osteoprotegerin-deficient mice develop early onset osteoporosis and arterial??calcification, Genes & Development, vol.12, issue.9, pp.1260-1268, 1998. ,
DOI : 10.1101/gad.12.9.1260
Spontaneous Production of Monocyte Chemoattractant Protein-1 and Interleukin-8 by the Human Lumbar Intervertebral Disc, Spine, vol.27, issue.13, pp.1402-1409, 1976. ,
DOI : 10.1097/00007632-200207010-00006
The FoxO code, Oncogene, vol.1769, issue.16, pp.2276-88, 2008. ,
DOI : 10.1046/j.0022-3042.2002.00783.x
Resident mesenchymal progenitors of articular cartilage, Matrix Biology, vol.39, pp.44-53, 2014. ,
DOI : 10.1016/j.matbio.2014.08.015
Aging Increases Stromal/Osteoblastic Cell-Induced Osteoclastogenesis and Alters the Osteoclast Precursor Pool in the Mouse, Journal of Bone and Mineral Research, vol.15, issue.9, pp.1659-68, 2005. ,
DOI : 10.1165/ajrcmb.17.2.2819
Aging Impairs IGF-I Receptor Activation and Induces Skeletal Resistance to IGF-I, Journal of Bone and Mineral Research, vol.142, issue.8, pp.1271-1280, 2007. ,
DOI : 10.1042/bj3240753
CTGF expression in mesangial cells: Involvement of SMADs, MAP kinase, and PKC, Kidney International, vol.62, issue.4, pp.1149-59, 2002. ,
DOI : 10.1111/j.1523-1755.2002.kid567.x
Identification of phenotypic discriminating markers for intervertebral disc cells and articular chondrocytes, Rheumatology, vol.20, issue.2, pp.1447-50, 2009. ,
DOI : 10.1016/S0736-0266(01)00110-3
Encoding for Sclerostin, a Bone Formation Inhibitor, Endocrinology, vol.152, issue.12, pp.4514-4538, 2011. ,
DOI : 10.1210/en.2011-1128
Intervertebral disc regeneration: a great challenge for tissue engineers, Trends in Biotechnology, vol.32, issue.9, pp.433-438, 2014. ,
DOI : 10.1016/j.tibtech.2014.05.006
URL : https://hal.archives-ouvertes.fr/inserm-01847223
Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells, Proceedings of the National Academy of Sciences, vol.97, issue.3, pp.7841-7846, 2001. ,
DOI : 10.1046/j.1365-2141.1997.902904.x
Soluble factors from the notochordal-rich intervertebral disc inhibit endothelial cell invasion and vessel formation in the presence and absence of pro-inflammatory cytokines, Osteoarthritis and Cartilage, vol.23, issue.3, pp.487-96, 2015. ,
DOI : 10.1016/j.joca.2014.12.010
Age-Related Osteogenic Potential of Mesenchymal Stromal Stem Cells from Human Vertebral Bone Marrow, Journal of Bone and Mineral Research, vol.89, issue.Suppl 1, pp.1115-1137, 1999. ,
DOI : 10.1007/BF03354656
Intercellular Signaling Pathways Active During Intervertebral Disc Growth, Differentiation, and Aging, Spine, vol.34, issue.5, pp.456-62, 1976. ,
DOI : 10.1097/BRS.0b013e3181913e98
Shh Signaling from the Nucleus Pulposus Is Required for the Postnatal Growth and Differentiation of the Mouse Intervertebral Disc, PLoS ONE, vol.33, issue.23, p.35944, 2012. ,
DOI : 10.1371/journal.pone.0035944.s004
Osteoporosis After Orchiectomy for Prostate Cancer, The Journal of Urology, vol.157, issue.2, pp.439-483, 1997. ,
DOI : 10.1016/S0022-5347(01)65165-6
Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage, Arthritis Research & Therapy, vol.14, issue.3, p.113, 2012. ,
DOI : 10.1002/art.23654
URL : https://arthritis-research.biomedcentral.com/track/pdf/10.1186/ar3839?site=arthritis-research.biomedcentral.com
