V. Wylde, Preoperative widespread pain sensitization and chronic pain after hip and knee replacement, PAIN, vol.156, issue.1, pp.47-54, 2015.
DOI : 10.1016/j.pain.0000000000000002

D. Fletcher, An exploratory study of the long-term impact of difficulty kneeling after total knee replacement, Disability and Rehabilitation, vol.27, pp.1-6, 2017.
DOI : 10.1371/journal.pone.0149306

V. Wylde, Systematic review of management of chronic pain after surgery, British Journal of Surgery, vol.343, issue.9, pp.1293-1306, 2017.
DOI : 10.1136/bmj.d5928

V. Wylde, Clinical- and cost-effectiveness of the STAR care pathway compared to usual care for patients with chronic pain after total knee replacement: study protocol for a UK randomised controlled trial, Trials, vol.82, issue.1, p.132, 2018.
DOI : 10.1212/01.wnl.0000438226.10353.1c

S. Sunderland, Regional Versus General Anesthesia and the Incidence of Unplanned Health Care Resource Utilization for Postoperative Pain After Wrist Fracture Surgery, Regional Anesthesia and Pain Medicine, vol.41, issue.1, pp.22-27, 2016.
DOI : 10.1097/AAP.0000000000000325

J. W. Barrington, Efficacy of periarticular injection with a long-acting local analgesic in joint arthroplasty, Am. J. Orthop, vol.44, pp.13-16, 2015.

C. H. King, Pharmacologic Properties of Novel Local Anesthetic Agents in Anesthesia Practice, Anesthesiology Clinics, vol.35, issue.2, pp.315-325, 2017.
DOI : 10.1016/j.anclin.2017.01.019

J. Golembiewski and J. Dasta, Evolving Role of Local Anesthetics in Managing Postsurgical Analgesia, Clinical Therapeutics, vol.37, issue.6, pp.1354-1371, 2015.
DOI : 10.1016/j.clinthera.2015.03.017

P. Lirk, Local anaesthetics, European Journal of Anaesthesiology, vol.31, issue.11, pp.575-585, 2014.
DOI : 10.1097/EJA.0000000000000137

T. Stueber, Quaternary Lidocaine Derivative QX-314 Activates and Permeates Human TRPV1 and TRPA1 to Produce Inhibition of Sodium Channels and Cytotoxicity, Anesthesiology, vol.124, issue.5, pp.1153-1165, 2016.
DOI : 10.1097/ALN.0000000000001050

M. Kuang, Is Adductor Canal Block Better Than Femoral Nerve Block in Primary Total Knee Arthroplasty? A GRADE Analysis of the Evidence Through a Systematic Review and Meta-Analysis, The Journal of Arthroplasty, vol.32, issue.10, pp.3238-3248, 2017.
DOI : 10.1016/j.arth.2017.05.015

J. Kuchálik, Implication, Scandinavian Journal of Pain, vol.6, issue.1, pp.223-230, 2017.
DOI : 10.1080/17453670710014950

B. Schmidt, Local Pathology and Systemic Serum Bupivacaine After Subcutaneous Delivery of Slow-Releasing Bupivacaine Microspheres, Anesthesia & Analgesia, vol.120, issue.1, pp.36-44, 2015.
DOI : 10.1213/ANE.0000000000000507

Z. Wang, Long-term effect of ropivacaine nanoparticles for sciatic nerve block on postoperative pain in rats, Int. J. Nanomed, vol.11, pp.2081-2090, 2016.

P. Ma, Local anesthetic effects of bupivacaine loaded lipid-polymer hybrid nanoparticles: In vitro and in vivo evaluation, Biomedicine & Pharmacotherapy, vol.89, pp.689-695, 2017.
DOI : 10.1016/j.biopha.2017.01.175

J. Wang, An alternative choice of lidocaine-loaded liposomes: lidocaine-loaded lipid???polymer hybrid nanoparticles for local anesthetic therapy, Drug Delivery, vol.9, issue.4, pp.1254-1260, 2016.
DOI : 10.1021/nn800275r

J. B. Mcalvin, Multivesicular liposomal bupivacaine at the sciatic nerve, Biomaterials, vol.35, issue.15, pp.4557-4564, 2014.
DOI : 10.1016/j.biomaterials.2014.02.015

J. Portillo, Safety of liposome extended-release bupivacaine for postoperative pain control, Frontiers in Pharmacology, vol.36, issue.45, p.90, 2014.
DOI : 10.1097/AAP.0b013e318228c835

D. C. Rice, Posterior Intercostal Nerve Block With Liposomal Bupivacaine: An Alternative to Thoracic Epidural Analgesia, The Annals of Thoracic Surgery, vol.99, issue.6, 1953.
DOI : 10.1016/j.athoracsur.2015.02.074

