M. Adams, Biomechanics of back pain, Acupuncture in Medicine, vol.22, issue.4, pp.178-88, 2004.
DOI : 10.1136/aim.22.4.178

URL : http://aim.bmj.com/content/22/4/178.full.pdf

M. Alini, P. J. Roughley, J. Antoniou, T. Stoll, and M. Aebi, A biological approach to treating disc degeneration: not for today, but maybe for tomorrow, Eur Spine J, vol.11, issue.2, pp.215-220, 2002.
DOI : 10.1007/978-3-642-18508-3_24

URL : http://europepmc.org/articles/pmc3611567?pdf=render

M. Alini, S. M. Eisenstein, K. Ito, C. Little, A. A. Kettler et al., Are animal models useful for studying human disc disorders/degeneration?, European Spine Journal, vol.63, issue.Suppl 2, pp.2-19, 2008.
DOI : 10.1097/00007632-200511150-00023

URL : http://europepmc.org/articles/pmc2365516?pdf=render

I. T. Arkesteijn, L. A. Smolders, S. Spillekom, F. M. Riemers, E. Potier et al., Effect of coculturing canine notochordal, nucleus pulposus and mesenchymal stromal cells for intervertebral disc regeneration, Arthritis Research & Therapy, vol.31, issue.Suppl 4, p.60, 2015.
DOI : 10.1097/01.brs.0000216593.97157.dd

URL : https://arthritis-research.biomedcentral.com/track/pdf/10.1186/s13075-015-0569-6?site=arthritis-research.biomedcentral.com

M. C. Battié, T. Videman, J. Kaprio, L. E. Gibbons, K. Gill et al., The Twin Spine Study: Contributions to a changing view of disc degeneration???, The Spine Journal, vol.9, issue.1, pp.47-59, 2009.
DOI : 10.1016/j.spinee.2008.11.011

M. Bendtsen, C. E. Bunger, X. Zou, C. Foldager, and H. Jorgensen, Autologous Stem Cell Therapy Maintains Vertebral Blood Flow and Contrast Diffusion Through the Endplate in Experimental Intervertebral Disc Degeneration, Spine, vol.36, issue.6, pp.373-379, 1976.
DOI : 10.1097/BRS.0b013e3181dce34c

L. M. Benneker, G. Andersson, J. C. Iatridis, D. Sakai, R. Hartl et al., Cell therapy for intervertebral disc repair: advancing cell therapy from bench to clinics, European Cells and Materials, vol.27, pp.5-11, 2014.
DOI : 10.22203/eCM.v027sa02

URL : http://europepmc.org/articles/pmc5072777?pdf=render

N. Boos, S. Weissbach, H. Rohrbach, C. Weiler, K. F. Spratt et al., Classification of Age-Related Changes in Lumbar Intervertebral Discs, Spine, vol.27, issue.23, pp.2631-2675, 2002.
DOI : 10.1097/00007632-200212010-00002

W. Brinjikji, P. H. Luetmer, B. Comstock, B. W. Bresnahan, L. E. Chen et al., Systematic Literature Review of Imaging Features of Spinal Degeneration in Asymptomatic Populations, American Journal of Neuroradiology, vol.69, issue.4, pp.811-817, 2015.
DOI : 10.1097/BRS.0b013e31824b2450

E. J. Carragee, A. S. Don, E. L. Hurwitz, J. M. Cuellar, J. A. Carrino et al., 2009 ISSLS Prize Winner: Does Discography Cause Accelerated Progression of Degeneration Changes in the Lumbar Disc, Spine, vol.34, issue.21, pp.2338-2383, 1976.
DOI : 10.1097/BRS.0b013e3181ab5432

S. P. Cohen, N. Bogduk, A. Dragovich, C. C. Buckenmaier, I. Griffi-th et al., Randomized, Double-blind, Placebo-controlled, Dose-response, and Preclinical Safety Study of Transforaminal Epidural Etanercept for the Treatment of Sciatica, Anesthesiology, vol.110, issue.5, pp.1116-1142, 2009.
DOI : 10.1097/ALN.0b013e3181a05aa0

