Synergy of entry inhibitors with direct-acting 1042 antivirals uncovers novel combinations for prevention and treatment of hepatitis C, Gut, vol.1043, pp.483-94, 2015. ,
Humanisation of a claudin-1-specific 1045 monoclonal antibody for clinical prevention and cure of HCV infection without escape, Gut, vol.1046, p.2017 ,
Monoclonal antibodies against 1048 extracellular domains of claudin-1 block hepatitis C virus infection in a mouse model, J Virol, vol.1049, pp.4866-79, 2015. ,
Efficient production of antibodies against a 1051 mammalian integral membrane protein by phage display, Protein Eng Des Sel, vol.24, pp.679-1052, 2011. ,
Novel human anti-claudin 1 mAbs inhibit 1054 ,
, hepatitis C virus infection and may synergize with anti-SRB1 mAb, J Gen Virol, vol.97, pp.82-1055, 2016.
Mutations that alter use of hepatitis C virus 1057 cell entry factors mediate escape from neutralizing antibodies, Gastroenterology, vol.1058, pp.223-256, 2012. ,
A novel occludin-targeting monoclonal 1060 antibody prevents hepatitis C virus infection in vitro, Oncotarget, vol.9, pp.16588-98, 2018. ,
Species-specific regions of occludin 1062 required by hepatitis C virus for cell entry, J Virol, vol.84, pp.11696-708, 2010. ,
New perspectives for preventing hepatitis C 1064 virus liver graft infection, Lancet Infect Dis, vol.16, pp.735-780, 2016. ,
Entry Inhibitors: A Perspective for Prevention of 1066 ,
, Hepatitis C Virus Infection in Organ Transplantation, ACS Infect Dis, vol.3, pp.620-623, 2017.
Expression and prognostic value of 1068 JAM-A in gliomas, J Neurooncol, vol.135, pp.107-124, 2017. ,
JAM-C promotes lymphangiogenesis and nodal 1097 metastasis in non-small cell lung cancer, Tumour Biol, vol.35, pp.5675-87, 2014. ,
The Junctional Adhesion Molecule-B 1099 regulates JAM-C-dependent melanoma cell metastasis, FEBS Lett, vol.586, pp.4046-51, 2012. ,
Junctional adhesion molecules are required 1101 for melanoma cell lines transendothelial migration in vitro, Pigment Cell Melanoma Res, vol.1102, pp.504-515, 2011. ,
A novel function of junctional adhesion molecule1104 C in mediating melanoma cell metastasis, Cancer Res, vol.71, pp.4096-105, 2011. ,
Endothelial cell junctional adhesion 1106 molecule C plays a key role in the development of tumors in a murine model of ovarian 1107 cancer, FASEB J, vol.27, pp.4244-53, 2013. ,
JAM3 maintains leukemia-initiating cell self-renewal 1109 through LRP5/AKT/beta-catenin/CCND1 signaling, J Clin Invest, vol.128, pp.1737-51, 2018. ,
Junctional Adhesion Molecules (JAMs): Cell Adhesion Receptors With 1111 ,
, Pleiotropic Functions in Cell Physiology and Development, Physiol Rev, vol.97, pp.1529-54, 2017.
The Coxsackie-adenovirus receptor has elevated 1113 expression in human breast cancer, Clin Exp Med, vol.5, pp.122-130, 2005. ,
Coxsackie and adenovirus receptor 1115 promotes adenocarcinoma cell survival and is expressionally activated after transition from 1116 preneoplastic precursor lesions to invasive adenocarcinomas, Clin Cancer Res, vol.1117, pp.4316-4336, 2005. ,
Coxsackievirus and adenovirus 1119 receptor expression in human endometrial adenocarcinoma: possible clinical implications ,
, World J Surg Oncol, vol.6, p.59, 2008.
Expression of the coxsackie and adenovirus receptor 1122 in human lung cancers, Tumour Biol, vol.34, pp.17-24, 2013. ,
Coxsackie and adenovirus receptor is a critical 1124 regulator for the survival and growth of oral squamous carcinoma cells, Oncogene, vol.1125, pp.1274-86, 2014. ,
Soluble isoforms but not the transmembrane 1127 form of coxsackie-adenovirus receptor are of clinical relevance in epithelial ovarian cancer ,
, Int J Cancer, vol.120, pp.2568-75, 2007.
