Water dynamics in silanized hydroxypropyl methylcellulose based hydrogels designed for tissue engineering

Abstract : Silanized hydroxypropyl methylcellulose based hydrogels were developed for cartilage and intervertebral disc tissue engineering. Herein, study of dynamics of confined water showed two different populations, identified as hydration and bulk-like water. The diffusion coefficient showed that bulk-like water diffuses over distances ∼10 μm without being affected by the hydrogel matrix. Addition of silica nanofibers leads to improved mechanical properties and enhanced diffusion coefficient. Good diffusion within hydrogels is essential for the application.
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https://www.hal.inserm.fr/inserm-01890208
Contributor : Valérie Pecqueret <>
Submitted on : Monday, October 8, 2018 - 2:18:53 PM
Last modification on : Friday, April 5, 2019 - 1:16:35 AM

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Nela Buchtova, Angelina D’orlando, Patrick Judeinstein, Olivier Chauvet, Pierre Weiss, et al.. Water dynamics in silanized hydroxypropyl methylcellulose based hydrogels designed for tissue engineering. Carbohydrate Polymers, Elsevier, 2018, 202, pp.404 - 408. ⟨10.1016/j.carbpol.2018.08.143⟩. ⟨inserm-01890208⟩

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