Le disque intervertébral lombal : du développement embryonnaire à la dégénérescence

Abstract : Lumbar intervertebral discs (IVD) are highly prone to degenerate as early as the skeletal maturity is achieved. This degeneration could explain about 40% of the low back pain cases in humans. Despite the efficiency of pain-relieving treatments, the scientific community seeks to develop innovative therapeutic approaches to limit the use of invasive surgical procedures (spine fusion and arthroplasty). As a prerequisite to the development of these therapeutic strategies, we first have to improve our fundamental knowledge on IVD physiopathology. Recently, several studies have demonstrated that the phenotype of Nucleus pulposus (NP) cells was singular and quite distinct from that of articular chondrocytes. In parallel, recent studies dealing with NP cell development and origin as well as their role in intervertebral tissue homesotasis allowed to gain new insights into the complex mechanisms governing disc degeneration. This review summarizes the actual knowledge on IVD physiology and on the complex cell-mediated processes of IVD degeneration that has recently led the scientific community to explore new biotherapeutic strategies.
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Contributor : Valérie Pecqueret <>
Submitted on : Wednesday, July 25, 2018 - 10:26:44 AM
Last modification on : Thursday, February 7, 2019 - 2:38:05 PM

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Pauline Colombier, Johann Clouet, Olivier Hamel, Laurent Lescaudron, Jérôme Guicheux. Le disque intervertébral lombal : du développement embryonnaire à la dégénérescence. Revue du Rhumatisme monographies, 2013, 80 (4), pp.210 - 214. ⟨10.1016/j.monrhu.2013.06.002⟩. ⟨inserm-01848740⟩

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