Part 1: Defining unproven cellular therapies, Cytotherapy, vol.18, pp.117-126, 2016. ,
Making the "unproven" "proven, Cytotherapy, vol.2, pp.120-123, 2016. ,
Part 6: The role of communication in better understanding unproven cellular therapies, Cytotherapy, vol.18, pp.143-151, 2016. ,
Part 4: Interaction between unproven cellular therapies and global medicinal product approval regulatory frameworks, Cytotherapy, vol.18, pp.127-164, 2016. ,
Understanding the manufacturing of unproven cellular therapy products, Cytotherapy, vol.3, pp.124-130, 2016. ,
Part 5: Unproven cell therapies and the commercialization of cellbased products, Cytotherapy, vol.18, pp.138-180, 2016. ,
Glioproliferative Lesion of the Spinal Cord as a Complication of "Stem-Cell Tourism, N Engl J Med, vol.375, pp.196-204, 2016. ,
Vision Loss after Intravitreal Injection of Autologous "Stem Cells" for AMD, N Engl J Med, vol.376, pp.1047-53, 2017. ,
Positioning a Scientific Community on Unproven Cellular Therapies: The 2015 International Society for Cellular Therapy Perspective, Cytotherapy, vol.17, pp.1663-1669, 2015. ,
, , 2018.
Regulatory Considerations for Human Cell, Tissues, and Cellular and Tissue-Based Products: Minimal Manipulation and Homologous Use; Guidance for Industry and Food and Drug Administration Staff, 2017. ,
Expedited Programs for Regenerative Medicine Therapies for Serious Conditions; Draft Guidance for Industry, 2017. ,
Guidance for Industry Expedited Programs for Serious Conditions À Drugs and Biologics, p.17, 2017. ,
Stem cell industry update: 2012 to 2016 reveals accelerated investment, but market capitalization and earnings lag, Cytotherapy, vol.19, pp.1131-1140, 2017. ,
The Stem-Cell Market for the Treatment of Knee Osteoarthritis: A Patient Perspective, J Knee Surg, vol.31, pp.551-557, 2018. ,
Cellular therapy injections in today's orthopedic market: A social media analysis, Cytotherapy, vol.19, pp.1392-1401, 2017. ,
Intra-Articular Cellular Therapy for Osteoarthritis and Focal Cartilage Defects of the Knee, J Bone Jt Surg, vol.98, pp.1511-1532, 2016. ,
Stem cell injections in knee osteoarthritis: a systematic review of the literature, Br J Sports Med, vol.51, pp.1125-1158, 2017. ,
Evidence for the Use of CellBased Therapy for the Treatment of Osteonecrosis of the Femoral Head: A Systematic Review of the Literature ,
, J Arthroplasty, vol.32, pp.1698-708, 2017.
Analysis of Cell Therapies Used in Clinical Trials for the Treatment of Osteonecrosis of the Femoral Head: A Systematic Review of the Literature ,
, J Arthroplasty, vol.32, pp.2612-2620, 2017.
Bone Marrow Cellular Therapies: Novel Therapy for Knee Osteoarthritis, J Knee Surg, vol.31, pp.22-28, 2018. ,
Platelet-Rich Plasma for the Treatment of ARTICLE, PRESS Proceedings, p.15 ,
, Knee Osteoarthritis: A Review, J Knee Surg, vol.30, pp.627-660, 2017.
