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Journal articles
Isolation of circulating tumor cells in a preclinical model of osteosarcoma: effect of chemotherapy: osteosarcoma and circulating tumor cells
Abstract : Osteosarcoma is a rare primary bone tumor, which mainly affects children and adolescents
and has a poor prognosis, especially for patients with metastatic disease. A poor therapeutic
response to the conventional chemotherapy is observed with the development of lung
metastases, highlighting the need for improving the current regimens and the identification of
early markers of the recurrent and metastatic disease. Circulating Tumour Cells (CTCs) play a
key role in the metastatic process and could be powerful biomarkers of the progressive
disease. The present study aimed to isolate CTCs by using a pre-clinical model of human
osteosarcoma and to monitor their kinetic of release and their modulation by ifosfamide.
CTCs were detectable into the bloodstream before any palpable primary tumors. Ifosfamide
increased CTCs count and in contrast decreased the number of lung tumor nodules. On
established tumors, ifosfamide slowed down the tumour growth and did not modulate CTC
count that could be explained by a release of cancer cells from the primary tumour with
reduced properties for inducing lung metastases. This report highlights the biological interest
of CTCs in osteosarcoma.
Cited literature [58 references]
https://www.hal.inserm.fr/inserm-01851614
Contributor : Dominique Heymann <>
Submitted on : Monday, July 30, 2018 - 3:15:40 PM
Last modification on : Thursday, June 18, 2020 - 5:48:01 PM
Long-term archiving on: : Wednesday, October 31, 2018 - 1:19:40 PM
Contributor : Dominique Heymann <>
Submitted on : Monday, July 30, 2018 - 3:15:40 PM
Last modification on : Thursday, June 18, 2020 - 5:48:01 PM
Long-term archiving on: : Wednesday, October 31, 2018 - 1:19:40 PM
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