J. I. Aguilo, J. Garaude, J. Pardo, M. Villalba, and A. Anel, Protein kinase C-theta is required for NK cell activation and in vivo control of tumor progression, 2009.

, J. Immunol, vol.182, pp.1972-1981

N. Allende-vega, E. Krzywinska, S. Orecchioni, N. Lopez-royuela, F. Reggiani et al., The presence of wild type p53 in hematological cancers improves the efficacy of combinational therapy targeting metabolism, Oncotarget, vol.6, issue.22, 2015.
DOI : 10.18632/oncotarget.4653

URL : https://hal.archives-ouvertes.fr/hal-01835529

A. Anel, J. I. Aguilo, E. Catalan, J. Garaude, M. G. Rathore et al., Protein kinase C-theta (PKC-theta) in natural killer cell function and anti-tumor immunity, Front. Immunol, vol.3, p.187, 2012.

C. Baier, A. Fino, C. Sanchez, L. Farnault, P. Rihet et al., Natural Killer Cells Modulation in Hematological Malignancies, Frontiers in Immunology, vol.4, p.459, 2013.
DOI : 10.3389/fimmu.2013.00459

URL : https://hal.archives-ouvertes.fr/hal-01455668

N. Bhatnagar, H. S. Hong, J. K. Krishnaswamy, A. Haghikia, G. M. Behrens et al., Cytokine-activated NK cells inhibit PMN apoptosis and preserve their functional capacity, Blood, vol.179, issue.3, pp.1308-1316, 2010.
DOI : 10.1086/314622

Y. T. Bryceson, S. C. Chiang, S. Darmanin, C. Fauriat, H. Schlums et al., Molecular Mechanisms of Natural Killer Cell Activation, Journal of Innate Immunity, vol.185, issue.3, pp.216-226, 2011.
DOI : 10.4049/jimmunol.1000784

K. F. Byth, L. A. Conroy, S. Howlett, A. J. Smith, J. May et al., CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation, Journal of Experimental Medicine, vol.183, issue.4, pp.1707-1718, 1996.
DOI : 10.1084/jem.183.4.1707

E. Catalán, S. Charni, J. Aguiló, J. Enríquez, J. Naval et al., MHC-I modulation due to metabolic changes regulates tumor sensitivity to CTL and NK cells. Oncoimmunology 4, e985924, 2015.

S. Charni, J. I. Aguilo, J. Garaude, G. De-bettignies, C. Jacquet et al., ERK5 Knockdown Generates Mouse Leukemia Cells with Low MHC Class I Levels That Activate NK Cells and Block Tumorigenesis, The Journal of Immunology, vol.182, issue.6, pp.3398-3405, 2009.
DOI : 10.4049/jimmunol.0803006

URL : https://hal.archives-ouvertes.fr/hal-00368654

S. Charni, G. De-bettignies, M. G. Rathore, J. I. Aguilo, P. J. Van-den-elsen et al., Oxidative Phosphorylation Induces De Novo Expression of the MHC Class I in Tumor Cells through the ERK5 Pathway, The Journal of Immunology, vol.185, issue.6, pp.3498-3503, 2010.
DOI : 10.4049/jimmunol.1001250

D. Chiesa, M. Muccio, L. Moretta, and A. , CMV induces rapid NK cell maturation in HSCT recipients, Immunology Letters, vol.155, issue.1-2, pp.11-13, 2013.
DOI : 10.1016/j.imlet.2013.09.020

C. I. Domaica, M. B. Fuertes, I. Uriarte, M. V. Girart, J. Sardanons et al., Human natural killer cell maturation defect supports in vivo CD56(bright) to CD56(dim) lineage development, PLoS One, vol.7, 2012.