An immunohistochemical study of mechanoreceptors in lumbar spine intervertebral discs, Journal of Clinical Neuroscience, vol.17, issue.6, pp.742-747, 2010. ,
DOI : 10.1016/j.jocn.2009.09.032
Flow-induced calcium oscillations in rat osteoblasts are age, loading frequency, and shear stress dependent, American Journal of Physiology-Cell Physiology, vol.273, issue.5, pp.1635-1676, 2001. ,
DOI : 10.1115/1.1287161
The surface of articular cartilage contains a progenitor cell population, Journal of Cell Science, vol.117, issue.6, pp.889-97, 2004. ,
DOI : 10.1242/jcs.00912
Silent information regulator (Sir)T1 inhibits NF-??B signaling to maintain normal skeletal remodeling, Journal of Bone and Mineral Research, vol.14, issue.5, pp.960-969, 2013. ,
DOI : 10.1016/j.cmet.2011.10.002
URL : http://onlinelibrary.wiley.com/doi/10.1002/jbmr.1824/pdf
Nucleus pulposus notochord cells secrete connective tissue growth factor and Up-regulate proteoglycan expression by intervertebral disc chondrocytes, Arthritis & Rheumatism, vol.14, issue.12, pp.3859-67, 2006. ,
DOI : 10.1093/oxfordjournals.jbchem.a002965
URL : http://onlinelibrary.wiley.com/doi/10.1002/art.22258/pdf
Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration, Arthritis Research & Therapy, vol.13, issue.6, p.215, 2011. ,
DOI : 10.1038/sj.cdd.4401826
URL : https://arthritis-research.biomedcentral.com/track/pdf/10.1186/ar3548?site=arthritis-research.biomedcentral.com
Types I and II collagens in intervertebral disc. Interchanging radial distributions in annulus fibrosus, Biochemical Journal, vol.157, issue.1, pp.267-70, 1976. ,
DOI : 10.1042/bj1570267
Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men, Journal of Clinical Investigation, vol.106, issue.12, pp.1553-60, 2000. ,
DOI : 10.1172/JCI10942
Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors, Science, vol.279, issue.5356, pp.1528-1558, 1998. ,
DOI : 10.1126/science.279.5356.1528
Changes in synovial PO2 and blood flow in the rabbit knee joint due to stimulation of the posterior articular nerve., The Journal of Physiology, vol.449, issue.1, pp.607-624, 1992. ,
DOI : 10.1113/jphysiol.1992.sp019104
Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans, Mechanisms of Ageing and Development, vol.128, issue.1, pp.92-105, 2007. ,
DOI : 10.1016/j.mad.2006.11.016
Inflammatory networks during cellular senescence: causes and consequences, Trends in Molecular Medicine, vol.16, issue.5, pp.238-284, 2010. ,
DOI : 10.1016/j.molmed.2010.03.003
URL : http://europepmc.org/articles/pmc2879478?pdf=render
VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis
during endochondral bone formation, Nature Medicine, vol.90, issue.6, pp.623-631, 1999. ,
DOI : 10.1073/pnas.90.16.7533
Aging-related inflammation in osteoarthritis, Osteoarthritis and Cartilage, vol.23, issue.11, pp.1966-71, 2015. ,
DOI : 10.1016/j.joca.2015.01.008
URL : https://doi.org/10.1016/j.joca.2015.01.008
Bovine articular chondrocyte function in vitro depends upon oxygen tension, Osteoarthritis and Cartilage, vol.8, issue.5, pp.386-92, 2000. ,
DOI : 10.1053/joca.1999.0314
URL : https://doi.org/10.1053/joca.1999.0314
Nutrient supply and intervertebral disc metabolism, J Bone Joint Surg Am, vol.88, issue.2, pp.30-35, 2006. ,
