Immunotherapy in Alzheimer’s Disease: Do We Have All the Pieces of the Puzzle?

Marie Sarazin 1, 2, 3, * Guillaume Dorothée 4, 5 Leonardo de Souza 5, 6 Pierre Aucouturier 4, 5 Leonardo Cruz de Souza 6
* Corresponding author
1 U894 / UMS 1266 - Institut de psychiatrie et neurosciences
2 Service de Neurologie [AP-HP Hôpital Pitié-Salpêtrière]
3 Service de Neurologie [CH Saint-Anne]
4 CR Saint-Antoine - Centre de Recherche Saint-Antoine
5 Laboratoire du Système Immunitaire et Maladies Conformationnelles [AP-HP Hôpital Saint-Antoine]
6 CRICM - Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière
Abstract : Results of Phase III studies involving a large number of Alzheimer's disease (AD) patients treated by passive immunotherapy with humanized anti-amyloid β monoclonal antibodies have recently been released. These approaches failed to show a significant clinical benefit in patients with mild to moderate AD. The most considered explanation is that the patients have been treated too late. Whereas targeting patients at asymptomatic stages of the disease is a critical step in the goal of improving the efficacy of such antibody-based strategies, several other important factors should be considered in the development and clinical evaluation of anti-amyloid β immunotherapies, including the as yet poorly understood relationship of AD with the immune system and the importance of cerebral amyloid angiopathy. Better understanding the role of immune responses in AD and their impact on immunotherapy appears essential in the design of alternative or combinatorial immunotherapy approaches in AD, which may imply effectors other than antibodies and even additional antigenic targets.
Keywords : cellular immunity antibodies amyloid beta Alzheimer's disease immunotherapy cerebral amyloid angiopathy
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Marie Sarazin, Guillaume Dorothée, Leonardo de Souza, Pierre Aucouturier, Leonardo Cruz de Souza. Immunotherapy in Alzheimer’s Disease: Do We Have All the Pieces of the Puzzle?. Biological Psychiatry, Elsevier, 2013, 74 (5), pp.329 - 332. ⟨10.1016/j.biopsych.2013.04.011⟩. ⟨inserm-01876544v2⟩

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