The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease

Alzheimer's disease (AD) is the most common neurodegenerative disorder in elderly people. AD is characterized by a progressive cognitive decline and it is neuropathologically defined by two hallmarks: extracellular deposits of aggregated β-amyloid (Aβ) peptides and intraneuronal fibrillar aggregates of hyper- and abnormally phosphorylated Tau proteins. AD results from multiple genetic and environmental risk factors. Epidemiological studies reported beneficial effects of caffeine, a non-selective adenosine receptors antagonist. In the present review, we discuss the impact of caffeine and of adenosinergic system modulation on AD, in terms of pathology and therapeutics.

Mots clés

Alzheimer’s disease adenosine adenosine receptors caffeine memory

Domaines

Neurosciences [q-bio.NC]

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fnins-12-00520.pdf (784.83 Ko)

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https://inserm.hal.science/inserm-01930487

Soumis le : jeudi 22 novembre 2018-09:18:00

Dernière modification le : mercredi 24 janvier 2024-09:54:24

Archivage à long terme le : samedi 23 février 2019-13:28:14

Dates et versions

inserm-01930487 , version 1 (22-11-2018)

Identifiants

HAL Id : inserm-01930487 , version 1
DOI : 10.3389/fnins.2018.00520
PUBMED : 30123104
PUBMEDCENTRAL : PMC6085480

Citer

Luc Cellai, Kevin Carvalho, Emilie Faivre, Aude Deleau, Didier Vieau, et al.. The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease. Frontiers in Neuroscience, 2018, 12, pp.520. ⟨10.3389/fnins.2018.00520⟩. ⟨inserm-01930487⟩

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