, CR1*2 CR1*2, pp.10-15
, Notes: AD = Alzheimer's disease; CR1 = complement receptor 1, where numbers following asterisk denote an isoform; HH = individuals homozygous for the H allele (HindIII polymorphism)
, HL = individuals heterozygous for the HindIII polymorphism; LL = individuals homozygous for the L allele (HindIII polymorphism)
, QQ = individuals homozygous for the Q allele
, QH = individuals heterozygous for the Q981H polymorphism
,
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease, Nature Genetics, vol.34, issue.10, pp.1088-1093, 2009. ,
DOI : 10.1212/WNL.56.1.127
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease, Nat. Genet, vol.43, pp.429-435, 2011. ,
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease, Nature Genetics, vol.12, issue.10, pp.1094-1099, 2009. ,
DOI : 10.1042/bj2930027
, Bis, J.C
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease, Nat. Genet. Vardarajan, B.N.; Buros, J.; Gallins, P.J. J.D, vol.45, pp.1452-1458, 2013. ,
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease, Nat. Genet, vol.43, pp.436-441, 2011. ,
Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease, JAMA, vol.303, issue.18, pp.1832-1840, 2010. ,
DOI : 10.1001/jama.2010.574
Late-Onset Alzheimer???s Disease Genes and the Potentially Implicated Pathways, Current Genetic Medicine Reports, vol.344, issue.2, pp.85-101 ,
DOI : 10.1136/bmj.e1662
Peripheral clearance of amyloid ?? peptide by complement C3-dependent adherence to erythrocytes, Neurobiology of Aging, vol.27, issue.12, pp.1733-1739, 2006. ,
DOI : 10.1016/j.neurobiolaging.2005.09.043
The clearance of tetanus toxoid/anti-tetanus toxoid immune complexes from the circulation of humans. Complement-and erythrocyte complement receptor 1-dependent mechanisms, J. Immunol, vol.140, pp.899-904, 1988. ,
Evaluation of the mechanisms responsible for the reduction in erythrocyte complement receptors when immune complexes form in vivo in primates, J. Immunol, vol.145, pp.4198-4206, 1990. ,
Primate erythrocyte-immune complex-clearing mechanism., Journal of Clinical Investigation, vol.71, issue.2, pp.236-247, 1983. ,
DOI : 10.1172/JCI110764
Peripheral complement interactions with amyloid ?? peptide: Erythrocyte clearance mechanisms, Alzheimer's & Dementia, vol.13, issue.12, pp.1397-1409, 2017. ,
DOI : 10.1016/j.jalz.2017.03.010
, J
Peripheral complement interactions with amyloid ? peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1, Alzheimers Dement, 2018. ,
Structure-function relationships of complement receptor type 1, Immunological Reviews, vol.180, issue.1, pp.112-122, 2001. ,
DOI : 10.1034/j.1600-065X.2001.1800110.x
A CR1 polymorphism associated with constitutive erythrocyte CR1 levels affects binding to C4b but not C3b, Immunology, vol.10, issue.4, pp.531-538, 2003. ,
DOI : 10.1046/j.1365-2249.1999.00940.x
URL : http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2567.2003.01579.x/pdf
The structure, genetic polymorphisms, expression and biological functions of complement receptor type 1 (CR1/CD35). Immunopharm. Immunot, pp.524-535, 2009. ,
DOI : 10.1080/08923970902845768
Peripheral catabolism of CR1 (the C3b receptor, CD35) on erythrocytes from healthy individuals and patients with systemic lupus erythematosus (SLE), Clinical & Experimental Immunology, vol.29, issue.3, pp.422-428, 1992. ,
DOI : 10.1042/bj2350815
Genomic determination of the CR1 (CD35) density polymorphism on erythrocytes using polymerase chain reaction amplification and HindIII restriction enzyme digestion, Journal of Immunological Methods, vol.136, issue.2, pp.193-197, 1991. ,
DOI : 10.1016/0022-1759(91)90006-2
Complement Receptor 1 Expression in Peripheral Blood Mononuclear Cells and the Association with Clinicopathological Features And Prognosis of Nasopharyngeal Carcinoma, Asian Pacific Journal of Cancer Prevention, vol.13, issue.12, pp.6527-6531, 2012. ,
DOI : 10.7314/APJCP.2012.13.12.6527
Alzheimer's disease is associated with low density of the long CR1 isoform, Neurobiology of Aging, vol.36, issue.4, pp.1766-1771, 2015. ,
DOI : 10.1016/j.neurobiolaging.2015.01.006
Identification of a restriction fragment length polymorphism by a CR1 cDNA that correlates with the number of CR1 on erythrocytes, Journal of Experimental Medicine, vol.164, issue.1, pp.50-59, 1986. ,
DOI : 10.1084/jem.164.1.50
Structure of the human CR1 gene. Molecular basis of the structural and quantitative polymorphisms and identification of a new CR1-like allele, Journal of Experimental Medicine, vol.169, issue.3, pp.847-863, 1989. ,