Effects of Ethnicity and Age or Menopause on the Remodeling and Turnover of Iliac Bone: Implications for Mechanisms of Bone Loss, Journal of Bone and Mineral Research, vol.125, issue.suppl 1, pp.498-508, 1997. ,
DOI : 10.7326/0003-4819-125-5-199609010-00009
Proteoglycans of articular cartilage: changes in aging and in joint disease Semin Arthritis Rheum1990, pp.12-33 ,
BMP-2 and TGF-??3 do not prevent spontaneous degeneration in rabbit disc explants but induce ossification of the annulus fibrosus, European Spine Journal, vol.21, issue.Suppl 2, pp.1724-1757, 2012. ,
DOI : 10.1097/BSD.0b013e31815ea897
Macromolecular Organization and In Vitro Growth Characteristics of Scaffold-free Neocartilage Grafts, Journal of Histochemistry & Cytochemistry, vol.88, issue.8, pp.853-66, 2007. ,
DOI : 10.1089/ten.2006.12.2435
Collagen fibrillogenesis in the development of the annulus fibrosus of the intervertebral disc, European Cells and Materials, vol.22, pp.226-267, 2011. ,
DOI : 10.22203/eCM.v022a18
Vascularization and Morphological Changes of the Endplate After Axial Compression and Distraction of the Intervertebral Disc, Spine, vol.36, issue.7, pp.505-516, 1976. ,
DOI : 10.1097/BRS.0b013e3181d32410
Macromolecular markers in joint disease, J Rheumatol Suppl, vol.27, pp.27-36, 1991. ,
Osteoclasts prefer aged bone, Osteoporosis International, vol.8, issue.Pt 3, pp.751-760, 2007. ,
DOI : 10.1016/S0002-9440(10)61221-7
Cellular Senescence in Aging Primates, Science, vol.311, issue.5765, 2006. ,
DOI : 10.1126/science.1122446
, Acta Orthopaedica, vol.87, pp.15-25, 2016.
Homeostatic Mechanisms in Articular Cartilage and Role of Inflammation in Osteoarthritis, Current Rheumatology Reports, vol.21, issue.1, p.375, 2013. ,
DOI : 10.1016/j.joca.2012.11.012
Mechanotransduction in bone repair and regeneration, The FASEB Journal, vol.28, issue.10, pp.3625-3657, 2010. ,
DOI : 10.1016/S8756-3282(02)00871-2
Advanced glycation end products cause collagen II reduction by activating Janus kinase/signal transducer and activator of transcription 3 pathway in porcine chondrocytes, Rheumatology, vol.32, issue.7, pp.1379-89, 2011. ,
DOI : 10.1016/j.ydbio.2007.10.001
Cytomorphology of notochordal and chondrocytic cells from the nucleus pulposus: a species comparison, Journal of Anatomy, vol.37, issue.5, pp.357-62, 2004. ,
DOI : 10.1097/00003086-200108000-00015
FOXOs attenuate bone formation by suppressing Wnt signaling, Journal of Clinical Investigation, vol.123, issue.8, pp.3409-3428, 2013. ,
DOI : 10.1172/JCI68049DS1
Sirtuin1 (Sirt1) Promotes Cortical Bone Formation by Preventing ??-Catenin Sequestration by FoxO Transcription Factors in Osteoblast Progenitors, Journal of Biological Chemistry, vol.1, issue.35, pp.24069-78, 2014. ,
DOI : 10.1016/j.cell.2013.11.037
Gene expression analysis of major lineage-defining factors in human bone marrow cells: Effect of aging, gender, and age-related disorders, Journal of Orthopaedic Research, vol.44, issue.7, pp.910-917, 2008. ,
DOI : 10.4049/jimmunol.164.10.5227
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms, Genes & Development, vol.13, issue.19, pp.2570-80, 1999. ,
DOI : 10.1101/gad.13.19.2570
Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients, Science, vol.310, issue.5751, pp.1193-1199, 2005. ,