G. P. Dunn, A. T. Bruce, H. Ikeda, L. J. Old, and R. D. Schreiber, Cancer immunoediting: from immunosurveillance to tumor escape, Nature Immunology, vol.93, issue.11, pp.991-998, 2002.
DOI : 10.1073/pnas.93.21.11798

L. A. Earl, S. Bi, and L. G. Baum, -Glycans Modulate Galectin-1 Binding, CD45 Signaling, and T Cell Death, Journal of Biological Chemistry, vol.162, issue.4, pp.2232-2244, 2010.
DOI : 10.1038/ni822

K. G. Elpek, M. P. Rubinstein, A. Bellemare-pelletier, A. W. Goldrath, and S. J. Turley, Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15R?? complexes, Proceedings of the National Academy of Sciences, vol.17, issue.4, pp.21647-21652, 2010.
DOI : 10.1016/j.cytogfr.2006.05.001

L. A. Fogel, M. M. Sun, T. L. Geurs, L. N. Carayannopoulos, and A. R. French, Markers of Nonselective and Specific NK Cell Activation, The Journal of Immunology, vol.190, issue.12, pp.6269-6276, 2013.
DOI : 10.4049/jimmunol.1202533

A. G. Freud, J. Yu, and M. A. Caligiuri, Human natural killer cell development in secondary lymphoid tissues, Seminars in Immunology, vol.26, issue.2, pp.132-137, 2014.
DOI : 10.1016/j.smim.2014.02.008

X. Fu, Y. Liu, L. Li, Q. Li, D. Qiao et al., Human natural killer cells expressing the memory-associated marker CD45RO from tuberculous pleurisy respond more strongly and rapidly than CD45RO??? natural killer cells following stimulation with interleukin-12, Immunology, vol.30, issue.1, pp.41-49, 2011.
DOI : 10.1002/(SICI)1521-4141(200005)30:5<1364::AID-IMMU1364>3.0.CO;2-U

H. Fujisaki, H. Kakuda, N. Shimasaki, C. Imai, J. Ma et al., Expansion of Highly Cytotoxic Human Natural Killer Cells for Cancer Cell Therapy, Cancer Research, vol.69, issue.9, pp.4010-4017, 2009.
DOI : 10.1158/0008-5472.CAN-08-3712

J. Garaude, S. Kaminski, S. Charni, J. I. Aguilo, C. Jacquet et al., Impaired anti-leukemic immune response in PKC??-deficient mice, Molecular Immunology, vol.45, issue.12, pp.3463-3469, 2008.
DOI : 10.1016/j.molimm.2008.03.016

M. L. Hermiston, J. Zikherman, and J. W. Zhu, CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells, CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells, pp.288-311, 2009.
DOI : 10.4049/jimmunol.179.7.4704

URL : http://europepmc.org/articles/pmc2739744?pdf=render

D. G. Hesslein, R. Takaki, M. L. Hermiston, A. Weiss, and L. L. Lanier, Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production, Proceedings of the National Academy of Sciences, vol.18, issue.1, pp.7012-7017, 2006.
DOI : 10.1016/S1074-7613(02)00505-8

D. G. Hesslein, E. H. Palacios, J. C. Sun, J. N. Beilke, S. R. Watson et al., Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases, Blood, vol.158, issue.4, pp.3087-3095, 2011.
DOI : 10.1128/MCB.18.7.4209

URL : http://www.bloodjournal.org/content/bloodjournal/117/11/3087.full.pdf

N. D. Huntington, Y. Xu, S. L. Nutt, and D. M. Tarlinton, A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells, The Journal of Experimental Medicine, vol.163, issue.9, pp.1421-1433, 2005.
DOI : 10.1084/jem.187.5.807

URL : http://jem.rupress.org/content/jem/201/9/1421.full.pdf

J. Irie-sasaki, T. Sasaki, W. Matsumoto, A. Opavsky, M. Cheng et al., CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling, Nature, vol.17, issue.6818, pp.349-354, 2001.
DOI : 10.1128/MCB.17.6.3295

K. Ito, K. Stannard, E. Gabutero, A. M. Clark, S. Y. Neo et al., Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment, Cancer and Metastasis Reviews, vol.286, issue.24, pp.763-778
DOI : 10.1074/jbc.M110.194597

S. Kaminski, O. Adjali, C. Jacquet, J. Garaude, A. Keriel et al., The protooncogene Vav1 regulates murine leukemia virus-induced T-cell leukemogenesis, OncoImmunology, vol.45, issue.5, pp.600-608, 2012.
DOI : 10.4049/jimmunol.1001250

