Acute renal failure with lambda light chain-derived crystals in a patient with IgD myeloma

Cécile Toly-Ndour 1, 2 Julie Peltier 3 Remi Piedagnel 2, 4 Paul Coppo 5, 1 Emmanuelle Sachon 6 Pierre Ronco 2, 4, 7 Eric Rondeau 2, 7, 3 Patrice Callard 8 Pierre Aucouturier 1, 2, *
* Corresponding author
1 CR Saint-Antoine - Centre de Recherche Saint-Antoine
2 UPMC - Université Pierre et Marie Curie - Paris 6
3 Urgences néphrologiques et transplantation rénale [CHU Tenon]
4 Remodelage et Reparation du Tissu Renal
5 Service d'hématologie clinique et de thérapie cellulaire [CHU Saint-Antoine]
6 Plateform of Mass Spectrometry [UPMC, Paris]
7 Service de Néphrologie et Dialyses [CHU Tenon]
8 Service d’Anatomie et cytologie pathologiques [CHU Tenon]
Abstract : Kidney involvement with immunoglobulin crystals usually relates to a light chain of the kappa type, in MGUS or smoldering myeloma, frequently causing Fanconi's syndrome with progressive renal insufficiency. We report on a case with severe myeloma featuring lambda light chain-derived crystals and acute kidney injury. Histology showed acute tubular necrosis and tubule obstruction with crystals, which were also abundant inside tubule epithelial cells, macrophages and bone marrow plasma cells. The light chain variable domain had a normal overall primary structure but included 11 somatic mutations, 3 of which likely increased the surface hydrophobicity, as observed in previously reported kappa-type crystals.
Keywords : myeloma immunoglobulin light chain acute kidney injury crystals
Document type :
Journal articles
Complete list of metadatas

Cited literature [14 references]  Display  Hide  Download
https://www.hal.inserm.fr/inserm-01931323
Contributor : Pierre Aucouturier <>
Submitted on : Thursday, November 22, 2018 - 4:40:25 PM
Last modification on : Thursday, March 21, 2019 - 12:26:14 PM
Long-term archiving on : Saturday, February 23, 2019 - 3:11:51 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

U938 | UPMC | SORBONNE-UNIVERSITE | SU-MEDECINE

Citation

Cécile Toly-Ndour, Julie Peltier, Remi Piedagnel, Paul Coppo, Emmanuelle Sachon, et al.. Acute renal failure with lambda light chain-derived crystals in a patient with IgD myeloma. Nephrology Dialysis Transplantation, Oxford University Press (OUP), 2011, 26 (9), pp.3057 - 3059. ⟨10.1093/ndt/gfr377⟩. ⟨inserm-01931323⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

65

Contact

CCSD