Stem Cell Therapies in Orthopaedic Trauma, J Orthop Trauma, vol.29, pp.24-31, 2015. ,
Tissue engineering of bone: material and matrix considerations, J Bone Joint Surg Am, vol.90, pp.36-42, 2008. ,
A systematic review of the clinical applications and complications of bone marrow aspirate concentrate in management of bone defects and nonunions, Int Orthop, vol.41, issue.11, pp.2213-2233, 2017. ,
Concise review: optimizing expansion of bone marrow mesenchymal stem/stromal cells for clinical applications, Stem Cells Transl Med, vol.3, pp.643-52, 2014. ,
The role of stem cells in fracture healing and nonunion, Int Orthop, vol.35, pp.1587-97, 2011. ,
Allogeneic mesenchymal stem cells regenerate bone in a critical-sized canine segmental defect, J Bone Joint Surg Am, vol.85, pp.1927-1962, 2003. ,
Cellular bone matrices: viable stem cell-containing bone graft substitutes, Spine J, vol.14, pp.2763-72, 2014. ,
,
Clinical evaluation of an allogeneic bone matrix containing viable osteogenic cells in patients undergoing one-and two-level posterolateral lumbar arthrodesis with decompressive laminectomy, J Orthop Surg Res, vol.11, p.63, 2016. ,
Prospective clinical and radiographic evaluation of an allogeneic bone matrix containing stem cells (Trinity Evolution Ò Viable Cellular Bone Matrix) in patients undergoing two-level anterior cervical discectomy and fusion, J Orthop Surg Res, vol.12, p.67, 2017. ,
A prospective clinical and radiographic 12-month outcome study of patients undergoing singlelevel anterior cervical discectomy and fusion for symptomatic cervical degenerative disc disease utilizing a novel viable allogeneic, cancellous, bone matrix (trinity evolution TM ) with a comparison to historical controls, Eur Spine J, vol.25, pp.2233-2241, 2016. ,
Engineering principles of clinical cell-based tissue engineering, J Bone Joint Surg Am, vol.86, pp.1541-58, 2004. ,
Practical Modeling Concepts for Connective Tissue Stem Cell and Progenitor Compartment Kinetics, J Biomed Biotechnol, pp.170-93, 2003. ,
Cellular strategies for enhancement of fracture repair, J Bone Joint Surg Am, vol.90, pp.111-120, 2008. ,
Delayed union and nonunions: epidemiology, clinical issues, and financial aspects, Injury, vol.45, pp.3-7, 2014. ,
Fracture healing: mechanisms and interventions, Nat Rev Rheumatol, vol.11, pp.45-54, 2014. ,
Concise review: bridging the gap: bone regeneration using skeletal stem cell-based strategies-where are we now?, Stem Cells, vol.32, pp.35-44, 2014. ,
Epidemiology of Fracture Nonunion in 18 Human Bones, JAMA Surg, vol.151, 2016. ,
The Efficiency of Bone Marrow Aspiration for the Harvest of Connective Tissue Progenitors from the Human Iliac Crest, J Bone Jt Surg, vol.99, pp.1673-82, 2017. ,
Assessment of Methods for Rapid Intraoperative Concentration and Selection of Marrow-Derived Connective Tissue Progenitors for Bone Regeneration Using the Canine Femoral Multidefect Model, Tissue Eng Part A, vol.22, pp.17-30, 2016. ,
In Vivo Transplantation of Autogenous Marrow-Derived Cells Following Rapid Intraoperative Magnetic Separation, Tissue Eng Part A, vol.19, pp.125-159, 2013. ,
Insurer and outof-pocket costs of osteoarthritis in the US: evidence from national survey data, Arthritis Rheum, vol.60, pp.3546-53, 2009. ,
Hip Osteoarthritis: A Primer, Perm J, vol.22, pp.85-90, 2018. ,
Prevalence of Hip Symptoms and Radiographic and Symptomatic Hip Osteoarthritis in African Americans and Caucasians: The Johnston County Osteoarthritis Project, J Rheumatol, vol.36, pp.809-824, 2009. ,
Surgical management of articular cartilage defects in the knee, Instr Course Lect, vol.59, pp.181-204, 2010. ,
Restoration of Articular Cartilage, J Bone Jt Surg, vol.96, pp.336-380, 2014. ,
Progenitor cells from different zones of human cartilage and their correlation with histopathological osteoarthritis progression, J Orthop Res, vol.36, pp.1728-1766, 2018. ,
Origin and function of cartilage stem/progenitor cells in osteoarthritis, Nat Rev Rheumatol, vol.11, pp.206-218, 2015. ,
Human Cartilage-Derived Progenitor Cells From Committed Chondrocytes for Efficient Cartilage Repair and Regeneration, Stem Cells Transl Med, vol.5, pp.733-777, 2016. ,
DOI : 10.5966/sctm.2015-0192
URL : https://stemcellsjournals.onlinelibrary.wiley.com/doi/pdf/10.5966/sctm.2015-0192
Cell-based articular cartilage repair: the link between development and regeneration ,
,
,
, Osteoarthr Cartil, vol.23, pp.351-62, 2015.
