Skip to Main content Skip to Navigation
Journal articles

Epigenetic metalloenzymes

Abstract : Epigenetics controls the expression of genes and is responsible for cellular phenotypes. The fundamental basis of these mechanisms involves in part the post-translational modifications (PTMs) of DNA and proteins, in particular, the nuclear histones. DNA can be methylated or demethylated on cytosine. Histones are marked by several modifications including acetylation and/or methylation, and of particular importance are the covalent modifications of lysine. There exists a balance between addition and removal of these PTMs, leading to three groups of enzymes involved in these processes: the writers adding marks, the erasers removing them, and the readers able to detect these marks and participating in the recruitment of transcription factors. The stimulation or the repression in the expression of genes is thus the result of a subtle equilibrium between all the possibilities coming from the combinations of these PTMs. Indeed, these mechanisms can be deregulated and then participate in the appearance, development and maintenance of various human diseases, including cancers, neurological and metabolic disorders. Some of the key players in epigenetics are metalloenzymes, belonging mostly to the group of erasers: the zinc-dependent histone deacetylases (HDACs), the iron-dependent lysine demethylases of the Jumonji family (JMJ or KDM) and for DNA the iron-dependent ten-eleven-translocation enzymes (TET) responsible for the oxidation of methylcytosine prior to the demethylation of DNA. This review presents these metalloenzymes, their importance in human disease and their inhibitors.
Keywords : epigenetic DNMT TET HDAC
Document type :
Journal articles
Complete list of metadata

Cited literature [280 references]  Display  Hide  Download
Contributor : Elizabeth Bernardo Connect in order to contact the contributor
Submitted on : Tuesday, October 2, 2018 - 7:39:09 AM
Last modification on : Wednesday, April 27, 2022 - 4:44:58 AM
Long-term archiving on: : Thursday, January 3, 2019 - 12:51:11 PM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document



Christophe Blanquart, Camille Linot, Pierre-François Cartron, Daniela Tomaselli, Antonello Mai, et al.. Epigenetic metalloenzymes. Current Medicinal Chemistry, Bentham Science Publishers, 2018, 25, pp.1 - 36. ⟨10.2174/0929867325666180706105903⟩. ⟨inserm-01885512⟩



Record views