Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics

Peter Ratcliffe 1, 2 Peppi Koivunen 3 Johanna Myllyharju 3 Jiannis Ragoussis 4 Judith Bovée 5 Ines Batinic-Haberle 6 Claire Vinatier 7, 8 Valérie Trichet 9 Florence Robriquet 10 Lisa Oliver 10 Betty Gardie 10, 11, *
* Corresponding author
1 TDI - Target Discovery Institute [Oxford, UK]
2 The Francis Crick Institute
3 Oulu Center for Cell-Matrix Research [Oulu, Finland]
4 Genome Quebec Innovation Centre [Montréal, Canada]
5 Department of Pathology [Leiden, The Netherlands]
6 Department of Radiation Oncology [Durham, NC, USA]
7 Université de Nantes - UFR Odontologie
8 Inserm U1229 - RMeS - Team STEP “Skeletal physiopathology and joint regenerative medicine”
RMeS - Regenerative Medicine and Skeleton research lab
9 INSERM U1238 - Sarcomes osseux et remodelage des tissus calcifiés - Phy-Os [Nantes]
10 CRCINA - Centre de recherche de Cancérologie et d'Immunologie / Nantes - Angers
11 EPHE - École pratique des hautes études
Abstract : The " Hypoxia Nantes 2016 " organized its second conference dedicated to the field of hypoxia research. This conference focused on " the role of hypoxia under physiological conditions as well as in cancer " and took place in Nantes, France, in October 6–7, 2016. The main objective of this conference was to bring together a large group of scientists from different spheres of hypoxia. Recent advances were presented and discussed around different topics: genomics, physiology, musculoskeletal, stem cells, microenvironment and cancer, and oxidative stress. This review summarizes the major highlights of the meeting.
Keywords : cancer oxidative stress musculoskeletal hypoxia genomics lipid metabolism
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Peter Ratcliffe, Peppi Koivunen, Johanna Myllyharju, Jiannis Ragoussis, Judith Bovée, et al.. Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics. Hypoxia, DovePress, 2017, 5, pp.11 - 20. ⟨10.2147/HP.S127042⟩. ⟨inserm-01845039⟩

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