Intra-Articular Cellular Therapy for Osteoarthritis and Focal Cartilage Defects of the Knee: A Systematic Review of the Literature and Study Quality Analysis, J Bone Joint Surg Am, vol.98, pp.1511-1532, 2016. ,
Current Therapeutic Strategies for Stem Cell-Based Cartilage Regeneration, Stem Cells Int, p.8490489, 2018. ,
Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal Cells, Circulation, vol.109, pp.1292-1300, 2004. ,
Management of fibrosis: the mesenchymal stromal cells breakthrough, Stem Cells Int, p.340257, 2014. ,
Variability in the Preparation, Reporting, and Use of Bone Marrow Aspirate Concentrate in Musculoskeletal Disorders, J Bone Jt Surg, vol.100, pp.517-542, 2018. ,
Mesenchymal stem cells for the management of inflammation in osteoarthritis: state of the art and perspectives, Osteoarthr Cartil, vol.23, pp.2027-2062, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01834450
Clinical efficacy and safety of mesenchymal stem cell transplantation for osteoarthritis treatment: a meta-analysis, PLoS One, vol.12, 2017. ,
Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis, Arthritis Res Ther, vol.16, p.482, 2014. ,
PPARb/d directs the therapeutic potential of mesenchymal stem cells in arthritis, Ann Rheum Dis, vol.75, pp.2166-74, 2016. ,
Single-Stage Cell-Based Cartilage Regeneration Using a Combination of Chondrons and Mesenchymal Stromal Cells, Am J Sports Med, vol.41, pp.2158-66, 2013. ,
RNA Microarray Analysis of Macroscopically Normal Articular Cartilage from Knees Undergoing Partial Medial Meniscectomy: Potential Prediction of the Risk for Developing Osteoarthritis, PLoS One, vol.11, 2016. ,
Mechanism and therapeutic effectiveness of nerve growth factor in osteoarthritis pain, Ther Clin Risk Manag, vol.13, pp.951-957, 2017. ,
Role of Interleukin-1 Inhibitors in Osteoarthritis, Drugs Aging, vol.29, pp.343-58, 2012. ,
Genome Engineering for Personalized Arthritis Therapeutics, Trends Mol Med, vol.23, pp.917-948, 2017. ,
Cartilage-Repair Innovation at a Standstill: Methodologic and Regulatory Pathways to Breaking Free, J Bone Joint Surg Am, vol.98, 2016. ,
A review on the use of cell therapy in the treatment of tendon disease and injuries, Journal of Tissue Engineering, vol.5, pp.1-18, 2014. ,
Stepwise Differentiation of Mesenchymal Stem Cells Augments Tendon-Like Tissue Formation and Defect Repair In Vivo, Stem Cells Transl Med, vol.5, pp.1106-1122, 2016. ,
Single-cell analysis reveals a nestin+ tendon stem/progenitor cell population with strong tenogenic potentiality, Sci Adv, vol.2, 2016. ,
Fos Promotes Early Stage Teno-Lineage Differentiation of Tendon Stem/Progenitor Cells in Tendon, Stem Cells Transl Med, vol.6, pp.2009-2028, 2017. ,
Mohawk promotes the tenogenesis of mesenchymal stem cells through activation of the TGFb signaling pathway, Stem Cells, vol.33, pp.443-55, 2015. ,
