Distribution of IgG subclass levels in normal adult sera as determined by a competitive enzyme immunoassay using monoclonal antibodies.

Abstract : IgG subclass levels were measured by an indirect competitive immunoenzymatic assay with selected monoclonal antibodies in sera from 180 adult blood donors. Mean levels were 6.35 mg/ml (65% of the sum of the subclasses) for IgG1, 2.61 mg/ml (26.2%) for IgG2, and 0.414 mg/ml (4.3%) for IgG3. IgG4 levels were significantly different in men (mean 0.456 mg/ml, 4.8% of the sum) and women (mean 0.29 mg/ml, 3.2%), with very wide ranges. The distribution of IgG2 levels was more homogeneous than that of IgG4 but more heterogeneous than those of IgG1 and IgG3, with a number of sera that displayed low levels of IgG2.
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Contributor : Pierre Aucouturier <>
Submitted on : Friday, October 19, 2018 - 6:33:26 PM
Last modification on : Wednesday, October 24, 2018 - 1:00:29 AM

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  • HAL Id : inserm-01899797, version 1
  • PUBMED : 4085174

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Pierre Aucouturier, Samir Mounir, Jean-Louis Preud'Homme. Distribution of IgG subclass levels in normal adult sera as determined by a competitive enzyme immunoassay using monoclonal antibodies.. Diagnostic immunology, 1985, 3 (4), pp.191-6. ⟨inserm-01899797⟩

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