M. Aebi, H. Hornig, and C. Weissmann, Cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5' splice region, not by the conserved GU, Cell, vol.50, pp.237-246, 1987.

A. Andreadis, M. E. Gallego, and B. Nadal-ginard, Generation of protein isoform diversity by alternative splicing, 1987.
URL : https://hal.archives-ouvertes.fr/inserm-01907541

, Annu. Rev. Cell Biol, vol.3, pp.207-242

A. G. Berk and P. A. Sharp, Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonucleasedigested hybrids, Cell, vol.12, pp.721-732, 1977.

R. E. Breitbart, A. Andreadis, and B. Nadal-ginard, Alternative splicing; a ubiquitous mechanism for the generation of multiple protein isoforms from single genes, Annu. Rev. Biochem, vol.56, pp.467-495, 1987.

E. Brody and J. Abelson, The "spliceosome": yeast pre-messenger RNA associates with a 40S complex in a splicing dependent reaction, Science, vol.228, pp.3-967, 1985.

J. D. Dignam, R. M. Lebovitz, and R. G. Roeder, Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei, Nucleic Acids Res, vol.11, pp.1475-1489, 1983.

L. P. Eperon, J. P. Estibeiro, and I. C. Eperon, The role of nucleotide sequences in splice site selection in eukaryotic pre-messenger RNA, Nature, vol.324, pp.280-282, 1986.

L. P. Eperon, I. R. Graham, A. D. Griffiths, and I. C. Eperon, Effects of RNA secondary structure on alternative splicing of pre-mRNA: is folding limited to a region behind the transcribing RNA polymerase, Cell, vol.54, pp.393-401, 1988.

J. Favoloro, R. Freisman, and R. Kamen, Transcription maps of polyoma virus-specific RNA: analysis by two-dimensional nuclease S1 gel mapping, Methods Enzymol, vol.65, pp.718-749, 1980.

D. Frendeway and W. Keller, The stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences, Cell, vol.42, pp.355-367, 1985.

X. Fu, H. Ge, and J. L. Manley, The role of the polypyrimidine stretch at the SV40 early pre-mRNA 3' splice site in alternative splicing, EMBO J, vol.7, pp.809-817, 1988.

P. J. Furdon and R. Kole, Inhibition of splicing but not cleavage at the 5' splice site by truncating human 3-globin pre-mRNA, Proc. Natl. Acad. Sci, vol.83, pp.927-931, 1986.

L. I. Garfinkel and N. Davidson, Developmentally regulated expression of a truncated myosin light-chain 1/3 gene, Mol. Cell. Biol, vol.7, pp.3826-3829, 1987.

Y. Gluzman, SV40 transformed simian cells support the replication of early SV40 mutants, Cell, vol.23, pp.175-182, 1981.

P. J. Grabowski, S. R. Seller, and P. A. Sharp, A multicomponent complex is involved in the splicing of messenger RNA precursors, Cell, vol.42, pp.345-353, 1985.

F. L. Graham and A. J. Van-der-eb, A new technique for the assay of infectivity of human adenovirus 5 DNA, Virology, vol.52, pp.456-467, 1973.

M. R. Green, Pre-mRNA splicing, Annu. Rev. Genet, vol.20, pp.671-708, 1986.
URL : https://hal.archives-ouvertes.fr/hal-00091127

K. R. Hampson, L. L. Follette, and M. F. Rottman, Alternative processing of bovine growth hormone mRNA is influenced by downstream exon sequences, Mol. Cell. Biol, vol.9, pp.1604-1610, 1989.

D. Helfman and W. M. Ricci, Branch point selection in alternative splicing of tropomyosin pre-mRNAs, Nucleic Acids Res, vol.17, pp.5633-5650, 1985.

D. H. Kedes and J. A. Steitz, Accurate 5' splice-site selection in mouse K immunoglobulin light chain premessenger RNAs is not cell type specific, Proc. Natl. Acad. Sci, vol.84, pp.7928-7932, 1987.

D. H. Kedes and J. A. Steitz, Correct in vivo splicing of the mouse immunoglobulin K light chain pre-mRNA is dependent on 5' splice-site position even in the absence of transcription, Genes Dev, vol.2, pp.1448-1459, 1988.

A. R. Krainer, T. Maniatis, B. Ruskin, and M. R. Green, Normal and mutant human P-globin pre-mRNAs are faithfully and efficiently spliced in vitro, Cell, vol.36, pp.993-1005, 1984.