DOI : 10.1126/science.1115535
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway, Current Biology, vol.14, issue.10, pp.885-90, 2004. ,
DOI : 10.1016/j.cub.2004.03.059
Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism, J Clin Endocrinol Metab, vol.81, issue.12, pp.4358-65, 1996. ,
Senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discs, The Spine Journal, vol.9, issue.8, pp.658-66, 2009. ,
DOI : 10.1016/j.spinee.2009.04.018
Everolimus suppresses cancellous bone loss, bone resorption, and cathepsin K expression by osteoclasts, Bone, vol.35, issue.5, pp.1144-56, 2004. ,
DOI : 10.1016/j.bone.2004.07.013
Wnt/??-Catenin???A Canonical Tale of Cell-Fate Choice in the Vertebrate Skeleton, Developmental Cell, vol.8, issue.5, pp.626-633, 2005. ,
DOI : 10.1016/j.devcel.2005.04.008
Intervertebral Disc Development Is Regulated by Wnt/??-catenin Signaling, Spine, vol.36, issue.8, pp.513-521, 1976. ,
DOI : 10.1097/BRS.0b013e3181f52cb5
Cellular Senescence, Vascular Disease, and Aging: Part 1 of a 2-Part Review, Circulation, vol.123, issue.15, pp.1650-60, 2011. ,
DOI : 10.1161/CIRCULATIONAHA.110.007021
Mutation of the mouse klotho gene leads to a syndrome resembling ageing, Nature, vol.390, issue.6655, pp.45-51, 1997. ,
DOI : 10.1038/36285
Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone, Nature, vol.188, issue.7492, pp.323-331, 2014. ,
DOI : 10.1083/jcb.200903137
Rosiglitazone Induces Decreases in Bone Mass and Strength that Are Reminiscent of Aged Bone, Endocrinology, vol.148, issue.6, pp.2669-80, 2007. ,
DOI : 10.1210/en.2006-1587
Vessels of rejuvenation, Nature, vol.366, issue.7492, pp.313-317, 2014. ,
DOI : 10.1056/NEJMp1202619
The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts, Molecular Pathology, vol.54, issue.3, pp.180-183, 2001. ,
DOI : 10.1136/mp.54.3.180
Evidence for a negative Pasteur effect in articular cartilage, Biochemical Journal, vol.321, issue.1, pp.95-102, 1997. ,
DOI : 10.1042/bj3210095
Comparison of growth factor and cytokine expression in patients with degenerated disc disease and herniated nucleus pulposus, Clinical Biochemistry, vol.42, issue.15, pp.1504-1515, 2009. ,
DOI : 10.1016/j.clinbiochem.2009.06.017
Rapamycin Promotes the Osteoblastic Differentiation of Human Embryonic Stem Cells by Blocking the mTOR Pathway and Stimulating the BMP/Smad Pathway, Stem Cells and Development, vol.19, issue.4, pp.557-68, 2010. ,
DOI : 10.1089/scd.2009.0147
Events in Articular Chondrocytes with Aging, Current Osteoporosis Reports, vol.58, issue.Pt 1, pp.196-201, 2011. ,
DOI : 10.1016/j.metabol.2009.05.025
The Age-Related Changes in Cartilage and Osteoarthritis, BioMed Research International, vol.30, issue.12, p.916530, 2013. ,
DOI : 10.1002/jor.22157
Age-Related Changes in the Musculoskeletal System and the Development of Osteoarthritis, Clinics in Geriatric Medicine, vol.26, issue.3, pp.371-86, 2010. ,
DOI : 10.1016/j.cger.2010.03.002
Reduction in the chondrocyte response to insulin???like growth factor 1 in aging and osteoarthritis: Studies in a non???human primate model of naturally occurring disease, Arthritis & Rheumatism, vol.43, issue.9, pp.2110-2130, 2000. ,
DOI : 10.1002/1529-0131(200009)43:9<2110::AID-ANR23>3.0.CO;2-U
Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1? and with chondrocyte resistance to insulin-like growth factor 1, Arthritis & Rheumatism, vol.9, issue.9, pp.2349-57, 2002. ,
DOI : 10.1053/joca.2000.0380
Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice, Arthritis & Rheumatism, vol.10, issue.Suppl 3, pp.705-722, 2012. ,
DOI : 10.1186/ar2376
The Hallmarks of Aging, Cell, vol.153, issue.6, pp.1194-217, 2013. ,
DOI : 10.1016/j.cell.2013.05.039
Oxygen tension in synovial fluids, Arthritis & Rheumatism, vol.37, issue.6, pp.769-76, 1970. ,
DOI : 10.1002/art.1780130606
Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis, Endocrine Reviews, vol.21, issue.2, pp.115-152, 2000. ,
DOI : 10.1210/er.21.2.115
Gone with the Wnts: ??-Catenin, T-Cell Factor, Forkhead Box O, and Oxidative Stress in Age-Dependent Diseases of Bone, Lipid, and Glucose Metabolism, Molecular Endocrinology, vol.21, issue.11, pp.2605-2619, 2007. ,
DOI : 10.1210/me.2007-0259
Telomere Erosion and Senescence in Human Articular Cartilage Chondrocytes, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.79, issue.4, pp.172-181, 2001. ,
DOI : 10.2106/00004623-199704000-00022
URL : https://academic.oup.com/biomedgerontology/article-pdf/56/4/B172/9743169/B172.pdf
Aging, articular cartilage chondrocyte senescence and osteoarthritis, Biogerontology, vol.3, issue.5, pp.257-64, 2002. ,
DOI : 10.1023/A:1020185404126
Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development, Disease Models & Mechanisms, vol.5, issue.1, pp.73-82, 2011. ,
DOI : 10.1242/dmm.008128
Conversion of vascular endothelial cells into multipotent stem-like cells, Nature Medicine, vol.16, issue.12, pp.1400-1406, 2010. ,
DOI : 10.1038/nm.2252
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209716
Aggrecan, versican and type VI collagen are components of annular translamellar crossbridges in the intervertebral disc, European Spine Journal, vol.201, issue.Pt 2, pp.314-338, 2008. ,
DOI : 10.1177/002215540305101010
Regulation of circulating sclerostin levels by sex steroids in women and in men, Journal of Bone and Mineral Research, vol.148, issue.1, pp.27-34, 2011. ,
DOI : 10.1111/j.1365-2141.2009.08009.x
Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR-??2 transcription factor and TGF-??/BMP signaling pathways, Aging Cell, vol.92, issue.6, pp.379-89, 2004. ,
DOI : 10.1074/jbc.R100034200
Down-regulation of mTOR leads to up-regulation of osteoprotegerin in bone marrow cells, Biochemical and Biophysical Research Communications, vol.384, issue.1, pp.82-88, 2009. ,
DOI : 10.1016/j.bbrc.2009.04.084
Red and yellow marrow in the femur: age-related changes in appearance at MR imaging Expression of fi bronectin and TGF- beta1 mRNA and protein suggest altered regulation of extracellular matrix in degenerated disc tissue, Radiology Eur Spine J, vol.1759, issue.141, pp.219-242, 1990. ,
TNF-??-induced NF-??B signaling reverses age-related declines in VEGF induction and angiogenic activity in intervertebral disc tissues, Journal of Orthopaedic Research, vol.18, issue.2, pp.229-264, 2009. ,
DOI : 10.1038/bjc.1993.457
URL : http://onlinelibrary.wiley.com/doi/10.1002/jor.20727/pdf
Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast-mediated stimulation of mineralization, Journal of Cellular Biochemistry, vol.24, issue.8, pp.1901-1908, 2013. ,
DOI : 10.1038/nm.2793
URL : http://europepmc.org/articles/pmc3895454?pdf=render
Mineralization and collagen orientation throughout aging at the vertebral endplate in the human lumbar spine, Journal of Structural Biology, vol.184, issue.2, pp.310-330, 2013. ,
DOI : 10.1016/j.jsb.2013.08.011
Vascular calcification and bone disease: the calcification paradox, Trends in Molecular Medicine, vol.15, issue.9, pp.405-421, 2009. ,
DOI : 10.1016/j.molmed.2009.07.001
Erratum: Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-??, Nature, vol.272, issue.6993, pp.771-777, 2004. ,
DOI : 10.1074/jbc.272.3.2013
URL : http://europepmc.org/articles/pmc2820247?pdf=render
Multilineage Potential of Adult Human Mesenchymal Stem Cells, Science, vol.284, issue.5411, pp.143-150, 1999. ,
DOI : 10.1126/science.284.5411.143
Regulation of angiogenesis by hypoxia: role of the HIF system, Nature Medicine, vol.34, issue.6, pp.677-84, 2003. ,
DOI : 10.1146/annurev.genet.34.1.1
Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability, The Spine Journal, vol.15, issue.5, pp.1060-1069, 2015. ,
DOI : 10.1016/j.spinee.2015.02.003
URL : http://europepmc.org/articles/pmc4416992?pdf=render
Phenotypic characteristics of the nucleus pulposus: expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2, Cell and Tissue Research, vol.308, issue.3, pp.401-408, 2002. ,
DOI : 10.1007/s00441-002-0563-6
Endothelial Notch activity promotes angiogenesis and osteogenesis in bone, Nature, vol.68, issue.7492, pp.376-80, 2014. ,
DOI : 10.1679/aohc.68.371
Regulation of tissue morphogenesis by endothelial cell-derived signals, Trends in Cell Biology, vol.25, issue.3, pp.148-57, 2015. ,
DOI : 10.1016/j.tcb.2014.11.007
Intervertebral Disc Degeneration, The American Journal of Pathology, vol.164, issue.3, pp.915-939, 2004. ,
DOI : 10.1016/S0002-9440(10)63179-3
A Unitary Model for Involutional Osteoporosis: Estrogen Deficiency Causes Both Type I and Type II Osteoporosis in Postmenopausal Women and Contributes to Bone Loss in Aging Men, Journal of Bone and Mineral Research, vol.96, issue.5, pp.763-73, 1998. ,
DOI : 10.1111/j.1532-5415.1987.tb02308.x
Defining the phenotype of young healthy nucleus pulposus cells: Recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting, Journal of Orthopaedic Research, vol.196, issue.3, pp.283-93, 2015. ,
DOI : 10.1159/000332985
Biochemical and Structural Properties of the Cartilage End-Plate and its Relation to the Intervertebral Disc, Spine, vol.14, issue.2, pp.166-74, 1976. ,
DOI : 10.1097/00007632-198902000-00005
Matrix Metalloproteinases And Aggrecanase, Spine, vol.25, issue.23, pp.3005-3018, 1976. ,
DOI : 10.1097/00007632-200012010-00007
The effect of erythropoietin on bone, Acta Orthop, vol.85, pp.1-27, 2014. ,
Adipocyte differentiation from the inside out, Nature Reviews Molecular Cell Biology, vol.280, issue.12, pp.885-96, 2006. ,
DOI : 10.1074/jbc.M503885200
Interleukin-7 levels in synovial fluid increase with age and MMP-1 levels decrease with progression of osteoarthritis, Acta Orthopaedica, vol.7, issue.2, pp.59-64, 2012. ,
DOI : 10.1186/ar1499
, Autophagy and aging. Cell, vol.146, issue.5, pp.682-95, 2011.
