USP15 stabilizes TGF-receptor I and promotes oncogenesis through the activation of TGF-signaling in glioblastoma, Nat. Med, vol.18, pp.429-435, 2012. ,
Transforming growth factor-signaling in cancer invasion and metastasis, Int. J. Cancer, vol.121, pp.2119-2124, 2007. ,
DOI : 10.1002/ijc.23113
URL : https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.23113
TGF-signalling and its role in cancer progression and metastasis, Cancer Metastasis Rev, vol.31, pp.553-568, 2012. ,
Epithelial-mesenchymal transitions in development and disease, Cell, vol.139, pp.871-890, 2009. ,
DOI : 10.1016/j.cell.2009.11.007
URL : https://doi.org/10.1016/j.cell.2009.11.007
Regulation of EMT by TGF in cancer, FEBS Lett, vol.586, pp.1959-1970, 2012. ,
Epidemiology of viral hepatitis and hepatocellular carcinoma, Gastroenterology, vol.142, pp.1264-1273, 2012. ,
Viral hepatitis and liver cancer: the case of hepatitis C, Oncogene, vol.25, pp.3834-3847, 2006. ,
Molecular pathogenesis of hepatocellular carcinoma: altering transforming growth factor-signaling in hepatocarcinogenesis, Dig. Dis, vol.29, pp.284-288, 2011. ,
Transforming growth factor beta in hepatitis C virus infection: in vivo and in vitro findings, J. Gastroenterol. Hepatol, vol.18, pp.393-403, 2003. ,
Laminin-5 with transforming growth factor-1 induces epithelial to mesenchymal transition in hepatocellular carcinoma, Gastroenterology, vol.129, pp.1375-1383, 2005. ,
DOI : 10.1053/j.gastro.2005.09.055
A crucial function of PDGF in TGFmediated cancer progression of hepatocytes, Oncogene, vol.25, pp.3170-3185, 2006. ,
,
A dual role for hypoxia inducible factor-1 in the hepatitis C virus lifecycle and hepatoma migration, J. Hepatol, vol.56, pp.803-809, 2012. ,
Liver cancer-derived hepatitis C virus core proteins shift TGF-responses from tumor suppression to epithelial-mesenchymal transition, PLoS ONE, vol.4, p.4355, 2009. ,
URL : https://hal.archives-ouvertes.fr/pasteur-00457811
Hepatitis C viral protein NS5A induces EMT and participates in oncogenic transformation of primary hepatocyte precursors, J. Hepatol, vol.57, pp.1021-1028, 2012. ,
Controlling TGF-signaling, Genes Dev, vol.14, pp.627-644, 2000. ,
Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-signaling, J. Biol. Chem, vol.275, pp.36818-36822, 2000. ,
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGFreceptor for degradation, Mol. Cell, vol.6, pp.1365-1375, 2000. ,
Ablation of Smurf2 reveals an inhibition in TGF-signalling through multiple mono-ubiquitination of Smad3, EMBO J, vol.30, pp.4777-4789, 2011. ,
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-pathways, Cell, vol.139, pp.757-769, 2009. ,
Distinct endocytic pathways regulate TGF-receptor signalling and turnover, Nat. Cell Biol, vol.5, pp.410-421, 2003. ,
New horizons for antiviral drug discovery from virus-host protein interaction networks, Curr. Opin. Virol, vol.2, pp.606-613, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-00965869
Hepatitis C virus infection protein network, Mol. Syst. Biol, vol.4, p.230, 2008. ,
URL : https://hal.archives-ouvertes.fr/pasteur-00456466
Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line, Science, vol.285, pp.110-113, 1999. ,
Growth of human hepatoma cells lines with differentiated functions in chemically defined medium, Cancer Res, vol.42, pp.3858-3863, 1982. ,
ViralORFeome: an integrated database to generate a versatile collection of viral ORFs, Nucleic Acids Res, vol.38, pp.371-378, 2010. ,
DOI : 10.1093/nar/gkp1000
URL : https://hal.archives-ouvertes.fr/pasteur-00455342
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources, Nat. Protoc, vol.4, pp.44-57, 2009. ,
DOI : 10.1038/nprot.2008.211
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists, Nucleic Acids Res, vol.37, pp.1-13, 2009. ,
VirHostNet: a knowledge base for the management and the analysis of proteome-wide virus-host interaction networks, Nucleic Acids Res, vol.37, pp.661-668, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-00428233
, , 2003.