Evaluation of coxsackievirus and 1130 adenovirus receptor expression in human benign and malignant thyroid lesions, APMIS, vol.1131, pp.210-231, 2010. ,
Coxsackie and adenovirus receptor is a 1133 target and a mediator of estrogen action in breast cancer, Endocr Relat Cancer, vol.18, pp.311-1134, 2011. ,
Connecting the missing link between 1136 dilated cardiomyopathy and viral myocarditis: virus, cytoskeleton, and innate immunity, Circulation, vol.115, pp.5-8, 1137. ,
Paradigms lost-an emerging role for over1139 expression of tight junction adhesion proteins in cancer pathogenesis, Ann Transl Med, vol.1140, p.184, 2015. ,
Claudins: multifunctional players in epithelial tight 1142 junctions and their role in cancer, Cell Mol Life Sci, vol.64, pp.17-28, 2007. ,
The organization of tight junctions in epithelia: implications for 1144 mammary gland biology and breast tumorigenesis, J Mammary Gland Biol Neoplasia, vol.1145, pp.449-62, 2003. ,
Anti-apoptotic effect of claudin-1 in tamoxifen1147 treated human breast cancer MCF-7 cells, BMC Cancer, vol.10, p.548, 2010. ,
Anti-apoptotic effect of claudin-1 on TNF-alpha-induced 1149 apoptosis in human breast cancer MCF-7 cells, Tumour Biol, vol.33, pp.2307-2322, 2012. ,
Down Regulation of CLDND1 Induces Apoptosis in 1151 ,
, Breast Cancer Cells. PLoS One, vol.10, p.130300, 2015.
Increased expressions of claudin-1 and claudin-7 during 1153 the progression of cervical neoplasia, Gynecol Oncol, vol.97, pp.53-62, 2005. ,
Selective up-regulation of claudin-1 and claudin1155 2 in colorectal cancer, Anticancer Res, vol.27, pp.3729-3763, 2007. ,
Claudin-1 Expression Is Elevated in Colorectal 1157 ,
, Cancer Precursor Lesions Harboring the BRAF V600E Mutation, Transl Oncol, vol.7, pp.456-1158, 2014.
Claudin-1 protein is a major factor involved in the 1160 tumorigenesis of colorectal cancer, Anticancer Res, vol.29, pp.851-858, 2009. ,
Claudin-1 is a strong prognostic indicator in 1162 stage II colonic cancer: a tissue microarray study, Mod Pathol, vol.18, pp.511-519, 2005. ,
Claudin-1 expression confers resistance to anoikis 1164 in colon cancer cells in a Src-dependent manner, Carcinogenesis, vol.33, pp.2538-2585, 2012. ,
Loss of claudins-1 and-7 and 1166 expression of claudins-3 and-4 correlate with prognostic variables in prostatic 1167 adenocarcinomas, Hum Pathol, vol.38, pp.564-573, 2007. ,
Tight junctions in thyroid 1169 carcinogenesis: diverse expression of claudin-1, claudin-4, claudin-7 and occludin in thyroid 1170 neoplasms, Mod Pathol, vol.21, pp.22-30, 2008. ,
CLDN-1 promoted the epithelial to migration and 1172 mesenchymal transition (EMT) in human bronchial epithelial cells via Notch pathway, 1173. ,
, Cell Biochem, vol.432, pp.91-99, 2017.
Involvement of claudin-1 in the beta-catenin/Tcf 1175 signaling pathway and its frequent upregulation in human colorectal cancers, Oncol Res, vol.1176, pp.469-76, 2001. ,
Crosstalk of tight junction components 1178 with signaling pathways, Biochim Biophys Acta, vol.1778, pp.729-56, 2008. ,
Claudin-2 is selectively enriched in and 1180 promotes the formation of breast cancer liver metastases through engagement of integrin 1181 complexes, Oncogene, vol.30, pp.1318-1346, 2011. ,
Claudin-2 is an independent negative 1183 prognostic factor in breast cancer and specifically predicts early liver recurrences, Mol Oncol, vol.1184, pp.119-147, 2014. ,
Lyn modulates Claudin-2 expression and is a 1186 therapeutic target for breast cancer liver metastasis, Oncotarget, vol.6, pp.9476-87, 2015. ,
Claudin-2 promotes breast cancer liver 1188 metastasis by facilitating tumor cell interactions with hepatocytes, Mol Cell Biol, vol.1189, pp.2979-91, 2012. ,
Symplekin promotes tumorigenicity by up1191 regulating claudin-2 expression, Proc Natl Acad Sci U S A, vol.107, pp.2628-2661, 2010. ,
Increase in claudin-2 expression by an ,
/ERK/c-Fos pathway in lung adenocarcinoma A549 cells, Biochim Biophys Acta, vol.1194, pp.1110-1118, 2012. ,
Nuclear distribution of claudin-2 increases cell 1196 proliferation in human lung adenocarcinoma cells, Biochim Biophys Acta, vol.1843, pp.2079-88, 2014. ,
Claudins 1, 2, 3, 4, 5 and 7 in solar 1198 keratosis and squamocellular carcinoma of the skin, Int J Clin Exp Pathol, vol.6, pp.2855-63, 2013. ,
Changes in expression and distribution of 1200 claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active 1201 ,
, Crohn's disease, Gut, vol.56, pp.61-72, 2007.
