, the Fondation pour la Recherche Medicale (MV), l'association CIEL, l'association L'Un pour l'Autre et la fédération Ensangble (MV), a grant FEDER, MV), the Association pour la Recherche contre le Cancer (MV)
, SOE2/P1/E341 from Sudoe/Interreg IV B (EU to MV) and fellowships from La Ligue Contre le Cancer (NL-R) and from the ARC and the Higher Education Commission
, References
Potent Antimyeloma Activity of a Novel ERK5/CDK Inhibitor, Clinical Cancer Research, vol.19, issue.10, pp.2677-87, 2013. ,
DOI : 10.1158/1078-0432.CCR-12-2118
ERK5/BMK1 Is a Novel Target of the Tumor Suppressor VHL: Implication in Clear Cell Renal Carcinoma, Neoplasia, vol.15, issue.6, pp.649-59, 2013. ,
DOI : 10.1593/neo.121896
Nicotinamide Blocks Proliferation and Induces Apoptosis of Chronic Lymphocytic Leukemia Cells through Activation of the p53/miR-34a/SIRT1 Tumor Suppressor Network, Cancer Research, vol.71, issue.13, pp.4473-83, 2011. ,
DOI : 10.1158/0008-5472.CAN-10-4452
Mitochondria: from bioenergetics to the metabolic regulation of carcinogenesis, Front Biosci, vol.14, pp.4015-4049, 2009. ,
Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors, Leukemia, vol.60, issue.10, pp.1751-1760, 2005. ,
DOI : 10.1007/s00018-003-3090-z
Abl-kinase-sensitive levels of ERK5 and its intrinsic basal activity contribute to leukaemia cell survival, EMBO reports, vol.62, issue.1, pp.63-72, 2005. ,
DOI : 10.1067/msy.2002.125389
Multifunctional role of Erk5 in multiple myeloma, Blood, vol.105, issue.11, pp.4492-4501, 2005. ,
DOI : 10.1182/blood-2004-08-2985
ERK5 Knockdown Generates Mouse Leukemia Cells with Low MHC Class I Levels That Activate NK Cells and Block Tumorigenesis, The Journal of Immunology, vol.182, issue.6, pp.3398-405, 2009. ,
DOI : 10.4049/jimmunol.0803006
URL : https://hal.archives-ouvertes.fr/hal-00368654
Oxidative Phosphorylation Induces De Novo Expression of the MHC Class I in Tumor Cells through the ERK5 Pathway, The Journal of Immunology, vol.185, issue.6, pp.3498-503, 2010. ,
DOI : 10.4049/jimmunol.1001250
Regulation of SIRT1 in cellular functions: Role of polyphenols, Archives of Biochemistry and Biophysics, vol.501, issue.1, pp.79-90, 2010. ,
DOI : 10.1016/j.abb.2010.05.003
miR-143 Interferes with ERK5 Signaling, and Abrogates Prostate Cancer Progression in Mice, PLoS ONE, vol.4, issue.10, p.7542, 2009. ,
DOI : 10.1371/journal.pone.0007542.g004
URL : https://hal.archives-ouvertes.fr/inserm-00431462
Removal in Brain Mitochondria via the Thioredoxin/Peroxiredoxin System, Journal of Biological Chemistry, vol.368, issue.36, pp.27850-27858, 2010. ,
DOI : 10.1128/MCB.20.19.7311-7318.2000
Analysis of sirtuin 1 expression reveals a molecular explanation of IL-2-mediated reversal of T-cell tolerance, Proceedings of the National Academy of Sciences, vol.29, issue.19, pp.899-904, 2012. ,
DOI : 10.1128/MCB.00407-09
ERK5 Activates NF-??B in Leukemic T Cells and Is Essential for Their Growth In Vivo, The Journal of Immunology, vol.177, issue.11, pp.7607-7624, 2006. ,
DOI : 10.4049/jimmunol.177.11.7607
URL : https://hal.archives-ouvertes.fr/hal-00119762
SUMOylation Regulates the Transcriptional Activity of JunB in T Lymphocytes, The Journal of Immunology, vol.180, issue.9, pp.5983-90, 2008. ,
DOI : 10.4049/jimmunol.180.9.5983
The Role of ERK5 in T-Cell Signalling, Scandinavian Journal of Immunology, vol.163, issue.6, pp.515-535, 2005. ,
DOI : 10.1128/MCB.20.22.8382-8389.2000
Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression, Biochemical and Biophysical Research Communications, vol.372, issue.1, pp.51-57, 2008. ,
DOI : 10.1016/j.bbrc.2008.04.176
Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth, Science Signaling, vol.2, issue.97, p.73, 2009. ,
DOI : 10.1126/scisignal.2000431
Distinctions and similarities of cell bioenergetics and the role of mitochondria in hypoxia, cancer, and embryonic development, The International Journal of Biochemistry & Cell Biology, vol.42, issue.5, pp.604-626, 2010. ,
DOI : 10.1016/j.biocel.2009.11.008
Nrf2:INrf2 (Keap1) signaling in oxidative stress, Free Radical Biology and Medicine, vol.47, issue.9, pp.1304-1313, 2009. ,
DOI : 10.1016/j.freeradbiomed.2009.07.035
Nrf2: friend or foe for chemoprevention?, Carcinogenesis, vol.100, issue.1, pp.90-99, 2010. ,
DOI : 10.1016/S0092-8674(00)81683-9
Laminar Flow Activation of ERK5 Protein in Vascular Endothelium Leads to Atheroprotective Effect via NF-E2-related Factor 2 (Nrf2) Activation, Journal of Biological Chemistry, vol.82, issue.48, pp.40722-40753, 2012. ,
DOI : 10.1186/1471-213X-3-11
High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells, International Journal of Cancer, vol.3, issue.9, pp.2044-55, 2012. ,
DOI : 10.1016/j.chom.2008.02.002
Altered Hematopoietic Cell Gene Expression Precedes Development of Therapy-Related Myelodysplasia/Acute Myeloid Leukemia and Identifies Patients at Risk, Cancer Cell, vol.20, issue.5, pp.591-605, 2011. ,
DOI : 10.1016/j.ccr.2011.09.011
Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib, Cancer Cell, vol.21, issue.2, pp.266-81, 2012. ,
DOI : 10.1016/j.ccr.2011.12.020
Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1??, Molecular Cell, vol.38, issue.6, pp.864-78, 2010. ,
DOI : 10.1016/j.molcel.2010.05.023
Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome, New England Journal of Medicine, vol.361, issue.11, pp.1058-66, 2009. ,
DOI : 10.1056/NEJMoa0903840
Flow Shear Stress and Atherosclerosis: A Matter of Site Specificity, Antioxidants & Redox Signaling, vol.15, issue.5, pp.1405-1419, 2011. ,
DOI : 10.1089/ars.2010.3679
Metformin rescues cell surface major histocompatibility complex class I (MHC-I) deficiency caused by oncogenic transformation, Cell Cycle, vol.405, issue.5, 2012. ,
DOI : 10.1016/j.bbrc.2011.01.075
URL : http://www.tandfonline.com/doi/pdf/10.4161/cc.11.5.19252?needAccess=true
Metabolism unhinged: IDH mutations in cancer, Nature Medicine, vol.28, issue.3, pp.291-294, 2011. ,
DOI : 10.1200/JCO.2010.28.3762
Nuclear Respiratory Factor 1 Controls Myocyte Enhancer Factor 2A Transcription to Provide a Mechanism for Coordinate Expression of Respiratory Chain Subunits, Journal of Biological Chemistry, vol.112, issue.18, pp.11935-11981, 2008. ,
DOI : 10.1016/j.ydbio.2003.12.004
Myocyte Enhancer Factor 2A Is Transcriptionally Autoregulated, Journal of Biological Chemistry, vol.20, issue.16, pp.10318-10347, 2008. ,
DOI : 10.1126/science.275.5296.90
URL : http://www.jbc.org/content/283/16/10318.full.pdf
The NF-??B member p65 controls glutamine metabolism through miR-23a, The International Journal of Biochemistry & Cell Biology, vol.44, issue.9, pp.1448-56, 2012. ,
DOI : 10.1016/j.biocel.2012.05.011
Inhibition of MEK5 by BIX02188 induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD, Biochemical and Biophysical Research Communications, vol.412, issue.2, pp.307-319, 2011. ,
DOI : 10.1016/j.bbrc.2011.07.089
Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells, J Biol Chem, vol.254, pp.2669-76, 1979. ,
NF-E2-related factor 2, a key inducer of antioxidant defenses, negatively regulates the CFTR transcription, Cellular and Molecular Life Sciences, vol.3, issue.2???3, pp.2297-309, 2010. ,
DOI : 10.1152/ajpcell.00457.2002
Energy Substrate Modulates Mitochondrial Structure and Oxidative Capacity in Cancer Cells, Cancer Research, vol.64, issue.3, pp.985-93, 2004. ,