B. M. Ilfeld, Safety and Side Effect Profile of Liposome Bupivacaine (Exparel) in Peripheral Nerve Blocks, Regional Anesthesia and Pain Medicine, vol.40, issue.5, pp.572-582, 2015.
DOI : 10.1097/AAP.0000000000000283

, 21

S. Liu, Comparison of periarticular anesthesia with liposomal bupivacaine with femoral nerve block for pain control after total knee arthroplasty, Medicine, vol.96, issue.13, pp.1-10, 2016.
DOI : 10.1097/MD.0000000000006462

A. Y. Rwei, Prolonged Duration Local Anesthesia Using Liposomal Bupivacaine Combined With Liposomal Dexamethasone and Dexmedetomidine, Anesthesia & Analgesia, vol.126, issue.4, pp.1170-1175, 2018.
DOI : 10.1213/ANE.0000000000002719

J. M. Bouler, Biphasic calcium phosphate ceramics for bone reconstruction: A review of biological response, Acta Biomaterialia, vol.53, pp.1-12, 2017.
DOI : 10.1016/j.actbio.2017.01.076

URL : https://hal.archives-ouvertes.fr/inserm-01856253

E. Verron, Controlling the biological function of calcium phosphate bone substitutes with drugs, Acta Biomaterialia, vol.8, issue.10, pp.3541-3551, 2012.
DOI : 10.1016/j.actbio.2012.06.022

URL : https://hal.archives-ouvertes.fr/hal-02140529

E. Verron, Calcium phosphate biomaterials as bone drug delivery systems: a review, Drug Discovery Today, vol.15, issue.13-14, pp.547-552, 2010.
DOI : 10.1016/j.drudis.2010.05.003

URL : https://hal.archives-ouvertes.fr/hal-02142555

E. Verron, Analgesic properties of calcium phosphate apatite loaded with bupivacaine on postoperative pain, Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol.50, pp.89-96, 2010.
DOI : 10.1002/jbm.a.30456

URL : https://hal.archives-ouvertes.fr/hal-02142556

Z. Irbe, Controlled release of local anesthetic from calcium phosphate bone cements, Materials Science and Engineering: C, vol.32, issue.6, pp.1690-1694, 2012.
DOI : 10.1016/j.msec.2012.04.069

, TCP cements. J. Mater. Sci. Biomater, vol.53, pp.7112-7124

M. Dupleichs, Pain Management After Bone Reconstruction Surgery Using an Analgesic Bone Cement: A Functional Noninvasive In Vivo Study Using Gait Analysis, The Journal of Pain, vol.doi, 2018.
DOI : 10.1016/j.jpain.2018.04.014

URL : https://hal.archives-ouvertes.fr/inserm-01848181

A. Y. Rwei, Multiply repeatable and adjustable on-demand phototriggered local anesthesia, Journal of Controlled Release, vol.251, pp.68-74, 2017.
DOI : 10.1016/j.jconrel.2017.01.031

URL : http://europepmc.org/articles/pmc5394744?pdf=render

C. Zhan, Phototriggered Local Anesthesia, Nano Letters, vol.16, issue.1, pp.177-181, 2016.
DOI : 10.1021/acs.nanolett.5b03440

C. Zhan, Ultrasensitive Phototriggered Local Anesthesia, Nano Letters, vol.17, issue.2, pp.660-665, 2017.
DOI : 10.1021/acs.nanolett.6b03588

URL : http://europepmc.org/articles/pmc5469101?pdf=render

A. Y. Rwei, Repeatable and adjustable on-demand sciatic nerve block with phototriggerable liposomes, Proceedings of the National Academy of Sciences, vol.112, pp.15719-15724, 2015.
DOI : 10.1073/pnas.1518791112

URL : https://www.pnas.org/content/pnas/112/51/15719.full.pdf

C. M. Schoellhammer, Defining optimal permeant characteristics for ultrasound-mediated gastrointestinal delivery, Journal of Controlled Release, vol.268, pp.113-119, 2017.
DOI : 10.1016/j.jconrel.2017.10.023

C. Fan, Drug-loaded bubbles with matched focused ultrasound excitation for concurrent blood???brain barrier opening and brain-tumor drug delivery, Acta Biomaterialia, vol.15, pp.89-101, 2015.
DOI : 10.1016/j.actbio.2014.12.026

A. Y. Rwei, Ultrasound-triggered local anaesthesia, Nature Biomedical Engineering, vol.35, issue.8, pp.644-653, 2017.
DOI : 10.1016/j.biomaterials.2014.02.015

URL : http://europepmc.org/articles/pmc5687284?pdf=render

W. Rangsimawong, Influence of sonophoresis on transdermal drug delivery of hydrophilic compound-loaded lipid nanocarriers, Pharmaceutical Development and Technology, vol.95, issue.4, pp.597-605, 2017.
DOI : 10.1016/j.jconrel.2005.01.005

