, REVUES and immunohistochemical analysis of canine nucleus pulposus and anulus fibrosus, Spine, vol.34, pp.1448-56, 1976.
Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation, Arthritis & Rheumatism, vol.9, issue.12, pp.3695-705, 2010. ,
DOI : 10.1089/ten.teb.2009.0705
Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development, Disease Models & Mechanisms, vol.5, issue.1, pp.73-82, 2012. ,
DOI : 10.1242/dmm.008128
Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: Implications for disk degeneration and chordoma formation, Developmental Dynamics, vol.18, issue.12, pp.3953-3961, 2008. ,
DOI : 10.1007/BF00186991
Observations on the postnatal structure of the intervertebral disc in man, J Anat, vol.86, pp.162-79, 1952. ,
Histology and pathology of the human intervertebral disc, J Bone Joint Surg Am, vol.88, issue.2, pp.10-14, 2006. ,
Nucleus pulposus notochord cells secrete connective tissue growth factor and Up-regulate proteoglycan expression by intervertebral disc chondrocytes, Arthritis & Rheumatism, vol.14, issue.12, pp.3859-67, 2006. ,
DOI : 10.1093/oxfordjournals.jbchem.a002965
URL : http://onlinelibrary.wiley.com/doi/10.1002/art.22258/pdf
Cell transplantation in lumbar spine disc degeneration disease, European Spine Journal, vol.13, issue.Suppl 2, pp.492-503, 2008. ,
DOI : 10.1042/bj2480373
URL : http://europepmc.org/articles/pmc2587656?pdf=render
Porcine Intervertebral Disc Repair Using Allogeneic Juvenile Articular Chondrocytes or Mesenchymal Stem Cells, Tissue Engineering Part A, vol.17, issue.23-24, pp.3045-55, 2011. ,
DOI : 10.1089/ten.tea.2011.0229
URL : http://europepmc.org/articles/pmc3226053?pdf=render
Multilineage Potential of Adult Human Mesenchymal Stem Cells, Science, vol.284, issue.5411, pp.143-150, 1999. ,
DOI : 10.1126/science.284.5411.143
Mesenchymal Stromal Cells: Sensors and Switchers of Inflammation, Cell Stem Cell, vol.13, issue.4, pp.392-402, 2013. ,
DOI : 10.1016/j.stem.2013.09.006
URL : https://doi.org/10.1016/j.stem.2013.09.006
Mesenchymal stem cells: immune evasive, not immune privileged, Nature Biotechnology, vol.9, issue.3, pp.252-60, 2014. ,
DOI : 10.1126/science.287.5460.2007
URL : http://europepmc.org/articles/pmc4320647?pdf=render
Role of hypoxia and growth and differentiation factor-5 on differentiation of human mesenchymal stem cells towards intervertebral nucleus pulposus-like cells, European Cells and Materials, vol.21, pp.533-580, 2011. ,
DOI : 10.22203/eCM.v021a40
Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype, Stem Cell Research & Therapy, vol.1, issue.2, p.18, 2010. ,
DOI : 10.1186/scrt18
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors, Cell, vol.131, issue.5, pp.861-72, 2007. ,
DOI : 10.1016/j.cell.2007.11.019
Cellules iPS humaines??: D??j????!, m??decine/sciences, vol.24, issue.1, pp.102-106, 2008. ,