URL : https://hal.archives-ouvertes.fr/inserm-00726759

R. Kaplan, B. Morse, K. Huebner, C. Croce, R. Howk et al., Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain., Proceedings of the National Academy of Sciences, vol.87, issue.18, pp.7000-7004, 1990.
DOI : 10.1073/pnas.87.18.7000

K. Karre, H. G. Ljunggren, G. Piontek, and R. Kiessling, Selective rejection of H???2-deficient lymphoma variants suggests alternative immune defence strategy, Nature, vol.135, issue.6055, pp.675-678, 1986.
DOI : 10.1038/319675a0

K. Kishihara, J. Penninger, V. A. Wallace, T. M. Kundig, K. Kawai et al., Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice, Cell, vol.74, issue.1, pp.143-156, 1993.
DOI : 10.1016/0092-8674(93)90302-7

C. Kung, J. T. Pingel, M. Heikinheimo, T. Klemola, K. Varkila et al., Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease, Nature Medicine, vol.17, issue.3, pp.343-345, 2000.
DOI : 10.1089/dna.1998.17.779

L. L. Lanier, Up on the tightrope: natural killer cell activation and inhibition, Nature Immunology, vol.179, issue.5, pp.495-502, 2008.
DOI : 10.1371/journal.pone.0000326

URL : http://europepmc.org/articles/pmc2669298?pdf=render

E. S. Lianidou, D. Mavroudis, and V. Georgoulias, Clinical challenges in the molecular characterization of circulating tumour cells in breast cancer, British Journal of Cancer, vol.27, issue.12, pp.2426-2432, 2013.
DOI : 10.1200/JCO.2005.04.5948

K. W. Lynch and A. Weiss, A Model System for Activation-Induced Alternative Splicing of CD45 Pre-mRNA in T Cells Implicates Protein Kinase C and Ras, Molecular and Cellular Biology, vol.20, issue.1, pp.70-80, 2000.
DOI : 10.1128/MCB.20.1.70-80.2000

E. Mamessier, F. Bertucci, R. Sabatier, D. Birnbaum, and D. Olive, ???Stealth??? tumors, OncoImmunology, vol.1, issue.3, pp.366-368, 2012.
DOI : 10.1200/JCO.2010.30.5037

URL : http://www.tandfonline.com/doi/pdf/10.4161/onci.18528?needAccess=true

E. Mamessier, L. C. Pradel, M. L. Thibult, C. Drevet, A. Zouine et al., Peripheral Blood NK Cells from Breast Cancer Patients Are Tumor-Induced Composite Subsets, The Journal of Immunology, vol.190, issue.5, pp.2424-2436, 2013.
DOI : 10.4049/jimmunol.1200140

URL : https://hal.archives-ouvertes.fr/hal-01612099

A. Marcais and T. Walzer, mTOR: A gate to NK cell maturation and activation, Cell Cycle, vol.13, issue.21, pp.3315-3316, 2014.
DOI : 10.1182/blood-2010-06-291633

L. H. Mason, J. Willette-brown, L. S. Taylor, and D. W. Mcvicar, Regulation of Ly49D/DAP12 Signal Transduction by Src-Family Kinases and CD45, The Journal of Immunology, vol.176, issue.11, pp.6615-6623, 2006.
DOI : 10.4049/jimmunol.176.11.6615

URL : http://www.jimmunol.org/content/jimmunol/176/11/6615.full.pdf

P. J. Mee, M. Turner, M. A. Basson, P. S. Costello, R. Zamoyska et al., Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice, European Journal of Immunology, vol.7, issue.9, pp.2923-2933, 1999.
DOI : 10.1128/MCB.16.9.4996

L. Moretta, Dissecting CD56dim human NK cells, Blood, vol.224, issue.19, pp.3689-3691, 2010.
DOI : 10.1111/j.1600-065X.2008.00651.x

URL : http://www.bloodjournal.org/content/bloodjournal/116/19/3689.full.pdf

T. Mustelin, T. Vang, and N. Bottini, Protein tyrosine phosphatases and the immune response, Nature Reviews Immunology, vol.278, issue.1, pp.43-57, 2005.
DOI : 10.1074/jbc.M307152200

