Skip to Main content Skip to Navigation
Journal articles

Tight junction proteins in gastrointestinal and liver disease

Abstract : Over the past two decades a growing body of evidence has demonstrated an important role of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease. On one side, TJ proteins exert their functional role as integral proteins of TJs in forming barriers in the gut and the liver. Furthermore, TJ proteins can also be expressed outside TJs where they play important functional roles in signalling, trafficking and regulation of gene expression. A hallmark of TJ proteins in disease biology is their functional role in epithelial-to-mesenchymal transition. A causative role of TJ proteins has been established in the pathogenesis of colorectal cancer and gastric cancer. Among the best characterised roles of TJ proteins in liver disease biology is their function as cell entry receptors for HCV-one of the most common causes of hepatocellular carcinoma. At the same time TJ proteins are emerging as targets for novel therapeutic approaches for GI and liver disease. Here we review our current knowledge of the role of TJ proteins in the pathogenesis of GI and liver disease biology and discuss their potential as therapeutic targets.
Complete list of metadata

Cited literature [97 references]  Display  Hide  Download
Contributor : Mirjam Zeisel Connect in order to contact the contributor
Submitted on : Monday, November 12, 2018 - 12:13:19 PM
Last modification on : Wednesday, November 3, 2021 - 4:35:07 AM
Long-term archiving on: : Wednesday, February 13, 2019 - 2:24:02 PM


Zeisel, Dhawan and Baumert Gut...
Files produced by the author(s)




Mirjam B. Zeisel, Punita Dhawan, Thomas F. Baumert. Tight junction proteins in gastrointestinal and liver disease. Gut, BMJ Publishing Group, In press, Epub ahead of print. ⟨10.1136/gutjnl-2018-316906⟩. ⟨inserm-01910162⟩



Record views


Files downloads