DOI : 10.1051/medsci/2008241102
URL : http://www.medecinesciences.org/articles/medsci/pdf/2008/02/medsci2008241p102.pdf
Perspectives on human clinical trials of therapies using iPS cells in Japan : reaching the forefront of stemcell therapies, Biosci Trends, vol.7, pp.157-165, 2013. ,
Changes in the Molecular Phenotype of Nucleus Pulposus Cells with Intervertebral Disc Aging, PLoS ONE, vol.293, issue.12, p.52020, 2012. ,
DOI : 10.1371/journal.pone.0052020.t002
Differentiation of Mouse Induced Pluripotent Stem Cells (iPSCs) into Nucleus Pulposus-Like Cells In Vitro, PLoS ONE, vol.23, issue.9, p.75548, 2013. ,
DOI : 10.1371/journal.pone.0075548.t003
URL : https://doi.org/10.1371/journal.pone.0075548
Reply, Journal of the American College of Cardiology, vol.62, issue.25, pp.2454-2460, 2013. ,
DOI : 10.1016/j.jacc.2013.09.014
Potential Applications for Using Stem Cells in Spine Surgery, Current Stem Cell Research & Therapy, vol.5, issue.4, pp.345-55, 2010. ,
DOI : 10.2174/157488810793351686
Immune cascades in human intervertebral disc : the pros and cons, Int J Clin Exp Pathol, vol.6, pp.1009-1023, 2013. ,
Modulation of Chondrocytic Properties of Fat-Derived Mesenchymal Cells in Co-Cultures with Nucleus Pulposus, Connective Tissue Research, vol.85, issue.2, pp.75-82, 2005. ,
DOI : 10.1182/asheducation-2002.1.369
Future perspectives of cell-based therapy for intervertebral disc disease, European Spine Journal, vol.430, issue.Suppl 2, pp.452-460, 2008. ,
DOI : 10.1097/01.brs.0000148152.04401.20
URL : http://europepmc.org/articles/pmc2587661?pdf=render
Prospective study of disc repair with allogeneic chondrocytes Presented at the 2012 Joint Spine Section Meeting, Journal of Neurosurgery: Spine, vol.12, issue.15 ,
DOI : 10.1097/BRS.0b013e318054e377
URL : http://thejns.org/doi/pdf/10.3171/2012.10.SPINE12512
, J Neurosurg Spine, vol.18, pp.85-95, 2013.
Intradiscal Injection of Hematopoietic Stem Cells in an Attempt to Rejuvenate the Intervertebral Discs, Stem Cells and Development, vol.15, issue.1, pp.136-143, 2006. ,
DOI : 10.1089/scd.2006.15.136
Disc Regeneration Therapy Using Marrow Mesenchymal Cell Transplantation, Spine, vol.35, issue.11, pp.475-80, 1976. ,
DOI : 10.1097/BRS.0b013e3181cd2cf4
Intervertebral Disc Repair by Autologous Mesenchymal Bone Marrow Cells: A Pilot Study, Transplantation, vol.92, issue.7, pp.822-830, 2011. ,
DOI : 10.1097/TP.0b013e3182298a15
, efficacité de cette stratégie d'ingénierie tissulaire sur l'amélioration de la résistance aux contraintes mécaniques des DIV traités. De multiples questions restent donc encore en suspens, à commencer par la définition du biomatériau le plus adapté ; la combinaison avec des types cellulaires, autres que les CSM non différenciées, 2014.
Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc, Biomaterials, vol.27, issue.3, pp.335-380, 2006. ,
DOI : 10.1016/j.biomaterials.2005.06.038
Experimental Intervertebral Disc Regeneration with Tissue-Engineered Composite in a Canine Model, Tissue Engineering Part A, vol.16, issue.7, pp.2381-2390, 2010. ,
DOI : 10.1089/ten.tea.2009.0770
Regeneration of the Intervertebral Disc With Nucleus Pulposus Cell-Seeded Collagen II/Hyaluronan/Chondroitin-6-Sulfate Tri-Copolymer Constructs in a Rabbit Disc Degeneration Model, Spine, vol.36, issue.26, pp.2252-2261, 1976. ,
DOI : 10.1097/BRS.0b013e318209fd85
Tissue engineering approaches to degenerative disc disease ??? A meta-analysis of controlled animal trials, Osteoarthritis and Cartilage, vol.20, issue.11, pp.1316-1341, 2012. ,
DOI : 10.1016/j.joca.2012.06.001
Les unit??s de th??rapie cellulaire ????l?????preuve de la r??glementation sur les??m??dicaments de th??rapie innovante, m??decine/sciences, vol.363, issue.4, pp.576-83, 2014. ,
DOI : 10.1056/NEJMoa1001294
, RÉFÉRENCES
The survival of engrafted neural stem cells within hyaluronic acid hydrogels, Biomaterials, vol.34, issue.22, pp.5521-5530, 2013. ,
DOI : 10.1016/j.biomaterials.2013.03.095
Role of biomechanics in intervertebral disc degeneration and regenerative therapies: what needs repairing in the disc and what are promising biomaterials for its repair?, The Spine Journal, vol.13, issue.3, pp.243-62, 2013. ,
DOI : 10.1016/j.spinee.2012.12.002
Tissue engineering strategies applied in the regeneration of the human intervertebral disk, Biotechnology Advances, vol.31, issue.8, pp.1514-1545, 2013. ,
DOI : 10.1016/j.biotechadv.2013.07.010
Tissue Engineering for Intervertebral Disk Degeneration, Orthopedic Clinics of North America, vol.42, issue.4, pp.575-83, 2011. ,
DOI : 10.1016/j.ocl.2011.07.003
A silanized hydroxypropyl methylcellulose hydrogel for the three-dimensional culture of chondrocytes, Biomaterials, vol.26, issue.33, pp.6643-51, 2005. ,
DOI : 10.1016/j.biomaterials.2005.04.057
URL : https://hal.archives-ouvertes.fr/inserm-00110465
An injectable vehicle for nucleus pulposus cell-based therapy, Biomaterials, vol.32, issue.11, pp.2862-70, 2011. ,
DOI : 10.1016/j.biomaterials.2011.01.018
Study, Tissue Engineering Part A, vol.16, issue.2, pp.695-703, 2010. ,
DOI : 10.1089/ten.tea.2009.0229
URL : https://hal.archives-ouvertes.fr/in2p3-00115430
Collagen II/hyaluronan/chondroitin-6-sulfate tri-copolymer scaffold for nucleus pulposus tissue engineering, J Biomed Mater Res B Appl Biomater, vol.92, pp.322-353, 2010. ,
DOI : 10.1002/jbm.b.31518
,
,
Code postal ,
,
,
,
,
, Date d'expiration
,
) aura été l'un des peintres les plus singuliers du XX e siècle. Les décors étranges où évoluent ses personnages l'ont longtemps inscrit dans la mouvance surréaliste, influence pourtant qu'il rejetait. Les poses suggestives de ses modèles, jeunes filles en fleur, adolescentes à peine pubères, ont incité maints commentateurs à le considérer comme un peintre érotique. Mais là encore Balthus réfutait pareille définition réductrice de son art, lui qui se revendiquant fervent catholique, Balthus, pp.978-980, 1908. ,
question à ses racines dans un souci de ne pas réduire à une interprétation simplificatrice une création si originale Quelle énigme recèle cette oeuvre ? Que nous disent les figures troublantes qui la hantent ? Que révèlent celles-ci de ce temps charnière qu'est l'adolescence ? Qu'en tant qu'âge de découverte de la génitalité et de la mort, elle est paradigmatique de la créativité à laquelle tout être humain est tenu de croire s'il veut échapper à la mélancolie ; qu'elle ouvre au mystère de la femme advenante, au secret du vivant, bref qu'interrogeant la puberté féminine en tant qu'elle symbolise l'origine, Balthus, selon la meilleure esthétique ,
Professeur honoraire des universités, il a fondé en 1983 et dirige depuis la revue Adolescence. Il est l'auteur de nombreux ouvrages, 1991. ,
Le génie adolescent, 2002. ,
, , 1100.
, Guicheux_Synthese.indd 1100 05, pp.53-0553, 2014.