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Journal articles
Biological relevance of double lipoxygenase products of polyunsaturated fatty acids, especially within blood vessels and brain
Abstract : The double lipoxygenation of polyunsaturated fatty acids (PUFA) is possible with PUFA having at least three methylene-interrupted double bonds. Several PUFA of the omega-3/n-3 and -6 families may be converted through this route, and the products show interesting inhibitory effects on blood platelet function and cyclooxygenase activities. This review focuses on two main omega-3 PUFA of nutritional interest, namely docosahexaenoic acid (DHA/22:6n-3) and alpha linolenic acid (ALA/18:3n-3). The chemical configuration of the double lipoxygenase end-product from DHA (protectin DX) is compared with that of protectin D1 which is produced through a mono-lipoxygenation step followed by an epoxidation and epoxide hydrolysis process. The different metabolic pathways are discussed as well as the different biological activities of both protectins.
Cited literature [33 references]
https://www.hal.inserm.fr/inserm-01872365
Contributor : Evelyne Vericel Connect in order to contact the contributor
Submitted on : Wednesday, September 12, 2018 - 9:07:30 AM
Last modification on : Monday, June 28, 2021 - 9:50:07 AM
Long-term archiving on: : Thursday, December 13, 2018 - 12:40:27 PM
Contributor : Evelyne Vericel Connect in order to contact the contributor
Submitted on : Wednesday, September 12, 2018 - 9:07:30 AM
Last modification on : Monday, June 28, 2021 - 9:50:07 AM
Long-term archiving on: : Thursday, December 13, 2018 - 12:40:27 PM
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Guichardant et al Biochimie 20...
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