Nanocomposite hydrogels for cartilage tissue engineering: mesoporous silica nanofibers interlinked with siloxane derived polysaccharide

Abstract : Injectable materials for mini-invasive surgery of cartilage are synthesized and thoroughly studied. The concept of these hybrid materials is based on providing high enough mechanical performances along with a good medium for chondrocytes proliferation. The unusual nanocomposite hydrogels presented herein are based on siloxane derived hydroxypropylmethylcellulose (Si-HPMC) interlinked with mesoporous silica nanofibers. The mandatory homogeneity of the nanocomposites is checked by fluorescent methods, which show that the silica nanofibres dispersion is realized down to nanometric scale, suggesting an efficient immobi-lization of the silica nanofibres onto the Si-HPMC scaffold. Such dispersion and immobilization are reached thanks to the chemical affinity between the hydrophilic silica nanofibers and the pendant silanolate groups of the Si-HPMC chains. Tuning the amount of nanocharges allows tuning the resulting mechanical features of these injectable biocom-patible hybrid hydrogels. hASC stem cells and SW1353 chondrocytic cells viability is checked within the nanocom-posite hydrogels up to 3 wt% of silica nanofibers.
Complete list of metadatas

Cited literature [40 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-01847751
Contributor : Valérie Pecqueret <>
Submitted on : Tuesday, July 24, 2018 - 8:36:34 AM
Last modification on : Monday, December 17, 2018 - 1:26:45 AM
Long-term archiving on : Thursday, October 25, 2018 - 2:11:45 PM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Citation

Nela Buchtová, Gildas Réthoré, Cécile Boyer, Jérôme Guicheux, Frederic Rambaud, et al.. Nanocomposite hydrogels for cartilage tissue engineering: mesoporous silica nanofibers interlinked with siloxane derived polysaccharide. Journal of Materials Science: Materials in Medicine, Springer Verlag, 2013, 24, pp.1875-1884. ⟨10.1007/s10856-013-4951-0⟩. ⟨inserm-01847751⟩

Share

Metrics

Record views

326