Disentangling complex parasite interactions: Protection against cerebral malaria by one helminth species is jeopardized by co-infection with another - Archive ouverte HAL Access content directly
Journal Articles PLoS Neglected Tropical Diseases Year : 2018

Disentangling complex parasite interactions: Protection against cerebral malaria by one helminth species is jeopardized by co-infection with another

(1, 2) , (3, 4) , (2) , (2, 5) , (6, 7, 8) , (1, 9, 10)
1
2
3
4
5
6
7
8
9
10

Abstract

Multi-species interactions can often have non-intuitive consequences. However, the study of parasite interactions has rarely gone beyond the effects of pairwise combinations of species , and the outcomes of multi-parasite interactions are poorly understood. We investigated the effects of co-infection by four gastrointestinal helminth species on the development of cerebral malaria among Plasmodium falciparum-infected patients. We characterized associations among the helminth parasite infra-community, and then tested for independent (direct) and co-infection dependent (indirect) effects of helminths on cerebral malaria risk. We found that infection by Ascaris lumbricoides and Trichuris trichiura were both associated with direct reductions in cerebral malaria risk. However, the benefit of T. trichiura infection was halved in the presence of hookworm, revealing a strong indirect effect. Our study suggests that the outcome of interactions between two parasite species can be significantly modified by a third, emphasizing the critical role that parasite community interactions play in shaping infection outcomes.
Fichier principal
Vignette du fichier
2018, Abbate - Disentangling complex parasite interactions.pdf (2.41 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

inserm-01872243 , version 1 (11-09-2018)

Identifiers

Cite

Jessica Lee Abbate, Vanessa O Ezenwa, Jean-François Guégan, Marc Choisy, Mathieu Nacher, et al.. Disentangling complex parasite interactions: Protection against cerebral malaria by one helminth species is jeopardized by co-infection with another. PLoS Neglected Tropical Diseases, 2018, 12 (5), pp.e0006483. ⟨10.1371/journal.pntd.0006483⟩. ⟨inserm-01872243⟩
143 View
115 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More