A. I. Lamond, M. M. Konarska, and P. A. Sharp, A mutational analysis of spliceosome assembly: evidence for splice site collaboration during spliceosome formation, Genes Dev, vol.1, pp.532-543, 1987.

D. Libri, J. Marie, E. Brody, and Y. M. Fiszman, A subfragment of the 3 tropomyosin gene is alternatively spliced when transfected into differentiating muscle cells, Nucleic Acids Res, vol.17, pp.6449-6462, 1989.

P. T. Lomedico, Use of recombinant DNA technology to program eukaryotic cells to synthesize rat proinsulin: a rapid expression assay for cloned genes, Proc. Natl. Acad. Sci. USA, vol.79, pp.5798-5802, 1982.

D. E. Lowery and B. G. Van-ness, In vitro splicing of kappa immunoglobulin precursor mRNA, Mol. Cell. Biol, vol.7, pp.1346-1351, 1987.

D. E. Lowery and B. G. Van-ness, Comparison of in vitro and in vivo splice site selection in K-immunoglobulin precursor mRNA, Mol. Cell. Biol, vol.8, pp.2610-2619, 1988.

T. Maniatis, E. F. Fritsch, and J. Sambrook, Molecular cloning: a laboratory manual, 1982.

T. Maniatis and R. Reed, The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing, Nature, vol.325, pp.673-678, 1987.

H. J. Mardon, G. Sebastio, and F. E. Baralle, A role for exon sequences in alternative splicing of the human fibronectin gene, Nucleic Acids Res, vol.15, pp.7725-7733, 1987.

W. I. Mattaj, A binding consensus: RNA-protein interactions in splicing, snRNPs, and sex, Cell, vol.57, pp.1-3, 1989.

A. Mayeda and Y. Oshima, Short donor site sequences inserted within the intron of ,-globin pre-mRNA serve for splicing in vitro, Mol. Cell. Biol, vol.8, p.4491, 1988.

D. A. Melton, P. A. Krieg, M. R. Reblagiati, T. Maniatis, K. Zinn et al., Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter, Nucleic Acids Res, vol.12, pp.7035-7056, 1984.

S. M. Mount, A catalogue of splice junction sequences, Nucleic Acids Res, vol.10, pp.459-472, 1982.

B. Nadal-ginard, Commitment, fusion, and biochemical differentiation of a myogenic cell line in the absence of DNA synthesis, Cell, vol.15, pp.855-864, 1978.

K. K. Nelson and M. R. Green, Splice site selection and ribonucleoprotein complex assembly during in vitro pre-mRNA splicing, Genes Dev, vol.2, pp.319-329, 1988.

Y. Ohshima and Y. Gotoh, Signals for the selection of a splice site in pre-mRNA, J. Mol. Biol, vol.195, pp.247-259, 1987.

R. A. Padgett, P. J. Grobowski, M. M. Konarska, S. Seiler, and P. A. Sharp, Splicing of messenger RNA precursors, Annu. Rev. Biochem, vol.55, pp.1119-1150, 1986.

B. A. Parker and G. R. Stark, Regulation of simian virus 40 transcription: sensitive analysis of the RNA present early in infections by virus or virus DNA, J. Virol, vol.31, pp.360-369, 1979.

M. Periasamy, E. E. Strehler, L. I. Garfinkel, R. M. Gubits, N. Ruiz-opazo et al., Fast skeletal muscle myosin light chains 1 and 3 are produced from a single gene by a combined process of differential RNA transcription and splicing, J. Biol. Chem, vol.259, pp.13595-13604, 1984.

R. Reed and T. Maniatis, Intron sequences involved in lariat formation during pre-mRNA splicing, Cell, vol.41, pp.95-105, 1985.

R. Reed and T. Maniatis, A role for exon sequences and splice site proximity in splice site selection, Cell, vol.46, pp.681-690, 1986.

R. Reed and T. Maniatis, The role of the mammalian branchpoint sequence in pre-mRNA splicing, Genes Dev, vol.2, pp.1268-1276, 1988.

W. S. Ruby and J. Abelson, An early hierarchic role of Ul small nuclear ribonucleoprotein in spliceosome assembly, Science, vol.242, pp.1028-1035, 1988.