Mechanisms of diarrhea in collagenous colitis ,
, Gastroenterology, vol.123, pp.433-476, 2002.
The claudin gene family: expression in normal and 1205 neoplastic tissues, BMC Cancer, vol.6, p.186, 2006. ,
Claudin-3 and claudin-4: distinct 1207 prognostic significance in triple-negative and luminal breast cancer, Appl Immunohistochem, p.1208 ,
, Mol Morphol, vol.22, pp.125-156, 2014.
Claudin-3 overexpression 1210 increases the malignant potential of colorectal cancer cells: roles of ERK1/2 and PI3K-Akt as 1211 modulators of EGFR signaling, PLoS One, vol.8, p.74994, 2013. ,
Claudin-3 and claudin-4 expression in 1213 serous papillary, clear-cell, and endometrioid endometrial cancer, Gynecol Oncol, vol.1214, pp.263-272, 2008. ,
, receptors in uterine serous papillary carcinoma: novel targets for a type-specific therapy 1217 using Clostridium perfringens enterotoxin (CPE), Cancer, vol.109, pp.1312-1334, 2007.
Cdx2 transcription factor regulates claudin-3 ,
, and claudin-4 expression during intestinal differentiation of gastric carcinoma, Pathol Int, vol.1220, pp.156-63, 2008.
Expression profile of tight junction protein claudin 3 1222 and claudin 4 in ovarian serous adenocarcinoma with prognostic correlation. Histol, Histopathol, vol.22, pp.1185-95, 1223. ,
Claudin-2 as a mediator of leaky gut barrier 1225 during intestinal inflammation, Tissue Barriers, vol.3, p.977176, 2015. ,
The complex interactions between Clostridium perfringens enterotoxin 1227 and epithelial tight junctions, Toxicon, vol.39, pp.1781-91, 2001. ,
Expression patterns of claudins 1, 4, and 7 and 1229 their prognostic significance in nasopharyngeal carcinoma, J BUON, vol.20, pp.212-219, 2015. ,
Expression of claudin-3 and claudin-4 in normal, p.1231 ,
, hyperplastic, and malignant endometrial tissue, Int J Gynecol Cancer, vol.17, pp.233-274, 2007.
Claudin family of proteins and cancer: an overview ,
, J Oncol, p.541957, 2010.
Claudin-7 promotes the epithelial-mesenchymal 1235 transition in human colorectal cancer, Oncotarget, vol.6, pp.2046-63, 2015. ,
Significant elevation of CLDN16 and HAPLN3 gene 1237 expression in human breast cancer, Oncol Rep, vol.24, pp.759-66, 2010. ,
Characterization of novel human 1239 ovarian cancer-specific transcripts (HOSTs) identified by serial analysis of gene expression ,
, Oncogene, vol.22, pp.7225-7257, 2003.
Expression of claudins in human clear cell renal cell 1242 carcinoma, Cancer Genomics Proteomics, vol.12, pp.1-8, 2015. ,
Paracellin-1, a renal tight junction protein required 1244 for paracellular Mg2+ resorption, Science, vol.285, pp.103-109, 1999. ,
Claudin-20 promotes an aggressive phenotype in 1246 human breast cancer cells, Tissue Barriers, vol.1, p.26518, 2013. ,
Dexamethasone induces the expression of 1248 metalloproteinase inhibitor TIMP-1 in the murine cerebral vascular endothelial cell line cEND ,
, J Physiol, vol.580, pp.937-986, 2007.
Glucocorticoid regulation of endothelial cell tight junction 1251 gene expression: novel treatments for diabetic retinopathy, Curr Eye Res, vol.30, pp.949-57, 2005. ,
Characterization and evaluation of the 1253 antitumour activity of a dual-targeting monoclonal antibody against claudin-3 and claudin-4 ,
, Anticancer Res, vol.30, pp.4555-62, 2010.
Development of an anti-claudin-3 and-4 bispecific 1256 monoclonal antibody for cancer diagnosis and therapy, J Pharmacol Exp Ther, vol.351, pp.206-1257, 2014. ,
Therapeutic antitumor efficacy of 1259 monoclonal antibody against Claudin-4 for pancreatic and ovarian cancers, Cancer Sci, vol.1260, pp.1623-1653, 2009. ,
, TJ proteins involved in 1310 the HCV entry process are depicted in black, non-TJ host entry factors are depicted in white, HCV infection increases CLDN1 expression