Activation of AKT-mTOR Signaling Directs Tenogenesis of Mesenchymal Stem Cells, Stem Cells, vol.36, pp.527-566, 2018. ,
Concise Review: Stem Cell Fate Guided By Bioactive Molecules for Tendon Regeneration, Stem Cells Transl Med, vol.7, pp.17-0206, 2018. ,
Gene and cell therapy for muscle regeneration, Curr Rev Musculoskelet Med, vol.8, pp.182-189, 2015. ,
Use of an Antifibrotic Agent Improves the Effect of Platelet-Rich Plasma on Muscle Healing After Injury, J Bone Jt Surg, vol.95, pp.980-988, 2013. ,
Customized platelet-rich plasma with transforming growth factor b1 neutralization antibody to reduce fibrosis in skeletal muscle, Biomaterials, vol.87, pp.147-56, 2016. ,
Intervertebral disc regeneration: from cell therapy to the development of novel bioinspired endogenous repair strategies, Adv Drug Deliv Rev, 2018. ,
URL : https://hal.archives-ouvertes.fr/inserm-01843976
Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain: 1-year follow-up of a phase I study, Stem Cell Res Ther, vol.8, p.262, 2017. ,
Autologous bone marrow concentrate intradiscal injection for the treatment of degenerative disc disease with three-year ARTICLE, PRESS Proceedings, vol.17 ,
, Int Orthop, vol.41, pp.2097-103, 2017.
,
Intervertebral Disc Repair by Allogeneic Mesenchymal Bone Marrow Cells: A Randomized Controlled Trial, Transplantation, vol.101, pp.1945-51, 2017. ,
Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain: 1-year follow-up of a phase I study, Stem Cell Res Ther, vol.8, p.262, 2017. ,
TGF-b1 and GDF5 Act Synergistically to Drive the Differentiation of Human Adipose Stromal Cells toward Nucleus Pulposus-like Cells, Stem Cells, vol.34, pp.653-67, 2016. ,
A Call for Standardization in Platelet-Rich Plasma Preparation Protocols and Composition Reporting, J Bone Jt Surg, vol.99, pp.1769-79, 2017. ,
Letter to the Editor, Clin Orthop Relat Res, vol.476, pp.1126-1134, 2018. ,
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement, Cytotherapy, vol.8, pp.315-322, 2006. ,
Minimum Information for Studies Evaluating Biologics in Orthopaedics (MIBO): Platelet-Rich Plasma and Mesenchymal Stem Cells, J Bone Joint Surg Am, vol.99, pp.809-828, 2017. ,
Test Method for Automated Colony Forming Unit (CFU) Assays-Image Acquisition and Analysis Method for Enumerating and Characterizing Cells and Colonies in Culture, ASTM Int, vol.2012, pp.1-11 ,
Variation in primary and culture-expanded cells derived from connective tissue progenitors in human bone marrow space, bone trabecular surface and adipose tissue, Cytotherapy, vol.20, pp.343-60, 2018. ,
Stem Cell Therapy for Knee Pain-What Exactly Are We Injecting, and Why?, J Bone Joint Surg Am, vol.98, pp.1509-1519, 2016. ,
, The Regenerative Medicine Standards Landscape, 2018.
