Osteoclast differentiation and activation, Nature, vol.20, issue.Suppl., pp.337-342, 2003. ,
DOI : 10.1007/s007740200049
The molecular understanding of osteoclast differentiation, Bone, vol.40, issue.2, pp.251-264, 2007. ,
DOI : 10.1016/j.bone.2006.09.023
Characterization of MCSF-induced proliferation and subsequent osteoclast formation in murine marrow culture, Journal of Bone and Mineral Research, vol.134, issue.7, pp.1025-1032, 1995. ,
DOI : 10.1101/SQB.1988.053.01.060
Commitment and Differentiation of Osteoclast Precursor Cells by the Sequential Expression of C-Fms and Receptor Activator of Nuclear Factor ??b (Rank) Receptors, The Journal of Experimental Medicine, vol.21, issue.12, pp.1741-1754, 1999. ,
DOI : 10.1084/jem.177.1.237
, Endocrinology, vol.142, issue.3, pp.1290-1295, 2001.
DOI : 10.1210/endo.142.3.8031
Involvement of p38 Mitogen-activated Protein Kinase Signaling Pathway in Osteoclastogenesis Mediated by Receptor Activator of NF-??B Ligand (RANKL), Journal of Biological Chemistry, vol.16, issue.40, pp.31155-31161, 2000. ,
DOI : 10.1128/MCB.16.3.1247
JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms, Journal of Cell Science, vol.115, issue.22, pp.4317-4325, 2002. ,
DOI : 10.1242/jcs.00082
The phosphatidylinositol 3-Kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation, Bone, vol.30, issue.1, pp.71-77, 2002. ,
DOI : 10.1016/S8756-3282(01)00657-3
Osteopetrosis in mice lacking NF-??B1 and NF-??B2, Nature Medicine, vol.266, issue.11, pp.1285-1289, 1997. ,
DOI : 10.1038/386081a0
Role of NF-??B in the skeleton, Cell Research, vol.171, issue.1, pp.169-182, 2011. ,
DOI : 10.1158/1541-7786.MCR-08-0108
Requirement for NF-kappa B in osteoclast and B-cell??development, Genes & Development, vol.11, issue.24, pp.3482-3496, 1997. ,
DOI : 10.1101/gad.11.24.3482
Autoamplification of NFATc1 expression determines its essential role in bone homeostasis, The Journal of Experimental Medicine, vol.96, issue.9, pp.1261-1269, 2005. ,
DOI : 10.1007/s00109-004-0612-6
Inhibition of RANKL-Induced Osteoclastogenesis by (???)-DHMEQ, a Novel NF-??B Inhibitor, Through Downregulation of NFATc1, Journal of Bone and Mineral Research, vol.10, issue.Suppl 1, pp.653-662, 2005. ,
DOI : 10.4049/jimmunol.171.10.5547
c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling, Science, vol.266, issue.5184, pp.443-448, 1994. ,
DOI : 10.1126/science.7939685
JNK/c-Jun Signaling Mediates an Anti-Apoptotic Effect of RANKL in Osteoclasts, Journal of Bone and Mineral Research, vol.156, issue.6, pp.907-914, 2008. ,
DOI : 10.1016/S0002-9440(10)64967-X
The Role of NFAT in Osteoclast Formation, Annals of the New York Academy of Sciences, vol.1116, issue.1, pp.227-237, 2007. ,
DOI : 10.1196/annals.1402.071
Dietary Intakes of Flavonols, Flavones and Isoflavones by Japanese Women and the Inverse Correlation between Quercetin Intake and Plasma LDL Cholesterol Concentration, The Journal of Nutrition, vol.88, issue.9, 2000. ,
DOI : 10.1172/JCI115499
, J Nutr, vol.130, pp.2243-2250
A Novel Dietary Flavonoid Fisetin Inhibits Androgen Receptor Signaling and Tumor Growth in Athymic Nude Mice, Cancer Research, vol.68, issue.20, pp.8555-8563, 2008. ,
DOI : 10.1158/0008-5472.CAN-08-0240
Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory, Proceedings of the National Academy of Sciences, vol.16, issue.3, pp.16568-16573, 2006. ,
DOI : 10.1517/13543784.11.1.1
ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease, Human Molecular Genetics, vol.87, issue.2, pp.261-270, 2011. ,
DOI : 10.1016/S0092-8674(00)81369-0
Flavonol-rich RVHxR from Rhus verniciflua Stokes and its major compound fisetin inhibits inflammation-related cytokines and angiogenic factor in rheumatoid arthritic fibroblast-like synovial cells and in vivo models, International Immunopharmacology, vol.9, issue.3, pp.268-276, 2009. ,
DOI : 10.1016/j.intimp.2008.11.005
Fisetin Inhibits Lipopolysaccharide-Induced Macrophage Activation and Dendritic Cell Maturation, Journal of Agricultural and Food Chemistry, vol.58, issue.20, 2010. ,
DOI : 10.1021/jf1017093
Osteoporosis and Inflammation, Nutrition Reviews, vol.65, issue.12, pp.147-151, 2007. ,
DOI : 10.1301/nr.2007.dec.S147-S151
Inflammatory bone loss: pathogenesis and therapeutic intervention, Nature Reviews Drug Discovery, vol.26, issue.3, pp.234-250, 2012. ,
DOI : 10.1002/jbmr.212
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand, Proceedings of the National Academy of Sciences, vol.273, issue.43, pp.3540-3545, 1999. ,
