Skip to Main content Skip to Navigation
Journal articles

The linker histone GH1-HMGA1 is involved in telomere stability and DNA damage repair

Abstract : Despite intensive searches, few proteins involved in telomere homeostasis have been identified in plants. Here, we used pull-down assays to identify potential telomeric interactors in the model plant species Arabidopsis (Arabidopsis thaliana). We identified the candidate protein GH1-HMGA1 (also known as HON4), an uncharacterized linker histone protein of the High Mobility Group Protein A (HMGA) family in plants. HMGAs are architectural transcription factors and have been suggested to function in DNA damage repair, but their precise biological roles remain unclear. Here, we show that GH1-HMGA1 is required for efficient DNA damage repair and telomere integrity in Arabidopsis. GH1-HMGA1 mutants exhibit developmental and growth defects, accompanied by ploidy defects, increased telomere dysfunction-induced foci, mitotic anaphase bridges, and degraded telomeres. Furthermore, mutants have a higher sensitivity to genotoxic agents such as mitomycin C and γ-irradiation. Our work also suggests that GH1-HMGA1 is involved directly in the repair process by allowing the completion of homologous recombination.
Document type :
Journal articles
Complete list of metadata

Cited literature [65 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01904862
Contributor : Charles White Connect in order to contact the contributor
Submitted on : Friday, May 29, 2020 - 9:41:57 PM
Last modification on : Wednesday, September 7, 2022 - 6:30:43 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Cyril Charbonnel, Oleh Rymarenko, Olivier da Ines, Fatiha Benyahya, Charles I. White, et al.. The linker histone GH1-HMGA1 is involved in telomere stability and DNA damage repair. Plant Physiology, Oxford University Press ; American Society of Plant Biologists, 2018, 177 (1), pp.311-327. ⟨10.1104/pp.17.01789⟩. ⟨inserm-01904862⟩

Share

Metrics

Record views

57