N. Ruiz-opazo and B. Nadal-ginard, Tropomyosin gene organization, J. Biol. Chem, vol.261, pp.4755-4765, 1987.

B. Ruskin and M. R. Green, An RNA processing activity that debranches RNA lariats, Science, vol.229, pp.135-140, 1985.

B. Ruskin, A. R. Krainer, T. Maniatis, and M. R. Green, Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro, Cell, vol.38, pp.317-331, 1984.

W. F. Scherer, J. T. Syverton, and G. 0. Gey, Studies on the propogation in vitro of poliomyelitis viruses. IV. Viral multiplication in a stable strain of human malignant epithelial cells (strain HeLa) derived from an epidermoid carcinoma of the cervix, J. Exp. Med, vol.97, pp.695-710, 1953.

B. Seraphin and M. Rosbash, Identification of functional Ul snRNA-pre-mRNA complexes committed to spliceosome assembly and splicing, Cell, vol.59, pp.349-358, 1989.

M. B. Shapiro and P. Senapathy, RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression, Nucleic Acids Res, vol.15, pp.7155-7174, 1987.

P. Sharp, Splicing of messenger RNA precursors, Science, vol.235, pp.766-771, 1987.

S. S. Sisodia, W. D. Cleveland, and B. Sollner-webb, A combination of RNAse H and S1 nuclease circumvents an artefact inherent to conventional S1 analysis of RNA splicing, Nucleic Acids Res, vol.15, pp.1995-2011, 1987.

C. W. Smith and B. Nadal-ginard, Mutually exclusive splicing of a-tropomyosin exons enforced by an unusual lariat branch point location: implications for constitutive splicing, Cell, vol.56, pp.749-758, 1989.

C. W. Smith, G. J. Patton, and B. Nadal-ginard, Alternative splicing in the control of gene expression, Annu. Rev. Genet, vol.23, pp.527-577, 1989.

, 2144 GALLEGO AND NADAL-GINARD, vol.10, 1990.

C. W. Smith, E. B. Porro, J. G. Patton, and B. Nadal-ginard, The 3' splice site of mamalian introns is defined by scanning from an independently specified branch point, Nature, vol.342, pp.243-247, 1989.

D. Solnick, Alternative RNA splicing caused by RNA secondary structure, Cell, vol.43, pp.667-676, 1985.

D. Solnick and S. I. Lee, Amount of RNA secondary structure required to induce an alternative splice, Mol. Cell. Biol, vol.7, pp.3194-3198, 1987.

E. E. Strehier, M. Periasamy, M. Strehler-page, and B. Nadal-gmard, Myosin light chain 1 and 3 gene has two structurally distinct and differentially regulated promoters evolving at different rates, Mol. Cell. Biol, vol.5, pp.3168-3182, 1985.

M. Streuli and H. Saito, Regulation of tissue specific alternative splicing: exon specific cis-elements govern the splicing of leukocyte common antigen pre-mRNA, EMBO J, vol.8, pp.787-794, 1989.

J. P. Ulfendahl, J. Kreivi, and G. Akusjarvi, Role of the branch/3/-splice site region in adenovirus-2 ElA pre-mRNA alternative splicing: evidence for 5'-and 3'-splice site cooperation, Nucleic Acids Res, vol.17, pp.925-938, 1989.

, MOL. CELL. BIOL

D. Wieczoreck, C. W. Smith, and B. Nadal-ginard, The rat a-tropomyosin gene generates a minimum of six different mRNAs coding for striated, smooth, and nonmuscle isoforms by alternative splicing, Mol. Cell. Biol, vol.8, pp.679-694, 1988.

D. Yaffe and . Saxel, Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle, Nature, vol.270, pp.725-727, 1977.

Y. Zhuang, M. A. Goldstein, and M. A. Weiner, UAC UAAC is the preferred branch site for mammalian mRNA splicing, Proc. Natl. Acad. Sci. USA, vol.86, pp.2752-2756, 1989.

Y. Zhuang, H. Leung, and A. M. Weiner, The natural 5' splice site of simian virus 40 large T antigen can be improved by increasing the base complementarity to Ul RNA, Mol. Cell. Biol, vol.7, pp.3018-3020, 1987.

Y. Zhuang and A. M. Weiner, A compensatory base change in Ul snRNA suppresses a 5' splice site mutation, Cell, vol.46, pp.827-835, 1986.

M. Ziliman, S. D. Rose, and S. M. Berget, Ul small nuclear ribonucleoproteins are required early during spliceosome assembly, Mol. Cell. Biol, vol.7, pp.2877-2883, 1987.