Biological relevance of double lipoxygenase products of polyunsaturated fatty acids, especially within blood vessels and brain

Abstract : The double lipoxygenation of polyunsaturated fatty acids (PUFA) is possible with PUFA having at least three methylene-interrupted double bonds. Several PUFA of the omega-3/n-3 and -6 families may be converted through this route, and the products show interesting inhibitory effects on blood platelet function and cyclooxygenase activities. This review focuses on two main omega-3 PUFA of nutritional interest, namely docosahexaenoic acid (DHA/22:6n-3) and alpha linolenic acid (ALA/18:3n-3). The chemical configuration of the double lipoxygenase end-product from DHA (protectin DX) is compared with that of protectin D1 which is produced through a mono-lipoxygenation step followed by an epoxidation and epoxide hydrolysis process. The different metabolic pathways are discussed as well as the different biological activities of both protectins.
Document type :
Journal articles
Complete list of metadatas

Cited literature [33 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01872365
Contributor : Evelyne Vericel <>
Submitted on : Wednesday, September 12, 2018 - 9:07:30 AM
Last modification on : Monday, September 23, 2019 - 3:32:04 PM
Long-term archiving on : Thursday, December 13, 2018 - 12:40:27 PM

Files

Guichardant et al Biochimie 20...
Files produced by the author(s)

Identifiers

Collections

Citation

Michel Guichardant, Evelyne Véricel, Michel Lagarde. Biological relevance of double lipoxygenase products of polyunsaturated fatty acids, especially within blood vessels and brain. Biochimie, Elsevier, 2018, Epub ahead of print. ⟨10.1016/j.biochi.2018.08.009⟩. ⟨inserm-01872365⟩

Share

Metrics

Record views

126

Files downloads

130