Premature Vertebral Endplate Ossification and Mild Disc Degeneration in Mice After Inactivation of One Allele Belonging to the Col2a1 Gene for Type II Collagen, Spine, vol.26, issue.23, pp.2558-65, 2001. ,
DOI : 10.1097/00007632-200112010-00008
Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc, Nature Communications, vol.34, issue.1, p.1264, 2012. ,
DOI : 10.1097/BRS.0b013e3181a55705
Aging of mesenchymal stem cells, Ageing Research Reviews, vol.5, issue.1, pp.91-116, 2006. ,
DOI : 10.1016/j.arr.2005.10.001
Lubricin Distribution in the Human Intervertebral Disc, The Journal of Bone and Joint Surgery-American Volume, vol.91, issue.9, pp.2205-2217, 2009. ,
DOI : 10.2106/JBJS.H.01344
Measurement of PH and Ionic Composition of Pericellular Sites [and Discussion], Philosophical Transactions of the Royal Society B: Biological Sciences, vol.271, issue.912, pp.261-72, 1975. ,
DOI : 10.1098/rstb.1975.0050
Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells,, Bone, vol.33, issue.6, pp.919-945, 2003. ,
DOI : 10.1016/j.bone.2003.07.005
Morphometry of cytoplasmic components of mammalian articular chondrocytes and corneal keratocytes: species and zonal variations of mitochondria in relation to nutrition, J Anat, vol.175, pp.251-61, 1991. ,
Age-related changes in human bone marrow-derived mesenchymal stem cells: Consequences for cell therapies, Mechanisms of Ageing and Development, vol.129, issue.3, pp.163-73, 2008. ,
DOI : 10.1016/j.mad.2007.12.002
Growth of human intervertebral discs and vertebral bodies, J Anat, vol.120, pp.49-68, 1975. ,
Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells, Cellular and Molecular Life Sciences, vol.19, issue.9, pp.1779-92, 2013. ,
DOI : 10.1101/gad.1302105
Caspases: Enemies Within, Science, vol.281, issue.5381, pp.1312-1318, 1998. ,
DOI : 10.1126/science.281.5381.1312
Regulation of CCN2/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc: role of Smad and activator protein 1 signaling, Arthritis Rheum, vol.62, issue.7, pp.1983-92, 2010. ,
Hypoxia-inducible Factor (HIF)-1?? and CCN2 Form a Regulatory Circuit in Hypoxic Nucleus Pulposus Cells, Journal of Biological Chemistry, vol.62, issue.18, pp.12654-66, 2013. ,
DOI : 10.4161/cc.20717
Molecular regulation of CCN2 in the intervertebral disc: Lessons learned from other connective tissues, Matrix Biology, vol.32, issue.6, pp.298-306, 2013. ,
DOI : 10.1016/j.matbio.2013.03.006
Age-dependent alteration of TGF-?? signalling in osteoarthritis, Cell and Tissue Research, vol.24, issue.Suppl 2, pp.257-65, 2012. ,
DOI : 10.1359/jbmr.080901
Genetics, Nature, vol.35, issue.12, p.620, 2003. ,
DOI : 10.1515/9781400827503
Tumor Necrosis Factor-????? and Interleukin-1?????Dependent Matrix Metalloproteinase-3 Expression in Nucleus Pulposus Cells Requires Cooperative Signaling via Syndecan 4 and Mitogen-Activated Protein Kinase???NF-??B Axis, The American Journal of Pathology, vol.184, issue.9, pp.2560-72, 2014. ,
DOI : 10.1016/j.ajpath.2014.06.006
Effect of aging on cellular mechanotransduction, Ageing Research Reviews, vol.10, issue.1, pp.1-15, 2011. ,
DOI : 10.1016/j.arr.2009.11.002
Age-Related Increases of Macroautophagy and Chaperone-Mediated Autophagy in Rat Nucleus Pulposus, Connective Tissue Research, vol.120, issue.5, pp.472-480, 2011. ,
DOI : 10.1126/science.1166088
Modulation of NF-??B-dependent transcription and cell survival by the SIRT1 deacetylase, The EMBO Journal, vol.19, issue.12, pp.2369-80, 2004. ,
DOI : 10.1016/S1097-2765(02)00477-X
Factors influencing the oxygen concentration gradient from the synovial surface of articular cartilage to the cartilage-bone interface: A modeling study, Arthritis & Rheumatism, vol.14, issue.12, pp.3915-3939, 2004. ,
DOI : 10.1113/expphysiol.1995.sp003841