DOI : 10.1084/jem.169.3.847
Quantitative alleles of CR1: Coding sequence analysis and comparison of haplotypes in two ethnic groups, J. Immunol, vol.163, pp.4939-4945, 1999. ,
Analysis of Complement Receptor Type 1 (CR1) Expression on Erythrocytes and of CR1 Allelic Markers in Caucasian and African American Populations, Clinical Immunology and Immunopathology, vol.87, issue.2, pp.176-183, 1998. ,
DOI : 10.1006/clin.1998.4529
Analysis of complement receptor Type 1 expression on red blood cells in negative phenotypes of the Knops blood group system, according to CR1 gene allotype polymorphisms, Transfusion, vol.64, issue.7, pp.1435-1443, 2010. ,
DOI : 10.1111/j.1365-2249.1992.tb03013.x
Characterization of a soluble form of the C3b/C4b receptor (CR1) in human plasma, J. Immunol, vol.134, pp.3332-3338, 1985. ,
Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins, Biochemistry, vol.30, issue.42, pp.10065-10074, 1991. ,
DOI : 10.1021/bi00106a001
Catabolism of the human erythrocyte C3b/C4b receptor (CR1, CD35) : vesiculation and/or proteolysis?, Immunopharmacology, vol.38, issue.1-2, pp.129-140, 1997. ,
DOI : 10.1016/S0162-3109(97)00066-0
Soluble form of complement C3b/C4b receptor (CR1) results from a proteolytic cleavage in the C-terminal region of CR1 transmembrane domain, Biochemical Journal, vol.329, issue.1, pp.183-190, 1998. ,
DOI : 10.1042/bj3290183
Deciphering Complement Receptor Type 1 Interactions with Recognition Proteins of the Lectin Complement Pathway, The Journal of Immunology, vol.190, issue.7, pp.3721-3731, 2013. ,
DOI : 10.4049/jimmunol.1202451
URL : https://hal.archives-ouvertes.fr/hal-01322429
The comparison of the podocyte expression of synaptopodin, CR1 and neprilysin in human glomerulonephritis: Could the expression of CR1 be clinically relevant?, Int. J. Biomed. Sci, vol.5, pp.28-36, 2009. ,
,
Analysis of the putative role of CR1 in Alzheimer's disease: Genetic association, expression and function, PLoS ONE, vol.2016, issue.11 ,
Genetics ignite focus on microglial inflammation in Alzheimer???s disease, Molecular Neurodegeneration, vol.6, issue.12, p.52, 2015. ,
DOI : 10.12703/P6-13
Complement in the pathogenesis of Alzheimer???s disease, Seminars in Immunopathology, vol.541, issue.7638, pp.113-124, 2018. ,
DOI : 10.1038/nature21029
Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites, Molecular Psychiatry, vol.28, issue.2, pp.223-233, 2012. ,
DOI : 10.1523/JNEUROSCI.0829-08.2008
Van Broeckhoven, C.; et al. Genetic association of CR1 with Alzheimer's disease: A tentative disease mechanism, Neurobiol. Aging, vol.33, pp.2949-2954, 2012. ,
Complement receptor 1 gene (CR1) intragenic duplication and risk of Alzheimer???s disease, Human Genetics, vol.169, issue.2235, pp.305-314, 2018. ,
DOI : 10.1098/rsif.2017.0057
Correlation between erythrocyte CR1 reduction and other blood proteinase markers in patients with malignant and inflammatory disorders, Blood, vol.75, pp.1699-1704, 1990. ,
Disease-associated loss of erythrocyte complement receptors (CR1, C3b receptors) in patients with systemic lupus erythematosus and other diseases involving autoantibodies and/or complement activation, J. Immunol, vol.135, pp.2005-2014, 1985. ,
Release of vesicles enriched in complement receptor 1 from human erythrocytes, J. Immunol, vol.151, pp.397-404, 1993. ,
Epidemiology of Alzheimer disease. CSH Perspect, Med. 2012 ,
A complement receptor-1 polymorphism with high frequency in malaria endemic regions of Asia but not Africa, Genes & Immunity, vol.91, issue.Suppl 1???2, pp.31-36, 2005. ,
DOI : 10.1073/pnas.91.7.2415
Diagnostic and Statistical Manual of Mental Disorders, 1994. ,
DOI : 10.1176/appi.books.9780890425596
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease, Neurology, vol.34, issue.7, pp.939-944, 1984. ,
DOI : 10.1212/WNL.34.7.939
Mouse monoclonal antibodies to the human C3b receptor, Mouse monoclonal antibodies to the human C3b receptor, pp.531-539, 1985. ,
DOI : 10.1016/0161-5890(85)90176-2
CR1 Density Polymorphism and Expression on Erythrocytes of Patients with Systemic Lupus Erythematosus, Autoimmunity, vol.35, issue.1, pp.53-58, 1996. ,
DOI : 10.1038/ki.1987.81
High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment, Journal of Visualized Experiments, issue.125, pp.125-56012, 2017. ,
DOI : 10.3791/56012
, Ceballos, J.; Bradt, B C
Peripheral complement interactions with amyloid ? peptide in Alzheimer's disease: 2. Relationship to amyloid ? immunotherapy, Alzheimers Dement, vol.14, pp.243-252, 2018. ,