Brain-derived neurotrophic factor, a new soluble biomarker for malignant pleural mesothelioma involved in angiogenesis

Patrick Smeele 1 Sènan D’almeida 1, 2, 3 Clément Meiller 4, 5, 6, 7 Anne-Laure Chéné 1, 8 Charly Liddell 1, 9 Laurent Cellerin 1 François Montagne 4, 5, 7, 6, 10, 11 Sophie Deshayes 1 Sarah Benziane 12, 13, 14 Marie-Christine Copin 15 Paul Hofman 16 Françoise Le Pimpec-Barthes 4, 5, 6, 7, 17 Henri Porte 18 Arnaud Scherpereel 12, 14, 13 Marc Grégoire 1 Didier Jean 4, 5, 6, 7 Christophe Blanquart 1, *
Abstract : Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer related to asbestos exposure. The discovery of soluble biomarkers with diagnostic/prognostic and/or therapeutic properties would improve therapeutic care of MPM patients. Currently, soluble biomarkers described present weaknesses preventing their use in clinic. This study aimed at evaluating brain-derived neurotrophic factor (BDNF), we previously identified using transcriptomic approach, in MPM. We observed that high BDNF expression, at the mRNA level in tumors or at the protein level in pleural effusions (PE), was a specific hallmark of MPM samples. This protein presented significant but limited diagnostic properties (area under the curve (AUC) = 0.6972, p < 0.0001). Interestingly, high BDNF gene expression and PE concentration were predictive of shorter MPM patient survival (13.0 vs 8.3 months, p < 0.0001, in PE). Finally, BDNF did not affect MPM cell oncogenic properties but was implicated in PE-induced angiogenesis. In conclusion, BDNF appears to be a new interesting biomarker for MPM and could also be a new therapeutic target regarding its implication in angiogenesis.
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Patrick Smeele, Sènan D’almeida, Clément Meiller, Anne-Laure Chéné, Charly Liddell, et al.. Brain-derived neurotrophic factor, a new soluble biomarker for malignant pleural mesothelioma involved in angiogenesis. Molecular Cancer, BioMed Central, 2018, 17 (1), pp.148. ⟨10.1186/s12943-018-0891-0⟩. ⟨inserm-01904612⟩

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