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Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator

Snehajyoti Chatterjee 1 Raphaelle Cassel 1 Anne Schneider‐anthony 1 Karine Mérienne 1 Brigitte Cosquer 1 Laura Tzeplaeff 1 Sarmistha Halder Sinha 2 Manoj Kumar 2 Piyush Chaturbedy 3 Muthusamy Eswaramoorthy 3 Stephanie Le Gras 4 Céline Keime 4 Olivier Bousiges 5, 1 Patrick Dutar 6, 7, 8 Petnoi Petsophonsakul 9 Claire Rampon 9 Jean‐christophe Cassel 1 Luc Buée 10 David Blum 10 Tapas Kundu 2, * Anne‐laurence Boutillier 1, *
* Corresponding author
1 LNCA - Laboratoire de neurosciences cognitives et adaptatives
2 Transcription and Disease Laboratory - Molecular Biology and Genetics Unit [Bangalore, India]
3 Chemistry and Physics of Materials Unit [Bangalore, India]
4 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
5 UNISTRA - Université de Strasbourg
6 U894 / UMS 1266 - Institut de psychiatrie et neurosciences
7 UPD5 - Université Paris Descartes - Paris 5
8 USPC - Université Sorbonne Paris Cité
9 CRCA - Centre de Recherches sur la Cognition Animale
10 JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837
Abstract : Chromatin acetylation, a critical regulator of synaptic plasticity and memory processes, is thought to be altered in neurodegenerative diseases. Here, we demonstrate that spatial memory and plasticity (LTD, dendritic spine formation) deficits can be restored in a mouse model of tauopathy following treatment with CSP-TTK21, a small-molecule activator of CBP/p300 histone acetyltransferases (HAT). At the transcriptional level, CSP-TTK21 re-established half of the hippocampal transcriptome in learning mice, likely through increased expression of neuronal activity genes and memory enhancers. At the epigenomic level, the hippocampus of tauopathic mice showed a significant decrease in H2B but not H3K27 acetylation levels, both marks co-localizing at TSS and CBP enhancers. Importantly, CSP-TTK21 treatment increased H2B acetylation levels at decreased peaks, CBP enhancers, and TSS, including genes associated with plasticity and neuronal functions, overall providing a 95% rescue of the H2B acetylome in tauopathic mice. This study is the first to provide in vivo proof-of-concept evidence that CBP/p300 HAT activation efficiently reverses epigenetic, transcriptional, synaptic plasticity, and behavioral deficits associated with Alzheimer's disease lesions in mice.
Keywords : CREB‐binding protein transcription acetylation learning Alzheimer's disease
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Snehajyoti Chatterjee, Raphaelle Cassel, Anne Schneider‐anthony, Karine Mérienne, Brigitte Cosquer, et al.. Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator. EMBO Molecular Medicine, Wiley Open Access, 2018, 10 (11), pp.e8587. ⟨10.15252/emmm.201708587⟩. ⟨inserm-01930486⟩

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