M. Zlowodzki, A. Lelwica, P. Tornetta, T. Einhorn, R. Buckley et al., ASTM: Standard Test Method for Time of Setting of Hydraulic-Cement Paste by Gillmore Needles. ASTM C266- 08 The Use of Calcium Phosphate Bone Cement in Fracture Treatment: A Meta-Analysis of Randomized Trials, J Bone Jt Surg-Am Vol, vol.90, issue.1, pp.1186-1196, 2008.

A. In, Journal of Pain Pain Management After Bone Reconstruction Surgery T a g g e d P 21, den Bergh J: NSAIDs and fracture healing, pp.524-555, 2013.

M. Ginebra, M. Espanol, E. Montufar, R. Perez, and G. Mestres, New processing approaches in calcium phosphate cements and their applications in regenerative medicine, Acta Biomaterialia, vol.6, issue.8, pp.2863-2873, 2010.
DOI : 10.1016/j.actbio.2010.01.036

M. Ginebra, T. Traykova, and J. Planell, Calcium phosphate cements as bone drug delivery systems: A review, Journal of Controlled Release, vol.113, issue.2, pp.102-110, 2006.
DOI : 10.1016/j.jconrel.2006.04.007

J. Goulet, L. Senunas, G. Desilva, and M. Greenfield, Autogenous Iliac Crest Bone Graft: Complications and Functional Assessment, Clinical Orthopaedics and Related Research, vol.339, pp.76-81, 1997.
DOI : 10.1097/00003086-199706000-00011

F. Hamers, A. Lankhorst, T. Van-laar, W. Veldhuis, and W. Gispen, Automated Quantitative Gait Analysis During Overground Locomotion in the Rat: Its Application to Spinal Cord Contusion and Transection Injuries, Journal of Neurotrauma, vol.18, issue.2, pp.187-201, 2001.
DOI : 10.1089/08977150150502613

G. Deumens, R. Brook, G. Gerver, J. Honig, W. Hamers et al., Strain and locomotor speed affect over-ground locomotion in intact rats, Physiol Behav, vol.92, pp.993-1001, 2007.

A. Lankhorst, M. Ter-laak, T. Van-laar, N. Van-meeteren, J. De-groot et al., Effects of Enriched Housing on Functional Recovery After Spinal Cord Contusive Injury in the Adult Rat, Journal of Neurotrauma, vol.18, issue.2, pp.203-215, 2001.
DOI : 10.1089/08977150150502622

K. Phan and R. Mobbs, Anterior cervical discectomy and fusion (ACDF) autograft versus graft substitutes: what do patients prefer??A clinical study, J Spine Surg, vol.2, pp.105-110, 2016.

R. Massart, S. Dymov, M. Millecamps, M. Suderman, S. Gregoire et al., Overlapping signatures of chronic pain in the DNA methylation landscape of prefrontal cortex and peripheral T cells, Scientific Reports, vol.52, issue.1, 2016.
DOI : 10.1111/j.1600-065X.2009.00835.x

C. Mellier, F. Fayon, F. Boukhechba, E. Verron, M. Leferrec et al., Design and properties of novel gallium-doped injectable apatitic cements, Acta Biomaterialia, vol.24, pp.322-332, 2015.
DOI : 10.1016/j.actbio.2015.05.027

URL : https://hal.archives-ouvertes.fr/hal-01391170

M. Miyagi, T. Ishikawa, H. Kamoda, S. Orita, K. Kuniyoshi et al., Assessment of Gait in a Rat Model of Myofascial Inflammation Using the CatWalk System, Assessment of Gait in a Rat Model of Myofascial Inflammation Using the CatWalk System, pp.1760-1764, 2011.
DOI : 10.1097/BRS.0b013e3182269732

K. M?-oller, O. Berge, F. Hamers, S. Cazalbou, I. Demnati et al., Using the CatWalk method to assess weight-bearing and pain behaviour in walking rats with ankle joint monoarthritis induced by carrageenan: Effects of morphine and rofecoxib Injectability, microstructure and release properties of sodium fusidate-loaded apatitic cement as a local drug-delivery system, J Neurosci Methods Mater Sci Eng C, vol.174, issue.59, pp.1-9177, 2008.

, ARTICLE IN PRESS Dupleichs et al The Journal of Pain, vol.11

B. Peter, O. Gauthier, S. La?-ib, B. Bujoli, J. Guicheux et al., Local delivery of bisphosphonate from coated orthopedic implants increases implants mechanical stability in osteoporotic rats, Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration, pp.133-14352, 2005.
DOI : 10.1007/978-2-8178-0851-2

URL : https://hal.archives-ouvertes.fr/hal-00320922

R. Pollock, I. Alcelik, C. Bhatia, G. Chuter, K. Lingutla et al., Donor site morbidity following iliac crest bone harvesting for cervical fusion: a comparison between minimally invasive and open techniques, European Spine Journal, vol.15, issue.6, pp.845-852, 2008.
DOI : 10.1054/jcms.2000.0105

, Rasche S, Koch T: [Regional anaesthesia versus general anaesthesia-pathophysiology and clinical implications

, Anaesthesiol Reanim, vol.29, pp.30-38, 2004.