D. H. Cortes, N. T. Jacobs, J. F. Delucca, and D. Elliott, Elastic, permeability and swelling properties of human intervertebral disc tissues: A benchmark for tissue engineering, Journal of Biomechanics, vol.47, issue.9, pp.2088-94, 2014.
DOI : 10.1016/j.jbiomech.2013.12.021

C. L. Dahia, E. Mahoney, and C. Wylie, Shh Signaling from the Nucleus Pulposus Is Required for the Postnatal Growth and Differentiation of the Mouse Intervertebral Disc, PLoS ONE, vol.33, issue.23, p.35944, 2012.
DOI : 10.1371/journal.pone.0035944.s004

D. R. Eyre, B. Caterson, P. Benya, D. Heinegard, T. R. Oegema et al., The intervertebral disc In: New Perspectives on Low Back Pain, Am Inst Orthop Surg, pp.147-209, 1991.

H. Feng, M. Danfelter, B. Stromqvist, and D. Heinegard, Extracellular matrix in disc degeneration, J Bone Joint Surg Am, vol.88, issue.2, pp.25-34, 2006.

B. J. Freeman, G. L. Ludbrook, S. Hall, M. Cousins, B. Mitchell et al., Randomized, Double-blind, Placebo-Controlled, Trial of Transforaminal Epidural Etanercept for the Treatment of Symptomatic Lumbar Disc Herniation, Spine, vol.38, issue.23, pp.1986-94, 1976.
DOI : 10.1097/01.brs.0000435140.61593.4c

R. Freynhagen and R. Baron, The evaluation of neuropathic components in low back pain, Current Pain and Headache Reports, vol.22, issue.Suppl24, pp.185-190, 2009.
DOI : 10.1155/2007/730785

F. Galbusera, R. M. Van, K. Ito, J. M. Huyghe, M. Brayda-bruno et al., Ageing and degenerative changes of the intervertebral disc and their impact on spinal fl exibility, Eur Spine J, vol.23, issue.3, pp.324-332, 2014.

H. E. Gruber, F. E. Riley, G. L. Hoelscher, J. A. Ingram, L. Bullock et al., Human annulus progenitor cells: Analyses of this viable endogenous cell population, Journal of Orthopaedic Research, vol.26, issue.8, pp.1351-60, 2016.
DOI : 10.1080/08977190802273814

T. Grunhagen, A. Fairbank, J. C. Urban, and J. , Intervertebral Disk Nutrition: A Review of Factors Influencing Concentrations of Nutrients and Metabolites, Orthopedic Clinics of North America, vol.42, issue.4, pp.465-77, 2011.
DOI : 10.1016/j.ocl.2011.07.010

H. Henriksson, M. Thornemo, C. Karlsson, O. Hagg, K. Junevik et al., Identification of Cell Proliferation Zones, Progenitor Cells and a Potential Stem Cell Niche in the Intervertebral Disc Region, Spine, vol.34, issue.21, pp.2278-87, 1976.
DOI : 10.1097/BRS.0b013e3181a95ad2

E. B. Hunziker, K. Lippuner, M. J. Keel, and N. Shintani, An educational review of cartilage repair: precepts & practice ??? myths & misconceptions ??? progress & prospects, Osteoarthritis and Cartilage, vol.23, issue.3, pp.334-50, 2015.
DOI : 10.1016/j.joca.2014.12.011

R. Kandel, S. Roberts, and J. Urban, Tissue engineering and the intervertebral disc: the challenges, European Spine Journal, vol.13, issue.12, pp.480-491, 2008.
DOI : 10.3109/ort.1960.31.suppl-43.01

URL : http://europepmc.org/articles/pmc2587666?pdf=render

D. Kletsas, Senescent cells in the intervertebral disc: numbers and mechanisms, The Spine Journal, vol.9, issue.8, pp.677-685, 2009.
DOI : 10.1016/j.spinee.2009.05.016

N. Kregar-velikonja, J. Urban, M. Frohlich, C. Neidlinger-wilke, D. Kletsas et al., Cell sources for nucleus pulposus regeneration, European Spine Journal, vol.3, issue.Suppl 2, pp.364-374, 2014.
DOI : 10.1038/ncomms2226