K. Cullion, Ultrasound-triggered liposomes for on-demand local anesthesia, Therapeutic Delivery, vol.11, issue.6, pp.5-8, 2018.
DOI : 10.1016/j.jconrel.2017.01.031

K. Cullion, High-frequency, low-intensity ultrasound and microbubbles enhance nerve blockade, Journal of Controlled Release, vol.276, pp.150-156, 2018.
DOI : 10.1016/j.jconrel.2018.02.027

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894346

F. F. Cruz, Anti-inflammatory properties of anesthetic agents, Critical Care, vol.2, issue.2, p.67, 2017.
DOI : 10.1016/S0140-6736(83)90043-0

S. Picardi, Local Anesthetic???Induced Inhibition of Human Neutrophil Priming, Regional Anesthesia and Pain Medicine, vol.38, issue.1, pp.9-15, 2013.
DOI : 10.1097/AAP.0b013e31827a3cbe

M. Burbridge and R. A. Jaffe, Exparel??, Anesthesia & Analgesia, vol.121, issue.4, pp.1113-1114, 2015.
DOI : 10.1213/ANE.0000000000000822

¨. Gergin and O. ¨. , Comparison of the Myotoxic Effects of Levobupivacaine, Bupivacaine, and Ropivacaine: An Electron Microscopic Study, Ultrastructural Pathology, vol.30, issue.3, pp.169-176, 2015.
DOI : 10.1046/j.1365-2044.1998.00632.x

C. Sung, Cytotoxic Effects of Ropivacaine, Bupivacaine, and Lidocaine on Rotator Cuff Tenofibroblasts, The American Journal of Sports Medicine, vol.173, issue.4, pp.2888-2896, 2014.
DOI : 10.1097/00115550-200407000-00007

X. Cai, Comparison of toxicity effects of ropivacaine, bupivacaine, and lidocaine on rabbit intervertebral disc cells in??vitro, The Spine Journal, vol.14, issue.3, pp.483-490, 2014.
DOI : 10.1016/j.spinee.2013.06.041

Y. Lee, Nerve conduction block in diabetic rats using high-intensity focused ultrasound for analgesic applications, British Journal of Anaesthesia, vol.114, issue.5, pp.840-846, 2015.
DOI : 10.1093/bja/aeu443

D. Brajkovic, Levobupivacaine vs. bupivacaine for third molar surgery: quality of anaesthesia, postoperative analgesia and local vascular effects, Clinical Oral Investigations, vol.26, issue.5, pp.1481-1488, 2014.
DOI : 10.1053/rapm.2001.19883

G. Villatte, Effect of local anaesthetic wound infiltration on acute pain and bleeding after primary total hip arthroplasty: the EDIPO randomised controlled study, International Orthopaedics, vol.36, issue.11, pp.2255-2260, 2016.
DOI : 10.1007/s00264-012-1623-5

N. Abu-mostafa, Hemodynamic changes following injection of local anesthetics with different concentrations of epinephrine during simple tooth extraction: A prospective randomized clinical trial, Journal of Clinical and Experimental Dentistry, vol.7, pp.471-476, 2015.
DOI : 10.4317/jced.52321

P. Kaur, Comparing hemodynamic and glycemic response to local anesthesia with epinephrine and without epinephrine in patients undergoing tooth extractions, National Journal of Maxillofacial Surgery, vol.7, issue.2, pp.166-172, 2016.
DOI : 10.4103/0975-5950.201370

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357929/pdf

S. H. Hashemi, Comparative Assessment of the Effects of Three Local Anesthetics: Lidocaine, Prilocaine, and Mepivacaine on Blood Pressure Changes in Patients with Controlled Hypertension, Global Journal of Health Science, vol.8, issue.10, p.54157, 2016.
DOI : 10.5539/gjhs.v8n10p227

T. Wu, Cytotoxicity of Local Anesthetics in Mesenchymal Stem Cells, American Journal of Physical Medicine & Rehabilitation, vol.97, issue.1, pp.50-55, 2018.
DOI : 10.1097/PHM.0000000000000837

C. Herencia, Procaine Inhibits Osteo/Odontogenesis through Wnt/??-Catenin Inactivation, PLOS ONE, vol.29, issue.7, 2016.
DOI : 10.1371/journal.pone.0156788.s001

URL : https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0156788&type=printable

A. Breu, Local anesthetic cytotoxicity on human mesenchymal stem cells during chondrogenic differentiation, Knee Surgery, Sports Traumatology, Arthroscopy, vol.27, issue.Suppl 2, pp.937-945, 2015.
DOI : 10.2165/00002018-200427140-00003

A. Gulihar, Articular cartilage and local anaesthetic: A systematic review of the current literature, Journal of Orthopaedics, vol.12, pp.200-210, 2015.
DOI : 10.1016/j.jor.2015.10.005