K. Nakamura, M. Nakayama, M. Kawano, T. Ishii, H. Harigae et al., NKcell fratricide: dynamic crosstalk between NK and cancer cells, 2013.
DOI : 10.4161/onci.26529

URL : http://www.tandfonline.com/doi/pdf/10.4161/onci.26529?needAccess=true

J. Pardo, S. Balkow, A. Anel, and M. M. Simon, Granzymes are essential for natural killer cell-mediated and perf-facilitated tumor control, European Journal of Immunology, vol.32, issue.10, pp.2881-2887, 2002.
DOI : 10.1002/1521-4141(2002010)32:10<2881::AID-IMMU2881>3.0.CO;2-K

URL : http://onlinelibrary.wiley.com/doi/10.1002/1521-4141(2002010)32:10<2881::AID-IMMU2881>3.0.CO;2-K/pdf

N. Ramírez-comet, J. I. Aguiló, M. G. Rathoré, E. Catalán, J. Garaude et al., IFN-? signaling through PKC-? is essential for anti-tumor NK cell function. Oncoimmunology 3, 2014.

I. Rhee and A. Veillette, Protein tyrosine phosphatases in lymphocyte activation and autoimmunity, Nature Immunology, vol.76, issue.5, pp.439-447, 2012.
DOI : 10.1016/j.immuni.2010.08.001

M. D. Roth, Interleukin 2 induces the expression of CD45RO and the memory phenotype by CD45RA+ peripheral blood lymphocytes, Journal of Experimental Medicine, vol.179, issue.3, pp.857-864, 1994.
DOI : 10.1084/jem.179.3.857

L. Ruggeri, A. Mancusi, E. Burchielli, F. Aversa, M. F. Martelli et al., Natural killer cell alloreactivity in allogeneic hematopoietic transplantation, Current Opinion in Oncology, vol.19, issue.2, pp.142-147, 2007.
DOI : 10.1097/CCO.0b013e3280148a1a

D. Sanchez-martinez, E. Krzywinska, M. G. Rathore, A. Saumet, A. Cornillon et al., All-trans retinoic acid (ATRA) induces miR-23a expression, decreases CTSC expression and granzyme B activity leading to impaired NK cell cytotoxicity, The International Journal of Biochemistry & Cell Biology, vol.49, pp.42-52, 2014.
DOI : 10.1016/j.biocel.2014.01.003

D. Sanchez-martinez, G. Azaceta, A. Muntasell, N. Aguilo, D. Nunez et al., lymphoblastoid cells overcome anti-apoptotic mechanisms of drug resistance in haematological cancer cells, OncoImmunology, vol.63, issue.3, 2015.
DOI : 10.1126/science.1068440

URL : https://hal.archives-ouvertes.fr/hal-01835574

L. Senovilla, E. Vacchelli, J. Galon, S. Adjemian, A. Eggermont et al., Trial watch, OncoImmunology, vol.28, issue.8, pp.1323-1343, 2012.
DOI : 10.1002/ijc.26123

J. Siewiera, H. Costa, J. Tabiasco, A. Berrebi, G. Cartron et al., Human cytomegalovirus infection elicits new decidual natural killer cell effector functions, PLoS Pathog, vol.9, 2013.
DOI : 10.1371/journal.ppat.1003257

URL : https://doi.org/10.1371/journal.ppat.1003257

K. Skak, K. S. Frederiksen, and D. Lundsgaard, Interleukin-21 activates human natural killer cells and modulates their surface receptor expression, Immunology, vol.176, issue.4, pp.575-583, 2008.
DOI : 10.4049/jimmunol.176.10.6347

URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2567.2007.02730.x/pdf

L. Soma, D. Wu, X. Chen, K. Edlefsen, J. R. Fromm et al., Apparent CD19 expression by natural killer cells: A potential confounder for minimal residual disease detection by flow cytometry in B lymphoblastic leukemia, Cytometry Part B: Clinical Cytometry, vol.88, pp.145-147, 2015.
DOI : 10.1002/cytob.21179

M. Stern, L. Ruggeri, A. Mancusi, M. E. Bernardo, C. De-angelis et al., Survival after T cell-depleted haploidentical stem cell transplantation is improved using the mother as donor, Blood, vol.28, issue.4, pp.2990-2995, 2008.
DOI : 10.1038/sj.bmt.1703146