G. Lyons, S. M. Eisenstein, and M. Sweet, Biochemical changes in intervertebral disc degeneration, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.673, issue.4, pp.443-53, 1981.
DOI : 10.1016/0304-4165(81)90476-1

H. J. Meisel, T. Ganey, W. C. Hutton, J. Libera, Y. Minkus et al., Clinical experience in cell-based therapeutics: intervention and outcome, European Spine Journal, vol.170, issue.8, pp.397-405, 2006.
DOI : 10.1097/00003086-197711000-00012

J. Mochida, D. Sakai, Y. Nakamura, T. Watanabe, Y. Yamamoto et al., Intervertebral disc repair with activated nucleus pulposus cell transplantation: a three-year, prospective clinical study of its safety, European Cells and Materials, vol.29, pp.202-214, 2015.
DOI : 10.22203/eCM.v029a15

M. Molinos, C. R. Almeida, R. M. Goncalves, and M. Barbosa, Improvement of bovine nucleus pulposus cells Isolation leads to identifi cation of three phenotypically distinct cell subpopulations, Tissue Eng Part A, vol.21, pp.15-16, 2015.

M. G. Muriuki, R. M. Havey, L. I. Voronov, G. Carandang, M. R. Zindrick et al., Effects of motion segment level, Pfi rrmann intervertebral disc degeneration grade and gender on lumbar spine kinematics, J Orthop Res, vol.2016, issue.8, pp.34-1389

Y. S. Nosikova, J. P. Santerre, M. Grynpas, G. Gibson, and R. A. Kandel, Characterization of the annulus fibrosus-vertebral body interface: identification of new structural features, Journal of Anatomy, vol.141, issue.Suppl 2, pp.577-89, 2012.
DOI : 10.1016/S1047-8477(02)00635-4

L. Orozco, R. Soler, C. Morera, M. Alberca, A. Sanchez et al., Intervertebral Disc Repair by Autologous Mesenchymal Bone Marrow Cells: A Pilot Study, Transplantation, vol.92, issue.7, pp.822-828, 2011.
DOI : 10.1097/TP.0b013e3182298a15

URL : http://pdfs.journals.lww.com/transplantjournal/2011/10150/Intervertebral_Disc_Repair_by_Autologous.20.pdf?token=method|ExpireAbsolute;source|Journals;ttl|1506619112970;payload|mY8D3u1TCCsNvP5E421JYK6N6XICDamxByyYpaNzk7FKjTaa1Yz22MivkHZqjGP4kdS2v0J76WGAnHACH69s21Csk0OpQi3YbjEMdSoz2UhVybFqQxA7lKwSUlA502zQZr96TQRwhVlocEp/sJ586aVbcBFlltKNKo+tbuMfL73hiPqJliudqs17cHeLcLbV/CqjlP3IO0jGHlHQtJWcICDdAyGJMnpi6RlbEJaRheGeh5z5uvqz3FLHgPKVXJzdGlb2qsojlvlytk14LkMXSGRX/5sS/KgYjFrnu5Wqy/9UhU+3E9A1TVBAf3/Gy5fi;hash|AgeDj5U652xsXHv7K72TmA==

G. Pattappa, Z. Li, M. Peroglio, N. Wismer, M. Alini et al., Diversity of intervertebral disc cells: phenotype and function, Journal of Anatomy, vol.6, issue.Suppl 3, pp.480-96, 2012.
DOI : 10.1016/j.arr.2007.08.001

URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1469-7580.2012.01521.x/pdf

M. Peroglio, D. Eglin, L. M. Benneker, M. Alini, and S. Grad, Thermoreversible hyaluronan-based hydrogel supports in??vitro and ex??vivo disc-like differentiation of human mesenchymal stem cells, The Spine Journal, vol.13, issue.11, pp.1627-1666, 2013.
DOI : 10.1016/j.spinee.2013.05.029

K. A. Pettine, M. B. Murphy, R. K. Suzuki, and T. Sand, Percutaneous Injection of Autologous Bone Marrow Concentrate Cells Significantly Reduces Lumbar Discogenic Pain Through 12 Months, STEM CELLS, vol.22, issue.1, pp.146-56, 2015.
DOI : 10.3122/jabfm.2009.01.080102

