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Journal articles
Nutraceuticals in joint health: animal models as instrumental tools
Elsa Mével
1, 2, 3, 4
Laurent-Emmanuel Monfoulet
5
Christophe Merceron
1, 3
Veronique Coxam
5
Y. Wittrant
6
Laurent Beck
1, 3
Jérôme Guicheux
1, 2, 3, *
*
Corresponding author
3
Groupe STEP - Inserm U791 - LIOAD - Groupe Skeletal Tissue Engineering and Physiopathology
LIOAD - Laboratoire d'ingénierie osteo-articulaire et dentaire
Elsa Mével 1, 2, 3, 4
Author
Laurent-Emmanuel Monfoulet 5
Author Employer institution : Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement IdHAL : laurent-emmanuel-monfoulet ResearcherId : http://www.researcherid.com/rid/O-6508-2016 ORCID : https://orcid.org/0000-0001-9836-0255
Christophe Merceron 1, 3
Author
Veronique Coxam 5
Author
Y. Wittrant 6
Author Employer institution : Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement IdHAL : yohann-wittrant ORCID : https://orcid.org/0000-0003-3811-8859
Laurent Beck 1, 3
Author
Jérôme Guicheux 1, 2, 3
Correspondent author
1
Université de Nantes - UFR Odontologie (1 place Alexis Ricordeau - BP 84215 - 44042 Nantes Cedex 1 - France)
- UN - Université de Nantes : 93263 (1, quai de Tourville - BP 13522 - 44035 Nantes cedex 1 - France)
2
PHU4 - OTONN - Service d'Odontologie Restauratrice et Chirurgicale [CHU Nantes] (France)
- CHU Nantes - Centre hospitalier universitaire de Nantes (1 Place Alexis-Ricordeau, 44000 Nantes - France)
3
Groupe STEP - Inserm U791 - LIOAD - Groupe Skeletal Tissue Engineering and Physiopathology (France)
- LIOAD - Laboratoire d'ingénierie osteo-articulaire et dentaire (Faculte de Chirurgie Dentaire 1, Place Alexis Ricordeau 44042 Nantes Cedex 1 - France)
- UN - Université de Nantes (1, quai de Tourville - BP 13522 - 44035 Nantes cedex 1 - France)
- IFR26 (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U791 (101, rue de Tolbiac, 75013 Paris - France)
4
Union Grap’Sud [Cruviers-Lascours, France] (France)
5
UNH - Unité de Nutrition Humaine (Site INRAE Theix : 63122 Saint-Gènes-Champanelle // Site Clermont : UFR de Médecine et de Pharmacie, TSA 50400, 28 Place Henri Dunant, 63001 Clermont-Ferrand - France)
- INRA - Institut National de la Recherche Agronomique : UMR1019 (France)
- UCA [2017-2020] - Université Clermont Auvergne [2017-2020] : UMR1019 (49, bd François-Mitterrand / CS 60032 / 63001 Clermont-Ferrand Cedex 1 - France)
6
UNH - Unité de Nutrition Humaine (Site INRAE Theix : 63122 Saint-Gènes-Champanelle // Site Clermont : UFR de Médecine et de Pharmacie, TSA 50400, 28 Place Henri Dunant, 63001 Clermont-Ferrand - France)
- INRA - Institut National de la Recherche Agronomique : UR1019 (France)
- UdA - Université d'Auvergne - Clermont-Ferrand I : UMR1019 (49, Boulevard François-Mitterrand / CS 60032 / 63001 Clermont-Ferrand Cedex 1 - France)
- Clermont Université (France)
Abstract : Osteoarthritis (OA) is a degenerative joint disease with no curative treatments. Many studies have begun to demonstrate the efficacy of nutraceuticals for slowing down OA. Animal models are utilized as a compulsory step in demonstrating the protective potential of these compounds on joint health. Nevertheless, there exist a wide variety of available OA models and selecting a suitable system for evaluating the effects of a specific compound remains difficult. Here, we discuss animal studies that have
investigated nutraceutical effects on OA. In particular, we highlight the large spectrum of animal models that are currently accepted for examining the OA-related effects of nutraceuticals, giving recommendations for their use.
Document type :
Journal articles
Complete list of metadatas
https://www.hal.inserm.fr/inserm-01847472
Contributor : Valérie Pecqueret <>
Submitted on : Monday, July 23, 2018 - 3:49:38 PM
Last modification on : Thursday, March 4, 2021 - 10:52:04 AM
Long-term archiving on: : Wednesday, October 24, 2018 - 3:53:40 PM
Contributor : Valérie Pecqueret <>
Submitted on : Monday, July 23, 2018 - 3:49:38 PM
Last modification on : Thursday, March 4, 2021 - 10:52:04 AM
Long-term archiving on: : Wednesday, October 24, 2018 - 3:53:40 PM
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Identifiers
- HAL Id : inserm-01847472, version 1
- DOI : 10.1016/j.drudis.2014.06.012
- PRODINRA : 270307
- PUBMED : 24955836
- WOS : 000343842500018
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INSERM | INRA | ACL-SVSAE | UNH | PRES_CLERMONT | UNIV-NANTES | RMES | INRAE
Citation
Elsa Mével, Laurent-Emmanuel Monfoulet, Christophe Merceron, Veronique Coxam, Y. Wittrant, et al.. Nutraceuticals in joint health: animal models as instrumental tools. Drug Discovery Today, Elsevier, 2014, 19 (10), pp.1649 - 1658. ⟨10.1016/j.drudis.2014.06.012⟩. ⟨inserm-01847472⟩
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