Implantation of bone marrow-derived mesenchymal stem cells demonstrates improved outcome in horses with overstrain injury of the superficial digital flexor tendon, Equine Vet J, vol.44, pp.25-32, 2012. ,
Mesenchymal stem cell therapy for equine tendinopathy, Disabil Rehabil, vol.30, pp.1752-1760, 2008. ,
Clinical outcome after intra-articular administration of bone marrow derived mesenchymal stem cells in 33 horses with stifle injury, Vet Surg, vol.43, pp.255-65, 2014. ,
Distribution of injected technetium(99m)-labeled mesenchymal stem cells in horses with naturally occurring tendinopathy, J Orthop Res, vol.31, pp.1096-102, 2013. ,
Regenerative Therapies for Equine Degenerative Joint Disease: A Preliminary Study, PLoS One, vol.9, 2014. ,
Evaluation of intra-articular mesenchymal stem cells to augment healing of microfractured chondral defects, Arthroscopy, vol.27, pp.1552-61, 2011. ,
Autologous and Allogeneic Equine Mesenchymal Stem Cells Exhibit Equivalent Immunomodulatory Properties In Vitro, Stem Cells Dev, vol.26, pp.503-514, 2017. ,
Autologous biologic treatment for equine musculoskeletal injuries: platelet-rich plasma and IL-1 receptor antagonist protein, Vet Clin North Am Equine Pract, vol.27, pp.275-98, 2011. ,
Intralesional injection of platelet-rich plasma followed by controlled exercise for treatment of midbody suspensory ligament desmitis in Standardbred racehorses, J Am Vet Med Assoc, vol.232, pp.1515-1535, 2008. ,
Clinical, biochemical, and histologic effects of intraarticular administration of autologous conditioned serum in horses with experimentally induced osteoarthritis, Am J Vet Res, vol.68, pp.290-296, 2007. ,
Evaluation of a single intra-articular injection of autologous protein solution for treatment of osteoarthritis in horses, Am J Vet Res, vol.75, pp.141-51, 2014. ,
Canine placenta: a promising potential source of highly proliferative and immunomodulatory mesenchymal stromal cells?, Vet Immunol Immunopathol, vol.171, pp.47-55, 2016. ,
Cell-Based Therapies for Joint Disease in Veterinary Medicine: What We Have Learned and What We Need to Know, Front Vet Sci, vol.5, p.70, 2018. ,
Osteogenesis in transplants of bone marrow cells, J Embryol Exp Morphol, vol.16, pp.381-90, 1966. ,
Precursor cells of mechanocytes, Int Rev Cytol, vol.47, pp.327-59, 1976. ,
The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells, Cell Tissue Kinet, vol.3, pp.393-403, 1970. ,
Conditions controlling the proliferation of haemopoietic stem cells in vitro, J Cell Physiol, vol.91, pp.335-379, 1977. ,
Stromal stem cells: marrowderived osteogenic precursors, Ciba Found Symp, vol.136, pp.42-60, 1988. ,
,
,
Mesenchymal stem cells, J Orthop Res, vol.9, pp.641-50, 1991. ,
Marrow stromal cells as stem cells for nonhematopoietic tissues, Science, vol.276, pp.71-75, 1997. ,
Multilineage potential of adult human mesenchymal stem cells, Science, vol.284, pp.143-150, 1999. ,
Pluripotency of mesenchymal stem cells derived from adult marrow, Nature, vol.418, pp.41-50, 2002. ,
Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies, BMC Med, vol.13, p.186, 2015. ,
Concise Review: Mesenchymal Stem/Multipotent Stromal Cells: The State of Transdifferentiation and Modes of Tissue Repair-Current Views, Stem Cells, vol.25, pp.2896-902, 2007. ,
Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine, Exp Mol Med, vol.45, 2013. ,
Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement, Cytotherapy, vol.7, pp.393-398, 2005. ,
The MSC: an injury drugstore, Cell Stem Cell, vol.9, pp.11-16, 2011. ,
Connective tissue progenitors: practical concepts for clinical applications, Clin Orthop Relat Res, vol.1, pp.66-80, 2002. ,
Hematopoietic stem cell: self-renewal versus differentiation, Wiley Interdiscip Rev Syst Biol Med, vol.2, pp.640-53, 2010. ,
Where Hematopoietic Stem Cells Live: The Bone Marrow Niche, Antioxid Redox Signal, vol.29, issue.2, pp.191-204, 2018. ,
