Immunotherapy in Alzheimer’s Disease: Do We Have All the Pieces of the Puzzle?

Abstract : Results of Phase III studies involving a large number of Alzheimer's disease (AD) patients treated by passive immunotherapy with humanized anti-amyloid β monoclonal antibodies have recently been released. These approaches failed to show a significant clinical benefit in patients with mild to moderate AD. The most considered explanation is that the patients have been treated too late. Whereas targeting patients at asymptomatic stages of the disease is a critical step in the goal of improving the efficacy of such antibody-based strategies, several other important factors should be considered in the development and clinical evaluation of anti-amyloid β immunotherapies, including the as yet poorly understood relationship of AD with the immune system and the importance of cerebral amyloid angiopathy. Better understanding the role of immune responses in AD and their impact on immunotherapy appears essential in the design of alternative or combinatorial immunotherapy approaches in AD, which may imply effectors other than antibodies and even additional antigenic targets.
Complete list of metadatas

Cited literature [45 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01876544
Contributor : Pierre Aucouturier <>
Submitted on : Tuesday, September 18, 2018 - 3:54:22 PM
Last modification on : Thursday, April 11, 2019 - 4:02:22 PM

File

Sarazin et al Biol Psych 2013...
Files produced by the author(s)

Identifiers

Citation

Marie Sarazin, Guillaume Dorothée, Leonardo de Souza, Pierre Aucouturier, Leonardo Cruz de Souza. Immunotherapy in Alzheimer’s Disease: Do We Have All the Pieces of the Puzzle?. Biological Psychiatry, Elsevier, 2013, 74 (5), pp.329 - 332. ⟨10.1016/j.biopsych.2013.04.011⟩. ⟨inserm-01876544v2⟩

Share

Metrics

Record views

308

Files downloads

199