URL : http://onlinelibrary.wiley.com/doi/10.1002/stem.1845/pdf

C. A. Pezowicz, P. A. Robertson, and N. Broom, The structural basis of interlamellar cohesion in the intervertebral disc wall, Journal of Anatomy, vol.68, issue.3, pp.317-347, 2006.
DOI : 10.1046/j.1469-7580.2002.00111.x

C. W. Pfi-rrmann, A. Metzdorf, M. Zanetti, J. Hodler, and N. Boos, Magnetic Resonance Classification of Lumbar Intervertebral Disc Degeneration, Spine, vol.26, issue.17, pp.1873-1881, 2001.
DOI : 10.1097/00007632-200109010-00011

A. J. Pockert, S. M. Richardson, L. Maitre, C. L. Lyon, M. Deakin et al., Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration, Arthritis & Rheumatism, vol.11, issue.Pt 6, pp.482-91, 2009.
DOI : 10.1016/S0167-4838(99)00279-4

M. V. Risbud and I. Shapiro, Role of cytokines in intervertebral disc degeneration: pain and disc content, Nature Reviews Rheumatology, vol.23, issue.1, pp.44-56, 2014.
DOI : 10.1007/s00586-009-0940-x

M. V. Risbud, E. Schipani, and I. Shapiro, Hypoxic Regulation of Nucleus Pulposus Cell Survival, The American Journal of Pathology, vol.176, issue.4, pp.1577-1583, 2010.
DOI : 10.2353/ajpath.2010.090734

URL : http://europepmc.org/articles/pmc2843446?pdf=render

M. V. Risbud, Z. R. Schoepfl-in, F. Mwale, R. A. Kandel, S. Grad et al., Defi ning the phenotype of young healthy nucleus pulposus cells: Recommendations of the Spine Research Interest Group at the 2014

O. Annual and . Meeting, J Orthop Res, vol.33, issue.3, pp.283-93, 2015.

S. Roberts, B. Caterson, J. Menage, E. H. Evans, D. C. Jaffray et al., Matrix Metalloproteinases And Aggrecanase, Spine, vol.25, issue.23, pp.3005-3018, 2000.
DOI : 10.1097/00007632-200012010-00007

S. Roberts, H. Evans, J. Trivedi, and J. Menage, Histology and pathology of the human intervertebral disc, J Bone Joint Surg Am, vol.88, issue.2, pp.10-14, 2006.

D. Sakai and G. Andersson, Stem cell therapy for intervertebral disc regeneration: obstacles and solutions, Nature Reviews Rheumatology, vol.27, issue.4, pp.243-256, 2015.
DOI : 10.1038/ncomms2226

D. Sakai and S. Grad, Advancing the cellular and molecular therapy for intervertebral disc disease, Advanced Drug Delivery Reviews, vol.84, pp.159-171, 2015.
DOI : 10.1016/j.addr.2014.06.009

D. Sakai, Y. Nakamura, T. Nakai, T. Mishima, S. Kato et al., Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc, Nature Communications, vol.34, issue.1, p.1264, 2012.
DOI : 10.1097/BRS.0b013e3181a55705

S. M. Schabrun, E. L. Elgueta-cancino, and P. Hodges, Smudging of the Motor Cortex Is Related to the Severity of Low Back Pain, SPINE, vol.42, issue.15
DOI : 10.1097/BRS.0000000000000938

S. Sivan, Y. Merkher, E. Wachtel, S. Ehrlich, and A. Maroudas, Correlation of swelling pressure and intrafibrillar water in young and aged human intervertebral discs, Journal of Orthopaedic Research, vol.4, issue.6, pp.1292-1300, 2006.
DOI : 10.1016/0005-2795(80)90129-4

S. S. Sivan, A. J. Hayes, E. Wachtel, B. Caterson, Y. Merkher et al., Biochemical composition and turnover of the extracellular matrix of the normal and degenerate intervertebral disc, European Spine Journal, vol.278, issue.Suppl 2, pp.344-353, 2014.
DOI : 10.1074/jbc.M302431200

S. S. Sivan, E. Wachtel, and P. Roughley, Structure, function, aging and turnover of aggrecan in the intervertebral disc, Biochimica et Biophysica Acta (BBA) - General Subjects, vol.1840, issue.10, pp.3181-3190, 2014.
DOI : 10.1016/j.bbagen.2014.07.013

R. Stockwell, The inter-relationship of cell density and cartilage thickness in mammalian articular cartilage, J Anat, vol.109, pp.411-433, 1971.