Syringe and Needle Size, Syringe Type, Vacuum Generation, and Needle Control in Aspiration Procedures, Cardiovasc Interv Radiol, vol.34, pp.590-600, 2011. ,
Aspiration to obtain osteoblast progenitor cells from human bone marrow: the influence of aspiration volume, J Bone Joint Surg Am, vol.79, pp.1699-709, 1997. ,
Human bone marrow fibroblast colony-forming units (CFU-F), Prog Clin Biol Res, vol.154, pp.209-245, 1984. ,
Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny, Blood, vol.56, pp.289-301, 1980. ,
Skeletal stem cells, Development, vol.142, pp.1023-1030, 2015. ,
Mesenchymal stem cells": fact or fiction, and implications in their therapeutic use, F1000Research, vol.6, 2017. ,
Concise Review: Conceptualizing Paralogous Stem-Cell Niches and Unfolding Bone Marrow Progenitor Cell Identities, Stem Cells, vol.36, pp.11-21, 2018. ,
Bone tissue engineering: recent advances and challenges, Crit Rev Biomed Eng, vol.40, pp.363-408, 2012. ,
Harmonizing standards for producing clinical-grade therapies from pluripotent stem cells, Nat Biotechnol, vol.32, pp.724-730, 2014. ,
Quantitative Approaches to Detect Donor and Passage Differences in Adipogenic Potential and Clonogenicity in Human Bone Marrow-Derived Mesenchymal Stem Cells, Tissue Eng Part C Methods, vol.18, pp.877-89, 2012. ,
International Society for Cellular Therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials, Cytotherapy, vol.18, pp.151-160, 2016. ,
No Identical "Mesenchymal Stem Cells" at Different Times and Sites: Human Committed Progenitors of Distinct Origin and Differentiation Potential Are Incorporated as Adventitial Cells in Microvessels, Stem Cell Reports, vol.6, pp.897-913, 2016. ,
mesenchymal") Stem Cells for Tissue Engineering, Methods Mol Med, vol.140, pp.83-99, 2007. ,
Stromal cells from the adipose tissuederived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT), Cytotherapy, vol.15, pp.641-649, 2013. ,
, , 2018.
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement, PLoS Med, vol.6, 2009. ,
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration, PLoS Med, vol.6, 2009. ,
Gratwohl A. A survey on cellular and engineered tissue therapies in Europe in 2008, Tissue Eng Part A, vol.16, pp.2419-2446, 2010. ,
The survey on cellular and tissue-engineered therapies in Europe and neighboring Eurasian countries in 2014 and 2015, Cytotherapy, vol.20, pp.1-20, 2018. ,
, Survey of cellular therapy and regenerative medicine in Europe-Patients Treated in 2016-ISCT n
, cellular-therapy-and-regenerative-medicine-in-EuropePatients-Treated-in-2016.htm, 2018.
Optimizing Clinical Use of Biologics in Orthopedic Surgery: Consensus Recommendations from the 2018 AAOS/NIH U-13 Symposium, J Am Acad Orthop Surg, 2018. ,
Optimizing Clinical Use of Biologics in Orthopedic Surgery: Consensus Recommendations from the 2018 AAOS/NIH U-13 Symposium, J Am Acad Orthop Surg, 2018. ,
Patient demographic and surgical characteristics in anterior cruciate ligament reconstruction: a description of registries from six countries, Br J Sports Med, vol.52, pp.716-738, 2018. ,
The American Joint Replacement Registry-the first 5 years, Arthroplast Today, vol.3, pp.67-76, 2017. ,
DOI : 10.1016/j.artd.2017.02.002
URL : https://doi.org/10.1016/j.artd.2017.02.002
Men and Women Differ in the Biochemical Composition of Platelet-Rich Plasma, Am J Sports Med, vol.46, pp.409-428, 2018. ,
Prognosis and predictors of ACL reconstructions using the MOON cohort: a model for comparative effectiveness studies, J Orthop Res, vol.31, pp.2-9, 2013. ,
Descriptive Epidemiology of the Multicenter ACL Revision Study (MARS) Cohort, Am J Sports Med, vol.38, pp.1979-86, 2010. ,
The Feasibility of Randomized Controlled Trials for Early Arthritis Therapies (EARTH) Involving Acute Anterior Cruciate Ligament Tear Cohorts, Am J Sports Med, vol.40, pp.2648-52, 2012. ,
,
,