Effectiveness of Montelukast on asthma control in infants: methodology of a French claims data study

Abstract : Background: This pilot study, conducted on a 1/97th representative sample of French claims data, prepared a project to assess the effectiveness of Montelukast (MTL-4) as add-on therapy for asthma in infants (6–24 months) compared to inhaled corticosteroids (ICS), based on real-world data. Due to the very recent opening of French claims data for effectiveness research, and the complex structure of this data source, we first tested the feasibility of identifying infants with asthma and outcome criteria, and the ability to perform relevant comparisons. Methods: We identified a cohort of infants with uncontrolled asthma and receiving ≥2 consecutive dispensations of any respiratory drug (R03 ATC classification) during a 6-month period. Uncontrolled asthma was identified either from exacerbations or from markers of acute loss of asthma control; date of occurrence of an event (exacerbation and/or acute loss of asthma control) was defined as index date. The study groups comprised infants receiving MTL-4 +/− ICS (MTL-4 group) or ICS without MTL-4 (ICS group) at index date. These two groups were matched on gender, age, quarter of index date, therapy before index date, past asthma-related hospitalization (ever), and were followed for 6 months. The outcome was the rate of infants with uncontrolled asthma, defined as above.
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Manon Belhassen, Gérard de Pouvourville, Laurent Laforest, Jacques Brouard, Jacques de Blic, et al.. Effectiveness of Montelukast on asthma control in infants: methodology of a French claims data study. BMC Pulmonary Medicine, BioMed Central, 2015, 15 (1), pp.51. ⟨10.1186/s12890-015-0047-6⟩. ⟨inserm-01840484⟩

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