - France)
- APHP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Saint-Antoine [APHP] (184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12 - France)
6
Plateform of Mass Spectrometry [UPMC, Paris] (France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
7
Service de Néphrologie et Dialyses [CHU Tenon] (4, rue de la Chine 75020 Paris - France)
- APHP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Tenon [APHP] (4 Rue de la Chine, 75020 Paris - France)
8
Service d’Anatomie et cytologie pathologiques [CHU Tenon] (France)
- APHP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Tenon [APHP] (4 Rue de la Chine, 75020 Paris - France)
Abstract : Kidney involvement with immunoglobulin crystals usually relates to a light chain of the kappa type, in MGUS or smoldering myeloma, frequently causing Fanconi's syndrome with progressive renal insufficiency. We report on a case with severe myeloma featuring lambda light chain-derived crystals and acute kidney injury. Histology showed acute tubular necrosis and tubule obstruction with crystals, which were also abundant inside tubule epithelial cells, macrophages and bone marrow plasma cells. The light chain variable domain had a normal overall primary structure but included 11 somatic mutations, 3 of which likely increased the surface hydrophobicity, as observed in previously reported kappa-type crystals.
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Journal articles
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https://www.hal.inserm.fr/inserm-01931323
Contributor : Pierre Aucouturier <>
Submitted on : Thursday, November 22, 2018 - 4:40:25 PM
Last modification on : Thursday, March 21, 2019 - 12:26:14 PM
Document(s) archivé(s) le : Saturday, February 23, 2019 - 3:11:51 PM
Contributor : Pierre Aucouturier <>
Submitted on : Thursday, November 22, 2018 - 4:40:25 PM
Last modification on : Thursday, March 21, 2019 - 12:26:14 PM
Document(s) archivé(s) le : Saturday, February 23, 2019 - 3:11:51 PM
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Identifiers
- HAL Id : inserm-01931323, version 1
- DOI : 10.1093/ndt/gfr377
- PUBMED : 21737515
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Cécile Toly-Ndour, Julie Peltier, Remi Piedagnel, Paul Coppo, Emmanuelle Sachon, et al.. Acute renal failure with lambda light chain-derived crystals in a patient with IgD myeloma. Nephrology Dialysis Transplantation, Oxford University Press (OUP), 2011, 26 (9), pp.3057 - 3059. ⟨10.1093/ndt/gfr377⟩. ⟨inserm-01931323⟩
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