URL : http://www.bloodjournal.org/content/bloodjournal/112/7/2990.full.pdf

E. Suzuki, T. R. Kataoka, M. Hirata, K. Kawaguchi, M. Nishie et al., Trogocytosis-mediated expression of HER2 on immune cells may be associated with a pathological complete response to trastuzumab-based primary systemic therapy in HER2-overexpressing breast cancer patients, BMC Cancer, vol.32, issue.33, p.39, 2015.
DOI : 10.1200/JCO.2013.54.5384

E. Z. Tchilian, D. L. Wallace, R. S. Wells, D. R. Flower, G. Morgan et al., A Deletion in the Gene Encoding the CD45 Antigen in a Patient with SCID, The Journal of Immunology, vol.166, issue.2, pp.1308-1313, 2001.
DOI : 10.4049/jimmunol.166.2.1308

M. F. Van-den-broek, D. Kagi, R. M. Zinkernagel, and H. Hengartner, Perforin dependence of natural killer cell-mediated tumor controlin vivo, European Journal of Immunology, vol.49, issue.12, pp.3514-3516, 1995.
DOI : 10.1002/eji.1830251246

A. Velardi, Role of KIRs and KIR ligands in hematopoietic transplantation, Current Opinion in Immunology, vol.20, issue.5, pp.581-587, 2008.
DOI : 10.1016/j.coi.2008.07.004

N. Vey, J. H. Bourhis, N. Boissel, D. Bordessoule, T. Prebet et al., A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission, Blood, vol.31, issue.9, pp.4317-4323, 2012.
DOI : 10.1016/j.it.2010.06.003

M. Villalba, M. G. Rathore, N. Lopez-royuela, E. Krzywinska, J. Garaude et al., From tumor cell metabolism to tumor immune escape, The International Journal of Biochemistry & Cell Biology, vol.45, issue.1, pp.106-113, 2013.
DOI : 10.1016/j.biocel.2012.04.024

URL : https://hal.archives-ouvertes.fr/inserm-00726717

M. Villalba, N. Lopez-royuela, E. Krzywinska, M. G. Rathore, R. A. Hipskind et al., Chemical Metabolic Inhibitors for the Treatment of Blood-Borne Cancers, Anti-Cancer Agents in Medicinal Chemistry, vol.14, issue.2, pp.223-232, 2014.
DOI : 10.2174/18715206113136660374

URL : https://hal.archives-ouvertes.fr/inserm-00916461

E. Vivier, E. Tomasello, M. Baratin, T. Walzer, and S. Ugolini, Functions of natural killer cells, Nature Immunology, vol.178, issue.5, pp.503-510, 2008.
DOI : 10.1073/pnas.050588297

URL : https://hal.archives-ouvertes.fr/hal-00294184

J. Wang and K. Pantopoulos, Regulation of cellular iron metabolism, Biochemical Journal, vol.18, issue.3, pp.365-381, 2011.
DOI : 10.1126/science.283.5402.676

URL : http://www.biochemj.org/content/ppbiochemj/434/3/365.full.pdf

H. S. Warren and L. J. Skipsey, Loss of activation-induced CD45RO with maintenance of CD45RA expression during prolonged culture of T cells and NK cells, Immunology, vol.74, pp.78-85, 1991.

R. Willemze, C. A. Rodrigues, M. Labopin, G. Sanz, G. Michel et al., KIR-ligand incompatibility in the graft-versus-host direction improves outcomes after umbilical cord blood transplantation for acute leukemia, Leukemia, vol.172, issue.3, pp.492-500, 2009.
DOI : 10.1016/j.immuni.2006.06.013

URL : http://www.nature.com/leu/journal/v23/n3/pdf/leu2008365a.pdf

Z. Xu and A. Weiss, Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms, Nature Immunology, vol.264, issue.8, pp.764-771, 2002.
DOI : 10.1084/jem.182.5.1585

D. Zarcone, E. F. Prasthofer, F. Malavasi, V. Pistoia, A. F. Lobuglio et al., Ultrastructural analysis of human natural killer cell activation, Blood, vol.69, pp.1725-1736, 1987.