Nutraceuticals in joint health: animal models as instrumental tools

Elsa Mével 1, 2, 3, 4 Laurent-Emmanuel Monfoulet 5 Christophe Merceron 1, 3 Veronique Coxam 5 Yohann Wittrant 6 Laurent Beck 1, 3 Jérôme Guicheux 1, 2, 3, *
* Corresponding author
1 Université de Nantes - UFR Odontologie
2 PHU4 - OTONN - Service d'Odontologie Restauratrice et Chirurgicale [CHU Nantes]
3 Groupe STEP - Inserm U791 - LIOAD - Groupe Skeletal Tissue Engineering and Physiopathology
LIOAD - Laboratoire d'ingénierie osteo-articulaire et dentaire
4 Union Grap’Sud [Cruviers-Lascours, France]
5 UNH - Unité de Nutrition Humaine - Clermont Auvergne
6 UNH - Unité de Nutrition Humaine
Abstract : Osteoarthritis (OA) is a degenerative joint disease with no curative treatments. Many studies have begun to demonstrate the efficacy of nutraceuticals for slowing down OA. Animal models are utilized as a compulsory step in demonstrating the protective potential of these compounds on joint health. Nevertheless, there exist a wide variety of available OA models and selecting a suitable system for evaluating the effects of a specific compound remains difficult. Here, we discuss animal studies that have investigated nutraceutical effects on OA. In particular, we highlight the large spectrum of animal models that are currently accepted for examining the OA-related effects of nutraceuticals, giving recommendations for their use.
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Elsa Mével, Laurent-Emmanuel Monfoulet, Christophe Merceron, Veronique Coxam, Yohann Wittrant, et al.. Nutraceuticals in joint health: animal models as instrumental tools. Drug Discovery Today, Elsevier, 2014, 19 (10), pp.1649 - 1658. ⟨10.1016/j.drudis.2014.06.012⟩. ⟨inserm-01847472⟩

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