T. Takeda, Three-dimensional observations of collagen framework of human lumbar discs, J Japan Orthop Assoc, vol.49, pp.45-57, 1975.

K. Takeno, S. Kobayashi, K. Negoro, K. Uchida, T. Miyazaki et al., Physical limitations to tissue engineering of intervertebral disc cells: effect of extracellular osmotic change on glycosaminoglycan production and cell metabolism, Journal of Neurosurgery: Spine, vol.586, issue.3, pp.637-681, 2007.
DOI : 10.1097/01.brs.0000146499.97948.52

A. A. Thorpe, A. L. Binch, L. B. Creemers, C. Sammon, L. Maitre et al., Nucleus pulposus phenotypic markers to determine stem cell differentiation: fact or fiction?, Oncotarget, vol.7, issue.3, pp.2189-200, 2016.
DOI : 10.18632/oncotarget.6782

M. Tibiletti, V. N. Kregar, J. P. Urban, and J. Fairbank, Disc cell therapies: critical issues, European Spine Journal, vol.79, issue.1, pp.375-384, 2014.
DOI : 10.1016/S0165-0270(97)00171-4

J. P. Urban and S. Roberts, Development and degeneration of the intervertebral discs, Molecular Medicine Today, vol.1, issue.7, pp.329-364, 1995.
DOI : 10.1016/S1357-4310(95)80032-8

B. Van-dijk, E. Potier, D. M. Van, M. Langelaan, N. Papen-botterhuis et al., Reduced tonicity stimulates an inflammatory response in nucleus pulposus tissue that can be limited by a COX-2-specific inhibitor, Journal of Orthopaedic Research, vol.22, issue.11, pp.1724-1755, 2015.
DOI : 10.1097/00007632-199608150-00004

URL : https://hal.archives-ouvertes.fr/hal-01758572

V. Forell, G. A. Stephens, T. K. Samartzis, D. Bowden, and A. , Low Back Pain, Spine, vol.40, issue.15, pp.1165-1172, 1976.
DOI : 10.1097/BRS.0000000000000982

N. Willems, H. Y. Yang, M. L. Langelaan, A. R. Tellegen, G. C. Grinwis et al., Biocompatibility and intradiscal application of a thermoreversible celecoxib-loaded poly-N-isopropylacrylamide MgFe-layered double hydroxide hydrogel in a canine model, Arthritis Research & Therapy, vol.473, issue.1, p.214, 2015.
DOI : 10.1007/s11999-014-3774-8

T. Yoshikawa, Y. Ueda, K. Miyazaki, M. Koizumi, and Y. Takakura, Disc Regeneration Therapy Using Marrow Mesenchymal Cell Transplantation, Spine, vol.35, issue.11, pp.475-480, 1976.
DOI : 10.1097/BRS.0b013e3181cd2cf4

R. Yu, R. L. Gollub, R. Spaeth, V. Napadow, A. Wasan et al., Disrupted functional connectivity of the periaqueductal gray in chronic low back pain, NeuroImage: Clinical, vol.6, pp.100-108, 2014.
DOI : 10.1016/j.nicl.2014.08.019

J. Yu, M. L. Schollum, K. R. Wade, N. D. Broom, and J. Urban, ISSLS Prize Winner, Spine, vol.40, issue.15, pp.1149-57, 1976.
DOI : 10.1097/BRS.0000000000000943

Y. Zeng, C. Chen, W. Liu, Q. Fu, Z. Han et al., Injectable microcryogels reinforced alginate encapsulation of??mesenchymal stromal cells for leak-proof delivery and??alleviation??of??canine disc degeneration, Biomaterials, vol.59, pp.53-65, 2015.
DOI : 10.1016/j.biomaterials.2015.04.029

D. Bendtsen and . Indd, , p.46

D. Bendtsen,