The Free Fatty Acid Receptor G Protein-coupled Receptor 40 (GPR40) Protects from Bone Loss through Inhibition of Osteoclast Differentiation

Abstract : Background: Long chain fatty acids have been shown to activate the membrane-bound receptor GPR40. Results: GPR40 agonist alters bone-resorbing cell differentiation through inhibition of the NF-B system. Conclusion: GPR40 exerts protective effects in vivo on bone tissue. Significance: GPR40 is a nutritional and therapeutic target opening up new avenues for clinical investigations in terms of metabolic and age-related bone disorders.
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Fabien Wauquier, Claire Philippe, Laurent Léotoing, Sylvie Mercier, Marie-Jeanne Davicco, et al.. The Free Fatty Acid Receptor G Protein-coupled Receptor 40 (GPR40) Protects from Bone Loss through Inhibition of Osteoclast Differentiation. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2013, 288 (9), pp.6542 - 6551. ⟨10.1074/jbc.M112.429084⟩. ⟨inserm-01848192⟩

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