DOI : 10.1158/0008-5472.CAN-03-1101
URL : http://cancerres.aacrjournals.org/content/canres/64/3/985.full.pdf
Mitochondrial Uncoupling and the Warburg Effect: Molecular Basis for the Reprogramming of Cancer Cell Metabolism, Cancer Research, vol.69, issue.6, pp.2163-2169, 2009. ,
DOI : 10.1158/0008-5472.CAN-08-3722
Global Gene Expression Analysis of ERK5 and ERK1/2 Signaling Reveals a Role for HIF-1 in ERK5-mediated Responses, Journal of Biological Chemistry, vol.83, issue.30, pp.20993-1003, 2006. ,
DOI : 10.1161/01.RES.83.3.295
Extracellular Signal-Regulated Kinase 5: A Potential Therapeutic Target for Malignant Mesotheliomas, Clinical Cancer Research, vol.19, issue.8, pp.2071-83, 2013. ,
DOI : 10.1158/1078-0432.CCR-12-3202
URL : http://clincancerres.aacrjournals.org/content/clincanres/19/8/2071.full.pdf
Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells, The International Journal of Biochemistry & Cell Biology, vol.43, issue.7, pp.950-68, 2011. ,
DOI : 10.1016/j.biocel.2010.05.003
The Role of Mitochondria in Reactive Oxygen Species Metabolism and Signaling, Annals of the New York Academy of Sciences, vol.281, issue.Suppl, pp.37-52, 2008. ,
DOI : 10.1042/bss0710097
PPAR control: it's SIRTainly as easy as PGC, Journal of Endocrinology, vol.204, issue.2, pp.93-104, 2010. ,
DOI : 10.1677/JOE-09-0359
URL : http://joe.endocrinology-journals.org/content/204/2/93.full.pdf
ERK5 Regulates Muscle Cell Fusion through Klf Transcription Factors, Developmental Cell, vol.20, issue.2, pp.192-205, 2011. ,
DOI : 10.1016/j.devcel.2010.12.005
URL : https://doi.org/10.1016/j.devcel.2010.12.005
Identification of pharmacological inhibitors of the MEK5/ERK5 pathway, Biochemical and Biophysical Research Communications, vol.377, issue.1, pp.120-125, 2008. ,
DOI : 10.1016/j.bbrc.2008.09.087
T cell metabolism and the immune response, Seminars in Immunology, vol.24, issue.6, pp.399-404, 2012. ,
DOI : 10.1016/j.smim.2012.12.006
Chemical Metabolic Inhibitors for the Treatment of Blood-Borne Cancers, Anti-Cancer Agents in Medicinal Chemistry, vol.14, issue.2, pp.223-255, 2014. ,
DOI : 10.2174/18715206113136660374
URL : https://hal.archives-ouvertes.fr/inserm-00916461
From tumor cell metabolism to tumor immune escape, The International Journal of Biochemistry & Cell Biology, vol.45, issue.1, pp.106-119, 2013. ,
DOI : 10.1016/j.biocel.2012.04.024
URL : https://hal.archives-ouvertes.fr/inserm-00726717
Regulation of cellular functions by the ERK5 signalling pathway, Cellular Signalling, vol.18, issue.6, pp.753-60, 2006. ,
DOI : 10.1016/j.cellsig.2005.11.003
Targeting HIF1?? Eliminates Cancer Stem Cells in Hematological Malignancies, Cell Stem Cell, vol.8, issue.4, pp.399-411, 2011. ,
DOI : 10.1016/j.stem.2011.02.006
On respiratory impairment in cancer cells, Science, vol.124, pp.269-70, 1956. ,
Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of ??-Ketoglutarate-Dependent Dioxygenases, Cancer Cell, vol.19, issue.1, pp.17-30, 2011. ,
DOI : 10.1016/j.ccr.2010.12.014
Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein, Cancer Cell, vol.18, issue.3, pp.258-67, 2010. ,
DOI : 10.1016/j.ccr.2010.08.008
Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis, Blood, vol.28, issue.32, pp.1904-1918, 2012. ,
DOI : 10.1038/onc.2009.147
The secrets of the bone marrow niche: Metabolic priming for AML, Nature Medicine, vol.4, issue.6, pp.865-872, 2012. ,
DOI : 10.1038/ncb2432
Big Mitogen-Activated Protein Kinase 1 Protects Cultured Rat Aortic Smooth Muscle Cells From Oxidative Damage, Journal of Pharmacological Sciences, vol.116, issue.2, pp.173-80, 2011. ,
DOI : 10.1254/jphs.11015FP