, Cytoscape: a software environment for integrated models of biomolecular interaction networks, Genome Res, vol.13, pp.2498-2504
Epithelial-to-mesenchymal transitions in the liver, Hepatology, vol.50, pp.2007-2013, 2009. ,
Analysis of RGS2 expression and prognostic significance in stage II and III colorectal cancer, Biosci. Rep, vol.30, pp.383-390, 2010. ,
Snail2 is an essential mediator of Twist1induced epithelial mesenchymal transition and metastasis. Cancer Res, vol.71, pp.245-254, 2011. ,
Use of the Fused NS4A peptide-NS3 protease domain to study the importance of the helicase domain for protease inhibitor binding to hepatitis C virus NS3-NS4A, Biochemistry, vol.48, pp.744-753, 2009. ,
Smad transcription factors, Genes Dev, vol.19, pp.2783-2810, 2005. ,
Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-/Smad3-mediated transcriptional activation, Oncogene, vol.23, pp.7821-7838, 2004. ,
Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex, Proc. Natl. Acad. Sci. U. S. A, vol.105, pp.14545-14550, 2008. ,
Targeting the TGFsignalling pathway in disease, Nat. Rev. Drug Discov, vol.11, pp.790-811, 2012. ,
Circulating transforming growth factor-and epidermal growth factor receptor as related to virus infection in liver carcinogenesis, Anticancer Res, vol.32, pp.141-145, 2012. ,
Epithelial-mesenchymal transition in hepatocellular carcinoma, Future Oncol, vol.5, pp.1169-1179, 2009. ,
Kruppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression, PLoS One, vol.7, p.43593, 2012. ,
DOI : 10.1371/journal.pone.0043593
URL : https://doi.org/10.1371/journal.pone.0043593
Nodal expression and detection in cancer: experience and challenges, Cancer Res, vol.72, pp.1915-1920, 2012. ,
DOI : 10.1158/0008-5472.can-11-3419
URL : http://cancerres.aacrjournals.org/content/canres/72/8/1915.full.pdf
CUX1/Wnt signaling regulates epithelial mesenchymal transition in EBV-infected epithelial cells, Exp. Cell Res, vol.315, pp.1819-1831, 2009. ,
DOI : 10.1016/j.yexcr.2009.04.001
Activation of Wnt11 by transforming growth factor-drives mesenchymal gene expression through non-canonical Wnt protein signaling in renal epithelial cells, J. Biol. Chem, vol.287, pp.21290-21302, 2012. ,
Possible involvement of Wnt11 in colorectal cancer progression, Mol. Carcinog, vol.52, pp.207-217, 2013. ,
Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNF-in MKN45 cells and up-regulation of WNT5B by-estradiol in MCF-7 cells, Int. J. Mol. Med, vol.10, pp.345-349, 2002. ,
Hepatitis C virus induces epithelial-mesenchymal transition in primary human hepatocytes, J. Virol, vol.86, pp.13621-13628, 2012. ,
DOI : 10.1128/jvi.02016-12
URL : http://jvi.asm.org/content/86/24/13621.full.pdf
Modulation of the transforming growth factor-signal transduction pathway by hepatitis C virus nonstructural 5A protein, J. Biol. Chem, vol.281, pp.7468-7478, 2006. ,
Hepatitis C virus core variants isolated from liver tumor but not from adjacent nontumor tissue interact with Smad3 and inhibit the TGF-pathway, Oncogene, vol.24, pp.6119-6132, 2005. ,
DOI : 10.1038/sj.onc.1208749
URL : https://www.nature.com/articles/1208749.pdf
A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20, Nat. Med, vol.18, pp.227-234, 2012. ,
DOI : 10.1038/nm.2596
URL : http://europepmc.org/articles/pmc3274650?pdf=render