R. Leighton, Rey C: Calcium phosphate biomaterials and bone mineral Differences in composition, structures and properties Comparison of Autogenous Bone Graft and Endothermic Calcium Phosphate Cement for Defect Augmentation in Tibial Plateau Fractures: A Multicenter , Prospective, Randomized Study, Biomaterials J Bone Jt Surg-Am Vol, vol.38, issue.90, pp.13-152057, 1990.

, Scheiman JM: NSAID-induced Gastrointestinal Injury: A Focused Update for Clinicians 2016 T a g g e d P 41. Schobelock MJ: Pain management: engineering successful outcomes, J Clin Gastroenterol J Healthc Mater Manage, vol.50, issue.10, pp.5-1061, 1992.

J. Silber, D. Anderson, S. Daffner, B. Brislin, J. Leland et al., Donor Site Morbidity After Anterior Iliac Crest Bone Harvest for Single-Level Anterior Cervical Discectomy and Fusion, Spine, vol.28, issue.2, pp.134-139, 2003.
DOI : 10.1097/00007632-200301150-00008

K. Singh, H. An, D. Samartzis, A. Nassr, J. Provus et al., A Prospective Cohort Analysis of Adjacent Vertebral Body Bone Mineral Density in Lumbar Surgery Patients With or Without Instrumented Posterolateral Fusion, Spine, vol.30, issue.15, pp.1750-1755, 2005.
DOI : 10.1097/01.brs.0000172228.74763.99

J. Taymans, C. Casteels, F. Coun, and Y. Ni, Smith G: Pain after surgery 1991 T a g g e d P 45. Tung I-C: In vitro drug release of antibiotic-loaded porous hydroxyapatite cement Automated quantitative gait analysis in animal models of movement disorders, Br J Anaesth Artif Cells Blood Substit Biotechnol BMC Neurosci, vol.441, issue.11, pp.233-23481, 1995.

J. Bouler and J. Guicheux, Controlling the biological function of calcium phosphate bone substitutes with drugs, Acta Biomater, vol.8, pp.3541-3551, 2012.

O. Gauthier, P. Janvier, L. Guen, H. Holopherne, D. Cavagna et al., Analgesic properties of calcium phosphate apatite loaded with bupivacaine on postoperative pain, J Biomed Mater Res B Appl Biomater, vol.94, pp.89-96, 2010.

O. Gauthier, P. Janvier, P. Pilet, J. Lesoeur, B. Bujoli et al., In vivo bone augmentation in an osteoporotic environment using bisphosphonate-loaded calcium deficient apatite, Biomaterials, vol.31, pp.7776-7784, 2010.

I. Khairoun, J. Guicheux, and J. Bouler, Calcium phosphate biomaterials as bone drug delivery systems: a review, Drug Discov Today, vol.15, pp.547-552, 2010.

M. Pissonnier, J. Lesoeur, V. Schnitzler, B. Fellah, H. Pascal-moussellard et al., Vertebroplasty using bisphosphonate-loaded calcium phosphate cement in a standardized vertebral body bone defect in an osteoporotic sheep model, Acta Biomater, vol.10, pp.4887-4895, 2014.
URL : https://hal.archives-ouvertes.fr/inserm-01847745

, Vrinten DH, Hamers FF: 'CatWalk'automated quantitative gait analysis as a novel method to assess mechanical allodynia in the rat; a comparison with von Frey testing, Pain, vol.102, pp.203-209, 2003.

, Wilder-Smith OH, Arendt-Nielsen L: Postoperative HyperalgesiaIts Clinical Importance and Relevance, J Am Soc Anesthesiol, vol.53, issue.104, pp.601-607, 2006.

R. Zaslansky, E. Eisenberg, B. Peskin, E. Sprecher, D. Reis et al., Early administration of oral morphine to orthopedic patients after surgery, Journal of Opioid Management, vol.2, issue.2, pp.88-92, 2006.
DOI : 10.5055/jom.2006.0014

J. Zhang, W. Liu, V. Schnitzler, F. Tancret, and J. Bouler, Calcium phosphate cements for bone substitution: Chemistry, handling and mechanical properties, Acta Biomaterialia, vol.10, issue.3, pp.1035-1049, 2014.
DOI : 10.1016/j.actbio.2013.11.001

URL : https://hal.archives-ouvertes.fr/hal-00988847