Dysregulated expression of long noncoding RNAs in gynecologic cancers

Abstract : Cancers of the female reproductive system include ovarian, uterine, vaginal, cervical and vulvar cancers, which are termed gynecologic cancer. The emergence of long noncoding RNAs (lncRNAs), which are believed to play a crucial role in several different biological processes, has made the regulation of gene expression more complex. Although the function of lncRNAs is still rather elusive, their broad involvement in the initiation and progression of various cancers is clear. They are also involved in the pathogenesis of cancers of the female reproductive system. LncRNAs play a critical physiological role in apoptosis, metastasis, invasion, migration and cell proliferation in these cancers. Different expression profiles of lncRNAs have been observed in various types of tumors compared with normal tissues and between malignant and benign tumors. These differential expression patterns may lead to the promotion or suppression of cancer development and tumorigenesis. In the current review, we present the lncRNAs that show a differential expression between cancerous and normal tissues in ovarian, cervical and endometrial cancers, and highlight the associations between lncRNAs and some of the molecular pathways involved in these cancers.
Type de document :
Article dans une revue
Molecular Cancer, BioMed Central, 2018, 16 (1), pp.107. 〈10.1186/s12943-017-0671-2〉
Liste complète des métadonnées

Littérature citée [67 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-01856076
Contributeur : Nathalie Duchange <>
Soumis le : jeudi 9 août 2018 - 15:34:37
Dernière modification le : mardi 14 août 2018 - 10:17:47

Fichier

s12943-017-0671-2.pdf
Publication financée par une institution

Identifiants

Collections

Citation

Elahe Hosseini, Matthieu Meryet-Figuière, Hamed Sabzalipoor, Hamed Kashani, Hossein Nikzad, et al.. Dysregulated expression of long noncoding RNAs in gynecologic cancers. Molecular Cancer, BioMed Central, 2018, 16 (1), pp.107. 〈10.1186/s12943-017-0671-2〉. 〈inserm-01856076〉

Partager

Métriques

Consultations de la notice

512

Téléchargements de fichiers

10