DOI : 10.1074/jbc.273.43.28355
A20-binding Inhibitor of Nuclear Factor-??B (NF-??B)-2 (ABIN-2) Is an Activator of Inhibitor of NF-??B (I??B) Kinase ?? (IKK??)-mediated NF-??B Transcriptional Activity, Journal of Biological Chemistry, vol.13, issue.37, pp.32277-32288, 2011. ,
DOI : 10.1158/1078-0432.CCR-10-1859
IFN-?? stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation, Journal of Clinical Investigation, vol.117, issue.1, pp.122-132, 2007. ,
DOI : 10.1172/JCI30074
Acute Endotoxin-Induced Thymic Atrophy Is Characterized By Intrathymic Inflammatory and Wound Healing Responses, PLoS ONE, vol.21, issue.3, p.17940, 2011. ,
DOI : 10.1371/journal.pone.0017940.s011
RANKL???RANK signaling in osteoclastogenesis and bone disease, Trends in Molecular Medicine, vol.12, issue.1, pp.17-25, 2006. ,
DOI : 10.1016/j.molmed.2005.11.007
Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer, Pharmacological Reviews, vol.60, issue.3, pp.261-310, 2008. ,
DOI : 10.1124/pr.107.00106
Diversity and specificity of the mitogen-activated protein kinase phosphatase-1 functions, Cellular and Molecular Life Sciences, vol.102, issue.5, 2012. ,
DOI : 10.1002/ijc.10746
Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome, Annual Review of Biochemistry, vol.78, issue.1, pp.477-513, 2009. ,
DOI : 10.1146/annurev.biochem.78.081507.101607
Adverse drug reactions to osteoporosis treatments, Expert Review of Clinical Pharmacology, vol.377, issue.5, pp.593-604, 2011. ,
DOI : 10.1016/S0140-6736(10)62349-5
Benefits and Risks of Bisphosphonate Therapy for Osteoporosis, The Journal of Clinical Endocrinology & Metabolism, vol.97, issue.7, pp.2272-2282, 2012. ,
DOI : 10.1210/jc.2012-1027
Is tamoxifen a genotoxic carcinogen in women?, Mutagenesis, vol.19, issue.3, pp.391-404, 2009. ,
DOI : 10.1021/tx0503045
Steroid hormone activity of flavonoids and related compounds, Breast Cancer Research and Treatment, vol.146, issue.1, pp.35-49, 2000. ,
DOI : 10.1093/oxfordjournals.aje.a009270
Detection of Weak Estrogenic Flavonoids Using a Recombinant Yeast Strain and a Modified MCF7 Cell Proliferation Assay, Chemical Research in Toxicology, vol.11, issue.6, pp.622-629, 1998. ,
DOI : 10.1021/tx970170y
Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-??B, European Journal of Pharmacology, vol.679, issue.1-3, pp.109-116, 2012. ,
DOI : 10.1016/j.ejphar.2012.01.002
Inhibition of LPS-induced pulmonary inflammation by specific flavonoids, Biochemical and Biophysical Research Communications, vol.382, issue.3, pp.598-603, 2009. ,
DOI : 10.1016/j.bbrc.2009.03.071
Fisetin, an Inhibitor of Cyclin-Dependent Kinase 6, Down-Regulates Nuclear Factor-??B-Regulated Cell Proliferation, Antiapoptotic and Metastatic Gene Products through the Suppression of TAK-1 and Receptor-Interacting Protein-Regulated I??B?? Kinase Activation, Molecular Pharmacology, vol.71, issue.6, pp.1703-1714, 2007. ,
DOI : 10.1124/mol.107.034512
Fisetin Inhibits Osteoclast Differentiation via Downregulation of p38 and c-Fos-NFATc1 Signaling Pathways, Evidence-Based Complementary and Alternative Medicine, vol.273, issue.5279, p.810563, 2012. ,
DOI : 10.1074/jbc.M408795200
URL : http://doi.org/10.1155/2012/810563
Fisetin Inhibits Osteoclastogenesis Through Prevention of RANKL-Induced ROS Production by Nrf2-Mediated Up-regulation of Phase II Antioxidant Enzymes, Journal of Pharmacological Sciences, vol.121, issue.4, pp.288-298, 2013. ,
DOI : 10.1254/jphs.12243FP
Antimetastatic potential of fisetin involves inactivation of the PI3K/Akt and JNK signaling pathways with downregulation of MMP-2/9 expressions in prostate cancer PC-3 cells, Molecular and Cellular Biochemistry, vol.61, issue.1-2, pp.169-180, 2010. ,
DOI : 10.1042/bj3360599
, Fisetin Promotes Bone Health PLOS ONE | www.plosone.org
Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease, Life Sciences, vol.90, issue.7-8, pp.237-248, 2012. ,
DOI : 10.1016/j.lfs.2011.11.017
Role of MKP-1 in Osteoclasts and Bone Homeostasis, The American Journal of Pathology, vol.175, issue.4, pp.1564-1573, 2009. ,
DOI : 10.2353/ajpath.2009.090035
Mitogen-activated protein kinase phosphatase 1 regulates bone mass, osteoblast gene expression, and responsiveness to parathyroid hormone, Journal of Endocrinology, vol.16, issue.7, pp.145-156, 2011. ,
DOI : 10.1359/jbmr.2001.16.7.1300
Reduced MAP Kinase Phosphatase-1 Degradation After p42/p44MAPK-Dependent Phosphorylation, Science, vol.286, issue.5449, pp.2514-2517, 1999. ,
DOI : 10.1126/science.286.5449.2514